Barbara Marte
@barbmarte.bsky.social
ð€ 5229
ð¥ 951
ð 152
Senior Editor @Nature for cancer and cell cycle. Views my own
and the News & Views
www.nature.com/articles/d41...
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https://www.nature.com/articles/d41586-025-03988-4
5 days ago
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new out in Nature
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Nutrient requirements of organ-specific metastasis in breast cancer - Nature
How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.
https://www.nature.com/articles/s41586-025-09898-9
5 days ago
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new News & Views out in Nature
www.nature.com/articles/d41...
on last week's
www.nature.com/articles/s41...
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How fasting boosts breast cancer therapy
A discovery in mice reveals why fasting enhances a type of breast cancer treatment â a hormone-signalling pathway and gene-expression changes have key roles.
https://www.nature.com/articles/d41586-025-03809-8
25 days ago
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new out in Nature this week
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Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature
The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophageâDC cross-priming and differentiation of protective memory T cells.
https://www.nature.com/articles/s41586-025-09828-9
about 1 month ago
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new out in Nature this week
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Somatic evolution following cancer treatment in normal tissue - Nature
High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factor...
https://www.nature.com/articles/s41586-025-09792-4
about 1 month ago
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new out in Nature this week
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Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma - Nature
Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.
https://www.nature.com/articles/s41586-025-09825-y
about 1 month ago
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new out in Nature this week
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Fasting boosts breast cancer therapy efficacy via glucocorticoid activation - Nature
Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting...
https://www.nature.com/articles/s41586-025-09869-0
about 1 month ago
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new out in Nature
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about 1 month ago
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and the Research Briefing to go with it
www.nature.com/articles/d41...
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Order in which cancer-driving mutations occur affects the chance of tumour development
Randomly acquired mutations face strong negative selection, except on certain cancer-promoting backgrounds.
https://www.nature.com/articles/d41586-025-03748-4
about 1 month ago
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new out in Nature
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about 1 month ago
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new out in Nature
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Polyclonal origins of human premalignant colorectal lesions - Nature
Nature - Polyclonal origins of human premalignant colorectal lesions
https://www.nature.com/articles/s41586-025-09930-y
about 2 months ago
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new out in Nature
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Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells - Nature
PD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.
https://www.nature.com/articles/s41586-025-09440-x
about 2 months ago
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new out in Nature
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NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature
Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...
https://www.nature.com/articles/s41586-025-09727-z
about 2 months ago
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reposted by
Barbara Marte
Johanna Joyce
2 months ago
New issue of Nature - with NINE studies on
#brain
#development
from the BRAIN Initiative Cell Atlas Network (BICAN) ð§ ð§ªð¬ An amazing set of resources for all scientists working on the brain! ð§ Immersive feature:
www.nature.com/immersive/d4...
ð§ Perspective:
www.nature.com/articles/s41...
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reposted by
Barbara Marte
Rob Clarke
2 months ago
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts:
urldefense.com/v3/__https:/...
Brilliant team science
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Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
https://urldefense.com/v3/__https://rdcu.be/eOqrx__;!!PDiH4ENfjr2_Jw!HpCkacdjlh1gXOv02IAWFgfMLJnnPyhaDOKmmkMoL41COINEPZh-osC4KeQIMnx_mPBkaSfNUqY_zzJH1_ki-J8-U_ZH-c66WCRxEKhZrP2B$
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reposted by
Barbara Marte
Nature Portfolio
2 months ago
Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. ð§ª
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://go.nature.com/3JDsUWD
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new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...
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BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
https://www.nature.com/collections/gjdefhadcj
2 months ago
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new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
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Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelialâstromal remode...
https://www.nature.com/articles/s41586-025-09684-7
2 months ago
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new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
https://www.nature.com/articles/s41586-025-09710-8
2 months ago
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reposted by
Barbara Marte
Magdalena Skipper
2 months ago
In praise of fundamental research Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different ð§ª
@nature.com
www.nature.com/articles/d41...
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From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
https://www.nature.com/articles/d41586-025-03470-1
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reposted by
Barbara Marte
Magdalena Skipper
3 months ago
We asked physicists which are the sci-fi films they like the most - two were consistently highlighted in interviews for their depictions of science: 2014âs Interstellar and 2006âs The Prestige â both of which were directed and co-written by Christopher Nolan ð§ª
www.nature.com/articles/d41...
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The sci-fi films that physicists love to watch â from Interstellar to Spider-Man
Nature surveyed scientists about their favourite cinematic moments to celebrate the International Year of Quantum Science and Technology.
https://www.nature.com/articles/d41586-025-03440-7
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and the News story
www.nature.com/articles/d41...
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People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer â in an unexpected way.
https://www.nature.com/articles/d41586-025-03432-7
3 months ago
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and the Clinical Briefing
www.nature.com/articles/d41...
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Tumours might be sensitized to immune therapy by COVID mRNA vaccines
COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.
https://www.nature.com/articles/d41586-025-03411-y
3 months ago
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new out in Nature
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
https://www.nature.com/articles/s41586-025-09655-y
3 months ago
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new out in Nature, a News & Views
www.nature.com/articles/d41...
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Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.
https://www.nature.com/articles/d41586-025-03133-1
3 months ago
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reposted by
Barbara Marte
VIB Training & Conferences
3 months ago
Tumors are complex ecosystems, where
#cancer
and non-cancer cells interact, shaping how tumors grow, evolve, and respond to treatment. At
#THPT25
, Prof. Itay Tirosh will reveal the secrets to fighting back smarter. Want to join this fight? Register before the deadline on 26 Nov:
vibbio.tech/49aIDGS
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new out in Nature
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Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers - Nature
Nature - Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
https://www.nature.com/articles/s41586-025-09679-4
3 months ago
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new out in Nature
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John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
https://www.nature.com/articles/d41586-025-03418-5
3 months ago
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new out in Nature
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Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
https://www.nature.com/articles/s41586-025-09713-5
3 months ago
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it was a pleasure! Thanks everyone for attending and contributing. And a big thanks to the EACR staff !
add a skeleton here at some point
3 months ago
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a new News & Views out in Nature
www.nature.com/articles/d41...
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Clues to why the weight-loss condition cachexia arises when cancer occurs
Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.
https://www.nature.com/articles/d41586-025-02594-8
3 months ago
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new out in Nature
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SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
https://www.nature.com/articles/s41586-025-09574-y
4 months ago
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and the News & Views
www.nature.com/articles/d41...
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A drugâdiet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
https://www.nature.com/articles/d41586-025-02824-z
4 months ago
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new out in Nature
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
4 months ago
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and the News & Views
www.nature.com/articles/d41...
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Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
https://www.nature.com/articles/d41586-025-02595-7
4 months ago
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new out in Nature
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
https://www.nature.com/articles/s41586-025-09489-8
4 months ago
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new out in Nature
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Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
https://www.nature.com/articles/s41586-025-09507-9
4 months ago
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reposted by
Barbara Marte
Annette Dittert
4 months ago
Will Dunn is right. An awful new trend. Lovely column.
add a skeleton here at some point
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reposted by
Barbara Marte
Nature Methods
4 months ago
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
www.nature.com/articles/s41...
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this is fun
www.nature.com/articles/d41...
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Tipsy bats and perfect pasta: Ig Nobels celebrate âimprobableâ research
The annual awards are a celebration of weird but thought-provoking science.
https://www.nature.com/articles/d41586-025-03045-0
4 months ago
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new out in Nature
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Basal cell of origin resolves neuroendocrineâtuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrineâtuft cancers, explaining neuroendocrineâtuft heterogeneity...
https://www.nature.com/articles/s41586-025-09503-z
4 months ago
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with a bit of delay, a new News & Views out in Nature
www.nature.com/articles/d41...
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Wired for growth: neuronâtumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
https://www.nature.com/articles/d41586-025-02705-5
4 months ago
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www.nature.com/articles/s41...
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Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
https://www.nature.com/articles/s41586-025-09492-z
4 months ago
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and last but not least two cancer neuroscience papers on small cell lung cancer. 1.
www.nature.com/articles/s41...
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Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
https://www.nature.com/articles/s41586-025-09434-9
4 months ago
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new out in Nature
www.nature.com/articles/s41...
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Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
https://www.nature.com/articles/s41586-025-09493-y
4 months ago
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new out in Nature
www.nature.com/articles/s41...
(the News & Views will come soon)
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
https://www.nature.com/articles/s41586-025-09502-0
4 months ago
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and the News & Views
www.nature.com/articles/d41...
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Epigenetic clues from cancerâs past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
https://www.nature.com/articles/d41586-025-02256-9
4 months ago
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new out in Nature
www.nature.com/articles/s41...
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Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
https://www.nature.com/articles/s41586-025-09374-4
4 months ago
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the deadline to register at the inaugural EACR cancer neuroscience is approaching fast: Sept 15th. Do join us for a fantastic line up of invited speakers, short talks and abstracts (yes, we have seen them) in the wonderful city of Bilbao (Guggenheim, Pintxos, Txakoli...).
eacr.org/conference/c...
.
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Introduction | Cancer Neuroscience | The European Association for Cancer Research
https://eacr.org/conference/cancerneuroscience2025?utm_source=confseries&utm_medium=web&utm_campaign=CN25&utm_content=&_gl=1*1l7sbxc*_gcl_aw*R0NMLjE3NTY3NDA5ODMuQ2p3S0NBaUFrYzI4QmhCMEVpd0FNMDAxVFhXenVNTndhUmRvdkgyVFNHeVRBeU9BbUw1TXNpZ3M2VGd3Skd4Y3o5TmhqTUs1TzFteEtob0NnQThRQXZEX0J3RQ..*_gcl_au*NjczMjY5MjU2LjE3NTU2Nzc4OTA
4 months ago
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new out in Nature
www.nature.com/articles/d41...
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Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
https://www.nature.com/articles/d41586-025-02768-4
4 months ago
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