Teamwork at its best!! Thank you Vijay, for sharing your technologies and computational talent, for the fun discussions and work together, at random hours of the day or night 😃

(2) we observe intrinsic asymmetry in single-molecule fiber structures assembled on lagging and leading strands. This is neither resolved by CAF-1/ASF1, nor addition of active ISWI remodeler (Isw1a). Will be exciting to identify the factors that restore symmetry in reconstituted setting!(6/n)

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Do not miss this opportunity!! Incredible science and mentor!

Check this out from our colleagues! Congratulations!

We thank Diego Dibitetto and @polosophie.bsky.social for sharing their research with the GIIN community today! Our next seminar will take place on Tuesday, October 7th featuring @fmattiroli.bsky.social and Marco Tigano. Subscribe here to join our mailing list: docs.google.com/forms/d/e/1F...

Check this out!!

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation. edu.nl/h436k If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out! Congratulations!! and happy we could contribute a tiny bit. Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

Thank you, Melina, for the interview!

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!

Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

Fantastic work!! And so interesting for the chromatin replication field! Congratulations!

Apply to our PhD program!!

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here www.biorxiv.org/content/10.1...

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

Big shoutout to this amazing work from our colleagues in the Knipscheer lab. Congratulations on discovering and dissecting yet another new molecular mechanism that keeps our genome safe! 👏🍾

We are excited to get on this project and learn more about chromatin organization! Great to share this good news with Ina and Matilde, congrats everyone!

If you are interested you n moving to Birmingham College of Medicine and Health sponsored by the Faraday Felllwship below, get in touch with our Fellowship Academy and we’ll help with your application! royalsociety.org/news/2025/05...

One more appointment with great science in a few days, one click away 👇

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

In this study, Franklin et al. show that histone chaperones, like the transcription-coupled SPT6 and the replication-coupled CAF-1, control cell differentiation and lineage choice through distinct mechanisms. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352316

We are hiring a new PhD student in #Bioinformatics and Organ #Regeneration using to join our team at the @hubrechtinstitute.bsky.social If you are interested in how the heart regenerates and want to work in a dynamic and experienced team please apply here. www.hubrecht.eu/job/phd-stud...

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

Devastating cuts in US science funding 🧪 www.nytimes.com/interactive/...

Good cover @economist.com

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org

Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

Don’t miss this opportunity!

That's me! Thanks to Bob and Linda and Gladstone for the award and thanks to the organizers at @asbmb.bsky.social for giving me the opportunity to share some of our as-yet-unpublished collaborative work between the labs of @vram142.bsky.social and @fmattiroli.bsky.social !

Application deadline is this Friday!

Exciting PhD project available in our lab (time sensitive)! 👇

This is very interesting!

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....