We just published this paper of which I am immensely proud: www.nature.com/articles/s41... In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of. Let's dive in... 🧵

Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...

@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

Come be our head of bioinformatics at @mrc-lms.bsky.social ! Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Oxford Biology is growing 📢 We’re appointing 3 Associate Professors in: 🌱 Plant Sciences 🦉 Animal Behaviour 🔬 Molecular Cell Biology 3 fields. 3 opportunities. One new home for Oxford Biology. Learn more 👉 bit.ly/41S2Tc7 Apply now 👉 bit.ly/488CNW3

We are looking for new SciLifeLab Fellows (group leaders) to join SciLifeLab and Karolinska Institutet @ki.se . @scilifelab.se is a great place to start your lab with generous funding. Deadline: 15th November. Apply and join us in beautiful #Stockholm #JuniorPI ki.varbi.com/en/what:job/...

Thanks to journalist @felixschmidtner.bsky.social for bringing the plight of the key scientific database @flybase.bsky.social to a German/European audience www.faz.net/aktuell/wiss...

W/ critical contributions from @mtrani.bsky.social, Alba Villaronga Luque, @yonitmms.bsky.social, Allyson Ryan, & in collab w/ @carldmodes.bsky.social @csbdresden.bsky.social & @campaslab.bsky.social @poldresden.bsky.social. Funded by #EICPathfinder @ec.europa.eu. Background thread coming soon!

Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!

Join us as a colleague in Göttingen!

Join EMBL as a research group leader in AI in biology. EMBL AI is our new initiative aiming to exploit the full potential of ML/AI-based approaches to advance our understanding of the most complex system in the known universe - life on Earth. embl.wd103.myworkdayjobs.com/en-US/EMBL/j... (1/3)

6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025 bsky.app/profile/jane...

🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

Excitingly, the lab of Jan-Michael Peters just reported largely concordant findings: The PDS5:NIPBL balance in cells tunes the rate/velocity of cohesin loop extrusion, shaping chromosomes from loops to compartments 🚅➰ www.biorxiv.org/content/10.1...

Join the Fragile Nucleosome Seminar featuring @gracebower.bsky.social, who will discuss our recent discovery of the Range Extender Element. (www.nature.com/articles/s41...)

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. www.nature.com/articles/s41...

Very interesting indeed! Also wondering what we see here are extrusion fountains in the RBCs?

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

#Preprint alert! 📣 We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements www.biorxiv.org/cgi/content/...

Interested in transposable elements in mammalian preimplantation development? It's not too late to register for the 'Development presents' webinar next Wednesday. Together with Anzy @anzymiller.bsky.social who will talk about her postdoc work as well!

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

We all know that cancers -even from the same subtype- are highly heterogeneous right? In a new study we asked whether this was also the case for the three-dimensional organization of the genome in breast cancer. The answer: it’s complicated. www.cell.com/iscience/ful...

Two days left to apply for a 3-year postdoc in #Chromatin #Cancer #Epigenetics at University of Oslo, Norway, co-supervised by @amathelier.bsky.social You will be part of @cancelluio.bosky.social. We focus on #Sarcoma #Epigenome #CRISPR and Drug screen studies. Find out more here: shorturl.at/DtLHM

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat... My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

Preprint alert! 🚨 Presenting MHC1-TIP: a scalable, cost-effective workflow for MHC-I ligandome + proteome profiling from diverse samples, to for example uncover intratumoral heterogeneity in RCC. Spearheaded by Mayukha Bathini, and big thanks to all collaborators! biorxiv.org/content/10.1...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains: www.epfl.ch/about/workin...

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Strong The Onion vibes with this one: www.nature.com/articles/d41...

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity! www.nature.com/naturecareer...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....