Great talk @weillinstitute.bsky.social on lysosomal damage in neurodegenerative disease by @shawnferguson.bsky.social @yalecellbiology.bsky.social! (Also: Go Habs!)

The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...

very nice to see the chemists get a moment in this article about daraxonrasib, Revolution Medicines' pancreatic cancer compound: www.nytimes.com/2026/05/12/h... #chemsky

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

Appalabhotla, Siesser, Bear, Haugh et al. developed a system enabling light-mediated recruitment of PLC-γ1 variants to dissect mechanisms underpinning #cancer-associated hyperactivity, and they show that recruitment of active PLC-γ1 robustly directs #fibroblast #migration rupress.org/jcb/article/...

This was a really fun story to see develop. OptoPLC does some fascinating things to cell motility

What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...

Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics

Thrilled to welcome @mbogyo.bsky.social, @danetteldaniels.bsky.social, @slavofflab.bsky.social, and Marcey Waters to Cornell for today’s annual Chemistry-Biology Interface Symposium!

I feel like an important lesson we could all remember, but especially if we are trying to convince people of something, is to KNOW your audience. Surprised that your provocative statement lands poorly? KNOW YOUR AUDIENCE

I had a blast visiting the Omenn Darling Bioengineering Institute @princeton.edu yesterday! Thanks so much to Tina Kim for hosting my visit! @christhechang.bsky.social @fredhughson.bsky.social & Ralph Kleiner

Dear Lipid and Membrane Enthusiasts, There is only one month!! left to register and submit your abstracts for the @embo.org Workshop “Lipid Code to Life”, which will be held from September 7–11, 2026, in Dresden, Germany. Workshop program and registration page: meetings.embo.org/event/26-lip...

Hello, Princeton! Excited for my visit to the Omenn Darling Bioengineering Institute tomorrow 😃

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

Now out in its final form in @jacs.acspublications.org: Reaction pathways & photoreaction yields of bifunctional lipid probes. The numbers that explain why we spend so much time optimizing protocols for cellular assays. 😉 pubs.acs.org/doi/10.1021/...

Interesting #lipidtime food science: eating melted cheese increases your triglycerides and cholesterol more than eating the *exact same cheese* unmelted — possibly due to changes at the molecular level in a phospholipid *trilayer* that encapsulates fat in dairy products!

Very excited to share our preprint showing S-acylation (aka Palmitoylation) of TDP-43, VCP, SQSTM1, FUS & C9Orf72 in Huntington Disease (HD), Amyotrophic Lateral Sclerosis (ALS), & Multisystem Proteinopathy (MSP). This tour de force was led by @firyalrphd.bsky.social! www.biorxiv.org/content/10.6...

What can’t JQ1 do? Check out this cool study in @pnas.org from my Cornell colleagues led by @paulacohen.bsky.social on its promise as a (starting point toward a) non-hormonal male contraceptive! www.pnas.org/doi/10.1073/...

Christian Ungermann opens the 77th Mosbach Kolloquium! Enjoy the meeting, there will be plenty of great science and special workshops for everyone.

Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

A breakthrough in lipid imaging: spatial lipid distributions in organelles! Fantastic work from @nadlerlab.bsky.social 🤯

Check out this super cool #lipidtime imaging story from @nadlerlab.bsky.social!!

Special day at Cornell Chemistry: welcoming back PhD alum @xiaoyuzhang.bsky.social (Hening Lin lab) from Northwestern for a phenomenal seminar on targeted protein degradation and chemical immunology!

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer @amypalmerzinc.bsky.social! Please join us in beautiful Boston April 3-6, 2027. Interested in organizing an ASBMB mini-symposia or workshop? Submit your proposals here!: www.asbmb.org/annual-meeti...

TODAY is Cornell Giving Day and a chance to support the impactful science happening at @weillinstitute.bsky.social. Every day, our scientists work to uncover the fundamental mechanisms of life and advance discoveries shaping the future of biology. Donate here: givingday.cornell.edu/campaigns/we...

Beautiful desert views. Beautiful membrane biology. Join us for the #FASEB Phospholipids in Aging and Disease SRC in Arizona, July 26–30 2026. Registration is now open! So much better than a Lipid Droplets conference. Also, we're co-located with FASEB Lipid Droplets 😜

Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social news.ohsu.edu/2026/02/25/n...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Huge thanks to my former PhD student and then postdoc Gaelen Guzman - this wouldn’t exist without his drive and craftsmanship. Also, big thanks to Carsten Schultz, @nadlerlab.bsky.social, and @jeremybaskin.bsky.social for their support and contributions.

Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...

This is SO COOL!!! academic.oup.com/bioinformati...

Congratulations new Sloan Fellow @stevenbanik.bsky.social @stanford-chemh.bsky.social 👏

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus. This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group. Link to posting below. Please share! jobrxiv.org/job/national...

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm! elifesciences.org/articles/88794 colab.research.google.com/github/Masaa...

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm! elifesciences.org/articles/88794 colab.research.google.com/github/Masaa...

Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/... #CellSignaling #Biochemistry

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Congratulations and welcome to the newest members of the #ACSBIOL Executive Committee! @freudlab.bsky.social, @doc-jlmeier.bsky.social, @tmweaver.bsky.social, @ebraselmann.bsky.social

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/... #CellSignaling

Thank you to @ibudin.bsky.social for highlighting our recent membrane editing–proximity labeling #lipidtime story with a News & Views in @natchembio.nature.com!

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

Here's the link for 50 days of free access: authors.elsevier.com/a/1mYmWHRzCb... Original paper (S. Sawada et al.): pubs.acs.org/doi/10.1021/... Many thanks to @jeremybaskin.bsky.social for the kind invitation!

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here Hogan, Laura and Thomas describe in detail our assay cascade (including step-by-step protocols) to identify inhibitors of sterol transport proteins. (1/2) www.sciencedirect.com/science/chap...

Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.

New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...