Beskid Niski, łemkowski cmentarz dawnej wsi Rostajne. Canon R, 24-105 mm

This, by @jonathan-watts.bsky.social, is a brilliant, fascinating and definitional article. If you want to understand what's happening around the world, you should read it. www.theguardian.com/us-news/ng-i...

Mój trzeci (i ostatni w serii) tekst na blogu @eksperymentmyslowy.bsky.social o roli antygenów grupowych P1PK w podatności na krwawe biegunki powodowane przez bakterie produkujące toksyny Shiga. tinyurl.com/kx95yy6n

Single-Molecule Glycan Discrimination Using a Graphite Nanopore Chandan Kumar Das and Maria Fyta pubs.rsc.org/en/Content/A... It's a #glycotime version of nanopore seq, using carbon like our LC-MS. There is some capacity for discrimination, so maybe there will be a company exploiting this soon?

Stará Ľubovňa, Słowacja. Widok z zamku na Tatry. 📷Canon R 🔘24-105 mm

Check out fascinating insights on nature’s most abundant polymers in our latest blog post. 🌱 Cellulose 🦀 Chitin (found in insects & fungi) 💪 Hyaluronan 🍚 Starch 🦠 Peptidoglycan Read research.bidmc.org/ncfg/blog/27... #Glycobiology #Science #Biochemistry #Nature #CellBiology #Glycotime

New piece from our lab: alpha-Gal syndrome from a glycobiologist's point of view. How glycans in ticks' saliva immunize us, and how our immune system responds to similar glycans present in red meat. Glycoproteins/glycolipids discussed. @alphagal-info.bsky.social tinyurl.com/55762ewu #glycotime

We've just published a preprint describing GlyComboCLI, a command-line tool for glycan composition assignment in MS data. Open-source, FAIR-compliant, and built for integration into automated bioinformatic workflows. #glycotime Link: www.biorxiv.org/content/10.6...

Interesting hypothesis suggests that there may be a bridge between glycated hemoglobin (HbA1c) and glycosylated RNA (glycoRNA). GlycoRNA may represent a complementary molecular indicator of metabolic stress, integrating glycosylation with immune modulation. tinyurl.com/nxv2tyxw #glycotime

Olchowiec, dolina Wilszni, Beskid Niski. 📷Canon R 🔘24-105 mm

How to harness the glycosylation changes that occur in breast cancer for therapeutic purposes? Interesting review explains. #glycotime tinyurl.com/2t2bft5h

Beskid Niski, Magurski Park Narodowy. Pilipów Wiech (664 m). W dole nieistniejąca wieś Ciechania, w oddali przełęcz Tepajec (570 mm). 📷Canon R 🔘24-105 mm

Zborov Castle, Slovakia. Hrad Zborov, Slovensko. 📷Canon R 🔘16 mm

Beskid Niski, las przy drodze Ciechania-Grab. Puszczyk uralski (Strix uralensis). 📷Canon R 🔘24-105 mm

Olchowiec, Beskid Niski, dzisiaj.

110 years ago #OnThisDay, brave Irish took up arms to fight for a free Ireland. Lest we forget☘️. #EasterRising

Para pleszek (Phoenicurus phoenicurus, common redstart) na budce w naszym ogrodzie. Samiec ma czarną głowę. 📷Canon R 🔘400 mm

"Listening to Cellular Whispers through Glycosphingolipids": everything that you wanted to know about glycosphingolipids, their analysis, quantification and annotation using modern machinery. Highly recommended for all involved in GSL analysis. tinyurl.com/c8esvcm2 #glycotime

Biały Kościół, Strzelin district, dolnośląskie voivodeship. 📷Minolta X-300 🔘50 mm 🎞️Ilford FP4+ #BelieveInFilm

Ropucha szara (Bufo bufo) in Stobrawa Lanscape Park, Opolskie Voivodeship. 📷Canon R 🔘24-105 mm

Thank you #NobelLaureate Jack Szostak for sharing these thoughts, which many US scientists and physicians resonate with newsletter.ofthebrave.org/p/im-a-nobel...

The TRAP complex (SSR1-SSR4 proteins) is important in protein translocation/folding/quality control. SSR3/SSR4 mutations are linked to CDG, SSR1/SSR3 are essential for glucose metabolism, while TRAP subunit genes are significantly upregulated in various cancers. tinyurl.com/uypnhwp9 #glycotime

Tatra Mountains seen from Prusy, some 100 km north. Arcelor Mittal steel mill in the foreground. 📷Canon R 🔘24-105 mm

Immunomodulation by glycosylation: bridging glycobiology to adaptive immunity and therapeutic innovation tinyurl.com/3rp3w8uj #glycotime

For all interested in glycolipids. Interesting review about synthesis of GSLs, their role in physiology, pathology, endocytosis/trafficking/secretion and GSL-targeting strategies in drug design. tinyurl.com/bdpy9zub #glycotime

Oś, Opolskie voivodeship. Evangelical cemetery. 📷Minolta XD7 🔘135 mm 🎞️Ilford FP4+ #BelieveInFilm

Wrocław, World War II Cemetery. 📷Bronica ETRS 🔘150 mm 🎞️Ilford FP4+ #BelieveInFilm

Jeśli zmęczyły was promocyjne gadki szefów Big Tech, jak ich innowacje zmienią wszystko na lepsze, mam dla was dobrą i złą wiadomość. Dobra: takich gadek jest coraz mniej. Zła: zastąpiło je przekonywanie, że musimy pogodzić się ze zmianami na gorsze. krytykapolityczna.pl/swiat/ai-pos...

Moje uwagi na temat książki Anny Wacławik i Marii Ciesielskiej "Fleck. Ocalony przez naukę". Wyjaśniam, co odkrył Ludwik Fleck i dlaczego jest to ważna postać. tinyurl.com/53bd6tfd

Z okazji 20. rocznicy śmierci Stanisława Lema, Piotr Gociek rozmawia z Markiem Oramusem. Bardzo ciekawe! www.youtube.com/watch?v=CG6o...

Domasłów, Kępno county, Poland. 📷Minolta XD7 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm #Turpism

Harjumaa, Estonia. Abandoned Soviet military base. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm #turpism

This is big!

@rkaczmarekdr.bsky.social commentary about the role of neutralizing anti-AAV antibodies (NAbs) in hemophilia B therapy. www.rpthjournal.org/article/S247...

Engineered OAA lectins as selective and sensitive high mannose glycan targeting tools - Uses LC-MS as a readout for pulldowns from these anti-glycan reagents. www.biorxiv.org/content/10.6...

Polecam wywiad prof. Dariusza Jemielniaka z prof. Victorem Ambrosem, jednym z odkrywców mikroRNA i laureatem Nagrody Nobla w 2024 r. academia.pan.pl/victor-ambro...

Interesting review about core fucose, its molecular targets and functions in inflammatory signaling pathways tinyurl.com/3yu3henn #glycotime

In a letter to the Editor of Glycoconjgate J., Amit Ranjan and Rajesh K. Gupta discuss the outstanding questions regarding glyco-RNA biology, and explain why new tools for accurate detection and characterization of glycans of glycosylated RNAs are so important. tinyurl.com/bd94nw2e #glycotime

Another great study from @drmpblakeley.bsky.social @anneimb.bsky.social: neutron macromolecular crystallography (NMX) of a lectin from P. aeruginosa reveals how the pathogen utilizes calcium-dependent lectin for binding to human sugars. tinyurl.com/243xbhbt #glycotime

If we made the green energy transition this war would be unthinkable and these authoritarians wouldn’t be in power — not in the US, not in Iran, not in Saudi Arabia, not in Russia. Hydrocarbons are killing our freedom and just plain killing us.

Stallhof, Residenzschloss, Dresden, Germany. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Warsaw, Evangelic Reformed Cemetery. Canon EOS 5, 70-300 mm, Ilford FP4+.

Łukasz Lamża o piszczeniu butów, jak AI radzi sobie w fizyce i układzie nerwowym żebropława (od 22.22). @pawelburkhardt.bsky.social www.youtube.com/watch?v=gIp4...

Warsaw, Staszic Square with the Kopernik monument. 📷Canon EOS 5 🔘17-40 mm 🎞️Ilford FP4+ #BelieveInFilm

Another great paper from @pawelburkhardt.bsky.social about the subepithelial nerve net (SNN) in ctenophores: it forms synaptic connections with effector cells (some 17 cell types). The signal processing within the aboral organ relies on synaptic and nonsynaptic communication. tinyurl.com/2j5ud64m

Under certain stress conditions, bacteria accumulate polyphosphate (polyP), which interacts with a long variant of CobB deacetylase, triggering a regulatory coupling to prevent DNA replication initiation tinyurl.com/2cu8cnx8

Even more excited — our paper is featured on the cover of Science Advances! Huge thanks to @alexandrejan.bsky.social who took this incredible photo of a ctenophore (aka comb jelly) and the editors. Here’s the cover 👇 www.science.org/doi/10.1126/...

Another great article by @mastroianni.bsky.social on the current #SciencePublishing system. Don't publish with for-profit publishers like Elsevier, Springer Nature, et al. It's really simple. There are so many cool #PlantScience society journals. #SciPub See also: bsky.app/profile/soms...

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

B4GALNT3, an enzyme that synthesizes GalNAcβ1-4GlcNAc, contains a unique non-catalytic PA14 domain, which is a lectin domain recognizing sulfated glycans (eg. Gal[6S]β1-4GlcNAc[6S]). Such sulfated glycans negatively regulate the PA14-dependent catalytic activity. tinyurl.com/3zymxxdh #glycotime