new out in Nature www.nature.com/articles/s41...

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

NASP Funding: Maximize Your Program’s Impact Researchers discovered that NASP, a key protein involved in chromatin organization, plays a surprising role in resistance to PARP inhibitors. Targeting NASP offers a new therapeutic strategy for cancer treatment.

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance go.nature.com/45vRWhd

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

new out in Nature yesterday www.nature.com/articles/s41...

Extremely cool!

I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.

This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.

NASP Controls Histone Turnover Behind PARP Resistance The emergence of poly(ADP-ribose) polymerase inhibitors (PARPi) as a transformative therapy for homologous recombination-deficient tumors has significantly altered the landscape of cancer treatment. These drugs exploit synthetic lethality to…