Oś, Opolskie voivodeship. Evangelical cemetery. 📷Minolta XD7 🔘135 mm 🎞️Ilford FP4+ #BelieveInFilm

Wrocław, World War II Cemetery. 📷Bronica ETRS 🔘150 mm 🎞️Ilford FP4+ #BelieveInFilm

Jeśli zmęczyły was promocyjne gadki szefów Big Tech, jak ich innowacje zmienią wszystko na lepsze, mam dla was dobrą i złą wiadomość. Dobra: takich gadek jest coraz mniej. Zła: zastąpiło je przekonywanie, że musimy pogodzić się ze zmianami na gorsze. krytykapolityczna.pl/swiat/ai-pos...

Moje uwagi na temat książki Anny Wacławik i Marii Ciesielskiej "Fleck. Ocalony przez naukę". Wyjaśniam, co odkrył Ludwik Fleck i dlaczego jest to ważna postać. tinyurl.com/53bd6tfd

Z okazji 20. rocznicy śmierci Stanisława Lema, Piotr Gociek rozmawia z Markiem Oramusem. Bardzo ciekawe! www.youtube.com/watch?v=CG6o...

Domasłów, Kępno county, Poland. 📷Minolta XD7 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm #Turpism

Harjumaa, Estonia. Abandoned Soviet military base. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm #turpism

This is big!

@rkaczmarekdr.bsky.social commentary about the role of neutralizing anti-AAV antibodies (NAbs) in hemophilia B therapy. www.rpthjournal.org/article/S247...

Engineered OAA lectins as selective and sensitive high mannose glycan targeting tools - Uses LC-MS as a readout for pulldowns from these anti-glycan reagents. www.biorxiv.org/content/10.6...

Polecam wywiad prof. Dariusza Jemielniaka z prof. Victorem Ambrosem, jednym z odkrywców mikroRNA i laureatem Nagrody Nobla w 2024 r. academia.pan.pl/victor-ambro...

Interesting review about core fucose, its molecular targets and functions in inflammatory signaling pathways tinyurl.com/3yu3henn #glycotime

In a letter to the Editor of Glycoconjgate J., Amit Ranjan and Rajesh K. Gupta discuss the outstanding questions regarding glyco-RNA biology, and explain why new tools for accurate detection and characterization of glycans of glycosylated RNAs are so important. tinyurl.com/bd94nw2e #glycotime

Another great study from @drmpblakeley.bsky.social @anneimb.bsky.social: neutron macromolecular crystallography (NMX) of a lectin from P. aeruginosa reveals how the pathogen utilizes calcium-dependent lectin for binding to human sugars. tinyurl.com/243xbhbt #glycotime

If we made the green energy transition this war would be unthinkable and these authoritarians wouldn’t be in power — not in the US, not in Iran, not in Saudi Arabia, not in Russia. Hydrocarbons are killing our freedom and just plain killing us.

Stallhof, Residenzschloss, Dresden, Germany. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Warsaw, Evangelic Reformed Cemetery. Canon EOS 5, 70-300 mm, Ilford FP4+.

Łukasz Lamża o piszczeniu butów, jak AI radzi sobie w fizyce i układzie nerwowym żebropława (od 22.22). @pawelburkhardt.bsky.social www.youtube.com/watch?v=gIp4...

Warsaw, Staszic Square with the Kopernik monument. 📷Canon EOS 5 🔘17-40 mm 🎞️Ilford FP4+ #BelieveInFilm

Another great paper from @pawelburkhardt.bsky.social about the subepithelial nerve net (SNN) in ctenophores: it forms synaptic connections with effector cells (some 17 cell types). The signal processing within the aboral organ relies on synaptic and nonsynaptic communication. tinyurl.com/2j5ud64m

Under certain stress conditions, bacteria accumulate polyphosphate (polyP), which interacts with a long variant of CobB deacetylase, triggering a regulatory coupling to prevent DNA replication initiation tinyurl.com/2cu8cnx8

Even more excited — our paper is featured on the cover of Science Advances! Huge thanks to @alexandrejan.bsky.social who took this incredible photo of a ctenophore (aka comb jelly) and the editors. Here’s the cover 👇 www.science.org/doi/10.1126/...

Another great article by @mastroianni.bsky.social on the current #SciencePublishing system. Don't publish with for-profit publishers like Elsevier, Springer Nature, et al. It's really simple. There are so many cool #PlantScience society journals. #SciPub See also: bsky.app/profile/soms...

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

B4GALNT3, an enzyme that synthesizes GalNAcβ1-4GlcNAc, contains a unique non-catalytic PA14 domain, which is a lectin domain recognizing sulfated glycans (eg. Gal[6S]β1-4GlcNAc[6S]). Such sulfated glycans negatively regulate the PA14-dependent catalytic activity. tinyurl.com/3zymxxdh #glycotime

Fucosylation inhibits pertussis toxin binding to the cell surface, while sialylation and N-linked glycosylation promote the binding, resulting in increased intracellular ERK phosphorylation tinyurl.com/bdza4j38 #glycotime

Alpha-Gal syndrome ⤵️🟡 sad #glycotime 😞

All you ever wanted to know about clinical gene therapy for hemophilia and globin disorders: in vivo and ex vivo methods, lentiviral and adeno-associated viral (AAV) vectors, and gene silencing by the CRISPR-Cas9 gene editing system. @rkaczmarekdr.bsky.social tinyurl.com/3yctsr5a #hemophilia

Calling all #ctenophore researchers and artists! Joe Ryan is organizing the Ctenopalooza Ctwo meeting, which we will host at MBARI in California August 23-25. 🦑🧪🌊 www.mbari.org/event/ctenop... Come swap notes with fellow enthusiasts about the latest news in comb jellies.

Jaki związek mogą mieć antygeny układu grupowego krwi P1PK z bąblowicą? Moje uwagi na blogu eksperymentmyslowy.pl tinyurl.com/24h5nh5k

Moje uwagi na temat "Solaris" Stanisława Lema: dlaczego ta książka jest ciągle aktualna? tinyurl.com/5dk5786v

Rail line Opole-Kluczbork with the rail bus SA103 approaching Kały station. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford FP4+ #BelieveInFilm

Now this is big: under freezing conditions, a small polymerase ribozyme called Q45 can synthesize itself and its complementary strand. It seems that life might have started in the cold: Earth’s natural freeze-thaw cycles may have helped concentrate life’s building blocks. tinyurl.com/36tnesn5

Wrocław, Kępa Mieszczańska. 📷Minolta X-300 🔘28 mm 🎞️Ilford Delta 100 #BelieveInFilm #Turpism

“The richest man in the world posted about how the white race was under threat, made allusions to race science or promoted anti-immigrant conspiracy content on 26 out of 31 days in January” www.theguardian.com/technology/2...

🔓Don't miss this #OpenAccess review from Dominik Weh & @delbiancom.bsky.social at @mpici.bsky.social in our latest issue looking at how mirror-image glycans can be leveraged to tailor carbohydrate materials Check it out in full on our website🔽

Murów, opolskie voivodeship. Abandoned rail station. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm #Turpism

Finally, a detailed review about C-mannosylation: mechanism of C-mannosyltransferases and the influence of the C-mannosylation on the function of several proteins. Highly recommended to everyone in this type of post-translational modification! tinyurl.com/3ywjmfk3 #glycotime

Zagwiździe, Opolskie voivodeship. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

"Jeden enzym, trzy antygeny, cztery fenotypy": moje uwagi o ludzkim układzie grupowym krwi P1PK na blogu eksperymentmyslowy.pl

Finally, an in-depth review #JBC about sialylation in cancer: dual role of sialyltransferases (the “writers”) and siglecs/selectins (the “readers”) in cancer progression. Must-read! tinyurl.com/yvauu3zj @mathd34.bsky.social @siglecdude.bsky.social #glycotime

Where is coagulation factor VIII (FVIII) produced? After decades of research, the new data show that FVIII comes from liver sinusoidal endothelial cells located in zones 2 and 3 of hepatic lobules in mice and humans, with minimal expression in Zone 1 @rkaczmarekdr.bsky.social tinyurl.com/ydtaar2a

Can adeno-associated virus (AAV) gene therapies for hemophilia trigger tumorigenesis? Not really, as @rkaczmarekdr.bsky.social explains... tinyurl.com/3wpfsw3p #hemophilia

Interesting preprint shows that P. vivax uses amplification of the PvDBP gene to avoid the hosts' anti-PvDBP immunity: the more inhibitory the Abs in the hosts’ plasma, the higher the proportion of multi-copy parasites. tinyurl.com/57xdv7za #malaria

Stare Budkowice, Opolskie voivodeship. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm #Turpism

Wrocław, Grabiszyn Park. 📷Bronica ETRS 🔘50 mm 🎞️Ilford HP5+ #BelieveInFilm

The final version appeared today! Our paper on the expression of antigens belonging to the P1PK human blood group system in birds, and how they make them resistant to Shiga toxins. tinyurl.com/bdv7zdaa #glycotime

New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...

„Pęka budowany z dużym wysiłkiem ład” – ostrzegają Ocalały z Auschwitz i dyrektor Muzeum [Wystąpienia] - https://oko.press/peka-budowany-z-duzym-wysilkiem-lad-ostrzegaja-ocalaly-z-auschwitz-i-dyrektor-muzeum-wystapienia