One week to go until my PhD defense ⏳🎓 To mark this occasion, @unileiden.bsky.social kindly featured my research in their most recent article - check it out below 🧬👩‍🔬

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity? Enhanced DNA repair www.nature.com/articles/s41... erictopol.substack.com/p/a-long-awa...

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Big congratulations to @sarahmoser.bsky.social @oncodeinstitute.bsky.social for being named a 2025 International Birnstiel Award laureate! Selected from 87 nominations, Sarah is one of just six doctoral researchers worldwide to receive this prestigious recognition in molecular life sciences.

Honoured (and excited!) I was named among this year's Birnstiel awardees for my PhD work! 🎉

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance go.nature.com/45vRWhd

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

🗓️ @mylliabio.bsky.social sponsors the first conference on "High-Content CRISPR Screening" from March 18-19, 2026 in Vienna: perturb2026.bio Scientific topics: 🔬 CRISPR-based screening strategies 🧬 Perturb-Seq & CROP-Seq 💻 Computational analyses 💻 AI models of human cells 📸 Image-based screens

New online! Making sense of the polygenicity of complex traits

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

🚨Roadmap 🚨 Alice Soragni @alice.soragnilab.com‬, Erik S. Knudsen ‪@roswellpark.bsky.social‬ ‪ & Co discuss the mechanisms of acquired resistance and the models to better study it to advance predictive and proactive prevention in cancer therapy. 📖 ⬇️

Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research. With @oncodeinstitute.bsky.social #AlpedHuZes #cancerresearch #ad6 #NKI

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...

In a remarkable new paper researchers take a very unconventional approach, introducing into yeast cells (S. cerevisiae) entirely new chromosomes whose DNA never existed in a eukaryotic nucleus. They do this by making the entire bacterial genome of two different bacteria into a yeast chromosome 3/n

Paired-Damage-seq is an in situ labeling-by-repair strategy for joint profiling of oxidative and ssDNA damage alongside gene expression, in single cells. www.nature.com/articles/s41...

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store. ➡️Check it out here: fusion-conferences.com/conference/177

BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...

🥳 First up in #NRCtop10of2024: Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang https://bit.ly/4hE1x... #cancerimaging #cancerscreening #cancerprevention @natureportfolio.bsky.social #NRCtop10of2024

30 years after the discovery of the BRCA1/2 genes, Khalizieva et al. provide a historical account of the key discoveries in BRCA1/2 genetics that contributed to our understanding of their function in DNA repair and cancer. Learn more here: ➡️ tinyurl.com/gd352083

“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽‍🔬

Happy to have contributed to this issue 🎉 @akhalizieva.bsky.social did an amazing job exploring our current knowledge on our two favourite genes, BRCA1 and BRCA2, and how this is being used to target BRCA1/2-mutated tumors. Check it out ⬇️ genesdev.cshlp.org/content/39/1...

Great perspective on the importance of conventional chemotherapy. Despite many many decades of successful use, do we understand how these drugs work? www.nature.com/articles/s41...

Despite the black picture below, we're really happy to have this illuminating story online! Careful molecular mechanistic from Niels and others in the lab work giving unexpected biological insight!

A little fun with numbers on this Sunday, showing just how successful DNA really is. First, here's what DNA looks like. I'll draw your attention to the "rise" in DNA, that is, the distance between two basepairs, which is 3.4 Angstroms, also known as 3.4x10^-10 meters...

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs