MIT Technology Review article about our research on human embryo models in this day & age. I didn't agree to interview because what i find as over-sensational writing style & i disagree with several things.. BUT Antonio managed to put together an interesting mix of events and ideas worth reading.

Last day of intense science discussions and presentations at the HFSP Science Summit Japan was held in Kyoto university. It has been an amazing 5 days of listening to great scientists from Japan and all over the world. An unforgettable visit.

Thanks to Leqian Yu and co and @cp-cellstemcell.bsky.social for highlighting recent work, including ours, on transgene free mouse high fidelity post gastrulation SEMs www.cell.com/cell-stem-ce...

Another great day in Japan science summit with Intriguing science and science policy discussions at University of Tokyo.

Finally .. incredible much awaited wok on deriving avian naive ESCs “Derivation of embryonic stem cells across avian species” www.nature.com/articles/s41...

This was a real fun event!

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026. Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open - w.molgen.mpg.de/embryo2026

Having fun @amartinezarias.bsky.social party! 🙏🏻🎉💐 Great meeting #InHoxWeSortOfTrust

🧪 HFSP & partners present Science Summit Japan 2025! 🗓️Oct 1–4 📍Tohoku University, RIKEN, UThe University of Tokyo & Kyoto University. ✨ Nobel Laureates, HFSP Nakasone Awardees & top researchers engaging with young scientists. More info 👉https://bit.ly/45WGRWM

Shout out re @isscr.org awards nomination deadline SEP 30 2025! Please note the great revision & efforts that have been made to recognize excellence in industry, policy makers, clinical translation etc & from across the globe. Self-nominations are equally welcomed! www.isscr.org/awards

Tnx to @hfspo.bsky.social for humbling opportunity to present our work #HFSPNakasoneAward lecture. Tnx to Hanna lab, current & former members, collaborators, mentors. @weizmanninstitute.bsky.social for critical backing, @isscr.org for guidelines, funding agencies & dear philanthropists for funding

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". www.cell.com/cell-stem-ce...

To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.

1/n Dear friends, in light of the current events in Palestine and to help spread awareness, a large number of filmmakers have made their FILMS about PALESTINE AVAILABLE FOR ONLINE FOR FREE Below, we are sharing links to films that you can watch and share to spread our message to the world:

1/n Very excited to share our recent paper published on @ScienceAdvances where we dissect the gene regulatory landscape guiding mouse sex determination! science.org/doi/10.1126/... A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!

Fascinating story today from @levfacher.bsky.social about a rehab center where patients are currently being treated for substance use disorder with GLP-1 drugs — even as clinical trials measuring their effectiveness as anti-addiction medications remain years from reading out data.

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

I was interviewed recently by @stemcellpodcast.com I witter on about morphogens, notochord, @dev-journal.bsky.social & how biology is becoming a data science Thanks @stemcellpodcast.com for talking to me stemcellpodcast.com/ep-299-spina...

🎉 Full house in Melbourne for the kickoff of the 24th HFSP Awardees Meeting! Congrats to @jacob-hanna.bsky.social, 2025 HFSP Nakasone Awardee, who was honored at today’s ceremony. Let the science begin! 🧪 #HFSPmtg2025 #NakasoneAward #sts

Fantastic work from @bulutkarslioglu.bsky.social group. we r happy to contribute on the role of hypoxia in proper gastrulation ex utero as originally noted in Aguilera-Castrejon et al. Nature 2021 for robust gastrulation. Now this is shown to be important for taking gastruloids to the next level.

These r very sad days for me & colleagues @WeizmannScience & many civilians in our region. Yet, i am also stoked to be the 2025 recipient of the Nakasone Award by the Human Frontiers - HFSP. I would have never imagined in my wildest dreams to be on such a list. Tnx! www.hfsp.org/hfsp-nakason...

After being stuck in Hong Kong after ISSCR meeting unable to fly back home, I managed to get on a plane to London to stay with family, only to learn in the air that our institute was hit. My team is all safe. My lab sustained serious blast damage but we shall overcome! #PeaceNow tnx for messages :)

thanks and also for a great meeting and great podcasts.

Beautiful work from @santoslab.bsky.social A 3D model of human amnion from hESCs These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops And check out the size of them in the video www.cell.com/cell/fulltex...

We truly enjoyed summarizing this tour de force work in Developmental Cell on understanding human cleavage stage ZGA arrest by using single-embryo single-cell allele-specific RNA-seq by Peng Yuan team, & catching up on other recent advancements in ZGA research. www.cell.com/developmenta...

Saddened by the news about the passing of Prof. Hannah Engelberg-Kulka. Beyond her great contributions to science, to me as a student & many others at the Hebrew University, she was a great source of kindness, mentorship & relentless encouragement. RIP www.haaretz.co.il/magazine/obi...

Excited that our new lab website is starting to come together - thanks to the team, particularly Pauline Marangoni and Zhulin Dixon, for assembling this, and stay tuned for additional updates ophirkleinlab.org

Kind of fun to see the Cell chose our 2022 paper on Mouse Synthetic Embryo Models among highlighted landmark studies they published in the last decade (Cell line 2014-2024).

Super nice work from the Naomi Morris group. The aspect of "co-development" elucidated by showing reciprocal interactions between somites & neural tube (via comparing somite only gastruloids vs. those that also have a neural tube) is a unique demonstration of the power of developmental models.

A true masterpiece .. from chick development , to careful dissection of progenitor populations identity , to signaling needed to induce them to recapitulate notochord in human pscs . (Great way to open my Christmas family retreat on the couch). www.nature.com/articles/s41...

Dear friends: While trying to make tripple knockin NUCLEAR fluorescent reporter lines, we've great signals with H2B-EGFP & H2B-tdTomato. But we r struggling with H2B-tagBFP regardless of the locus targeted. Anyone has a suggestion for a different H2B flourescent tag to combine with GFP & tdTomato?

We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis #IInNumbersWeTrust #NotInTheGenes

Somebody sent me this from Paris. Since it is not me in the photo, i guess i may have a clone or twin brother working there.

#50ScientistsThatInspire 🧪 Valentina Greco, a developmental biologist, explores the mechanisms governing an organism’s cellular communication.. "I hope that one day, our #diverse genders, races, countries of origin, sexual orientations, etc. will be welcomed in any field we choose to enter" 🧵

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

When you officially buy Shawarma sandwich holders for the lab TC room, because it is the best way to make aggregates settle in a flask! Welcome to the middle east!

Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025 Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts) www.grc.org/developmenta...