☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis. @berkeleymcb.bsky.social bit.ly/49mTeyF

Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...

Here the authors further support the link between #leptin signaling and tissue #fibrosis demonstrating that a leptin-neutralizing antibody may be a promising therapeutic approach for reducing fibrosis in the kidney, liver, lung, heart, and blood vessels www.science.org/doi/10.1126/...

Familial hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early cardiovascular disease www.thelancet.com/journals/lan... #familial #hypercholesterolaemia #ASCVD #MedSky #EndoSky #CardioSky

Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha-ortiz.bsky.social @neuro-explorer-lc.bsky.social @luisci22.bsky.social and @joele-r.bsky.social. #NDiSTEM2025 #SACNAS #STEMResearch #PLI @sacnas.bsky.social 🧪🔬🥼

Published in @lancetgh.bsky.social Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky

Use of GLP-1 medicines in patients with HFrEF and implanted cardiac devices. Caution please www.jacc.org/doi/10.1016/...

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr... New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale. 1/n

Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.

Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions. www.biorxiv.org/content/10.1...

Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again? End rant.

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit. arboretum.wisc.edu/news/arboret...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!

Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year

Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...

#ENDO2025 has been the renewal of hope I needed. I feel the joy in seeing mentors including @intmedabel.bsky.social and Barbara Kahn, meeting up with friends, and seeing the transformation of the metabolic disease space. Onward to new discoveries. Thanks to #NIDDK for organizing our session.

Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.

Great work by Mugagga, Lainy and Jess from the Simcox Lab! SCD1 is known to regulate the production of monounsaturated fatty acids and development of diabetes in response of high carbohydrate diet. We showed loss of SCD1 also controls acylcarnitine levels.

Research from the James Ntambi and @judisimcox.bsky.social Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies. More on their latest research: biochem.wisc.edu/2025/07/02/r...

Congratulations to Integrated Program in Biochemistry graduate student Gina Wade and Biochem postdoc Jericha Mill, who we recognize for their excellence in teaching and mentorship! Wade and Mill work in the @judisimcox.bsky.social Lab. Read more: biochem.wisc.edu/2025/06/30/s...

Congratulations Gina and Jericha for the well deserved recognition of their teaching and mentorship!

Research from the @judisimcox.bsky.social Lab uncovers new details about the relationship between metabolic disease, cells' energy expenditure, and how cells regulate the breakdown of a lipid. Learn more: biochem.wisc.edu/2025/06/17/r...

AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

It’s finally out! Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊 Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social pubmed.ncbi.nlm.nih.gov/40473211/

Proud of the Simcox and Parks labs, at our annual retreat we spent the afternoon volunteering to remove invasive plants from the arboretum and making beds for shelter cats.

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...

May was a whirlwind of Simcox lab celebrations. Congratulations to @hunger4science for a successful thesis defense and starting her new position at Pharmaceutical Product Development (PPD, Thermofisher)! Andrea obtained the WISL Award for Communicating PhD Research to the Public.

Excited for Simcox lab member Jericha Mill to give her talk at #ASMS2025 Ballroom I 9:30am. Jericha will talk about metabolomics in age-related disease and the impact of rapamycin treatment in mice and humans. She also received an ASMS postdoc career development award: www.asms.org/about-asms-a...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41... full text available here 👉 rdcu.be/em0VG and thread 👇

Exciting news! Our most important work is out as preprint! We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use. Next step is the clinical trial starting early next year! www.medrxiv.org/content/10.1...

Following lipidomic and proteomic analyses, Vanessa Linke @massspecvanili.bsky.social Agnieszka Chacinska and colleagues identify a role for OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

Congratulations to my @uwbiochem.bsky.social colleague Chris Gisriel for receipt of the 2025 distinguished postdoc mentoring award

Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab! @natcomms.nature.com www.nature.com/articles/s41...

Emerging potential mechanisms that regulate cristae membrane shape

It’s been difficult to talk about, but I’m part of this percentage of terminated NSF grants and represent a portion of this statistic. But our work for the Center for Indigenous Research to Create Learning and Excellence (CIRCLE) will go forward in a good way somehow.

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

📎 This study bridges lipidomics, cold physiology, and hepatic lysosomal biology; highlighting BMPs as therapeutic targets. 👏🏻 Nice work from @judisimcox.bsky.social in @cp-cellmetabolism.bsky.social. 🔗 doi.org/10.1016/j.cm... 🧪 5/5

"Our finding suggest that first-generation GLP1-RA treatment does not increase ORC [obesity related cancers] risk in patients receiving GLP-1 treatment for diabetes and weight loss." www.thelancet.com/journals/ecl...