A genetically encoded peptide inhibitor of mTORC1 is developed and reveals that nuclear mTORC1 regulates a specific set of genes and promotes cancer cell proliferation www.nature.com/articles/s41...

The potency of a class of RAF kinase inhibitors is found to depend on cancer cell signaling activity, and MEK inhibitors can be reengineered to sensitize RAF kinases to inhibitors for synergistic RAF-MEK inhibitor combinations www.nature.com/articles/s41...

A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference www.nature.com/articles/s41...

A new platform screens for and enables the design of peptide biosensors of dysregulated proteolytic activity in tumors for tumor detection and therapeutic development www.nature.com/articles/s41...

A bioorthogonal, clickable dopamine probe enables chemoproteomic mapping of dopaminylated proteins, revealing a role for histone H4 dopaminylation in cell growth www.nature.com/articles/s41...

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

Our May issue is live! www.nature.com/nchembio/vol... The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites

A new Perspective discusses recent developments in RNA modifications on chromatin-associated RNAs, how they modulate chromatin states, and future direction for studying RNA regulatory elements to control gene expression www.nature.com/articles/s41...

A condensation-independent intramodular translocation mechanism in trans-acyltransferase polyketide synthases www.nature.com/articles/s41...

A cell-permeable nanobody stabilizes misfolded F508del cystic fibrosis transmembrane conductance regulator (CFTR) and restores CFTR activity www.nature.com/articles/s41...

Hypocrealean fungi form symbiotic relationships with plants while antagonizing pests. A survey of 5221 of their biosynthetic gene clusters reveals that ~80% encode unknown products, which could have potential for pest control www.nature.com/articles/s41...

A tubulin isotype-modulated allosteric network governs paclitaxel-binding affinities and affects paclitaxel efficacy against cancer cells www.nature.com/articles/s41...

A new paper reveals how a group I intron from an Anabaena pre-tRNA undergoes structural changes to splice RNA and form circular RNA. The structures define key catalytic steps and offer a blueprint for engineering more efficient circular RNA systems www.nature.com/articles/s41...

Biological sulfation reactions require PAPS as the sulfate donor. Now, MESH1 is identified as the PAPS-degrading enzyme that controls sulfation in animals www.nature.com/articles/s41...

Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment www.nature.com/articles/s41...

A molecular glue CLEO4-88 binds to E3 ligase subunit GID4 to induce a conformational change conducive to binding ACAA1 and inhibiting ACAA1 enzymatic activity instead of triggering ACAA1 degradation www.nature.com/articles/s41...

CenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...

Charged molecular glue discovery enabled by targeted degron display www.nature.com/articles/s41...

Inhibitors of Munc13-4-syntaxin 7, essential for endosomal maturation, impair endosomal TLR overactivation and systemic inflammation www.nature.com/articles/s41...

A new paper reports a cytosine hypermodification pathway in phage HY126 that confers nuclease resistance www.nature.com/articles/s41...

A new paper finds that biomolecular condensates can catalyze reductive amination of metabolites through a nonenzymatic mechanism, mediating C-N bond formation in vitro and impacting cellular metabolism in E. coli www.nature.com/articles/s41...

The maturation of the unique FeMo-cofactor of molybdenum nitrogenase is a multistep process requiring the sequential action of a series of maturase complexes. Cryo-EM structures capture trafficking of a key intermediate of cofactor assembly www.nature.com/articles/s41...

Our April issue is live with a focus on redox chemical biology www.nature.com/nchembio/vol... The cover image with negative-stain electron microscopy grid and structure highlights the diversity of heteromeric structures of peroxiredoxin involved in redox biology

FYI, the first transparent peer review file @natchembio.nature.com has been published with this paper 👀 Yes, we publish them now if the authors elect to!

A new paper reports a high-throughput platform for quantifying the rare earth metal selectivity of lanmodulin proteins, enabling high-purity rare earth metal recovery and separations www.nature.com/articles/s41...

Activation and regulation of the dynein-dynactin-NuMa complex in organizing microtubules in mitotic spindle assembly www.nature.com/articles/s41...

A new paper reports that IDO1 regulates rhythmic oscillations of ROS dynamics, which are lost in hypoxic tumor cells. AhR mediates disordered ROS accumulation, and dual inhibition of IDO1 and AhR is shown to be a potential cancer therapeutic strategy www.nature.com/articles/s41...

A new Comment discusses how an integrative cross-disciplinary research program in China aims to link RNA biology with traditional drug discovery to accelerate RNA innovation in RNA-centered therapeutics www.nature.com/articles/s41...

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here, the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity www.nature.com/articles/s41...

A deep redox proteomics study identifies redox-regulated and druggable cysteines in immune proteins www.nature.com/articles/s41...

A CRISPR-based system records cell signaling activity as DNA edits readable by imaging www.nature.com/articles/s41...

Peroxiredoxins from diverse organisms are found to assemble into hybrid complexes, not just identical ones. These mixed assemblies reshape structure and stability, challenging a long-held view of peroxiredoxin assembly in cells www.nature.com/articles/s41...

The three enzymes ALG3, ALG9, and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, their structures reveal the molecular logic of oligomannose core assembly #glycotime www.nature.com/articles/s41...

Our March issue is live! www.nature.com/nchembio/vol... The cover depicts the neuron as a plant with the nodules surrounding the roots representing condensates of SARM1, which lead to axonal fragmentation, illustrated as fractured roots

Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6

Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases www.nature.com/articles/s41...

A new Review discusses current research and future directions in protein persulfidation and polysulfidation to enable their full potential in redox-based therapeutic efforts www.nature.com/articles/s41...

A chemigenetic DNA nanoprobe enables rapid and selective mapping of norepinephrine dynamics in organelles and is used to show that norepinephrine bursts in the ER trigger neuronal death during traumatic brain injury www.nature.com/articles/s41...

Drug-controlled DROP-CARs enable reversible extracellular control of CAR T cell function via human-derived protein switches that modulate cell-cell interactions and support dual-antigen targeting as well as logic-gated signaling www.nature.com/articles/s41...

Mechanosensitive PIEZO channels sense and open through membrane tension, but their dynamic gating mechanisms remain unclear. A multi-scale simulation approach and electrophysiology reveal a clockwork mechanism for PIEZO2 involving two open states www.nature.com/articles/s41...

A high-throughput approach modifies existing ligands into molecular glue degraders www.nature.com/articles/s41...

A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication www.nature.com/articles/s41...

Nuclear reactive electrophilic stress suppresses translation through HNEylation at C436 of NCBP1, triggering alternative splicing of S6K1, a key regulator of translation www.nature.com/articles/s41...

Polymerization-inducing chimeras (PINCHs) are a novel bifunctional modality that sequesters target homodimers in a polymeric state, thereby inhibiting their function www.nature.com/articles/s41...

CRISPR-Cas9 in S. pyogenes prevents self-cleavage through abasic CRISPR RNA oxidations. A new paper reports the design of chemically modified abasic guide RNAs to enhance genome-editing specificity of SpCas9 and suppress off-target toxicity www.nature.com/articles/s41...

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

🎉🎉 Our paper on temperature-dependent protein control using AsLOV2 variants is now published at @natchembio.nature.com: www.nature.com/articles/s41... including some new insights from extend variant characterizations.

Monoclonal antibodies against pseudaminic acid (Pse) – present in bacterial LPS, capsular polysaccharides, and glycoproteins – have been developed that enable Pse glycoproteome profiling and show therapeutic potential #glycotime www.nature.com/articles/s41...

Inhibitory probes for spatiotemporal analysis of Gα_s protein signaling www.nature.com/articles/s41...

Optogenetic manipulation of spindle dynamics reveals that microtubule shortening at kinetochores limits spindle elongation rather than moving chromosomes, revealing local chromosome-spindle interactions www.nature.com/articles/s41...