this is so cool! 🦕

Do not miss this great symposium in Utrecht! Stellar speakers, free registration and fun audience in a great institute!! 🤩 Registration is open now

Super happy to work with this team!! Looking forward to the science 🧪

Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones) But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ : www.biorxiv.org/content/10.6...

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC). No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403 Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...

Our story on the kinetochore composition of the ciliate Tetrahymena thermophila is out now on bioRxiv! We find surprisingly many orthologs of conventional kinetochore components, but also components that have very different evolutionary origins. A 🧵 (1/11) Check it out here: tinyurl.com/4ectm9x4

Do you want an excuse to visit Japan and also hear great science on chromosome dynamics?! Check out this great meeting. registrations are open now

The most amazing thing I ever saw: hundreds and hundreds of dolphins

Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!

Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers: @andrea-musacchio.bsky.social and @colindascheele.bsky.social and the rest of the program will be by early-career scientists. Info: www.dutchcancerbiology.nl

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Thank you for “taking us with you” with these updates. So jealous! Hope it brings lots of specimens and discoveries!

#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH

Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!

Very excited to present OpenCGChromatin🔥🔥🔥 A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

📢 Last days to apply! 📢 Fully funded PhD position, starting Oct 2026. Deadline Nov 16th. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD Apply: tinyurl.com/ApplyICR The lab: CosterLab.com

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Beautiful work!!

This is really great news for the Dutch structural biology community, a much needed upgrade of the national EM infrastructure. Thank you Friedrich and the many others who put in a lot of work to make this a reality!

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

I'm excited to share our work on the regulation of endomitosis in worm intestines: www.biorxiv.org/content/10.1... We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

Save the date! The second Hubrecht Symposium will take place on March 26, 2026. This year’s theme is “Molecular Machines in Development”, with Petra Hajkova, Andrea Pauli and @danielgerlich.bsky.social as keynote speakers. Registration opens soon, stay tuned via hubrecht.eu/hubrecht-symposium/. ‬

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization. www.science.org/doi/10.1126/...

Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403 Register here to become part of our community: docs.google.com/forms/d/e/1F...

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Teamwork at its best!! Thank you Vijay, for sharing your technologies and computational talent, for the fun discussions and work together, at random hours of the day or night 😃

(2) we observe intrinsic asymmetry in single-molecule fiber structures assembled on lagging and leading strands. This is neither resolved by CAF-1/ASF1, nor addition of active ISWI remodeler (Isw1a). Will be exciting to identify the factors that restore symmetry in reconstituted setting!(6/n)

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Do not miss this opportunity!! Incredible science and mentor!

Check this out from our colleagues! Congratulations!

We thank Diego Dibitetto and @polosophie.bsky.social for sharing their research with the GIIN community today! Our next seminar will take place on Tuesday, October 7th featuring @fmattiroli.bsky.social and Marco Tigano. Subscribe here to join our mailing list: docs.google.com/forms/d/e/1F...

Check this out!!

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation. edu.nl/h436k If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out! Congratulations!! and happy we could contribute a tiny bit. Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

Thank you, Melina, for the interview!

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!

Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...