We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...). We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇

🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program. Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin. 👉 Apply now: www.mdc-berlin.de/career/jobs/...

Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....

What happens when you change the promoter of my favorite gene? Sox9?

My new lab at the @molgen.mpg.de will be following up on some of the nuclear organization aspects of ecDNA so please do reach out if this is of interest :)

Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.

📢 We are hiring! 👩🏾‍⚕️Research technician/Lab manager 📍 @cabd-upo-csic.bsky.social , Sevilla, Spain 🧬 Gene regulation in animal development & evolution Check the details 👇 & join us! drive.google.com/file/d/1cZJi... #ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology

Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀 Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬

super cool to see this out! looking forward to now read the details! Congratulations, Yad and @mmasoura.bsky.social

What mediates enhancer-promoter compatibility? Get some answers & learn about the important of the promoter-proximal region here 👇 Congratulations @blanka-majchrzycka.bsky.social @danielibrahim.bsky.social on this beautiful work!!!!🥂🥂

Yay! Congratulations @blanka-majchrzycka.bsky.social and @danielibrahim.bsky.social ! Good to see this beautiful dissection out !

A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

a really cool work! everyone check it out! congratulations 🎉👏🏽

If you’re interested in a PhD that explores the ins and outs of genomes and the nucleus - don’t look further but apply here!!! It is excellent 👌

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work. 🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

🚨JOB ALERT🚨 FRIENDS PLEASE SPREAD and RT We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility. See below 2 calls👇

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Paris-Berlin sleeper: low carbon, 2 years old, constantly full, but currently losing SNCF a few million EUR/yr Intl Jet fuel tax exemptions are 80 years old and cost the EU 22 million EUR/yr for the Paris-Berlin route alone. And you're cutting... the sleeper? www.theguardian.com/travel/2025/...

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

This has been such a great collaboration with @dlwagnerlabs.bsky.social! You really need to check it out One-pot PASTA 🍝 - a one-step protocol to knock-in large transgenes. I feel tempted to think about one-pot PIZZA 🍕 next! First authors Isabell and @therealjonaskath.bsky.social were amazing!!

🚀 In preparation for releasing two new stories, @therealjonaskath.bsky.social is revisiting the journey so far—sharing the lab’s last six papers. What a ride it’s been… 🙌🧬🧪🧫

Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...

🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

Congratulations to Aydan Bulut-Karslıoğlu on receiving the GSCN Young Investigator Award 2025! The award recognizes her lab’s research on dormancy. Read more: www.molgen.mpg.de/news-2025-gs... @bulutkarslioglu.bsky.social

I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉 We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

☎️ Berlin Calling: Your Research. Our City. A Perfect Match. The Einstein Postdoctoral Grant for early career researchers or the Einstein Visiting Fellowship for distinguished scholars – our funding opportunities offer pathways into Berlin’s research landscape. berlincalling.einsteinfoundation.de

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

We are hiring a scientist to lead our 'Build' team at the Seattle Hub for Synthetic Biology. @alleninstitute.org Job posting below: alleninstitute.org/careers/jobs... Please reach out if you have any questions!

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually. www.nature.com/ng/volumes/5...

Thrilled to see our revised preprint now published in Nature Ecology & Evolution! If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers! www.nature.com/articles/s41...

SOOOO MANY GENOMICS MODELSSSS! 😱 Often unclear which is best since they benchmark differently! In this preprint, we introduce GAME, a new framework that utilizes APIs to enable sustainable, uniform model evaluation so we can see which is actually best for each task. doi.org/10.1101/2025...

The evolution of high-order genome architecture revealed from 1,000 species www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/xjtu-omics/H...

so many cool things in there!! My favourite is the cell-type specific TE activity, others might prefer the viral-like particle mechanismone way or another - very much worth the read! congratulations 🙌

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

In Nature Genetics, @danielibrahim.bsky.social (MPIMG/BIH) and his team have developed a bioinformatic tool to identify evolutionary conserved regulatory regions of the genome that have transformed so much over time that their DNA sequences have changed completely. 👉 www.molgen.mpg.de/4927054

Mustering the courage to share my latest scicomm endeavour: I channelled my love for writing into a blog where I can hopefully bring the marvels of evolutionary biology and non-coding DNA to all Science lovers! darkgenomevo.wordpress.com/2025/06/22/i...

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested. www.fmi.ch/education-ca...

I'm supposed to give a 20 min talk right after @avsecz.bsky.social at ASBMB in Kansas City on Friday. I'm planning to use the "Ziga ate my slides for lunch" excuse (which is the dog ate my homework excuse in AI for genomics) & stand quietly in the corner for 20 mins. 😂😂😂 1/

We are excited to officially welcome a new group leader at the MPI-IE in #Freiburg. 🎉 Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025... Welcome, @julianeg.bsky.social!