Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

#Preprint alert! 📣 We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements www.biorxiv.org/cgi/content/...

🗒️‼️Do not miss this exciting new #preprint from the @radaiglesiaslab.bsky.social, led by @eharo84.bsky.social: a master of building synergy ⏫- both in #enhancer research and at the lab! #DarkGenome #Transcription #GeneRegulation #Development #Genomics

EMBL is back on hiring faculty! Check out the multiple open positions: 3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble 1 Head of Unit (Cell Biology & Biophysics, Heidelberg). Closing deadlines in Sep! +3 more positions to come out then, stay tuned... @embl.org

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

Enhancers are "just DNA" - finding all of them in the genome is hard. www.nature.com/articles/s41...

Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains: www.epfl.ch/about/workin...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs

Congratulations, Sergio! Are we sharing issue!? 🤔😂

Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...

Glad to see this work finally out🥳. It has been a real pleasure to be a character on this play 🎭. An excellent work produced by @radaiglesiaslab.bsky.social with @mariamafau.bsky.social as the director & main character (alongside her inseparable friend ZIC2🧠). Take a look at the full plot! 👁️👇🍿

Thrilled to share the story stemming from my PhD! We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.

Extremely proud to share the PhD work of @mariamafau.bsky.social in which we have investigated the role of ZIC2 during neural induction. It turns out that ZIC2 has a dual life, first as a promiscuous pioneer and then as a lineage-specific activator. Find out more here 👇 bsky.app/profile/mari...

How bats developed their wings? 🦇 Turns out they reutilize existing gene programs 🔧 Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs www.nature.com/articles/s41...

Thrilled to see our revised preprint now published in Nature Ecology & Evolution! If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers! www.nature.com/articles/s41...

This is the result of a truly multidisciplinary team 🧑‍🤝‍🧑🧑‍🤝‍🧑, led by @gp83.bsky.social , @dalyaf.bsky.social and @martinfranke.bsky.social and joined by @radaiglesiaslab.bsky.social and myself for this new chapter. #GeneticDiagnostics #NonCodingGenome #RareDisease 3/3

🚨 Ultimos días para registrarse en el Curso Nacional de Genética 2025 (deadline 15 julio) 😲 Top speakers y registro gratuito 🧬 Organizado por @segenetica.bsky.social junto con Conexión Genoma 👥 Coordinadores: @aruizherrera.bsky.social & & myself 🔗 Info y programa: segenetica.es/curso/cng2025/

🏃‍♂️🏃🏽🏃🏻‍♀️

🎉ONLINE @natgenet.nature.com 📰Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes. By @julianeg.bsky.social, Giulia Cova, Stefan Mundlos and colleagues. ⬇️ www.nature.com/articles/s41...

🧵1/3 Our new preprint is out! Proud to have contributed to this collaborative study. We identified the enhancer cluster responsible for GPR101 overexpression in X-linked acrogigantism (X-LAG) - a key step toward understanding this rare pituitary disorder 🧠🧬 🔗 www.medrxiv.org/content/10.1...

🧬🎤 Very excited for the start of the EMBO Workshop in Enhancer Mechanics and Enhanceropathies this afternoon in Middelfart! Many thanks to the organizers @smandrup.bsky.social @radaiglesiaslab.bsky.social and Minna Kaikkonen for putting together an amazing programme! #EMBOenhanceropathies

If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!

Yet the expression levels of genes interacting with primed enhancers were significantly higher than the expression levels of genes interacting with poised enhancers, which are truly inactive in pluripotent stem cells, as @radaiglesiaslab.bsky.social‬ and others have established.

📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells! Moderated by @stefanschoenfelder.bsky.social Register: us02web.zoom.us/webinar/regi... #Genomics #VirtualSeminar

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

📣 New pre-print from the lab: 👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM 📝 Read the #BioRxiv here: doi.org/10.1101/2025...

If you are attending #EMBLChromatin, go and check @mariamafau.bsky.social poster and learn more about how ZIC2 controls neural induction and patterning by playing a dual and sequential regulatory role.

#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

Please RT ! Gordon Conference “Histone and RNA modifications” Tuscany 🇮🇹 20.-25. July 25 🗓️ Theme: Regulation of genome function by histone and nucleic acid modifications. Great speaker lineup. >20 talks will be chosen from abstracts. Submit yours soon ➡️ shorturl.at/hBjyT

Our BAT paper is accepted in Nature Ecology & Evolution! Single cell, gene regulation, TADs and key TFs that shape the bat wing. Genomics goes Evodevo 😍

Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.

📣 A reminder about an open postdoctoral position in our group! 🧫 Are you interested in mechanisms of gene regulation, human facial development and disease? How our DNA shapes the way we look? Do you love chromatin and enhancers? 🧬 If so, reach out for an informal chat! 💬 longlab.co.uk

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Te quedan tres días (solo hasta el lunes 31 de marzo) para hacerte con algún ejemplar de los pocos que quedan de dos de mis libros editados por #NextDoor #EditandoGenes sobre #CRISPR y #PorQueMiHijo sobre #enfermedadesraras Los tienes disponibles en: www.nextdoorpublishers.com/libros/

Postdoc position #2 is now also live! Note a different duration and salary range. Feel free to apply for both if they both sound suitable. www.imperial.ac.uk/jobs/search-...

This is a super-interesting, though speculative, paper from Adrian Bird. He is challenging the prevailing view that the protein cohesin organizes chromatin for functionality (transcription) by creating loops that allow genes to access their regulatory regions... www.cell.com/molecular-ce...

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...

📣 Four more days left to submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies". Submit now and present your latest work in one of our short talks 📣 #EMBOenhanceropathies 👇