Lipids are kind of the ignored middle children of origins of life research. It's time they got a bit of attention, too! This week's post is a Q&A with geoscientist-turned-??? (interdisciplinary folks know the struggle) @jamessaenz.bsky.social about why there's no cutting the fat from origins. 🧪

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Congratulations @cwecks.bsky.social on a first class thesis defense! It’s been a privilege to work with you for the last 6 years. And touche casting shade on my britishisms!

Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs

Channeling my Robert Millikan!

So much looking forward to get going!

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

Josh Morgan discusses how progress in cell biology is hindered by significance testing and the need for a shift to effect size estimation. rupress.org/jcb/article/... 📕 In #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...

Always good to read JB and his lab's insights into one of the most important cancer targets, especially with their incredibly clear illustrations. So simple a basic cell biologist can follow it!

Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids Read the OA paper in JCB

How do swelling lysosomes not burst? Because they literally suck more lipids into their membranes from the ER via this protein straw. Amazing piece of this particular molecular puzzle from my colleague jay tab!

This is such a beautiful mechanism for #phosphoinositide mediated regulation of integral membrane protein. Highly recommended #lipidtime read!!

This is the author of an eye-opening paper - tracking back through evolution to figure out the still very enigmatic function of a lipid kinase. It’s changed my view on these enzymes, and leaves me with many questions. That's what all the best papers do!

Whoa! Your weekend #lipidtime read: Our best view yet of lipids flowing along a bridge. Stunning work! If only we could see the “one-way” sign… www.nature.com/articles/s41...

The last #lipids and membranes session at #asbmb25 starts at 9 am. Hear everything you didn’t know about the biology of neurodegeneration!

Join us for a firecracker of a #lipids and membranes session on lysosomal lipids at 9 am tomorrow #asbmb25

They’re lining up to learn more after @wumin-lab.bsky.social gave a fantastic talk on dynamic PI signaling in the opening #lipids and membranes session at #asbmb25!

Emma Drew from U Oregon giving an amazing talk in the first #lipids and membranes session at #ASBMB2025. Single molecule experiments to show real time activation of a lipid phosphatase 🤯

Volker Haucke kicks off our #lipids and membranes theme at #ASBMB25! Fantastic session

And I am giving a talk tomorrow morning #asbmb25! Cheers Batman

Excited for the start for #ASBMB25!

We have some #lipids talks at #asbmb25 on PI signaling that will blow your mind! Join us Sunday at 9 a.m. in room W179

📣For lipid-focused sessions at #ASBMB25, add the symposium on #lipids and membranes, organized by @gerryhammond.bsky.social of the University of Pittsburgh and @judisimcox.bsky.social of the University of Wisconsin–Madison, to your schedule: www.asbmb.org/annual...#ASBMB25,

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...

Matching dieticians & shoppers at risk for #cardiovasculardisease is just one of the innovative clinical trials Robert Helsley, Shaw Award winner, has managed: ow.ly/vSqF50VxLUH. ➡️Attend his lecture at #ASBMB25 at 2:25 p.m. CDT on 4/15: ow.ly/jOQh50VxLUI#cardiovasculardisease#ASBMB25#Lipids

Judith Storch won the Avanti Award in #Lipids. Her lab studies lipid traffic in cells, w/emphasis on the proteins that bind long-chain fatty acids, monoacylglycerols & #cholesterol. ow.ly/GK6K50VxOy4 ➡️Attend her lecture at 1:50 p.m. CDT on April 15: ow.ly/HEsg50VxOy7#Lipids.#cholesterol.#ASBMB25

Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!

I am beyond thrilled to co-organize this FASEB #LipidDroplet conference with Mike @hennelab.bsky.social in 2026! Check out the lineup and plan to participate - you do not want to miss this one!! #lipidtime

If you're heading to Chicago for the #ASBMB annual meeting, we have many #lipidtime treats for you! Here's one: want to know the real pathway for BMP synthesis? Check out this session on Monday 4/14 at 9 am: @judisimcox.bsky.social chairing events.rdmobile.com/Sessions/Det...

The antibiotic Neomycin is too nephrotoxic and ototoxic to use systemically. Why is a decades-old mystery... Until now, with a sure-to-be classic from the Graham lab at Vanderbilt. It’s all about #phosphoinositides 🤯 Your #lipidtime weekend read www.biorxiv.org/content/10.1...

Join us March 26th at 12pm ET - @asbmb.bsky.social LRD seminar series. We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab. Register here! www.asbmb.org/meetings-eve...

This #lipidtime paper is HUGE peeps: many of us long suspected that vesicular traffic doesn't really sort lipids - Its often a statement I make and struggle to find references. Now we have a beautiful, elegant approach that gives us firm quantitative evidence. Hat doffed!

Well, I’m at least happy to be a PI who eats pie this pi day. Happy 3/14 everyone!

Really beautiful #lipidtime data on the cellular function of BLTP2 from the De Camille group on biorxiv: For me, it’s yet another example of how PI4P is a master controller of non vesicular lipid transport dx.doi.org/10.1101/2025...

Beautiful tour-de-force of #lipidtime biochemistry in science last week. Do we know how BMP is made now? www.science.org/doi/10.1126/...

First time playing around with single molecule STORM imaging of PI3P on endosomes using recombinant biosensors. This was great fun with our new fellow Ruby Peters and I see lots of potential for this in the future!

My annual Valentine’s post of this image that happens to land on #FluorescenceFriday this year! An axon approaching a kidney glomerulus doing its best to look like a rose.

The most frequently asked question we get: do #lipidtime genetically encoded lipid biosensors compete out cells’ native effector proteins? Victoria Holmes and Morgan Ricci led a paper in JCB that answers this question: rupress.org/jcb/article/... Read on for a brief thread.

@jeremymberg.bsky.social is doing such an amazing job keeping us all informed on what's happening with NIH. Thank you Jeremy!

As if I needed more reason to rage against AI summaries in google searches. 🤬 @coronin.bsky.social

Please welcome Contact: The Journal of Inter-Organelle Communication @contactctc.bsky.social to Bluesky!

Just read this awesome #lipidtime review on the enigmatic PIP4K lipid kinases. Just a beautifully structured piece of work that is a dream to reference. I even recommend it just for general info on small molecule inhibitors and their caveats! doi.org/10.1111/febs...

Sorkin lab continues to illuminate the cellular itinerary of EGF signaling by endogenous tagging of effectors. Super cool paper!

Excited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15

What’s not to love about this?

Made one of these for lipids, will update continuously. Please share and let me know who I've missed go.bsky.app/A27yZA6

Very cool #lipidtime preprint from Taki Nishimura and colleagues: engineering of new lipid-binding probes from PH domains and nanobodies from a high-throughput assay where liposomes bind to cell surfaces displaying members of the protein probe library. www.biorxiv.org/content/10.1...

Taking the "on" out of the PIK3CA oncogene: a paradigm shift in PI3K signaling just out from @ralitsamadsen.bsky.social Ralista will be talking about this in the New frontiers in inositol lipid signaling at the #ASBMB annual meeting this April - don’t miss it! www.asbmb.org/annual-meeti...

To everyone that celebrates it…

#proudmentor! Great @FASEBorg #phospholipids meeting in MN with Morgan Ricci picking up best poster and Claire Weckerly getting a best short talk! This is why I don’t meddle in my trainees’ presentations…