Now this is big: under freezing conditions, a small polymerase ribozyme called Q45 can synthesize itself and its complementary strand. It seems that life might have started in the cold: Earth’s natural freeze-thaw cycles may have helped concentrate life’s building blocks. tinyurl.com/36tnesn5

Wrocław, Kępa Mieszczańska. 📷Minolta X-300 🔘28 mm 🎞️Ilford Delta 100 #BelieveInFilm #Turpism

“The richest man in the world posted about how the white race was under threat, made allusions to race science or promoted anti-immigrant conspiracy content on 26 out of 31 days in January” www.theguardian.com/technology/2...

🔓Don't miss this #OpenAccess review from Dominik Weh & @delbiancom.bsky.social at @mpici.bsky.social in our latest issue looking at how mirror-image glycans can be leveraged to tailor carbohydrate materials Check it out in full on our website🔽

Murów, opolskie voivodeship. Abandoned rail station. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm #Turpism

Finally, a detailed review about C-mannosylation: mechanism of C-mannosyltransferases and the influence of the C-mannosylation on the function of several proteins. Highly recommended to everyone in this type of post-translational modification! tinyurl.com/3ywjmfk3 #glycotime

Zagwiździe, Opolskie voivodeship. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

"Jeden enzym, trzy antygeny, cztery fenotypy": moje uwagi o ludzkim układzie grupowym krwi P1PK na blogu eksperymentmyslowy.pl

Finally, an in-depth review #JBC about sialylation in cancer: dual role of sialyltransferases (the “writers”) and siglecs/selectins (the “readers”) in cancer progression. Must-read! tinyurl.com/yvauu3zj @mathd34.bsky.social @siglecdude.bsky.social #glycotime

Where is coagulation factor VIII (FVIII) produced? After decades of research, the new data show that FVIII comes from liver sinusoidal endothelial cells located in zones 2 and 3 of hepatic lobules in mice and humans, with minimal expression in Zone 1 @rkaczmarekdr.bsky.social tinyurl.com/ydtaar2a

Can adeno-associated virus (AAV) gene therapies for hemophilia trigger tumorigenesis? Not really, as @rkaczmarekdr.bsky.social explains... tinyurl.com/3wpfsw3p #hemophilia

Interesting preprint shows that P. vivax uses amplification of the PvDBP gene to avoid the hosts' anti-PvDBP immunity: the more inhibitory the Abs in the hosts’ plasma, the higher the proportion of multi-copy parasites. tinyurl.com/57xdv7za #malaria

Stare Budkowice, Opolskie voivodeship. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford XP2 #BelieveInFilm #Turpism

Wrocław, Grabiszyn Park. 📷Bronica ETRS 🔘50 mm 🎞️Ilford HP5+ #BelieveInFilm

The final version appeared today! Our paper on the expression of antigens belonging to the P1PK human blood group system in birds, and how they make them resistant to Shiga toxins. tinyurl.com/bdv7zdaa #glycotime

New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...

„Pęka budowany z dużym wysiłkiem ład” – ostrzegają Ocalały z Auschwitz i dyrektor Muzeum [Wystąpienia] - https://oko.press/peka-budowany-z-duzym-wysilkiem-lad-ostrzegaja-ocalaly-z-auschwitz-i-dyrektor-muzeum-wystapienia

On the importance of preprints, regardless of whether you are Team Sponge or Team Jelly: 'King says that she wishes she had posted the study as a preprint so that the errors could have been caught sooner.' www.nature.com/articles/d41...

Interesting study identifies Gb3 as a multifunctional and clinically relevant lipid species, and shows that Gb3-synthase A4GALT is an epigenetically regulated driver of tumor invasiveness in gastrointestinal cancer. tinyurl.com/3rufrxk4 #glycotime

"Structural analysis enabled us to convert Tn-specific mAbs into STn-specific mAbs through modification of VH complementarity-determining region 3, demonstrating the versatility of this approach" #glycotime 😎🧪 www.nature.com/articles/s41...

N-Glycosylation of Band 3 is essential for the binding of Ganoderma lucidum immunomodulatory protein rLZ-8 tinyurl.com/4zuknrcz #glycotime

Kraków, Rakowicki Cemetery. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford HP5+ #BelieveInFilm

Thermal proteome profiling of proteins with distinct glycan structures shows that cells mount a stress response to diverse glycosylation perturbations (esp. Sia, Fuc), causing protein flux change toward degradation. Must-read! @carolynbertozzi.bskyverified.social tinyurl.com/3v262a3v #glycotime

Wrocław, Odra River. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+

"Expanding roles of N-glycosylation in the endoplasmic reticulum": interesting review about the oligosaccharyltransferase (OST)-A and OST-B, and how they regulate stability of the ER chaperone HSP90B1 influencing multiple signaling receptors that are HSP90B1 clients. tinyurl.com/maxawa9c #glycotime

Our lab works on various aspects of hormone regulation by O-GlcNAcylation, including pituitary hormones @aknier.bsky.social and placental hormones(Lily Massman). So we wrote a review, "O-GlcNAcylation in Endocrinology: The Sweet Link". Check it out! academic.oup.com/endo/article...

Everything that you wanted to know about glycomics in clinical science: Paweł Link-Lenczowski presents the first-hand experience about the evaluation of glycans in cancer, autoimmune disorders, inflammation, CDGs, and neurodegenerative diseases. Must-read! tinyurl.com/2ep55zfj #glycotime

Wrocław, Włodkowica Street. 📷Minolta XD7 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Interesting! Inhibition of oligosaccharyltransferase complex results in a 50% reduction in cell surface expression of the prion protein PrP(c). Such molecules cannot convert into multiple strains of PrP(Sc). OST as a novel therapeutic target in proion diseases? tinyurl.com/2s4a29zr #glycotime #prion

Wrocław, Odra River and A8 highway bridge. 📷Minolta X-300 🔘28-70 mm 🎞️Ilford FP4+ #BelieveInFilm #turpism

Dworki, commune of Nowa Ruda, Dolnośląskie voivodeship. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Wrocław, Grabiszyn World War 2 Cemetery. 📷Bronica ETRS 🔘50 mm 🎞️Ilford HP5+ #BelieveInFilm

Włodzickie Hills, Nowa Ruda commune. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Wrocław, South Park. 📷Bronica ETRS 🔘150 mm 🎞️Ilford HP5+ #BelieveInFilm #LiminalSpace

Interesting review about basigin (CD147). It acts as a major receptor to P. falciparum, but it is also a critical regulator of tumor progression, immune modulation, and metabolic adaptation. tinyurl.com/3jae56ed

Wrocław, Grabiszyn Park. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm

Interesting review about the role of cervicovaginal mucus and cervicovaginal fluid glycans in pathogen-host interactions. Vaginitis particularly discussed. tinyurl.com/3eu8ceew #glycotime

Wrocław, Ptasia Street. 📷Minolta X-300 🔘28 mm 🎞️Ilford FP4+ #BelieveInFilm #turpism

Haapsalu, Estonia. 📷Minolta X-300 🔘28-70 mm 🎞️Ilford FP4+ #BelieveInFilm

New from our lab! Anna Bereznicka et al show the role of glycolipids and glycoproteins encoded by different forms of α1,4-galactosyltransferase (A4GALT) and acting as decoy receptors in resistance to Shiga toxins. tinyurl.com/3yhwmabk #glycotime

Paczków, city walls. 📷Canon EOS 5 🔘17-40 mm 🎞️Ilford FP4+ #BelieveInFilm

Interesting paper shows how ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming, which is associated with signalling profiles of tumor cells tinyurl.com/4pyhnv4f

Działamy od trzech lat i opublikowaliśmy już 800 wpisów dotyczących różnych dziedzin wiedzy: nauk ścisłych i przyrodniczych, medycyny, techniki, humanistyki… Nic, co ludzkie, nie jest nam obce. eksperymentmyslowy.pl/spis-tresci/

Dolomites, Provincia Belluno, Lago Antorno. View toward Misurina Lake and the Sorapiss group. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford FP4+ #BelieveInFilm

Linking the glycome and transcriptome at the single cell level #glycotime

Paczków, old cemetery. 📷Canon EOS 5 🔘17-40 mm 🎞️Ilford FP4+ #BelieveInFilm #turpism

Bacteria associated with beetle increase the plant's emission of VOCs, incl. GLVs and benzenoids. The blend content & amount of induced VOCs in plants depends on the insect's developmental stage and the type of damage to the plant #insect #holobiont #microbiome link.springer.com/article/10.1...

Letting the light in - capturing magical moments with my little half frame companion, the light breaking through the clouds created such an incredible atmosphere, stunning and dramatic 📷Pentax 17 🎞️Ilford HP5 🧪DDX #believeinfilm #fridayfavourites #HFF #filmphotography

Wrocław, South Park. 📷Canon EOS 5 🔘70-300 mm 🎞️Ilford FP4+ #BelieveInFilm