A very interesting tool with an unexpected finding from @krishnanyamuna.bsky.social and collaborators. Do read, enjoy, and use!

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

Yes. That’s why I say “don’t stop commenting” on SCOTUS decisions and practices. It matters.

Please, amplify.

OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy www.federalregister.gov/documents/20...

Very very interesting and fundamentally important. I’m shocked this wasn’t discovered earlier.

Join the Reck-Peterson lab in NYC as a HHMI Research Technician! This role will support our new work on the cell biology of secondary metabolite production in filamentous fungi. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Trump's in the Epstein files over 600 times.

Epstein redactions aren't believable, and they are valuable to fascists specifically because they aren't believable. Fascists prefer lies to truth. Believing in a lie is preferable to believing a truth, if what you want is to dominate. Believing lies dominates truth. So they believe lies.

I think this is why fascists love AI art, not because it is good, but because it is bad. Not because it is original, but because it is stolen. To make art as an expression of skill and craft and humanity reinforces humanity. To push a button that steals art and call it your own is domination.

Those who have risen to the top in any system (including NYT writers, editors and publishers) always want to believe the status quo will hold. “Hitler no longer a threat, nothing big will change, we can just keep on doing what we are doing.” that’s one lesson I’ve learned over the last decade

Funding a research institute of some hundred people for 10 years? 1.5 Billion. Funding continued defense of a small country in a war for 2 or so years? 90 Billion. Elon Musk’s personal wealth? Estimated 750 Billion. We are fine! Please move on, there is nothing to see here… 🙏

Tl;dr scientists who think science should be "apolitical" are either fools or complicit

I’m excited to share that I’ve joined the Editorial Board of the Journal of Biological Chemistry. I look forward to serving this incredible community journal and engaging with exciting science! @asbmb.bsky.social 🧪

DC residents have been refusing to call that airport anything but National for almost thirty years, we certainly can refuse to call that arts center anything but the Kennedy Center for three

When I'm feeling particularly hopeless about the future of professoring as a profession, I try to remind myself: That's what they want. They want us to not want to be professors anymore.

Great analogy for why multiyear funding is a problem.

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Former NSA employee (16 years) with a pro tip for you. Released controlled document on the left, Epstein on the right. See the difference? In real redactions, some words, headers, and bits will almost always still be visible, but especially classification headers. These documents are UNCLASSIFIED

The atomic ensemble time scale at the NIST Boulder campus has failed.

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Chicago, Aerial View

Very cool! Suggests the possibility of intra-organelle navigation using pH gradients.

This is so cool! Congratulations @krishnanyamuna.bsky.social and Krishnan lab team!!

Late job posting: My department is hiring a tenure-track faculty member in microbiology! Please share with anyone interested in working at a PUI. We have a preference for someone who can teach Medical Microbiology, but other than that the focus is open-ended. Happy to answer qs.

Lincoln Park Lights, Chicago.

very unusual - a tRNA regulated anion channel

I had a panic attack in a crowded hotel lobby the night of his first election. I *knew.* I am Cassandra. And a great quote from the piece: "I’m not opposed to discussion, I’m opposed to having a discussion with people whose beginning point for the discussion is the deprivation of my liberty.”

This is a paradigm shift @krishnanyamuna.bsky.social . Living in the diagnostic world, I wonder whether this could be a signature to identify diseases at the cellular level, and more importantly can we use it follow recovery to normality after stress ?

No thank you for doing all the hard work and writing it up in a way that is clear *and* understandable. The world needs this, my kids need this, not me. Science on!

This is precisely how fascism works, by grabbing at and taking away a little more freedom whenever events lend themselves to it. Bit by bit you lose your rights, until you turn around and realize the road you're on has been long, and democracy is well behind you over the horizon.

One argument I used to make to my students about why it was important to learn history (and historical thinking) is that someone was always going to be trying to tell you things were natural or had always been this way and that you needed to be able to see that as an exercise of power.

Faculty position at the department of medicine, University of Chicago. Please share.

I warned my parents about this last yr after reading through Project 2025, and they told me they had it on personal information that Trump would be a huge supporter of science. So many people in this country were taken for rubes. They were told what they wanted to hear and we are all paying for it.

To all the young people in New York and across our country who count on gender-affirming care: I won't let this administration come for you, your doctors, or your lifesaving health care.  Your health care is still legal and protected.  I'll always fight for you.

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

“The report concludes that the cumulative result of sexual harassment in academic sciences, engineering, and medicine is significant damage to research integrity and a costly loss of talent in these fields.” www.nationalacademies.org/projects/PGA...

Elon Musk’s net worth has now surpassed $600 billion, just weeks after Tesla approved his 10-year, $1 trillion pay package. That could amount to $100 billion per year — more than 1.4 million elementary school teachers’ paychecks combined. Still wondering if inequality is out of control?

Y'all, I just got out of the NSF-BIO webinar where they explained changes to peer review. It's not good. 🧪 scienceforeveryone.science/changes-to-n...

Just to be clear. It’s the John F Kennedy center legally. Just like it’s still the department of defense

This year has been brutal for science, especially early career researchers and those working with communities further marginalized by this administration. Please read the experiences of these scientists. And when you’re done reading, find a way to fight back. theconversation.com/this-year-ne...

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

Are these the same companies that told us the robot could do it?

Seriously, though, investigations into localized (sub-organelle scale) metabolism have been pitched since a long time, but one thing that is lacking is a good proxy for local bulk metabolic rates. Protons are probably the most common product/reactant in biochemical reactions...

Yes!! I love it when dogma is challenged.

Who doesn’t love a good diffusion paper

And here is the book

wowowowow

This is the most interesting thing I've seen in ages. If intra-cellular membrane-less hydrogen ion gradients are biologically meaningful/useful things then so too might be membrane-less gradients of everything else - from bigger ions with discrete point-sources through protein complexes.