Francesca Mattiroli
@fmattiroli.bsky.social
📤 1584
📥 788
📝 130
Biochemist with a love for chromatin. Group leader at the Hubrecht Institute.
pinned post!
The latest work from ours and
@vram142.bsky.social
lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and
@palindromephd.bsky.social
. Learning so much from Vijay’s amazing technologies! RT
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5 months ago
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Beautiful work from our neighboring lab! Congrats Juan and team!!
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Francesca Mattiroli
Hubrecht Institute
6 days ago
Excited to see so many registrations for the Hubrecht Symposium 2026! We’re close to full capacity, but there are still a few spots left. Alongside an excellent speaker line-up, we’re welcoming abstract submissions for selected talks and posters until February 15.
www.hubrecht.eu/hubrecht-sym...
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Don’t miss this great work on how RSV virus infects our cells! Congratulations Marvin and team!
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Abstract submission is still open, till February 15th! Join us in Utrecht for a great symposium
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6 days ago
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Congratulations Karolin!! Well deserved recognition!! 🍾👏
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7 days ago
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Kumar Somyajit & Lab
11 days ago
Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉
rdcu.be/e1bBt
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PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.
https://rdcu.be/e1bBt
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EMBL Events
12 days ago
Do you work in DNA replication, genome maintenance, chromosome organisation, chromatin maintenance, or a related field? 🧬 Join us for #EESReplication – submissions are welcome from researchers at all career stages! 20 – 23 October 2026 Send your abstract by 28 July:
s.embl.org/ees26-13-bl
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Don’t miss the 2026 Hubrecht symposium. Submit your abstract before February 1st. Stellar speakers:
@pauligroup.bsky.social
@gerlichlab.bsky.social
Petra Hajkova
@tinekelenstra.bsky.social
@foijer-lab.bsky.social
Joost Gribnau, Melissa Rinaldin
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14 days ago
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Marvin Tanenbaum
21 days ago
New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.
www.biorxiv.org/content/10.6...
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In vivo kinetics of protein degradation by individual proteasomes
Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.64898/2026.01.19.700426v1
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Maximilian Madern
21 days ago
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions.
www.biorxiv.org/content/10.6...
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21 days ago
#Post-doc
position available in our lab at I. Curie, Paris Application and job details here:
emploi.cnrs.fr/Offres/CDD/U...
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Portail Emploi CNRS - Offre d'emploi - post-doctorat biologie moléculaire et cellulaire (H/F)
Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler
https://emploi.cnrs.fr/Offres/CDD/UMR144-EDWNOR-004/Default.aspx
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The Groth lab
26 days ago
Congratulations to
@groth-anja.bsky.social
on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳
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Francesca Mattiroli
Hubrecht Institute
about 2 months ago
Register now for the second Hubrecht Symposium, themed Molecular Machines in Development in Utrecht on March 26, 2026. Visit
hubrecht.eu/hubrecht-symposium-2026/
for registration and abstract submission. Abstract submission deadline: February 1, 2026.
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Do not miss this great symposium in Utrecht! Stellar speakers, free registration and fun audience in a great institute!! 🤩 Registration is open now
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about 2 months ago
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Alessandro Costa
about 1 month ago
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the
@biochemsoc.bsky.social
— four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by
@lapassmore.bsky.social
, Dana Branzei, me.
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Alice Ting
about 1 month ago
Can we design mutations that bias proteins towards desired conformational states? Today in
@science.org
, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
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Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
https://www.science.org/doi/10.1126/science.adv7953
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Lori Passmore
about 1 month ago
Alessandro Costa
@costalaboratory.bsky.social
, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by
@biochemsoc.bsky.social
Register now - lots of opportunities for selected talks
www.eventsforce.net/biochemsoc/f...
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https://www.eventsforce.net/biochemsoc/frontend/reg/thome.csp?pageID=133716&eventID=246
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Amanda Andersson-Rolf
about 1 month ago
We are hiring! Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute
@ki.se
. If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out!
#hiring
#sciencejob
#STEMJobs
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Ina Sonnen
about 2 months ago
Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With
@hansclevers.bsky.social
. Great work by
@tnoordzij.bsky.social
&
@martinacelotti.bsky.social
www.biorxiv.org/content/10.6...
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this is so cool! 🦕
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about 2 months ago
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Do not miss this great symposium in Utrecht! Stellar speakers, free registration and fun audience in a great institute!! 🤩 Registration is open now
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about 2 months ago
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Super happy to work with this team!! Looking forward to the science 🧪
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about 2 months ago
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Srinivas Ramachandran
about 2 months ago
Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones) But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2025.12.12.693854v1
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Di Jiang
2 months ago
@science.org
🧬🔬 Multiscale structure of
#chromatin
condensates explains phase separation and material properties | Science
www.science.org/doi/10.1126/...
@janhuemar.bsky.social
et al.
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Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
https://www.science.org/doi/10.1126/science.adv6588
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GIIN
2 months ago
❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC). No pre-registration needed, simply join via Zoom:
uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here:
docs.google.com/forms/d/e/1F...
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James Briscoe
2 months ago
Applications are open for
@dev-journal.bsky.social
2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word...
www.biologists.com/grants/devel...
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Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
https://www.biologists.com/grants/development-pathway-independence/
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Max Raas
2 months ago
Our story on the kinetochore composition of the ciliate Tetrahymena thermophila is out now on bioRxiv! We find surprisingly many orthologs of conventional kinetochore components, but also components that have very different evolutionary origins. A 🧵 (1/11) Check it out here:
tinyurl.com/4ectm9x4
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https://tinyurl.com/4ectm9x4
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Do you want an excuse to visit Japan and also hear great science on chromosome dynamics?! Check out this great meeting. registrations are open now
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2 months ago
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Buzz Baum
2 months ago
The most amazing thing I ever saw: hundreds and hundreds of dolphins
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Reyes-Lamothe lab
3 months ago
Happy to share our most recent work
www.pnas.org/doi/10.1073/...
. Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!
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Genome integrity relies on rapid recycling of DNA Pol III in bacteria | PNAS
DNA replication requires precise coordination between DNA unwinding and DNA synthesis. In all domains of life, protein–protein interactions at the ...
https://www.pnas.org/doi/10.1073/pnas.2511725122
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Gerben Vader
3 months ago
Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers:
@andrea-musacchio.bsky.social
and
@colindascheele.bsky.social
and the rest of the program will be by early-career scientists. Info:
www.dutchcancerbiology.nl
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Ernst Schmid
3 months ago
Thrilled to share that the final piece of my PhD work is now on bioRxiv!
biorxiv.org/content/10.1...
With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at
predictomes.org/hp
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Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
http://biorxiv.org/content/10.1101/2025.11.10.687652v1
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Thank you for “taking us with you” with these updates. So jealous! Hope it brings lots of specimens and discoveries!
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3 months ago
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Francesca Mattiroli
Schmidt Ocean Institute
3 months ago
#AsgardArchaea
team, led by
@archaeal.bsky.social
fr
@texasscience.bsky.social
— sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life.
bit.ly/3MdniTH
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Aga Gambus
3 months ago
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
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Rosana Collepardo
3 months ago
Very excited to present OpenCGChromatin🔥🔥🔥 A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation Brilliantly led by
@kieran-russell.bsky.social
, with the Rosen and Orozco groups
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The Coster lab 🧬🔬
3 months ago
📢 Last days to apply! 📢 Fully funded PhD position, starting Oct 2026. Deadline Nov 16th. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details:
tinyurl.com/CosterPhD
Apply:
tinyurl.com/ApplyICR
The lab:
CosterLab.com
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Typos in the genome: Defining the molecular mechanism of replication slippage
Typos in the genome: Defining the molecular mechanism of replication slippage
https://tinyurl.com/CosterPhD
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Anja Groth
3 months ago
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by
@sbantele.bsky.social
and Jiri Lukas published in
@science.org
🙌 Happy we could contribute. See 👇
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Beautiful work!!
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3 months ago
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This is really great news for the Dutch structural biology community, a much needed upgrade of the national EM infrastructure. Thank you Friedrich and the many others who put in a lot of work to make this a reality!
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3 months ago
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Friedrich Förster
3 months ago
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
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33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
https://www.uu.nl/en/news/33-million-euro-investment-for-national-electron-microscope-facility-empower
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Matilde Galli
6 months ago
I'm excited to share our work on the regulation of endomitosis in worm intestines:
www.biorxiv.org/content/10.1...
We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
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Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine
During development, many cell types transition from canonical to non-canonical cell cycles, suchas endomitosis and endoreplication, in which they duplicate their DNA but do not divide, giving rise to ...
https://www.biorxiv.org/content/10.1101/2025.08.04.668394v1
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MRC Laboratory of Molecular Biology
4 months ago
John Gurdon, former Group Leader and Head of
@cellbiol-mrclmb.bsky.social
has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More:
www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
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Hubrecht Institute
4 months ago
Save the date! The second Hubrecht Symposium will take place on March 26, 2026. This year’s theme is “Molecular Machines in Development”, with Petra Hajkova, Andrea Pauli and
@danielgerlich.bsky.social
as keynote speakers. Registration opens soon, stay tuned via
hubrecht.eu/hubrecht-symposium/
.
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Edda Schulz
4 months ago
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
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Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
https://www.nature.com/articles/s41594-025-01686-3
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Camille Moore
4 months ago
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
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ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
https://www.science.org/doi/10.1126/science.adr0018
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GIIN
4 months ago
Next week GIIN webinar will feature
@fmattiroli.bsky.social
and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom:
uniroma1.zoom.us/j/95149984403
Register here to become part of our community:
docs.google.com/forms/d/e/1F...
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Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.
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4 months ago
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Teamwork at its best!! Thank you Vijay, for sharing your technologies and computational talent, for the fun discussions and work together, at random hours of the day or night 😃
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5 months ago
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Vijay Ramani
5 months ago
(2) we observe intrinsic asymmetry in single-molecule fiber structures assembled on lagging and leading strands. This is neither resolved by CAF-1/ASF1, nor addition of active ISWI remodeler (Isw1a). Will be exciting to identify the factors that restore symmetry in reconstituted setting!(6/n)
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