Very excited to share our preprint showing S-acylation (aka Palmitoylation) of TDP-43, VCP, SQSTM1, FUS & C9Orf72 in Huntington Disease (HD), Amyotrophic Lateral Sclerosis (ALS), & Multisystem Proteinopathy (MSP). This tour de force was led by @firyalrphd.bsky.social! www.biorxiv.org/content/10.6...

What can’t JQ1 do? Check out this cool study in @pnas.org from my Cornell colleagues led by @paulacohen.bsky.social on its promise as a (starting point toward a) non-hormonal male contraceptive! www.pnas.org/doi/10.1073/...

Christian Ungermann opens the 77th Mosbach Kolloquium! Enjoy the meeting, there will be plenty of great science and special workshops for everyone.

Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

A breakthrough in lipid imaging: spatial lipid distributions in organelles! Fantastic work from @nadlerlab.bsky.social 🤯

Check out this super cool #lipidtime imaging story from @nadlerlab.bsky.social!!

Special day at Cornell Chemistry: welcoming back PhD alum @xiaoyuzhang.bsky.social (Hening Lin lab) from Northwestern for a phenomenal seminar on targeted protein degradation and chemical immunology!

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer @amypalmerzinc.bsky.social! Please join us in beautiful Boston April 3-6, 2027. Interested in organizing an ASBMB mini-symposia or workshop? Submit your proposals here!: www.asbmb.org/annual-meeti...

TODAY is Cornell Giving Day and a chance to support the impactful science happening at @weillinstitute.bsky.social. Every day, our scientists work to uncover the fundamental mechanisms of life and advance discoveries shaping the future of biology. Donate here: givingday.cornell.edu/campaigns/we...

Beautiful desert views. Beautiful membrane biology. Join us for the #FASEB Phospholipids in Aging and Disease SRC in Arizona, July 26–30 2026. Registration is now open! So much better than a Lipid Droplets conference. Also, we're co-located with FASEB Lipid Droplets 😜

Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social news.ohsu.edu/2026/02/25/n...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Huge thanks to my former PhD student and then postdoc Gaelen Guzman - this wouldn’t exist without his drive and craftsmanship. Also, big thanks to Carsten Schultz, @nadlerlab.bsky.social, and @jeremybaskin.bsky.social for their support and contributions.

Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...

This is SO COOL!!! academic.oup.com/bioinformati...

Congratulations new Sloan Fellow @stevenbanik.bsky.social @stanford-chemh.bsky.social 👏

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus. This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group. Link to posting below. Please share! jobrxiv.org/job/national...

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm! elifesciences.org/articles/88794 colab.research.google.com/github/Masaa...

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm! elifesciences.org/articles/88794 colab.research.google.com/github/Masaa...

Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/... #CellSignaling #Biochemistry

👀

Congratulations and welcome to the newest members of the #ACSBIOL Executive Committee! @freudlab.bsky.social, @doc-jlmeier.bsky.social, @tmweaver.bsky.social, @ebraselmann.bsky.social

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/... #CellSignaling

Thank you to @ibudin.bsky.social for highlighting our recent membrane editing–proximity labeling #lipidtime story with a News & Views in @natchembio.nature.com!

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

Here's the link for 50 days of free access: authors.elsevier.com/a/1mYmWHRzCb... Original paper (S. Sawada et al.): pubs.acs.org/doi/10.1021/... Many thanks to @jeremybaskin.bsky.social for the kind invitation!

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here Hogan, Laura and Thomas describe in detail our assay cascade (including step-by-step protocols) to identify inhibitors of sterol transport proteins. (1/2) www.sciencedirect.com/science/chap...

Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.

New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...

We're hiring! We're looking for a Locum Editor to cover our chemical biology/biochem. The role can be located in either our London or Pune offices. Planned start date is June 1st. Closing date for applications is Feb 2nd. #chemjobs #chemsky springernature.wd3.myworkdayjobs.com/SpringerNatu...

In any case, if you want to venture into a lipid biology project, the entire issue is a great place to start reading up on the latest methodology. @jeremybaskin.bsky.social assembled a great team of contributors!

Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

Come work with us at Nature Chemistry! We're hiring a locum editor to handle our chembio content in London or Pune.

#chembio and #bioorganic crowd. Mark your calendars for ESBOC 2026, registration opens soon! www.esboc.org.uk ⏱️ 27th-30th May 2026 🏰 The beautiful Schlosshotel Pillnitz GmbH in Dresden/Germany

Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

Exciting new work from @aliceyting.bsky.social and coworkers @stanfordbiosci.bsky.social @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

Experimental tour-de-force from Anne-Claude Gavin's lab: selectivity mapping of 39 lipid transfer proteins reveals ~500 new LTP-lipid pairs. Molecular modeling by @mahmoudmoqadam.bsky.social, @rezatalandahti.bsky.social & Florian Echelard. @cbubergen.bsky.social www.nature.com/articles/s41...

TFW you read just the paper title and you know which lab it came from. Read this awesome paper!

Woah, this is cool!

This is a crucial study and moves us forward towards understanding fundamental biological questions about how cells integrate information related to how components within cells are regulated. These are Nobel worthy questions and the folks who answer them are moving us towards that understanding.

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days. www.nature.com/articles/s41...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Great study and a nicely succinct explanation below!