Phosphatidylserine and RhoB connect PI4P and PA #metabolism to maintain plasma #membrane identity. New study from Shiying Huang, Tamas Balla, Jeremy M. Baskin @jeremybaskin.bsky.social, @weillinstitute.bsky.social and colleagues: rupress.org/jcb/article/... #lipid

The last leg of my trip to Japan was at the 55th Naito Conference on Chemical Biology: inspiring science in beautiful Hokkaido at the incomparable Chateraisé Gateaux Kingdom — a 3-in-1 hotel, spa, and sweets factory. I’ve been surrounded by so many delicious lipids all week! 🤤

Excited and grateful to have been promoted to Professor. Many thanks to the outstanding students and postdocs in my lab and to my colleagues at Cornell and across the #chembio and #lipidtime communities for your continued support!

Fantastic #lipidtime conversations yesterday at UTokyo — thank you to Noboru Mizushima for hosting my visit!

Thrilled to share this #lipidtime mechanism story in @jcb.org where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

How does the plasma #membrane preserve its #lipid identity under stress? In @jcb.org, the Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/... @jeremybaskin.bsky.social

Jeremy Baskin @cornellupress.bsky.social sharing exciting new #lipidtime discoveries @onoinitiative.bsky.social chem bio symposium @stanford-chemh.bsky.social

Hello, Stanford — excited to be in town for the @onoinitiative.bsky.social symposium today! @stanford-chemh.bsky.social

New online: A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling

Just want to point out the GM of the Stanley Cup winning team is a chemist who was in Jeff Long’s first class of graduate students. (I was an undergrad in the group at the same time and know him!) en.wikipedia.org/wiki/Eric_Tu...

My primary academic conference is in a few weeks. I have given a good number of conference presentations over the years, and possibly moderated even more often than I've presented. Advice for anyone who wants it, in a thread:

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

10/10 for this hilarious #lipidtime parody — no notes

The ZMBH welcomes Dr. James Sáenz @jamessaenz.bsky.social as new Professor in Molecular Biology. James previously led a research group at B CUBE - Center for Molecular Bioengineering of Dresden University of Technology.

💡Join us for the SMART Symposium on Decoding the Glycome: Illuminating Biology's Last Uncharted Frontier 📆11–14 Nov 2026 | Shenzhen 🌏From glycan mapping to glyco‑engineered therapies 🔗Register: symposia.smart.org.cn #SMARTSymposia #SMARTshenzhen #Glycome #Glycobiology

Join us at the SMART Symposium: Decoding the Glycome! #glycotime

Hallo, Dresden, you hotbed of #lipidtime research! Thanks to @nadlerlab.bsky.social for hosting me at @mpi-cbg.de yesterday — and looking forward to giving the plenary talk at the European Symposia of Bioorganic Chemistry meeting later today!

Great talk @weillinstitute.bsky.social on lysosomal damage in neurodegenerative disease by @shawnferguson.bsky.social @yalecellbiology.bsky.social! (Also: Go Habs!)

The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...

very nice to see the chemists get a moment in this article about daraxonrasib, Revolution Medicines' pancreatic cancer compound: www.nytimes.com/2026/05/12/h... #chemsky

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

Appalabhotla, Siesser, Bear, Haugh et al. developed a system enabling light-mediated recruitment of PLC-γ1 variants to dissect mechanisms underpinning #cancer-associated hyperactivity, and they show that recruitment of active PLC-γ1 robustly directs #fibroblast #migration rupress.org/jcb/article/...

This was a really fun story to see develop. OptoPLC does some fascinating things to cell motility

What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...

Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics

Thrilled to welcome @mbogyo.bsky.social, @danetteldaniels.bsky.social, @slavofflab.bsky.social, and Marcey Waters to Cornell for today’s annual Chemistry-Biology Interface Symposium!

I feel like an important lesson we could all remember, but especially if we are trying to convince people of something, is to KNOW your audience. Surprised that your provocative statement lands poorly? KNOW YOUR AUDIENCE

I had a blast visiting the Omenn Darling Bioengineering Institute @princeton.edu yesterday! Thanks so much to Tina Kim for hosting my visit! @christhechang.bsky.social @fredhughson.bsky.social & Ralph Kleiner

Dear Lipid and Membrane Enthusiasts, There is only one month!! left to register and submit your abstracts for the @embo.org Workshop “Lipid Code to Life”, which will be held from September 7–11, 2026, in Dresden, Germany. Workshop program and registration page: meetings.embo.org/event/26-lip...

Hello, Princeton! Excited for my visit to the Omenn Darling Bioengineering Institute tomorrow 😃

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

Now out in its final form in @jacs.acspublications.org: Reaction pathways & photoreaction yields of bifunctional lipid probes. The numbers that explain why we spend so much time optimizing protocols for cellular assays. 😉 pubs.acs.org/doi/10.1021/...

Interesting #lipidtime food science: eating melted cheese increases your triglycerides and cholesterol more than eating the *exact same cheese* unmelted — possibly due to changes at the molecular level in a phospholipid *trilayer* that encapsulates fat in dairy products!

Very excited to share our preprint showing S-acylation (aka Palmitoylation) of TDP-43, VCP, SQSTM1, FUS & C9Orf72 in Huntington Disease (HD), Amyotrophic Lateral Sclerosis (ALS), & Multisystem Proteinopathy (MSP). This tour de force was led by @firyalrphd.bsky.social! www.biorxiv.org/content/10.6...

What can’t JQ1 do? Check out this cool study in @pnas.org from my Cornell colleagues led by @paulacohen.bsky.social on its promise as a (starting point toward a) non-hormonal male contraceptive! www.pnas.org/doi/10.1073/...

Christian Ungermann opens the 77th Mosbach Kolloquium! Enjoy the meeting, there will be plenty of great science and special workshops for everyone.

Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

A breakthrough in lipid imaging: spatial lipid distributions in organelles! Fantastic work from @nadlerlab.bsky.social 🤯

Check out this super cool #lipidtime imaging story from @nadlerlab.bsky.social!!

Special day at Cornell Chemistry: welcoming back PhD alum @xiaoyuzhang.bsky.social (Hening Lin lab) from Northwestern for a phenomenal seminar on targeted protein degradation and chemical immunology!

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer @amypalmerzinc.bsky.social! Please join us in beautiful Boston April 3-6, 2027. Interested in organizing an ASBMB mini-symposia or workshop? Submit your proposals here!: www.asbmb.org/annual-meeti...

TODAY is Cornell Giving Day and a chance to support the impactful science happening at @weillinstitute.bsky.social. Every day, our scientists work to uncover the fundamental mechanisms of life and advance discoveries shaping the future of biology. Donate here: givingday.cornell.edu/campaigns/we...

Beautiful desert views. Beautiful membrane biology. Join us for the #FASEB Phospholipids in Aging and Disease SRC in Arizona, July 26–30 2026. Registration is now open! So much better than a Lipid Droplets conference. Also, we're co-located with FASEB Lipid Droplets 😜

Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social news.ohsu.edu/2026/02/25/n...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Huge thanks to my former PhD student and then postdoc Gaelen Guzman - this wouldn’t exist without his drive and craftsmanship. Also, big thanks to Carsten Schultz, @nadlerlab.bsky.social, and @jeremybaskin.bsky.social for their support and contributions.

Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...