Barbara Marte
@barbmarte.bsky.social
đ€ 5290
đ„ 952
đ 163
Senior Editor @Nature for cancer and cell cycle. Views my own
new out in Nature
www.nature.com/articles/s41...
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A disease model resource reveals core principles of tissue-specific cancer evolution - Nature
The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.
https://www.nature.com/articles/s41586-026-10187-2
3 days ago
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OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours - Nature
The identification of âboostersâ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.
https://www.nature.com/articles/s41586-026-10149-8
3 days ago
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SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer - Nature
SLAMF6 functions exclusively as a T cell inhibitory receptor, which is triggered by cis homotypic interactions.
https://www.nature.com/articles/s41586-026-10106-5
17 days ago
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new out in Nature
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Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature
ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming...
https://www.nature.com/articles/s41586-025-10036-8
24 days ago
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new out in Nature
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ZFTAâRELA ependymomas make itaconate to epigenetically drive fusion expression - Nature
The ZFTAâRELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.
https://www.nature.com/articles/s41586-025-10005-1
24 days ago
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and the new story
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How tumours trick the brain into shutting down cancer-fighting cells
Lung cancer in mice hijacks neurons to send a signal that subdues the immune system, study finds.
https://www.nature.com/articles/d41586-026-00338-w
24 days ago
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and the News & Views
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A tumour-to-brain pathway hinders anticancer defences
Sensory neurons detect internal and external cues in organs and send this information to the brain. Lung cancer exploits this pathway to lessen immune responses.
https://www.nature.com/articles/d41586-026-00170-2
24 days ago
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new out in Nature, very nice cancer neuroscience story
www.nature.com/articles/s41...
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Tumourâbrain crosstalk restrains cancer immunity via a sensoryâsympathetic axis - Nature
Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...
https://www.nature.com/articles/s41586-025-10028-8
24 days ago
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new out in Nature
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Critical role for a high-plasticity cell state in lung cancer - Nature
The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...
https://www.nature.com/articles/s41586-025-09985-x
about 1 month ago
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Temporal tissue dynamics from a spatial snapshot - Nature
One-shot tissue dynamics reconstruction can infer changes in tissue composition over time, from single-time-point spatial proteomics of human cancers.
https://www.nature.com/articles/s41586-025-09876-1
about 1 month ago
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new out in Nature
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Client Challenge
https://www.nature.com/articles/s41586-025-09913-z
about 1 month ago
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and the News & Views
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https://www.nature.com/articles/d41586-025-03988-4
about 2 months ago
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new out in Nature
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Nutrient requirements of organ-specific metastasis in breast cancer - Nature
How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.
https://www.nature.com/articles/s41586-025-09898-9
about 2 months ago
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on last week's
www.nature.com/articles/s41...
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How fasting boosts breast cancer therapy
A discovery in mice reveals why fasting enhances a type of breast cancer treatment â a hormone-signalling pathway and gene-expression changes have key roles.
https://www.nature.com/articles/d41586-025-03809-8
2 months ago
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Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature
The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophageâDC cross-priming and differentiation of protective memory T cells.
https://www.nature.com/articles/s41586-025-09828-9
3 months ago
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new out in Nature this week
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Somatic evolution following cancer treatment in normal tissue - Nature
High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factor...
https://www.nature.com/articles/s41586-025-09792-4
3 months ago
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new out in Nature this week
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Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma - Nature
Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.
https://www.nature.com/articles/s41586-025-09825-y
3 months ago
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new out in Nature this week
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Fasting boosts breast cancer therapy efficacy via glucocorticoid activation - Nature
Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting...
https://www.nature.com/articles/s41586-025-09869-0
3 months ago
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new out in Nature
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3 months ago
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and the Research Briefing to go with it
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Order in which cancer-driving mutations occur affects the chance of tumour development
Randomly acquired mutations face strong negative selection, except on certain cancer-promoting backgrounds.
https://www.nature.com/articles/d41586-025-03748-4
3 months ago
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new out in Nature
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3 months ago
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new out in Nature
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Polyclonal origins of human premalignant colorectal lesions - Nature
Nature - Polyclonal origins of human premalignant colorectal lesions
https://www.nature.com/articles/s41586-025-09930-y
3 months ago
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Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells - Nature
PD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.
https://www.nature.com/articles/s41586-025-09440-x
3 months ago
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new out in Nature
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NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature
Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...
https://www.nature.com/articles/s41586-025-09727-z
3 months ago
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reposted by
Barbara Marte
Johanna Joyce
4 months ago
New issue of Nature - with NINE studies on
#brain
#development
from the BRAIN Initiative Cell Atlas Network (BICAN) đ§ đ§ȘđŹ An amazing set of resources for all scientists working on the brain! đ§ Immersive feature:
www.nature.com/immersive/d4...
đ§ Perspective:
www.nature.com/articles/s41...
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reposted by
Barbara Marte
Rob Clarke
4 months ago
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts:
urldefense.com/v3/__https:/...
Brilliant team science
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Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
https://urldefense.com/v3/__https://rdcu.be/eOqrx__;!!PDiH4ENfjr2_Jw!HpCkacdjlh1gXOv02IAWFgfMLJnnPyhaDOKmmkMoL41COINEPZh-osC4KeQIMnx_mPBkaSfNUqY_zzJH1_ki-J8-U_ZH-c66WCRxEKhZrP2B$
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reposted by
Barbara Marte
Nature Portfolio
4 months ago
Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. đ§Ș
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://go.nature.com/3JDsUWD
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new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://www.nature.com/collections/gjdefhadcj
4 months ago
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new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
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Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelialâstromal remode...
https://www.nature.com/articles/s41586-025-09684-7
4 months ago
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new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
https://www.nature.com/articles/s41586-025-09710-8
4 months ago
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Barbara Marte
Magdalena Skipper
4 months ago
In praise of fundamental research Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different đ§Ș
@nature.com
www.nature.com/articles/d41...
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From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
https://www.nature.com/articles/d41586-025-03470-1
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reposted by
Barbara Marte
Magdalena Skipper
4 months ago
We asked physicists which are the sci-fi films they like the most - two were consistently highlighted in interviews for their depictions of science: 2014âs Interstellar and 2006âs The Prestige â both of which were directed and co-written by Christopher Nolan đ§Ș
www.nature.com/articles/d41...
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The sci-fi films that physicists love to watch â from Interstellar to Spider-Man
Nature surveyed scientists about their favourite cinematic moments to celebrate the International Year of Quantum Science and Technology.
https://www.nature.com/articles/d41586-025-03440-7
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www.nature.com/articles/d41...
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People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer â in an unexpected way.
https://www.nature.com/articles/d41586-025-03432-7
4 months ago
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and the Clinical Briefing
www.nature.com/articles/d41...
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Tumours might be sensitized to immune therapy by COVID mRNA vaccines
COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.
https://www.nature.com/articles/d41586-025-03411-y
4 months ago
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new out in Nature
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
https://www.nature.com/articles/s41586-025-09655-y
4 months ago
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new out in Nature, a News & Views
www.nature.com/articles/d41...
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Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.
https://www.nature.com/articles/d41586-025-03133-1
4 months ago
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Barbara Marte
VIB Training & Conferences
4 months ago
Tumors are complex ecosystems, where
#cancer
and non-cancer cells interact, shaping how tumors grow, evolve, and respond to treatment. At
#THPT25
, Prof. Itay Tirosh will reveal the secrets to fighting back smarter. Want to join this fight? Register before the deadline on 26 Nov:
vibbio.tech/49aIDGS
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new out in Nature
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Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers - Nature
Nature - Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
https://www.nature.com/articles/s41586-025-09679-4
4 months ago
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new out in Nature
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John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
https://www.nature.com/articles/d41586-025-03418-5
4 months ago
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Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
https://www.nature.com/articles/s41586-025-09713-5
4 months ago
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it was a pleasure! Thanks everyone for attending and contributing. And a big thanks to the EACR staff !
add a skeleton here at some point
4 months ago
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a new News & Views out in Nature
www.nature.com/articles/d41...
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Clues to why the weight-loss condition cachexia arises when cancer occurs
Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.
https://www.nature.com/articles/d41586-025-02594-8
5 months ago
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new out in Nature
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SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
https://www.nature.com/articles/s41586-025-09574-y
5 months ago
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and the News & Views
www.nature.com/articles/d41...
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A drugâdiet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
https://www.nature.com/articles/d41586-025-02824-z
5 months ago
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new out in Nature
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
5 months ago
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and the News & Views
www.nature.com/articles/d41...
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Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
https://www.nature.com/articles/d41586-025-02595-7
5 months ago
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new out in Nature
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
https://www.nature.com/articles/s41586-025-09489-8
5 months ago
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new out in Nature
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Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
https://www.nature.com/articles/s41586-025-09507-9
5 months ago
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reposted by
Barbara Marte
Annette Dittert
5 months ago
Will Dunn is right. An awful new trend. Lovely column.
add a skeleton here at some point
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reposted by
Barbara Marte
Nature Methods
5 months ago
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
www.nature.com/articles/s41...
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