Barbara Marte
@barbmarte.bsky.social
📤 5206
📥 951
📝 139
Senior Editor @Nature for cancer and cell cycle. Views my own
reposted by
Barbara Marte
Johanna Joyce
20 days ago
New issue of Nature - with NINE studies on
#brain
#development
from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
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reposted by
Barbara Marte
Rob Clarke
20 days ago
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts:
urldefense.com/v3/__https:/...
Brilliant team science
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Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
https://urldefense.com/v3/__https://rdcu.be/eOqrx__;!!PDiH4ENfjr2_Jw!HpCkacdjlh1gXOv02IAWFgfMLJnnPyhaDOKmmkMoL41COINEPZh-osC4KeQIMnx_mPBkaSfNUqY_zzJH1_ki-J8-U_ZH-c66WCRxEKhZrP2B$
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reposted by
Barbara Marte
Nature Portfolio
20 days ago
Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. 🧪
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://go.nature.com/3JDsUWD
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new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://www.nature.com/collections/gjdefhadcj
20 days ago
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new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
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Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...
https://www.nature.com/articles/s41586-025-09684-7
20 days ago
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new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
https://www.nature.com/articles/s41586-025-09710-8
20 days ago
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reposted by
Barbara Marte
Magdalena Skipper
26 days ago
In praise of fundamental research Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different 🧪
@nature.com
www.nature.com/articles/d41...
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From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
https://www.nature.com/articles/d41586-025-03470-1
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reposted by
Barbara Marte
Magdalena Skipper
29 days ago
We asked physicists which are the sci-fi films they like the most - two were consistently highlighted in interviews for their depictions of science: 2014’s Interstellar and 2006’s The Prestige — both of which were directed and co-written by Christopher Nolan 🧪
www.nature.com/articles/d41...
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The sci-fi films that physicists love to watch — from Interstellar to Spider-Man
Nature surveyed scientists about their favourite cinematic moments to celebrate the International Year of Quantum Science and Technology.
https://www.nature.com/articles/d41586-025-03440-7
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and the News story
www.nature.com/articles/d41...
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People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
https://www.nature.com/articles/d41586-025-03432-7
about 1 month ago
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and the Clinical Briefing
www.nature.com/articles/d41...
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Tumours might be sensitized to immune therapy by COVID mRNA vaccines
COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.
https://www.nature.com/articles/d41586-025-03411-y
about 1 month ago
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new out in Nature
www.nature.com/articles/s41...
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
https://www.nature.com/articles/s41586-025-09655-y
about 1 month ago
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new out in Nature, a News & Views
www.nature.com/articles/d41...
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Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.
https://www.nature.com/articles/d41586-025-03133-1
about 1 month ago
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reposted by
Barbara Marte
VIB Training & Conferences
about 1 month ago
Tumors are complex ecosystems, where
#cancer
and non-cancer cells interact, shaping how tumors grow, evolve, and respond to treatment. At
#THPT25
, Prof. Itay Tirosh will reveal the secrets to fighting back smarter. Want to join this fight? Register before the deadline on 26 Nov:
vibbio.tech/49aIDGS
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new out in Nature
www.nature.com/articles/s41...
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Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers - Nature
Nature - Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
https://www.nature.com/articles/s41586-025-09679-4
about 1 month ago
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new out in Nature
www.nature.com/articles/d41...
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John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
https://www.nature.com/articles/d41586-025-03418-5
about 1 month ago
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new out in Nature
www.nature.com/articles/s41...
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Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
https://www.nature.com/articles/s41586-025-09713-5
about 1 month ago
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it was a pleasure! Thanks everyone for attending and contributing. And a big thanks to the EACR staff !
add a skeleton here at some point
about 1 month ago
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a new News & Views out in Nature
www.nature.com/articles/d41...
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Clues to why the weight-loss condition cachexia arises when cancer occurs
Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.
https://www.nature.com/articles/d41586-025-02594-8
about 2 months ago
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new out in Nature
www.nature.com/articles/s41...
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SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
https://www.nature.com/articles/s41586-025-09574-y
2 months ago
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and the News & Views
www.nature.com/articles/d41...
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A drug–diet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
https://www.nature.com/articles/d41586-025-02824-z
2 months ago
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new out in Nature
www.nature.com/articles/s41...
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
2 months ago
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7
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and the News & Views
www.nature.com/articles/d41...
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Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
https://www.nature.com/articles/d41586-025-02595-7
2 months ago
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new out in Nature
www.nature.com/articles/s41...
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
https://www.nature.com/articles/s41586-025-09489-8
2 months ago
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new out in Nature
www.nature.com/articles/s41...
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Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
https://www.nature.com/articles/s41586-025-09507-9
2 months ago
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reposted by
Barbara Marte
Annette Dittert
2 months ago
Will Dunn is right. An awful new trend. Lovely column.
add a skeleton here at some point
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reposted by
Barbara Marte
Nature Methods
2 months ago
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
www.nature.com/articles/s41...
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this is fun
www.nature.com/articles/d41...
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Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research
The annual awards are a celebration of weird but thought-provoking science.
https://www.nature.com/articles/d41586-025-03045-0
2 months ago
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new out in Nature
www.nature.com/articles/s41...
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Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity...
https://www.nature.com/articles/s41586-025-09503-z
2 months ago
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with a bit of delay, a new News & Views out in Nature
www.nature.com/articles/d41...
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Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
https://www.nature.com/articles/d41586-025-02705-5
2 months ago
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www.nature.com/articles/s41...
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Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
https://www.nature.com/articles/s41586-025-09492-z
3 months ago
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and last but not least two cancer neuroscience papers on small cell lung cancer. 1.
www.nature.com/articles/s41...
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Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
https://www.nature.com/articles/s41586-025-09434-9
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
https://www.nature.com/articles/s41586-025-09493-y
3 months ago
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new out in Nature
www.nature.com/articles/s41...
(the News & Views will come soon)
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
https://www.nature.com/articles/s41586-025-09502-0
3 months ago
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and the News & Views
www.nature.com/articles/d41...
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Epigenetic clues from cancer’s past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
https://www.nature.com/articles/d41586-025-02256-9
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
https://www.nature.com/articles/s41586-025-09374-4
3 months ago
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the deadline to register at the inaugural EACR cancer neuroscience is approaching fast: Sept 15th. Do join us for a fantastic line up of invited speakers, short talks and abstracts (yes, we have seen them) in the wonderful city of Bilbao (Guggenheim, Pintxos, Txakoli...).
eacr.org/conference/c...
.
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Introduction | Cancer Neuroscience | The European Association for Cancer Research
https://eacr.org/conference/cancerneuroscience2025?utm_source=confseries&utm_medium=web&utm_campaign=CN25&utm_content=&_gl=1*1l7sbxc*_gcl_aw*R0NMLjE3NTY3NDA5ODMuQ2p3S0NBaUFrYzI4QmhCMEVpd0FNMDAxVFhXenVNTndhUmRvdkgyVFNHeVRBeU9BbUw1TXNpZ3M2VGd3Skd4Y3o5TmhqTUs1TzFteEtob0NnQThRQXZEX0J3RQ..*_gcl_au*NjczMjY5MjU2LjE3NTU2Nzc4OTA
3 months ago
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new out in Nature
www.nature.com/articles/d41...
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Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
https://www.nature.com/articles/d41586-025-02768-4
3 months ago
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and the News & Views
www.nature.com/articles/d41...
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Depriving brain tumours of an amino acid could enhance chemotherapy
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.
https://www.nature.com/articles/d41586-025-02531-9
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
https://www.nature.com/articles/s41586-025-09460-7
3 months ago
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new out in Nature this week
www.nature.com/articles/s41...
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Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
https://www.nature.com/articles/s41586-025-09445-6
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
https://www.nature.com/articles/s41586-025-09411-2
3 months ago
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a News & Views on a recent JCO paper
www.nature.com/articles/d41...
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Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma
A clinical trial reports data from one of the first groups of people with the blood cancer myeloma to receive a type of immunotherapy called CAR T cells.
https://www.nature.com/articles/d41586-025-02592-w
3 months ago
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just out this News & Views on a recent NEJM paper
www.nature.com/articles/d41...
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Exercise improves survival of some people with colon cancer, clinical trial shows
Most studies on how exercise affects the survival of people with cancer have been observational. A clinical trial provides compelling evidence of the benefits of physical activity.
https://www.nature.com/articles/d41586-025-02591-x
3 months ago
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and the Research Briefing to go with it
www.nature.com/articles/d41...
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Anticancer compounds that exploit a compromised checkpoint in the cell cycle
In E2F-driven cancers, inhibitors of proteins called cyclins paradoxically cause cell death by enhancing the activity of cyclin B.
https://www.nature.com/articles/d41586-025-02606-7
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature
Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.
https://www.nature.com/articles/s41586-025-09433-w
3 months ago
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new out in Nature
www.nature.com/articles/s41...
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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature
Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with a...
https://www.nature.com/articles/s41586-025-09370-8
3 months ago
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new out in Nature yesterday
www.nature.com/articles/s41...
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Clone copy number diversity is linked to survival in lung cancer - Nature
A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...
https://www.nature.com/articles/s41586-025-09398-w
3 months ago
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new out in Nature yesterday
www.nature.com/articles/s41...
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NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
https://www.nature.com/articles/s41586-025-09414-z
3 months ago
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reposted by
Barbara Marte
Nature
4 months ago
Latest from the Nature Podcast 🔊 Underwater glue shows its sticking power in rubber duck test
go.nature.com/3Uh3a3Z
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Underwater glue shows its sticking power in rubber duck test
Hear the biggest stories from the world of science | 06 August 2025
https://go.nature.com/3Uh3a3Z
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and the News & Views to go with it
www.nature.com/articles/d41...
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High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse
DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.
https://www.nature.com/articles/d41586-025-02421-0
4 months ago
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