🚨 1/ Preprint Alert! Sex determination outcome is conserved across vertebrates (i.e. generating 2 compatible sexes) ♀️♂️ But are the cell types and gene programs behind them conserved too? 🧬 Spoiler: not really 👀 Find out in our new preprint ⬇️ www.biorxiv.org/content/10.6...

🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist! #Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟 📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain) 🕒 Full-time, 3-year position (start March 2026) 📅 Apply by Feb 15, 2026 👉 drive.google.com/file/d/1M8rp...

📢 We are hiring! 👩🏾‍⚕️Research technician/Lab manager 📍 @cabd-upo-csic.bsky.social , Sevilla, Spain 🧬 Gene regulation in animal development & evolution Check the details 👇 & join us! drive.google.com/file/d/1cZJi... #ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology

We’re looking for a research technician to join our teams with @christinapaliou.bsky.social Passionate about Zebrafish and gene regulation? 🐟🧬 Apply now and dive into exciting research with us! ✨ See the job offer below 👇

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

#Preprint alert! 📣 We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements www.biorxiv.org/cgi/content/...

Great work from the #CABD researchers in this call of @ageinves.bsky.social for the ‘Proyectos de generación de conocimientos’! The provisional resolution proposes funding for: 🟢 13 projects 🟢 3 PhD contracts 🟢 ~ 3,5 million € Way to go!!!

No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Congratulations, Julian @julianeg.bsky.social! It was an exciting project, and I am happy to have contributed. Wonderful to see the paper in its final form.

🧵1/3 Our new preprint is out! Proud to have contributed to this collaborative study. We identified the enhancer cluster responsible for GPR101 overexpression in X-linked acrogigantism (X-LAG) - a key step toward understanding this rare pituitary disorder 🧠🧬 🔗 www.medrxiv.org/content/10.1...

Happy birthday, UCSC genome browser! www.nature.com/articles/d41...

I am very proud of you, Marta. You did outstanding work in the lab, and your defence was spotless. I am also very happy to now know an expert in gene compensation between paralogous genes!

Comparison between a neuronal massively parallel reporter assay for 50,000 sequences and 20,000 variants with mouse enhancer assays provide complimentary information. Great work by Michael Kosicki, Dianne Laboy Cintrón, Len Pennacchio, Martin Kircher lab & many others. www.nature.com/articles/s41...

🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...

Our BAT paper is accepted in Nature Ecology & Evolution! Single cell, gene regulation, TADs and key TFs that shape the bat wing. Genomics goes Evodevo 😍

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...

We’ve just launched our new website! 🚀 Check it out and stay tuned for updates! 🖥️ 🧬 🧫 🐁 fmreallab.github.io/website/

Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development. Loss of a single CTCF motif is sufficient to cause embryonic lethality. www.sciencedirect.com/science/arti...

Wow, Google... #GeographyFun or just going the extra mile to keep someone happy?

Tumors need a lot of nutrients to grow. By engineering and implanting fat cells to outcompete cancers for nutrients we can suppress them. Novel cancer therapy called Adipose Manipulation Transplantation (AMT). AMAZING work led by and dedicated to Hai Nguyen. www.nature.com/articles/s41...

X account deactivated. Rest in peace, Twitter. "Ich kann nicht so viel fressen, wie ich kotzen möchte." Max Liebermann, 1933

Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.110… 1/17

Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes https://www.biorxiv.org/content/10.1101/2024.11.30.626178v1

🚨Preprint alert! tinyurl.com/2zkmynsd Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays? Then Spatial-scERA is the method for you! #spatialOMICs

Ever wondered how bats develop wings from their hands? 🦇✨ Check out our new preprint and the thread below! 🤓 👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂 www.biorxiv.org/content/10.1...