Glover, Wilkinson, @ianofbristol.bsky.social et al. show that cells subject to mitochondrial protein import failure induce Intercellular Mitochondrial Transfer via tunnelling nanotubes. rupress.org/jcb/article/... #Organelles #Biochemistry #Mitochondria

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/bacteri...

🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇

Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky

New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...

Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane

This amazing work by @danialv.bsky.social and Bodan Hu is now out in peer-reviewed form at @cp-cell.bsky.social with a lot of new simulations! Check it out if interested in lipid transport!

I'm incredibly proud to share our paper on the preclinical evaluation of the BNT164 mRNA tuberculosis vaccine candidates. Now online in the final version at Nature Immunology. www.nature.com/articles/s41...

A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanieaw.bsky.social www.nature.com/articles/s41...

What would happen if Darwin, Russell Wallace and Koch walked into a bar? We present our new way to study mycobacteria, employing a macroevolution framework (species not strains). Possibilities are endless!! Thanks to Fernanda Subtil for pushing this. elifesciences.org/articles/101...

🚀 Sponsorship opportunities still available 📍 Lyon, France | 14–16 October 2026 Registration opening soon. Stay tuned for further announcements! #CGML2026 #MachineLearning #MolecularModeling #CoarseGrained #DrugDiscovery #Formulations #MaterialsScience

Check out our new review article on intrinsically disordered #microproteins now out in @acs.org Biochemistry! pubs.acs.org/doi/10.1021/...

Some very cool simulations, look at those little guys climb that ladder! #MolecularNodes

StruCloze: A Unified Framework for Backmapping and Inpainting Biomolecule Structures doi.org/10.1021/acs....

Streaming Molecular Dynamics Simulation Data for On-the-fly Processing and Analysis arxiv.org/abs/2605.24271

Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins and their 20,546 transmembrane domains, showing that transmembrane domains inserted by different pathways can tolerate different biophysical properties. rupress.org/jcb/article/...

How does the mycobacterial vacuole go from damage that can still be repaired to full rupture? 👀 Our new preprint shows that EsxA and PDIM act sequentially: EsxA initiates repairable lesions, and PDIM helps push them past host repair capacity toward cytosolic escape. doi.org/10.64898/202...

Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...

Are you analysing hydrophobicity in disordered proteins and still using the Kyte & Doolittle scale? Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs doi.org/10.1021/acs....

Very happy to share our @cbitoulouse.bsky.social perspective article with @jzanet.bsky.social team in @proteinsociety.bsky.social Protein Science: “Sketching microprotein portraits”. onlinelibrary.wiley.com/doi/10.1002/... poke @johnprensner.bsky.social @thomasmartinez.bsky.social #microprotein

🚨 Lipid Time 🚨 New preprint out! Using high-throughput Martini 2 simulations, we studied ~5,000 transmembrane helices in a phase-separating membrane. Most helices preferred disordered environments, some localized at domain interfaces, but none in the liquid-ordered phase! doi.org/10.64898/202...

What happens when you put a snake in shag carpeting with some little soft, bendable posts in the way (and also it can't see the posts). If you answered: "It behaves like a light particle moving through a diffraction grating" then congratulations! You win! Let's talk about SNAKE DIFFRACTION.

Today is the last day to submit your abstract for the EMBO Bacterial Networks (BacNet) meeting #EMBOBacNet! 🧫 Selected participants will be informed by June 30th. meetings.embo.org/event/26-bac...

Here's our latest model development effort, with a set of Martini 3 steroid hormones parameterized straight from structures in the PDB. A big shout out to Tâmela and the team for the impressive work! Preprint: chemrxiv.org/doi/full/10.... Repo: github.com/Martini-Forc... #compchem #compbiol

Postdoctoral Position and PhD Fellowship in studies of the structure-function relationships and conservation of metabolic enzyme filaments in Kelli Hvorecny's newly established group at my department at the University of Copenhagen

Tb cell envelope people take note of this from Christine Hardy at UC Irvine. Beautiful structure and interesting interaction. www.science.org/doi/pdf/10.1...

LinkedIn as an employer looking for candidates is like ipTM: great for filtering candidates discovered elsewhere, but absolute dogshit for discovery. Quite a few people find ways to fluff up mostly-empty CVs and post a firehose of AI-generated posts. Anyway, role still open

Really important and relevant study in TB from @danbarberphd.bsky.social and colleagues. We need to re-think many assumptions. Nitric oxide production in mice has been a confounding factor. #tuberculosis

📯Proud to share a preprint of a joint paper with Michael Timme and @melolab.bsky.social on how ceramides disrupt hexokinase binding to VDACs and modulate channel tilting. Our CG-MD simulations reveal a potential mechanism by which ceramides may induce apoptotic cell death📯 bsky.app/profile/bior...

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉 Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release www.pnas.org/doi/10.1073/...

Excited to share recent work led by the Seiradake lab, for which we have contributed, published in Nature Communications: “Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.” www.nature.com/articles/s41...

Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was. This is how it all started... /1

Excited to announce this postdoc position at the intersection of experiment and computation for time-resolved cryo-EM! It's a collaboration between the Enchev group at the Crick and myself and @pilarcossio.bsky.social at the Flatiron Institute! Plz share. crick.wd3.myworkdayjobs.com/External/job...

Finding a cure for #Parkinsons Disease will require funding of basic research to increase understanding. One study, performed by the group of Professor E Yvonne Jones, investigated the structure of the protein Frizzled3, thought to play a role in Parkinson’s.

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

🚀 Introducing the LUMEN White Label Platform (Alpha) We’re excited to share a major milestone for LUMEN: the release of the alpha version of our White Label discovery platform. wlp.netseven.work (temporary URL) 🔍This is just the start — LUMEN is working toward a full open-source release this year.

For all interested in glycolipids. Interesting review about synthesis of GSLs, their role in physiology, pathology, endocytosis/trafficking/secretion and GSL-targeting strategies in drug design. tinyurl.com/bdpy9zub #glycotime

It's a win for Toulouse!

@robincorey.bsky.social @ianofbristol.bsky.social good luck! Toulouse vs Bristol 🏉

latest #molstar publication pulling all details on its graphics engine together - lots of pretty pictures with Gianluca Tomasello (@proteinimaging.bsky.social), Áron Samuel Kovács, @ludovicautin.bsky.social, David Sehnal pmc.ncbi.nlm.nih.gov/articles/PMC...

Trying some procedural animation for #molstar. Not real in any sense but intended to convey dynamics. github.com/molstar/mols...

This was fun to pull together! Such a fast moving field!

‼️ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!

After three inspiring days filled with excellent science our @cecamevents.bsky.social meeting has come to an end!

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

March 24, 1882 Koch identified the #TB bacterium, launching the breakthroughs that eventually made #tuberculosis treatable. Today TB remains a leading infectious killer, driven by #AMR, gaps in diagnosis and care +social factors: poverty, undernutrition, diabetes, and HIV www.who.int/campaigns/wo...

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...