“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline” www.science.org/doi/10.1126/...

Check out the very important topic: how does poverty influence childhood cancer biology and treatment response? wonderful work from Birgit Knoechel and Kira Bona! @huntsmancancer.bsky.social @danafarber.bsky.social www.biorxiv.org/content/10.6...

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex... This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011. @cp-cell.bsky.social @cellpress.bsky.social

From the great @xuebingwu.bsky.social and team! Highly recommend 👀

“The power of the people is greater than the people in power” Even at 10F. Ann Arbor this evening.

Systematic analysis of C-termini of small open reading frame-encoded peptides. #Riboseq #proteomics #darkproteome pubs.acs.org/doi/10.1021/...

The inside/ outside temperature differential exceeds 75 degrees this morning in Ann Arbor!

Lunch at Cafe du Lys in Geneva today. Magnificent!

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Nice to see strong support in Congress: “In an 82-15 vote, the Senate approved a minibus budget bill to fund agencies involved in science and the environment, among other issues, through Sept. 30. The bill passed in the House last week by a vote of 397 to 28.” www.nbcnews.com/politics/pol...

Time for some fun! A lovely paper on mathematical oncology. 🧪 #Math #Cancer #CANsky www.biorxiv.org/content/10.6...

Ann Arbor- where even the buses love to think about alternative polyadenylation sequences. #RNAsky

#ChildhoodCancer advocates- This is a powerful piece on the negative impact of Trump administration policies on children with brain cancer, written by a spouse who lived this horror. #DMG/DIPG #ETMR #Medulloblastoma #PEDCAN www.theguardian.com/us-news/ng-i...

Read our full statement by AAP President Dr. Andrew Racine on today’s HHS announcement about the childhood immunization schedule: www.aap.org/en/news-room...

Introducing you all to @mishamehta.bsky.social who has spent tireless hours advocating for children with brain tumors, supporting researchers doing their work, and building community for other families. We are indebted to her: www.youtube.com/watch?v=_r_7... #PEDCan #CanSky #CancerSurvivors

A new #ScienceAdvances study shows that commercial whaling in the Southern Ocean over the past century reduced the genetic diversity—and possibly the evolutionary fitness—of the region’s humpback whales. https://scim.ag/4anxPpM

My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!

Wow this is a seriously serious supplementary figure from @cellpress.bsky.social today. Panels A through UU. I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here? www.cell.com/cell/fulltex...

Whoa!

New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:

The room is almost all elephant. Almost none of it isn’t. Pretty much solid elephant. So there’s no room to talk about it. -Kay Ryan, “The Elephant in the Room” #everynightapoem

So honored to take this position with @wearecbtn.bsky.social and it will be delightful to work on behalf of the pediatric brain tumor community!

Very well done story on 60 Minutes about the harms of grant terminations and freezes at Harvard with Joan Brugge, Don Engbar, David Liu, and a very compelling young cancer patient, now cured with Liu's technology. Transcript and video here www.cbsnews.com/news/researc...

The R2 platform : Democratizing bioinformatics through an easily accessible public online software platform for non-experts in the field of Genomics r2platform.com #genomics #datascience #expertise #fair #public #science #bioinformatics #nocode #tcga #gtex #depmap

💬 Viewpoint: The evolving health care landscape necessitates a new clinician-scholar paradigm incorporating humanities and social sciences to address complex challenges and enhance scientific inquiry and health outcomes. ja.ma/4qtBLL0

I feel like I’m going to reference this all the time. A+ meme.

Fred Hutch's Human Biology Division is recruiting an Assistant or Associate Professor to lead a laboratory-based research program focused on the biological mechanisms of solid tumor cancers and their clinical translation. Learn more and apply: https://apply.interfolio.com/174007

In 1983, the MacNeil/Lehrer NewsHour became the nation’s first hour-long nightly broadcast of national news, says Deema Zein.

Just an afternoon in Ypsilanti, Michigan with a thousand friends. #NoKings

Check out our new paper @jci.org High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma www.jci.org/articles/vie... We show that chr8 gains drive poor outcome in EwS via 4E-BP-1 @dkfz.bsky.social @nct-heidelberg.bsky.social @uniheidelberg.bsky.social

The pangenome resources and genome assembly/inference approaches we are building will eventually enable complete, personalized “T2T” genomes for everyone. This is the thesis of the Q100 project (www.biorxiv.org/content/10.1...) and what my group is currently working towards. Stay tuned... [10/10]

Wow!

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

After testing virtually all reasonable permutations of sample prep, spectra acquisition, database selection, data processing... This team (convincingly, I think) demonstrates that ~85% of the small, *annotated* bacterial proteins are undetectable by mass spec—much less non-annotated ones. (1/4) 🧵

Supporting the #chadtough run to support #DMG/DIPG research for children with #childhoodcancer. What a great run!

EWS::WT1 Isoform-Dependent Regulation of Neogenes in Desmoplastic Small Round Cell Tumors https://www.biorxiv.org/content/10.1101/2025.09.22.676906v1

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

The reference genome of the human diploid cell line RPE-1. #HumanReferenceGenome #HumanDiploidCellLine @natcomms.nature.com 🧬 🖥️ www.nature.com/articles/s41...

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...

Back to school shopping with kids, and seeing the 90s baggy sign, and remembering that my 90s baggy pants are actually from the 90s, and reflecting on how time passes….

Pediatric Brain Cancer Group to Lose Federal Funding. A respected network of hospitals and cancer centers is halting enrollment in clinical trials for children with brain cancer after the federal government said it would no longer provide funding to the group. www.nytimes.com/2025/08/28/w...

Thank you @nytimes.com for featuring this upsetting news about the loss of #childhoodcancer funding for #braintumors. It was my pleasure to speak with #NinaAgrawal for this piece. But I wish circumstances were different and we didn't need this article at all. www.nytimes.com/2025/08/28/w...

Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social: www.nature.com/articles/s41...