Congrats @agamilab.bsky.social, @peeperlab.bsky.social & @thijnbrummel.bsky.social for being shortlisted in this year’s ‪@cancergrand.bsky.social‬! They’ll compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges bit.ly/41KM1DS #CancerGrandChallenges

#FederatedLearning enhances #prostate cancer detection https://doi.org/10.1148/ryai.240485#FederatedLearning#prostaterug.nl @nkinl.bsky.social #MICCAI2025 #imaging #AI #ComputerVision #MachineLearning

NEW Review of neoadjuvant #immunotherapy in melanoma by Francesca Fallarino & Christian Blank @nkinl.bsky.social discusses where the field is heading next in terms of understanding immune education in therapy resistance and biomarker-driven personalization #immunology #oncology #cancer #melanoma

We scrambled the genome. What happens when you cut, flip, and relocate DNA at scale? 🧬 A new method from the Netherlands Cancer Institute reveals surprising rules of genome organization. Publications in Science & Nature Structural & Molecular Biology. Read more ➡️ www.nki.nl/news-events/...

CCE kicks off its first Exchange Program! Adrià Marcos @vhio.bsky.social trained at @nkinl.bsky.social, and Zuhir Elkarghali (NKI) will soon join VHIO. Strengthening collaboration across #CCE 🚀 @nct-heidelberg.bsky.social @gustaveroussy.fr @ki.se @crukcamcentre.bsky.social

Check out our spotlight article on an exciting study! Lipid-sensing chemosensors influence macrophage behavior. Really enjoyed reflecting on this work and what it could mean for macrophage targeting approaches! 😊

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

Big congratulations to @sarahmoser.bsky.social @oncodeinstitute.bsky.social for being named a 2025 International Birnstiel Award laureate! Selected from 87 nominations, Sarah is one of just six doctoral researchers worldwide to receive this prestigious recognition in molecular life sciences.

🌟 Partner spotlight: Netherlands Cancer Institute @nkinl.bsky.social. In #PredictAYA, the research group on personalised oncology in adolescents and young adults leads communication, dissemination and stakeholder engagement and supports studies on late effect of cancer treatment on European cohorts.

New ERC Starting Grant @erc.europa.eu for Gordon Watt to study how autoimmune disease and cancer treatments interact in shaping the risk of second breast cancer. His team will explore how the immune system influences long-term cancer outcomes ➡️ #ERCStG bit.ly/3VyvvDs #ERCStG #cancerresearch

Researcher Hendrik Messal is starting his own lab! He will explore how the tumor environment shapes cancer growth combining imaging, genetics & data science. More: www.nki.nl/news-events/...

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

We all know that cancers -even from the same subtype- are highly heterogeneous right? In a new study we asked whether this was also the case for the three-dimensional organization of the genome in breast cancer. The answer: it’s complicated. www.cell.com/iscience/ful...

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.

A new study in @lancetrh-europe.bsky.social finds that survival rates for most AYA cancer survivors match those of their peers within just four years of diagnosis. The findings support calls to revise the rules around the ‘Right to be Forgotten’ for cancer survivors. More: doi.org/10.1016/j.la...

Researchers Veer Keizer and @riklindeboom.bsky.social have both received a Veni grant from the Dutch Research Council to set up and strengthen their own independent research lines ➡️ www.nki.nl/news-events/...

I'm very proud that our paper, and with that the main project of my PhD, has just been published by @natcomms.nature.com! 🎉 Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance. doi.org/10.1038/s414...

❤️🧡💛💚💙 The traditional Canal Parade marked the end of Pride 2025 this past Saturday. Eighty boats took part, with number 72 proudly representing our Institute. We believe that an inclusive organization, where you can be yourself, is the foundation for strong collaboration and excellent research.

📣Meet Prof. Emile Voest, Medical Oncologist and Group Leader at the @nkinl.bsky.social, who has been a key part of the #CCE journey. Know more about him and his contributions 🔗 www.cancercoreeurope.eu/meet-emile-v...

Taking over the hospital for prideweek with gendercupcakes @nkinl.bsky.social @florencevb.bsky.social #diversity

Last week we proudly hosted the annual meeting and summer school of EMERALD PhD Programme for MDs. This international EU-life program aims to help bridge the gap between laboratory research and clinical practice. #PhD4MDs #PhysicianScientists #BridgeTheGap #research #clinicalpractice

Cancer researcher Karin de Visser is to receive the Josephine Nefkens Prize 2025 on November 4. This triennial award recognizes exceptional cancer researchers who combine scientific excellence with societal engagement. Read more ➡️ www.nki.nl/news-events/...

Scientists at the NKI have made a remarkable discovery: a new protein duo that can turn genes on and off. They have named this duo Zincore. Together, these proteins help other proteins bind more firmly to the DNA, allowing them to perform their functions more effectively www.nki.nl/news-events/...

New study shows why immunotherapy doesn’t always wipe out an entire tumor. Even within a single tumor, cancer cells can vary in how well the immune system sees them, and that difference is written in their DNA ➡️ www.nki.nl/news-events/...

New study: Women exposed to DES before birth do not have a higher risk of breast cancer later in life. Vaginal cancer risk remains increased, but is still rare ➡️ www.nki.nl/news-events/...

In a new Nature Genetics paper our researchers identified a synthetic lethal interaction in 50% of cancers. Tumors lacking CDS1 depend entirely on CDS2. Blocking CDS2 kills cancer cells while sparing healthy tissue ➡️ www.nki.nl/news-events/...

Women with breast cancer who receive silicone implants don’t have a higher risk of symptoms linked to Breast Implant Illness. This is the conclusion of a large Dutch study involving over 6,000 women ➡️ www.nki.nl/news-events/...

🔍 A #CCE delegation visited @nkinl.bsky.social to learn more about data, digital oncology & trials. Thanks to Wilbert Zwat Michiel van der Heijden Ruud Weijer & team for the insightful discussions. @joseptabernero.bsky.social @carmonasfj.bsky.social Elena Chavarria Irene Brana @vhio.bsky.social

The results, based on a survey of more than 2,500 cancer patients across 25 European countries, are a cause for concern: 💰 56% lost income 💰 28% saw their income drop with up to €800/month 💰 86% faced extra costs & 16% delayed or skipped care #EuropeanFairPricingNetwork

Cancer is pushing many patients in Europe in financial dire straits – even in countries with strong healthcare systems. A new #EuropeanFairPricingNetwork study shows that patients lose income, face additional costs & skip care after diagnosis ➡️ www.nki.nl/news-events/...

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK

1️⃣8️⃣ researchers 1️⃣5️⃣ performances 🎤 From rap to drama, the EU-LIFE #ScienceVision Talk Contest brought science to life like never before! 📺 Missed it or want to relive it? Watch the event's recording here: youtu.be/iqh6xNYsqkM?... 🎥 @ceitec.eu

Congratulations Karin!

Extremely grateful to be granted a two year post-doctoral fellowship by @embo.org to study the earliest phases of mutant to malignant cell transition during breast cancer initiation using intravital microscopy. Thank to @vanrheenenlab.bsky.social for the immense support! @nkinl.bsky.social

🎓 PhD student Iris Nederlof found that immunotherapy can lead to complete tumor disappearance in a small group of patients with triple-negative breast cancer. @amsterdamumc.bsky.social ➡️ www.nki.nl/news-events/...

Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research. With @oncodeinstitute.bsky.social #AlpedHuZes #cancerresearch #ad6 #NKI

🎓 Breast reconstruction can be performed immediately after surgery, even if radiation therapy is still required, concludes PhD candidate Merel Kooijman www.nki.nl/news-events/...

We’re proud that John Haanen @haanenjohn.bsky.social has been selected as a candidate for Chair of the ESMO Nomination Committee. A great recognition of his dedication and expertise. #ESMO #ESMOMembers

Do you want to learn more about our animal research? Check out this insightful article from our magazine: www.nki.nl/media/w1dlfb... #BOARD25

“It was bizarre to have my own DNA analyzed for genes I’ve been studying for so long.” Time for a conversation with group leader Hein te Riele, in preparation for his retirement ➡️ bit.ly/44V9d4N The research is financially supported by KWF Dutch Cancer Society. #NKI #research

🌟 The very first NKI Early Cancer Detection Conference 2025 took place this week, and we’re still buzzing with energy and inspiration. "During this conference we built a community for early cancer detection. From now on, it is: YES!" Want to learn more?➡️ nkicecd.nl/conference #EarlyCancerDetection

Gerrit Meijer from the @su2cscience.bsky.social-#KWF MEDOCC team presented the Team’s work in developing the multi-target FIT test for colorectal cancer at the @nkinl.bsky.social Early Cancer Detection Conference #StandUpToCancer #NetherlandsCancerInstitute #colorectalcancer

Day 2 of the NKI Early cancer Detection conference is off to a great start with a keynote from David Crosby @cancerresearchuk.org

Predicting gene expression from DNA sequence using deep learning models go.nature.com/3F8r0Li #Review by Lucía Barbadilla-Martínez, Noud Klaassen, Bas van Steensel & Jeroen de Ridder @nkinl.bsky.social @umcutrecht.bsky.social

Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/

Seven years of research into DCIS, funded by @cancergrand.bsky.social and Dutch Cancer Society, delivered crucial breakthroughs: more personalized care, fewer unnecessary treatments and a better quality of life for women with DCIS. Read more➡️ www.nki.nl/news-events/... #cancerresearch #breastcancer

“Researchers are already under great pressure. Responsibilities for #sustainability should primarily lie with institutions,” said Henri van Luenen, representative of the Netherlands Cancer Institute @nkinl.bsky.social and EU-LIFE ⬇️ #EuropeanResearch #ResearchCareers #EUcompetitiveness

💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵 www.sciencedirect.com/science/arti...

Very excited to see this out! We used scRNAseq to show increased neutrophil production in the bone marrow in breast cancer, indicating systemic inflammation. These neutrophils promote metastasis. However, this can be blocked by treating mice with an IL1-b inhibitor! See 🧵 and paper for details.