Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.

Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions. www.biorxiv.org/content/10.1...

Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again? End rant.

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit. arboretum.wisc.edu/news/arboret...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!

Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year

Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...

#ENDO2025 has been the renewal of hope I needed. I feel the joy in seeing mentors including @intmedabel.bsky.social and Barbara Kahn, meeting up with friends, and seeing the transformation of the metabolic disease space. Onward to new discoveries. Thanks to #NIDDK for organizing our session.

Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.

Great work by Mugagga, Lainy and Jess from the Simcox Lab! SCD1 is known to regulate the production of monounsaturated fatty acids and development of diabetes in response of high carbohydrate diet. We showed loss of SCD1 also controls acylcarnitine levels.

Research from the James Ntambi and @judisimcox.bsky.social Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies. More on their latest research: biochem.wisc.edu/2025/07/02/r...

Congratulations to Integrated Program in Biochemistry graduate student Gina Wade and Biochem postdoc Jericha Mill, who we recognize for their excellence in teaching and mentorship! Wade and Mill work in the @judisimcox.bsky.social Lab. Read more: biochem.wisc.edu/2025/06/30/s...

Congratulations Gina and Jericha for the well deserved recognition of their teaching and mentorship!

Research from the @judisimcox.bsky.social Lab uncovers new details about the relationship between metabolic disease, cells' energy expenditure, and how cells regulate the breakdown of a lipid. Learn more: biochem.wisc.edu/2025/06/17/r...

AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

It’s finally out! Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊 Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social pubmed.ncbi.nlm.nih.gov/40473211/

Proud of the Simcox and Parks labs, at our annual retreat we spent the afternoon volunteering to remove invasive plants from the arboretum and making beds for shelter cats.

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...

May was a whirlwind of Simcox lab celebrations. Congratulations to @hunger4science for a successful thesis defense and starting her new position at Pharmaceutical Product Development (PPD, Thermofisher)! Andrea obtained the WISL Award for Communicating PhD Research to the Public.

Excited for Simcox lab member Jericha Mill to give her talk at #ASMS2025 Ballroom I 9:30am. Jericha will talk about metabolomics in age-related disease and the impact of rapamycin treatment in mice and humans. She also received an ASMS postdoc career development award: www.asms.org/about-asms-a...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41... full text available here 👉 rdcu.be/em0VG and thread 👇

Exciting news! Our most important work is out as preprint! We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use. Next step is the clinical trial starting early next year! www.medrxiv.org/content/10.1...

Following lipidomic and proteomic analyses, Vanessa Linke @massspecvanili.bsky.social Agnieszka Chacinska and colleagues identify a role for OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

Congratulations to my @uwbiochem.bsky.social colleague Chris Gisriel for receipt of the 2025 distinguished postdoc mentoring award

Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab! @natcomms.nature.com www.nature.com/articles/s41...

Emerging potential mechanisms that regulate cristae membrane shape

It’s been difficult to talk about, but I’m part of this percentage of terminated NSF grants and represent a portion of this statistic. But our work for the Center for Indigenous Research to Create Learning and Excellence (CIRCLE) will go forward in a good way somehow.

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

📎 This study bridges lipidomics, cold physiology, and hepatic lysosomal biology; highlighting BMPs as therapeutic targets. 👏🏻 Nice work from @judisimcox.bsky.social in @cp-cellmetabolism.bsky.social. 🔗 doi.org/10.1016/j.cm... 🧪 5/5

"Our finding suggest that first-generation GLP1-RA treatment does not increase ORC [obesity related cancers] risk in patients receiving GLP-1 treatment for diabetes and weight loss." www.thelancet.com/journals/ecl...

Excited for @hunger4science to defend her thesis in 1 week! Andrea has pushed forward our work employing CRISPR screens to identify mechanisms of lipid transport and metabolism. #05SimcoxGrad.

…and a big thanks to our awesome collaborators @judisimcox.bsky.social & Gina for their contributions and expertise in lipidomics, and to Kathryn from the UWCCC flow cytometry lab for invaluable help and advice! 2/n

excited to share our latest work now online @natmetabolism.nature.com, led by @kyle-flickinger.bsky.social, where we unravel a mechanistic basis for the conditional essentiality of NADK, one of the many interesting hits from our previously reported CRISPR screening with HPLM rdcu.be/ekpu6

I’m both grateful and mad that this awesome woman paused her metastatic breast cancer fight to fly to DC and lobby for research funding. Janet Ramsey has had her life prolonged by clinical trials and is pushing our representatives to keep investing in life saving discoveries.

Big thanks to @holthuislab.bsky.social for an inspiring @sfb1348.bsky.social talk on interrogating lipid dynamics at sites of membrane permeabilization and repair! 🔬🧬 His work sheds light on the beautifully complex dance of lipids during cellular stress. #LipidResearch #ScienceLecture

"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍 www.nature.com/articles/s41...

May is set to be a busy month for the Simcox lab starting with a thesis defense from Gina Wade #04SimcoxGrad. ipib.wisc.edu/2025/04/18/i...

Now online! Anna’s fantastic work on the structure of the Human adult Muscle-type nicotinic receptor. Wonderful collab with Yin Dong at the @imm.ox.ac.uk www.biorxiv.org/content/10.1...

I have exhorted others to share positive news even in these uncertain times for US science. I am really excited that @tamanash.bsky.social’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online. Follow along here 🧪🧵