Pavel Barahtjan
@pavelbarahtjan.bsky.social
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📥 392
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Lipids | Membranes | Tardigrades | Chemical Biology | PostDoc @EPFL | MPICBG Alumnus
reposted by
Pavel Barahtjan
James Saenz
6 days ago
🌶️ Lipids bring the heat 🔥 Lipids don’t just shape membranes, they influence cellular metabolism. We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠 Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
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Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
https://www.biorxiv.org/content/10.1101/2025.09.12.675810v2
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reposted by
Pavel Barahtjan
Milena Schuhmacher
26 days ago
So honored to be awarded the ERC Starting Grant! I am very grateful for this support and looking forward to more exciting
#lipidtime
🥳 Also, we will have positions available next year. So stay tuned!
add a skeleton here at some point
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reposted by
Pavel Barahtjan
26 days ago
We are all super happy and proud to see our work on the function and evolution of the
#cephalic
#furrow
published in
@nature.com
. Let me say a few things about the background and history of this work on the
#Evolution_of_Morphogenesis
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reposted by
Pavel Barahtjan
Giovanni D’Angelo
27 days ago
Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging. With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology
#MSI
#lipidtime
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Unified mass imaging maps the lipidome of vertebrate development
Nature Methods - uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
https://www.nature.com/articles/s41592-025-02771-7.epdf?sharing_token=K5iHw1c3Jkq0HBI6pQtJNdRgN0jAjWel9jnR3ZoTv0O0dqgsACWV1axX8CzMM4T7iI1XKGp3N-81HgCRS-XXxftpPp3pUNuwYw1DBxUrNsq_lsZHO-zWSflih1WxTQah_5HFsLyD8DN9QPvkFm6CzdtR5nIyDK9dJegr1uk_77g%3D
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reposted by
Pavel Barahtjan
André Nadler
about 1 month ago
Out today in
@nature.com
: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
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reposted by
Pavel Barahtjan
Jeremy Baskin
about 1 month ago
Quite a week for
#lipidtime
: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from
@nadlerlab.bsky.social
and colleagues is now out
@nature.com
!
www.nature.com/articles/s41...
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Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
https://www.nature.com/articles/s41586-025-09432-x
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reposted by
Pavel Barahtjan
Milena Schuhmacher
about 2 months ago
We are hiring! If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland! More information on
www.epfl.ch/labs/gr-schu...
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Open positions
GR-SCHUHMACHER
https://www.epfl.ch/labs/gr-schuhmacher/open-positions/
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The world is small... Randomly found out that
@mikelangelipid.bsky.social
and I are both in Osaka, so we met up for some drinks and
#lipidtime
talk.
4 months ago
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reposted by
Pavel Barahtjan
Rita Mateus
5 months ago
Think biosensors that give absolute measurement values! So happy this is out :) congrats to everyone involved, especially
@sascha-kuhn.bsky.social
and
@nadlerlab.bsky.social
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reposted by
Pavel Barahtjan
André Nadler
5 months ago
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear.
@pavelbarahtjan.bsky.social
addresses this question:
www.biorxiv.org/content/10.1...
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reposted by
Pavel Barahtjan
André Nadler
5 months ago
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by
@sascha-kuhn.bsky.social
. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint:
doi.org/10.1101/2025...
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reposted by
Pavel Barahtjan
Coskun Lipid Cellar @ ZML Dresden
5 months ago
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of
@ox.ac.uk
this was and is one among the must fun collaborations I ever had.
www.science.org/doi/10.1126/...
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Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
https://www.science.org/doi/10.1126/science.adt5827
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Really happy that my main PhD story is out! Huge thanks to everyone involved - especially
@nadlerlab.bsky.social
- for giving me the opportunity to work on this amazing topic.
add a skeleton here at some point
5 months ago
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Amazing work! Of course LA is the answer to all questions :D
add a skeleton here at some point
7 months ago
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reposted by
Pavel Barahtjan
9 months ago
Amazing review to learn about single-cell lipid biology ! Congratulations to all authors
@antonino-asaro.bsky.social
@Agostina Crotta Asis
@giodang.bsky.social
published in
@cp-trendscellbio.bsky.social
!
www.cell.com/trends/cell-...
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Single cell lipid biology
Lipids are major cell constituents endowed with astonishing structural diversity. The pathways responsible for the assembly and disposal of different lipid species are energetically demanding, and gen...
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00255-1?rss=yes&utm_source=dlvr.it&utm_medium=twitter
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