Very happy to share our @cbitoulouse.bsky.social perspective article with @jzanet.bsky.social team in @proteinsociety.bsky.social Protein Science: “Sketching microprotein portraits”. onlinelibrary.wiley.com/doi/10.1002/... poke @johnprensner.bsky.social @thomasmartinez.bsky.social #microprotein

🚨 Lipid Time 🚨 New preprint out! Using high-throughput Martini 2 simulations, we studied ~5,000 transmembrane helices in a phase-separating membrane. Most helices preferred disordered environments, some localized at domain interfaces, but none in the liquid-ordered phase! doi.org/10.64898/202...

What happens when you put a snake in shag carpeting with some little soft, bendable posts in the way (and also it can't see the posts). If you answered: "It behaves like a light particle moving through a diffraction grating" then congratulations! You win! Let's talk about SNAKE DIFFRACTION.

Today is the last day to submit your abstract for the EMBO Bacterial Networks (BacNet) meeting #EMBOBacNet! 🧫 Selected participants will be informed by June 30th. meetings.embo.org/event/26-bac...

Here's our latest model development effort, with a set of Martini 3 steroid hormones parameterized straight from structures in the PDB. A big shout out to Tâmela and the team for the impressive work! Preprint: chemrxiv.org/doi/full/10.... Repo: github.com/Martini-Forc... #compchem #compbiol

Postdoctoral Position and PhD Fellowship in studies of the structure-function relationships and conservation of metabolic enzyme filaments in Kelli Hvorecny's newly established group at my department at the University of Copenhagen

Tb cell envelope people take note of this from Christine Hardy at UC Irvine. Beautiful structure and interesting interaction. www.science.org/doi/pdf/10.1...

LinkedIn as an employer looking for candidates is like ipTM: great for filtering candidates discovered elsewhere, but absolute dogshit for discovery. Quite a few people find ways to fluff up mostly-empty CVs and post a firehose of AI-generated posts. Anyway, role still open

Really important and relevant study in TB from @danbarberphd.bsky.social and colleagues. We need to re-think many assumptions. Nitric oxide production in mice has been a confounding factor. #tuberculosis

📯Proud to share a preprint of a joint paper with Michael Timme and @melolab.bsky.social on how ceramides disrupt hexokinase binding to VDACs and modulate channel tilting. Our CG-MD simulations reveal a potential mechanism by which ceramides may induce apoptotic cell death📯 bsky.app/profile/bior...

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉 Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release www.pnas.org/doi/10.1073/...

Excited to share recent work led by the Seiradake lab, for which we have contributed, published in Nature Communications: “Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.” www.nature.com/articles/s41...

Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was. This is how it all started... /1

Excited to announce this postdoc position at the intersection of experiment and computation for time-resolved cryo-EM! It's a collaboration between the Enchev group at the Crick and myself and @pilarcossio.bsky.social at the Flatiron Institute! Plz share. crick.wd3.myworkdayjobs.com/External/job...

Finding a cure for #Parkinsons Disease will require funding of basic research to increase understanding. One study, performed by the group of Professor E Yvonne Jones, investigated the structure of the protein Frizzled3, thought to play a role in Parkinson’s.

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

🚀 Introducing the LUMEN White Label Platform (Alpha) We’re excited to share a major milestone for LUMEN: the release of the alpha version of our White Label discovery platform. wlp.netseven.work (temporary URL) 🔍This is just the start — LUMEN is working toward a full open-source release this year.

For all interested in glycolipids. Interesting review about synthesis of GSLs, their role in physiology, pathology, endocytosis/trafficking/secretion and GSL-targeting strategies in drug design. tinyurl.com/bdpy9zub #glycotime

It's a win for Toulouse!

@robincorey.bsky.social @ianofbristol.bsky.social good luck! Toulouse vs Bristol 🏉

latest #molstar publication pulling all details on its graphics engine together - lots of pretty pictures with Gianluca Tomasello (@proteinimaging.bsky.social), Áron Samuel Kovács, @ludovicautin.bsky.social, David Sehnal pmc.ncbi.nlm.nih.gov/articles/PMC...

Trying some procedural animation for #molstar. Not real in any sense but intended to convey dynamics. github.com/molstar/mols...

This was fun to pull together! Such a fast moving field!

‼️ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!

After three inspiring days filled with excellent science our @cecamevents.bsky.social meeting has come to an end!

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

March 24, 1882 Koch identified the #TB bacterium, launching the breakthroughs that eventually made #tuberculosis treatable. Today TB remains a leading infectious killer, driven by #AMR, gaps in diagnosis and care +social factors: poverty, undernutrition, diabetes, and HIV www.who.int/campaigns/wo...

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

We are launching something very exciting next week!! If you are a lipid researcher, love lipids or might need a lipid collaborator in the future, please follow and share! #lipids #lipidresearch

During microbial warfare, #bacteria deploy toxins to inhibit or kill competitors. @ebayersantos.bsky.social &co reveal lipid-targeting #antibacterial #toxins & novel toxin domains within #Salmonella T6SS effectors, broadening known toxin enzymatic diversity @plosbiology.org 🧪 plos.io/40zTyEP

When it rains myco publications in pours myco publications! Now out in PNAS tinyurl.com/2a6833n4 When @zestytoast.bsky.social accidentally isolated the long-chain acyl-CoA carboxylase, we quickly realized we were looking at a fascinating machine essential for building the mycobacterial membrane...

Looking forward welcoming next week all the participants of the CECAM workshop organized with @sonyahanson.bsky.social , Celia Plisson-Chastang, and @bonomimax.bsky.social at the Museum of Toulouse Full program: www.cecam.org/workshop-det...

📖🔓 Promue depuis bientôt dix ans, la science ouverte s’est durablement implantée. Loin de se cantonner à la seule question des données et publications scientifiques, elle a transformé en profondeur les pratiques de recherche. Explications ⤵️

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN pubmed.ncbi.nlm.nih.gov/41755834/ #cryoem

Now published in JCTC pubs.acs.org/doi/10.1021/... Works also for ENM!

Amazing PhD @cristianrocharoa.bsky.social and I have collected our thoughts and questions (many!) on lipid scramblases in this review: www.sciencedirect.com/science/arti... If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

Really happy to participate to the @lumen-eu.bsky.social project. Here a first glimpse on how to link the different scientific communities (Molecular Dynamics, Mathematics, Hearth Science, and Humanities) through the LUMEN Data Mesh.

PhD positions in my lab (AI for Science), but with special preference for people who complement our current activities or are enthusiastic about contributing to our on going work. Looking for technically strong, independent and proactive candidates. www.chalmers.se/en/about-cha...

Check out our latest paper on the glycine receptor with @chakrapanilab.bsky.social where we show the interplay between the orthosteric and allosteric binding sites. www.science.org/doi/10.1126/...

New preprint: “When lipids embrace RNA” www.biorxiv.org/content/10.6... Using multiscale simulations (🍸 #Martini + constant-pH MD), we show that: • Local pKa ≠ global pKa • Endosomal escape is limited by persistent protonation. #LNP #MolecularDynamics

Our paper about Bentopy is now published in Protein Science! Bentopy makes assembling large-scale MD models accessible and fast. doi.org/10.1002/pro.... @janstevens.bsky.social, @cg-martini.bsky.social

Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell model👇

Beautiful and extensive work from the @carobarisch.bsky.social and @soldatilab.bsky.social labs demonstrating that nutrient utilization in intracellular mycobacteria is dependent on their intracellular location. Visionary work!! www.biorxiv.org/content/10.6...

Happy that simulations, performed by Gabriel Diaz, stellar master student in the team, helped to decipher how PIP2 lipids help recruiting Munc13 protein to prime synaptic vesicle Collaborative work led by F. Pincet @normalesup.bsky.social full story at @pnas.org : www.pnas.org/doi/10.1073/...

Lipids challenge ligands to control receptors The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in. 🔗 buff.ly/G1Zl6cZ