Alan Au
@au-ho-yu.bsky.social
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Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells.
www.biorxiv.org/content/10.6...
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SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
https://www.biorxiv.org/content/10.64898/2025.12.08.692985v1
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