Monoclonal antibodies against pseudaminic acid (Pse) – present in bacterial LPS, capsular polysaccharides, and glycoproteins – have been developed that enable Pse glycoproteome profiling and show therapeutic potential #glycotime www.nature.com/articles/s41...

Inhibitory probes for spatiotemporal analysis of Gα_s protein signaling www.nature.com/articles/s41...

Optogenetic manipulation of spindle dynamics reveals that microtubule shortening at kinetochores limits spindle elongation rather than moving chromosomes, revealing local chromosome-spindle interactions www.nature.com/articles/s41...

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions #glycotime www.nature.com/articles/s41...

Tau phosphorylation impedes functionality of protective tau envelopes against microtubule-severing enzymes, providing a potential explanation for microtubule destabilization observed in neuropathology www.nature.com/articles/s41...

De novo design of potent CRISPR-Cas13 inhibitors provides a strategy to rapidly design off-switches for RNA-editing systems www.nature.com/articles/s41...

A new paper reports thymine DNA glycosylase (TDG) as a synthetic lethal target in p53-deficient cancers and a covalent small-molecule inhibitor to target TDG www.nature.com/articles/s41...

A new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...

Our February issue is live! www.nature.com/nchembio/vol... The cover depicts the mapping of ligand-induced changes in the E. coli Lac repressor captured by HX-MS data, used to calculate ensemble free energies of opening for proteins.

A new paper reports the cryo-EM structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a reactive cysteine intermediate www.nature.com/articles/s41...

Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues www.nature.com/articles/s41...

A cell-penetrating peptide blocking ERK lactylation slows KRAS-mutant tumor development www.nature.com/articles/s41...

HDAC1 condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner www.nature.com/articles/s41...

Using activity-based chemical probes, oncogenic IDH1-R132H but not the WT was found to acquire a unique autopalmitoylation at C269 that is critical for the enzyme’s abnormal activity in cancer www.nature.com/articles/s41...

A peptide inhibitor selectively blocks the ATAC histone complex by targets the YEATS2 YEATS domain and suppresses tumor growth in non-small cell lung cancer www.nature.com/articles/s41...

Directed evolution of functional intrinsically disordered proteins www.nature.com/articles/s41...

Structural basis for the catalytic mechanism of human lipid phosphate phosphatases www.nature.com/articles/s41...

Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity www.nature.com/articles/s41...

LipoID profiles lipid droplet interactions and identifies interorganelle regulators www.nature.com/articles/s41...

RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription www.nature.com/articles/s41...

Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes www.nature.com/articles/s41...

Short fatty acids, custom synthesized by engineered yeast 🧫 Here it is: doi.org/10.1038/s415... 🤝✨ Fantastic team effort — thanks to Yongjin Zhou! Science made possible at @goetheuni.bsky.social 🏛️🔬

Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity www.nature.com/articles/s41...

Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation www.nature.com/articles/s41...

A new paper developed a photo-crosslinking platform to capture ligands from complex samples, identifying Little-LEN as a ligand for GPR50 which coordinately regulates body metabolism www.nature.com/articles/s41...

A new paper reports the upper S1-S4 pocket as a multifunctional regulatory hub for TRPM5. Its probing reveals the mechanism of communication between the transmembrane and intracellular domains in the modulation of TRPM5 activity www.nature.com/articles/s41...

A new paper reports on a synthetic yeast toolbox that programs cell-cell adhesion and cross-feeding, enabling spatial patterning coupled with division of labor, boosting high-value antioxidant resveratrol production www.nature.com/articles/s41...

Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system www.nature.com/articles/s41...

Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime www.nature.com/articles/s41...

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms www.nature.com/articles/s41...

A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement www.nature.com/articles/s41...

The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function www.nature.com/articles/s41...

Our January issue is live! www.nature.com/nchembio/vol... The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

A new paper developed a deep-learning-based de novo design strategy that enables simultaneous scaffolding of three distinct epitopes and demonstrates the potential of generative models for complex multisite protein engineering www.nature.com/articles/s41...

Come join our team! The deadline is December 7, but the application is quick. Only a cover letter, CV, and a short Research Highlight are needed #chemsky #chemjob #chembio

Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism www.nature.com/articles/s41...

Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase www.nature.com/articles/s41...

Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system www.nature.com/articles/s41...

Our December issue is live! www.nature.com/nchembio/vol... The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1

Job vacancy: Nature Chemical Biology is hiring Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China. springernature.wd3.myworkdayjobs.com/en-US/Spring...

A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR www.nature.com/articles/s41...

Nitrogen fixation by nitrogenase requires a metallocofactor built by dedicated multiprotein machinery. Structural snapshots of a precursor entering a key maturase reveal the dynamic process of FeMo-cofactor assembly www.nature.com/articles/s41...

A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases www.nature.com/articles/s41...

A large-scale metagenomic, single-bacterial sequencing and biochemical study reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts in marine sponges www.nature.com/articles/s41...

A new Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand, and water molecules, expanding insights into the protein conformational landscape for drug design www.nature.com/articles/s41...

A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology www.nature.com/articles/s41...

A new paper developed a small molecule that exploits the high abundance of mutant p53 and binds p53 Y220C delivering a mitosis blocker, killing TP53 mutant cancer cells while sparing healthy ones www.nature.com/articles/s41...

Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven www.nature.com/articles/s41...