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Congratulations and welcome to the newest members of the #ACSBIOL Executive Committee! @freudlab.bsky.social, @doc-jlmeier.bsky.social, @tmweaver.bsky.social, @ebraselmann.bsky.social

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/... #CellSignaling

Thank you to @ibudin.bsky.social for highlighting our recent membrane editing–proximity labeling #lipidtime story with a News & Views in @natchembio.nature.com!

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

Here's the link for 50 days of free access: authors.elsevier.com/a/1mYmWHRzCb... Original paper (S. Sawada et al.): pubs.acs.org/doi/10.1021/... Many thanks to @jeremybaskin.bsky.social for the kind invitation!

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here Hogan, Laura and Thomas describe in detail our assay cascade (including step-by-step protocols) to identify inhibitors of sterol transport proteins. (1/2) www.sciencedirect.com/science/chap...

Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.

New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...

We're hiring! We're looking for a Locum Editor to cover our chemical biology/biochem. The role can be located in either our London or Pune offices. Planned start date is June 1st. Closing date for applications is Feb 2nd. #chemjobs #chemsky springernature.wd3.myworkdayjobs.com/SpringerNatu...

In any case, if you want to venture into a lipid biology project, the entire issue is a great place to start reading up on the latest methodology. @jeremybaskin.bsky.social assembled a great team of contributors!

Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

Come work with us at Nature Chemistry! We're hiring a locum editor to handle our chembio content in London or Pune.

#chembio and #bioorganic crowd. Mark your calendars for ESBOC 2026, registration opens soon! www.esboc.org.uk ⏱️ 27th-30th May 2026 🏰 The beautiful Schlosshotel Pillnitz GmbH in Dresden/Germany

Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

Exciting new work from @aliceyting.bsky.social and coworkers @stanfordbiosci.bsky.social @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

Experimental tour-de-force from Anne-Claude Gavin's lab: selectivity mapping of 39 lipid transfer proteins reveals ~500 new LTP-lipid pairs. Molecular modeling by @mahmoudmoqadam.bsky.social, @rezatalandahti.bsky.social & Florian Echelard. @cbubergen.bsky.social www.nature.com/articles/s41...

TFW you read just the paper title and you know which lab it came from. Read this awesome paper!

Woah, this is cool!

This is a crucial study and moves us forward towards understanding fundamental biological questions about how cells integrate information related to how components within cells are regulated. These are Nobel worthy questions and the folks who answer them are moving us towards that understanding.

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days. www.nature.com/articles/s41...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Great study and a nicely succinct explanation below!

So in awe of our neighbors, another important study from the Baskin lab using such powerfully clever and elegant tools. Feeding-Fishing for the win!

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

We are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead! news.cornell.edu/stories/2026...

Beautiful study from our @weillinstitute.bsky.social neighbors @rvig.bsky.social @fromme-lab.bsky.social starting with an AlphaFold interactome screen and ending up with a new class of GTPase-activating proteins with effects on membrane trafficking and cell migration. Read the thread for more: 👇

Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...

Farewell to Dr. Lin Luan (seen here signing her lab bench in Sharpie according to lab tradition) — best of luck in your next adventure at the OpenCell team @czbiohub.bsky.social @manu-leo.bsky.social!!

Great Thread/ summary about interesting lipid related papers of 2025 👇

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

2025 was a year full of great scientific discoveries and breakthroughs. Here, I want to highlight 10 papers that got me really excited. Of course, this is a highly subjective selection and I am sure I am forgetting some papers that I would love to include, but here it goes: (1/12)

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime: rupress.org/jcb/article/...

ACTUAL GOOD NEWS EVERYONE: The Paleontological Research Institution and the Museum of the Earth have made it through the crisis! Thanks to everyone who shared or donated-every donation mattered! Please share the good news just as widely!⚒️🧪🦑 Together we did #savePRI www.ithaca.com/news/ithaca/...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch? And we mean scratch: a blinded study. TLDR: 26 days. And the binders work…and led to new cancer biology. We’re coming for you AI…. chemrxiv.org/engage/chemr...

Beware “fear of the experiment”!

Great advice received as a postdoc: Do the easiest thing. I was 3 years into my postdoc and juggling projects w/nothing concrete = career crisis I went to my advisor Paul Sternberg for help. He asked what was going on & what mutant had the strongest phenotype. "Clone the easiest one." It worked.

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

before I started my lab, I asked several senior PIs what their one piece of advice would be and PI pointedly said: “Know when to drop a project.” And that advice has been invaluable in my lab. There are always other projects to follow up on, dropping one isn’t a failure in and of itself.

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Happy holidays! Guess who won chem bio jeopardy?

Beginning of a new era for the @weillinstitute.bsky.social — welcome to @tarafisch.bsky.social!