Our April issue is live with a focus on redox chemical biology www.nature.com/nchembio/vol... The cover image with negative-stain electron microscopy grid and structure highlights the diversity of heteromeric structures of peroxiredoxin involved in redox biology

FYI, the first transparent peer review file @natchembio.nature.com has been published with this paper 👀 Yes, we publish them now if the authors elect to!

A new paper reports a high-throughput platform for quantifying the rare earth metal selectivity of lanmodulin proteins, enabling high-purity rare earth metal recovery and separations www.nature.com/articles/s41...

Activation and regulation of the dynein-dynactin-NuMa complex in organizing microtubules in mitotic spindle assembly www.nature.com/articles/s41...

A new paper reports that IDO1 regulates rhythmic oscillations of ROS dynamics, which are lost in hypoxic tumor cells. AhR mediates disordered ROS accumulation, and dual inhibition of IDO1 and AhR is shown to be a potential cancer therapeutic strategy www.nature.com/articles/s41...

A new Comment discusses how an integrative cross-disciplinary research program in China aims to link RNA biology with traditional drug discovery to accelerate RNA innovation in RNA-centered therapeutics www.nature.com/articles/s41...

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here, the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity www.nature.com/articles/s41...

A deep redox proteomics study identifies redox-regulated and druggable cysteines in immune proteins www.nature.com/articles/s41...

A CRISPR-based system records cell signaling activity as DNA edits readable by imaging www.nature.com/articles/s41...

Peroxiredoxins from diverse organisms are found to assemble into hybrid complexes, not just identical ones. These mixed assemblies reshape structure and stability, challenging a long-held view of peroxiredoxin assembly in cells www.nature.com/articles/s41...

The three enzymes ALG3, ALG9, and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, their structures reveal the molecular logic of oligomannose core assembly #glycotime www.nature.com/articles/s41...

Our March issue is live! www.nature.com/nchembio/vol... The cover depicts the neuron as a plant with the nodules surrounding the roots representing condensates of SARM1, which lead to axonal fragmentation, illustrated as fractured roots

Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6

Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases www.nature.com/articles/s41...

A new Review discusses current research and future directions in protein persulfidation and polysulfidation to enable their full potential in redox-based therapeutic efforts www.nature.com/articles/s41...

A chemigenetic DNA nanoprobe enables rapid and selective mapping of norepinephrine dynamics in organelles and is used to show that norepinephrine bursts in the ER trigger neuronal death during traumatic brain injury www.nature.com/articles/s41...

Drug-controlled DROP-CARs enable reversible extracellular control of CAR T cell function via human-derived protein switches that modulate cell-cell interactions and support dual-antigen targeting as well as logic-gated signaling www.nature.com/articles/s41...

Mechanosensitive PIEZO channels sense and open through membrane tension, but their dynamic gating mechanisms remain unclear. A multi-scale simulation approach and electrophysiology reveal a clockwork mechanism for PIEZO2 involving two open states www.nature.com/articles/s41...

A high-throughput approach modifies existing ligands into molecular glue degraders www.nature.com/articles/s41...

A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication www.nature.com/articles/s41...

Nuclear reactive electrophilic stress suppresses translation through HNEylation at C436 of NCBP1, triggering alternative splicing of S6K1, a key regulator of translation www.nature.com/articles/s41...

Polymerization-inducing chimeras (PINCHs) are a novel bifunctional modality that sequesters target homodimers in a polymeric state, thereby inhibiting their function www.nature.com/articles/s41...

CRISPR-Cas9 in S. pyogenes prevents self-cleavage through abasic CRISPR RNA oxidations. A new paper reports the design of chemically modified abasic guide RNAs to enhance genome-editing specificity of SpCas9 and suppress off-target toxicity www.nature.com/articles/s41...

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

🎉🎉 Our paper on temperature-dependent protein control using AsLOV2 variants is now published at @natchembio.nature.com: www.nature.com/articles/s41... including some new insights from extend variant characterizations.

Monoclonal antibodies against pseudaminic acid (Pse) – present in bacterial LPS, capsular polysaccharides, and glycoproteins – have been developed that enable Pse glycoproteome profiling and show therapeutic potential #glycotime www.nature.com/articles/s41...

Inhibitory probes for spatiotemporal analysis of Gα_s protein signaling www.nature.com/articles/s41...

Optogenetic manipulation of spindle dynamics reveals that microtubule shortening at kinetochores limits spindle elongation rather than moving chromosomes, revealing local chromosome-spindle interactions www.nature.com/articles/s41...

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions #glycotime www.nature.com/articles/s41...

Tau phosphorylation impedes functionality of protective tau envelopes against microtubule-severing enzymes, providing a potential explanation for microtubule destabilization observed in neuropathology www.nature.com/articles/s41...

De novo design of potent CRISPR-Cas13 inhibitors provides a strategy to rapidly design off-switches for RNA-editing systems www.nature.com/articles/s41...

A new paper reports thymine DNA glycosylase (TDG) as a synthetic lethal target in p53-deficient cancers and a covalent small-molecule inhibitor to target TDG www.nature.com/articles/s41...

A new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...

Our February issue is live! www.nature.com/nchembio/vol... The cover depicts the mapping of ligand-induced changes in the E. coli Lac repressor captured by HX-MS data, used to calculate ensemble free energies of opening for proteins.

A new paper reports the cryo-EM structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a reactive cysteine intermediate www.nature.com/articles/s41...

Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues www.nature.com/articles/s41...

A cell-penetrating peptide blocking ERK lactylation slows KRAS-mutant tumor development www.nature.com/articles/s41...

HDAC1 condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner www.nature.com/articles/s41...

Using activity-based chemical probes, oncogenic IDH1-R132H but not the WT was found to acquire a unique autopalmitoylation at C269 that is critical for the enzyme’s abnormal activity in cancer www.nature.com/articles/s41...

A peptide inhibitor selectively blocks the ATAC histone complex by targets the YEATS2 YEATS domain and suppresses tumor growth in non-small cell lung cancer www.nature.com/articles/s41...

Directed evolution of functional intrinsically disordered proteins www.nature.com/articles/s41...

Structural basis for the catalytic mechanism of human lipid phosphate phosphatases www.nature.com/articles/s41...

Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity www.nature.com/articles/s41...

LipoID profiles lipid droplet interactions and identifies interorganelle regulators www.nature.com/articles/s41...

RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription www.nature.com/articles/s41...

Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes www.nature.com/articles/s41...

Short fatty acids, custom synthesized by engineered yeast 🧫 Here it is: doi.org/10.1038/s415... 🤝✨ Fantastic team effort — thanks to Yongjin Zhou! Science made possible at @goetheuni.bsky.social 🏛️🔬

Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity www.nature.com/articles/s41...

Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation www.nature.com/articles/s41...