Alice Ting
@aliceyting.bsky.social
📤 3194
📥 49
📝 63
Molecular designer
We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)
11 days ago
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Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing.
tinyurl.com/32pf6b8p
11 days ago
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Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states CB part starts at 14:55 Thanks to Peter Cavanagh and Andrew Xue – amazing graduate students who co-led this work
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Alice Ting Rosettacon keynote 2025
YouTube video by Alice Ting
https://www.youtube.com/watch?v=4v_ZqWoAQAM&t=3s
3 months ago
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Can we design mutations that bias proteins towards desired conformational states? Today in
@science.org
, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
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Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
https://www.science.org/doi/10.1126/science.adv7953
3 months ago
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New work describes our efforts to achieve CRISPR editing of the mitochondrial genome.
www.biorxiv.org/lookup/conte...
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Towards CRISPR-based editing of the mitochondrial genome in yeast
Mitochondria, which evolved from symbiotic bacteria, possess their own genomes (mtDNA) and support independent transcription and translation within the organelle. Given the essential role of mtDNA in ...
https://www.biorxiv.org/lookup/content/short/2025.12.09.693232v1
4 months ago
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reposted by
Alice Ting
Jingchuan Luo
7 months ago
I'm thrilled to share our work from
@weissmanlab.bsky.social
(
www.sciencedirect.com/science/arti...
). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
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Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman
@weissmanlab.bsky.social
‬ and Jingchuan Luo
7 months ago
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LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee
www.sciencedirect.com/science/arti...
add a skeleton here at some point
7 months ago
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reposted by
Alice Ting
Nature Chemical Biology
8 months ago
A new paper from
@aliceyting.bsky.social
reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces
www.nature.com/articles/s41...
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Directed evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical Biology
LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th...
https://www.nature.com/articles/s41589-025-01973-6?utm_source=bluesky&utm_medium=social&utm_campaign=nchembio
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Can a single researcher test over half a million chemical reactions in <3 days? Yes, using Jeff Martell’s new DNA-encoded combinatorial screening platform. Check out his lab’s exciting new preprint 👇
add a skeleton here at some point
7 months ago
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We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is...
about 1 year ago
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Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
about 1 year ago
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Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for neuroscience,
about 1 year ago
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Are you a Japanese student interested in a postdoctoral fellowship in the US? The Chan Zuckerberg Initiative has an exciting new fully-funded Global Science Scholars program to pair students who have received their undergraduate or doctoral degrees in Japan with US bioengineering and biomedical...
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Global Science Scholars Postdoctoral Fellowship Program SS-F
Apply for the new international postdoctoral fellowship program from the CZ Biohub Network and Stellar Science Foundation.
https://czbiohub.org/program-ssfcz-global-science-scholars/
about 1 year ago
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Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
over 1 year ago
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