What happens when you change the promoter of my favorite gene? Sox9?

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

📢To all the sex determination lovers! 📢 Get ready for the 10th International Symposium on the Biology of Vertabrate Sex Determination (VSD). We exchange the nostalgic Hawaii beaches with the gorgeous Crete beaches 🏖! The meeting will take place on 23-27 March 2026. biology-of-vsd.my.canva.site

Publishing an exciting paper and getting an ISF grant, both at the same week, is a good justification of Pizza and Prosecco in the middle of the day! 🍾🥂 Huge congrats to Isabelle, Meshi and Elisheva for this superb publication 💪

1/n Very excited to share our recent paper published on @ScienceAdvances where we dissect the gene regulatory landscape guiding mouse sex determination! science.org/doi/10.1126/... A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!

Alpha Genome by DeepMind... Will it be as good as AlphaFold?? deepmind.google/discover/blo...

Male mouse fetuses can develop female organs in utero if their mother is iron deficient during pregnancy https://go.nature.com/43N7f4s

One of the coolest papers in the field of sex determination! It is the first evidence that environmental aspects can affect mammalian sex determination!! www.nature.com/articles/s41...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Had the best time in Geneva, visiting my friend and collaborator Serge Nef. I saw the beautiful city of Geneva, gave a seminar at the Medicine Faculty of Geneva University and met many brilliant scientists!! Heading next to Zurich for the #TT2025 meeting to hear about transgenic mice technologies!

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

Very cool and about time! www.sciencealert.com/hormone-free...

Highly recommend all scientist to watch the movie Joy on Netflix! It tells the story of IVF and the birth of Louise Joy Brown in 1978 and all the scientific endeavour behind. Millions of failures for 1 amazing success! This is what science is all about m.imdb.com/title/tt1024...

Exonic enhancers are a widespread class of dual-function regulatory elements x.com/biorxiv_geno...

Among the fun parts of being a scientist is going to conferences!! A first time in Washington D.C where I will present our work at the #asa_ica25conf tomorrow. Come and hear me if you are here

Ready for it??? To all the **sex determination lovers** 📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!! Great community, amazing science, excellent speakers and superb location 🏝 📢 March 23-26, 2026 📢

Israeli friends! Interested in learning & practicing the thinking tools of the creative process in science? Join the Night Science workshop in Tel Aviv University next week! Register here: forms.office.com/r/xVhzcHTy1t Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

An excellent article about the biology of sex and how it is being regarded by the US government thehill.com/opinion/whit...

Me and all my XYs... Love them!

After many postpones due to war, military service and just general depression, we went out today for a super fun day in Tel Aviv. I have such an AMAZING lab and I am so happy to be thier friend, mentor, and just doing science and fun togerher ❤️

It will be very bad if this will happen. Far less research on females in many topics that will eventually harm 50% of the population www.thetransmitter.org/policy/exclu...

www.ynet.co.il/environment-... ושום גרנט לא יוקרתי כמו פרסום ב YNET 🤣 שמחה להיות ה XX היחידה ברשימה יוקרתית ונכבדת של 11 XY.

Thankful for the @ERC_Research for their continuous support in our research with an ERC PoC. We plan to generate testis organoids from pre-pubertal boys testis biopsies, taken prior to chemotherapy.

How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n

The Gonen Lab lighting the fifth Chanukah candle together ❤️

Makhtesh Ramon in the Negev Desert. Beautiful and peaceful place. Apparently 80/96 of the chemical elements in the periodic table can be found here!!!

It was great to gather around today all the PIs at the Life Sciences Faculty @Bar_ilan, light the second Candle of Hanukkah, have our dean Cyrille Cohen playing, and giving a talk about my lab science in my home base. Superb Faculty and such a great feeling of home

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

Boyond excited to announce that @MeshiRidnik is the first PhD student to graduate from my lab. Meshi had a superb PhD that she presented amazingly well today in her PhD seminar. I could not be more proud of the first newborn PhD (XX) of the GONEN LAB 🥳🥳. Such an amotional moment!

Come and join me at the Life Sciences Faculty @Bar_ilan!! Tenure track PI positions available. Amazing faculty, people, atmosphere and students! Could not be happier with my decision at the time 💪 www.scienceabroad.org.il/job/academy-...