Barbara Marte
@barbmarte.bsky.social
đ€ 5162
đ„ 949
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Senior Editor @Nature for cancer and cell cycle. Views my own
new out in Nature
www.nature.com/articles/s41...
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SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
https://www.nature.com/articles/s41586-025-09574-y
12 days ago
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and the News & Views
www.nature.com/articles/d41...
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A drugâdiet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
https://www.nature.com/articles/d41586-025-02824-z
12 days ago
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new out in Nature
www.nature.com/articles/s41...
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
12 days ago
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and the News & Views
www.nature.com/articles/d41...
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Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
https://www.nature.com/articles/d41586-025-02595-7
12 days ago
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new out in Nature
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
https://www.nature.com/articles/s41586-025-09489-8
12 days ago
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new out in Nature
www.nature.com/articles/s41...
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Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
https://www.nature.com/articles/s41586-025-09507-9
12 days ago
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reposted by
Barbara Marte
Annette Dittert
18 days ago
Will Dunn is right. An awful new trend. Lovely column.
add a skeleton here at some point
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reposted by
Barbara Marte
Nature Methods
19 days ago
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
www.nature.com/articles/s41...
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this is fun
www.nature.com/articles/d41...
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Tipsy bats and perfect pasta: Ig Nobels celebrate âimprobableâ research
The annual awards are a celebration of weird but thought-provoking science.
https://www.nature.com/articles/d41586-025-03045-0
18 days ago
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new out in Nature
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Basal cell of origin resolves neuroendocrineâtuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrineâtuft cancers, explaining neuroendocrineâtuft heterogeneity...
https://www.nature.com/articles/s41586-025-09503-z
18 days ago
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with a bit of delay, a new News & Views out in Nature
www.nature.com/articles/d41...
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Wired for growth: neuronâtumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
https://www.nature.com/articles/d41586-025-02705-5
18 days ago
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Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (Îł-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
https://www.nature.com/articles/s41586-025-09492-z
27 days ago
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and last but not least two cancer neuroscience papers on small cell lung cancer. 1.
www.nature.com/articles/s41...
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Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
https://www.nature.com/articles/s41586-025-09434-9
27 days ago
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new out in Nature
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Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
https://www.nature.com/articles/s41586-025-09493-y
27 days ago
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new out in Nature
www.nature.com/articles/s41...
(the News & Views will come soon)
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
https://www.nature.com/articles/s41586-025-09502-0
27 days ago
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and the News & Views
www.nature.com/articles/d41...
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Epigenetic clues from cancerâs past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
https://www.nature.com/articles/d41586-025-02256-9
27 days ago
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new out in Nature
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Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
https://www.nature.com/articles/s41586-025-09374-4
27 days ago
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the deadline to register at the inaugural EACR cancer neuroscience is approaching fast: Sept 15th. Do join us for a fantastic line up of invited speakers, short talks and abstracts (yes, we have seen them) in the wonderful city of Bilbao (Guggenheim, Pintxos, Txakoli...).
eacr.org/conference/c...
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Introduction | Cancer Neuroscience | The European Association for Cancer Research
https://eacr.org/conference/cancerneuroscience2025?utm_source=confseries&utm_medium=web&utm_campaign=CN25&utm_content=&_gl=1*1l7sbxc*_gcl_aw*R0NMLjE3NTY3NDA5ODMuQ2p3S0NBaUFrYzI4QmhCMEVpd0FNMDAxVFhXenVNTndhUmRvdkgyVFNHeVRBeU9BbUw1TXNpZ3M2VGd3Skd4Y3o5TmhqTUs1TzFteEtob0NnQThRQXZEX0J3RQ..*_gcl_au*NjczMjY5MjU2LjE3NTU2Nzc4OTA
29 days ago
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new out in Nature
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Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
https://www.nature.com/articles/d41586-025-02768-4
about 1 month ago
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and the News & Views
www.nature.com/articles/d41...
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Depriving brain tumours of an amino acid could enhance chemotherapy
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.
https://www.nature.com/articles/d41586-025-02531-9
about 1 month ago
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new out in Nature
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Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
https://www.nature.com/articles/s41586-025-09460-7
about 1 month ago
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new out in Nature this week
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Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumourâmicroenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
https://www.nature.com/articles/s41586-025-09445-6
about 1 month ago
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new out in Nature
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Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
https://www.nature.com/articles/s41586-025-09411-2
about 2 months ago
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a News & Views on a recent JCO paper
www.nature.com/articles/d41...
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Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma
A clinical trial reports data from one of the first groups of people with the blood cancer myeloma to receive a type of immunotherapy called CAR T cells.
https://www.nature.com/articles/d41586-025-02592-w
about 2 months ago
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just out this News & Views on a recent NEJM paper
www.nature.com/articles/d41...
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Exercise improves survival of some people with colon cancer, clinical trial shows
Most studies on how exercise affects the survival of people with cancer have been observational. A clinical trial provides compelling evidence of the benefits of physical activity.
https://www.nature.com/articles/d41586-025-02591-x
about 2 months ago
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and the Research Briefing to go with it
www.nature.com/articles/d41...
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Anticancer compounds that exploit a compromised checkpoint in the cell cycle
In E2F-driven cancers, inhibitors of proteins called cyclins paradoxically cause cell death by enhancing the activity of cyclin B.
https://www.nature.com/articles/d41586-025-02606-7
about 2 months ago
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new out in Nature
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Targeting G1âS-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature
Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.
https://www.nature.com/articles/s41586-025-09433-w
about 2 months ago
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new out in Nature
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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature
Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with a...
https://www.nature.com/articles/s41586-025-09370-8
about 2 months ago
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new out in Nature yesterday
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Clone copy number diversity is linked to survival in lung cancer - Nature
A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...
https://www.nature.com/articles/s41586-025-09398-w
about 2 months ago
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new out in Nature yesterday
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NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
https://www.nature.com/articles/s41586-025-09414-z
about 2 months ago
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reposted by
Barbara Marte
Nature
2 months ago
Latest from the Nature Podcast đ Underwater glue shows its sticking power in rubber duck test
go.nature.com/3Uh3a3Z
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Underwater glue shows its sticking power in rubber duck test
Hear the biggest stories from the world of science | 06 August 2025
https://go.nature.com/3Uh3a3Z
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and the News & Views to go with it
www.nature.com/articles/d41...
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High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse
DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.
https://www.nature.com/articles/d41586-025-02421-0
2 months ago
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new out in Nature this week
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Excised DNA circles from V(D)J recombination promote relapsed leukaemia - Nature
Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis, causing adv...
https://www.nature.com/articles/s41586-025-09372-6
2 months ago
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new out in Nature
www.nature.com/articles/s41...
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NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers - Nature
A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and...
https://www.nature.com/articles/s41586-025-09299-y
2 months ago
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reposted by
Barbara Marte
Nature
2 months ago
Nature research paper: ACLY inhibition promotes tumour immunity and suppresses liver cancer
go.nature.com/4l7n4t8
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ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature
Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.
https://go.nature.com/4l7n4t8
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new out in Nature: cell cycle meets metabolism
www.nature.com/articles/s41...
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Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature
APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
https://www.nature.com/articles/s41586-025-09328-w
2 months ago
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new out in Nature: ACLY inhibition promotes tumour immunity and suppresses liver cancer
www.nature.com/articles/s41...
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ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature
Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...
https://www.nature.com/articles/s41586-025-09297-0
2 months ago
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plus a News story
www.nature.com/articles/d41...
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âSleepingâ cancer cells in the lungs can be roused by COVID and flu
Inflammation from the respiratory infections seems to be the culprit, study in mice finds.
https://www.nature.com/articles/d41586-025-02420-1?utm_source=bluesky&utm_medium=social&utm_campaign=nature&linkId=15998075
2 months ago
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and the accompanying News & Views
www.nature.com/articles/d41...
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Inflammation during viral infection can rouse dormant cancer cells
Sometimes, cancer cells that have spread become âdormantâ but can start proliferating again later. A cue that can reactivate them has been discovered.
https://www.nature.com/articles/d41586-025-02137-1
2 months ago
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new out in Nature: Respiratory viral infections awaken metastatic breast cancer cells in lungshttps://www.nature.com/articles/s41586-025-09332-0
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Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
https://www.nature.com/articles/s41586-025-09332-0
2 months ago
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reposted by
Barbara Marte
Nature
2 months ago
Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades â until they one day trigger a relapse
go.nature.com/41iIdJR
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âSleepingâ cancer cells in the lungs can be roused by COVID and flu
Inflammation from the respiratory infections seems to be the culprit, study in mice finds.
https://go.nature.com/41iIdJR
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a great opportunity to join the Nature team. We're looking for an an editor to handle applied AI
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences)
Title: Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences) Organization: Nature Portfolio Locations: New York or Jersey City â Hybrid Working Model Closing Date: September 2...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor_JR103750
3 months ago
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new out in Nature
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Humoral determinants of checkpoint immunotherapy - Nature
Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.
https://www.nature.com/articles/s41586-025-09188-4
3 months ago
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new out in Nature
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NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...
https://www.nature.com/articles/s41586-025-09303-5
3 months ago
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new out in Nature
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Microbiota-driven antitumour immunity mediated by dendritic cell migration - Nature
A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the activation of tumour-...
https://www.nature.com/articles/s41586-025-09249-8
3 months ago
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and the News & Views
www.nature.com/articles/d41...
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Genome doubling fuels ovarian cancer evolution and immune dysregulation
Single-cell analysis reveals the extent of genome doubling in ovarian cancer, its variability and its role in enabling tumours to evade the immune system.
https://www.nature.com/articles/d41586-025-02059-y
3 months ago
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new out in Nature
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Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...
https://www.nature.com/articles/s41586-025-09240-3
3 months ago
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new out in Nature
www.nature.com/articles/s41...
3 months ago
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new out in Nature this week
www.nature.com/articles/s41...
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PPP2R1A mutations portend improved survival after cancer immunotherapy - Nature
Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathwa...
https://www.nature.com/articles/s41586-025-09203-8
3 months ago
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new out in Nature this week
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Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery - Nature
A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer âarmouredâ CAR T cells that secrete proinflammatory cytokines directly within a tumour without causing...
https://www.nature.com/articles/s41586-025-09212-7
3 months ago
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