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A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR www.nature.com/articles/s41...

The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells www.nature.com/articles/s41...

I loved this simulation-guided paper with reaaally state-of-the-art simulations at first sight 😍

Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem www.nature.com/articles/s41...

Engineered bispecific Notch agonists “pull” on and mechanically activate Notch receptors in the presence of desired biomarkers www.nature.com/articles/s41...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

The design of STAT biosensors enables real-time tracking of STAT activation in live cells, inhibitor screening, and probing the activity of cancer-associated STAT mutants www.nature.com/articles/s41...

Arginylation is a post-translational modification that is difficult to distinguish from arginine residues using mass spec. Now a method has been developed to profile protein arginylation ex vivo www.nature.com/articles/s41...

The Red Hen in DC for Italian food. I had to wait a month for the reservation! Worth it

#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes www.nature.com/articles/s41...

A new paper reports that the primary mechanism of capsaicin entry into the vanilloid-binding site of TRPV1 is a targetable hydrophobic tunnel at the TRPV1-membrane interface www.nature.com/articles/s41...

#glycotime Legionella effector LtpM is found to recognize strict two-residue sequons for site-specific O-glucosylation with minimal perturbations to a target protein and is used to show that O-glucose can act as a constitutively active O-GlcNAc mimic www.nature.com/articles/s41...

Molecular recording of cellular protein kinase activity with chemical labeling: www.nature.com/articles/s41... Congratulations to De-en Sun and the entire team.

The newest paper from the lab is now out @natchembio.nature.com! A hard-won effort by Rebecca and @xujunc.bsky.social uncovers a previously undescribed post-translationally modified site that regulates STING signaling and proposes a new strategy for inhibition. www.nature.com/articles/s41...

oh god 😖 🤦🏻‍♂️

A new paper from the Institute for Protein Design at UW presents RFpeptides, an extension of RoseTTAFold2 and RFdiffusion for de novo design of macrocyclic peptide binders www.nature.com/articles/s41...

Another cool protein eng. paper for you -- Designed "chauffeurs" shuttle transporters and integral membrane enzymes folded in the ER to the peroxisomal membrane. This expands the repertoire of biosynthetic pathways that can be compartmentalized in the peroxisome www.nature.com/articles/s41...

and check out the associated News & Views by Yang Zhou, Xiaoding Ma, and Haifeng Ye on the innovations of this chemically induced proximity system called SAMBA www.nature.com/articles/s41...

A highly compact chemically induced proximity system dependent on salicylic acid or aspirin enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects www.nature.com/articles/s41...

“if it is allowed…” 😞

c-di-AMP is found to be a second messenger in eukaryotes generated by ADCY7 and connects TLR9 stimulation to NLRP3 inflammasome activation #immunology #ChemBio www.nature.com/articles/s41...

My first Memorial Day Weekend spread 🤤

It’s #lipidtime. The authors capture oscillations in the abundance of different phospholipid species during the yeast cell cycle, suggesting regulation and interplay of phospholipid synthesis, membrane fluidity, and metabolic efficiency during cell division www.nature.com/articles/s41...

Here to report UltraSelex which uses single-round selection and ranking algorithm for high-affinity RNA aptamer discovery #RNA #ChemBio #chemsky #drugdiscovery www.nature.com/articles/s41...

We’re starting to be able to see larger-scale multimers of mRNA species, and it’s a whole new world to explore:

A first-in-class inhibitor of the PASB domain of circadian regulator BMAL1 is reported with an important tie-in to the crosstalk between circadian biology and immunology #chemsky #ChemBio www.nature.com/articles/s41...

I think I got the wrong booster at the doctor's (tetanus instead of MMR) now that there's a measles case in DC 😐

We grew up learning about ribosomes in science textbooks, and it's cool that we're just now starting to really see that they're structurally and functionally heterogeneous. Also in reference to a recent Science paper www.science.org/doi/10.1126/.... Long live science!

"I think we have to see"?!!! Incredible. He doesn't even have the facts. We. already know that they took away many NIH training grants and several big research grants (including large grants for Cancer and Alzheimer's). If this is the response from the Democratic Senate leader, God help us all!

Ligand-controlled transportable condensates to different cell compartments! Enjoy! #ChemBio #synbio www.nature.com/articles/s41...

We're incredibly proud to feature so many incredible women in our special collection for International Women's Day 2025 - highlighting some of the excellent women doing research in physical chemistry, chemical physics and biophysical chemistry! Read the collection at pubs.rsc.org/en/journals/...

It's kind of annoying how I come up with my best writing (e.g. for Research Highlights) in the shower but forget it when I get out

What I Ordered vs What I Got

This Italian market in DC was a discovery. The best variety of vermouths, gins, bitters, and mid- and high-range European wines 😍

I don't know if I can report the exact number of papers, but the number I've gone through is a very big number considering it's only February, and it makes me feel 😵‍💫

A TRPM4 agonist is discovered, but very potent as it leads to sodium overload and a unique type of necrotic cell death #ionchannels #drugdiscovery #ChemBio www.nature.com/articles/s41...

A binary population of biomimetic membraneless organelles delivers molecular messages with controllable feedback #synbio #ChemBio www.nature.com/articles/s41...

I come back to this album so much (Muse - Absolution), and it's channeling the shock, anger, and sadness I feel and the edge I need into a coherent wavelength right now

Is this the immunological equivalent of a turducken? That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

A compound binding to a site peripheral to the KCNQ2 pore acts as either a channel activator (Ebio2) or inhibitor (Ebio3) by a change of a functional group, with the inhibitor having a unique mechanism causing the channel gates to close #ionchannel #ChemBio #chemsky www.nature.com/articles/s41...

And out now from @synbiogaolab.bsky.social: Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced risk of immunogenicity #synbio #ChemBio www.nature.com/articles/s41...

#synbio is still going strong in January: A signal amplification circuit based on recycling nucleic acid inputs (called polymerase strand recycling) improves the sensitivity of transcription factor-based cell-free biosensors www.nature.com/articles/s41...

Someone dropped flowers in front of my door? Thanks!

A new paper from Lingchong You's group develops a cool amplification circuit that expands the dynamic range of plasmid transfer #ChemBio #synbio #microsky www.nature.com/articles/s41...

It’s #glycotime Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains www.nature.com/articles/s41...

I'm happy to see this paper I handled finally out! -- Directed evolution in mammalian cells using an orthogonal alphaviral RNA replication system with antiviral-induced mutagenesis #ChemBio #synbio www.nature.com/articles/s41...

What? I have to return to work in the morning?

What's essential for a happy Xmaths? A very merry equation, of course!😉😁🤗

The Nature Chem Bio account nchembio.bsky.social is up and running! Please give it a follow. Our January issue will also go live before the new year 😉 #ChemBio #chemsky