Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

Repost! Please apply by October 15th for full consideration.

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

A microneedle device for rapid dermal interstitial fluid sampling @stanforduniversity.bsky.social 🇺🇲 www.science.org/doi/10.1126/...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells www.nature.com/articles/s42...

I am thrilled to share that I have received an ERC Starting Grant for our project SpaceMet! I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support! Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants. www.biorxiv.org/content/10.1.... pls check @olzmannlab.bsky.social www.biorxiv.org/content/10.1... #ferroptosis #FSP1 #antioxidants

Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo... @abcamofficial.bsky.social

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

Fantastic meeting 🤩🤩 thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event! #ferroptosis #faseb #Ros

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy https://www.biorxiv.org/content/10.1101/2025.07.13.664609v1

1/ If you are in the Midwest and ❤️ metabolism, take note! This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference. www.vai.org/event/2025-m...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social jci.org/articles/vie... 1/6

Congrats to Dr. patrickjonker.bsky.social for successfully defending his thesis!

I'm excited to share the final version of some fun work from our lab. A few interesting phenotypes - depleting host glutathione causes intracellular Rickettsia to form long chains and get restricted by antibacterial autophagy. Congrats to the team! urldefense.com/v3/__https:/...

It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉

Last day! Please consider sending in a public comment about Schedule F!

Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...

HIRING! We're looking for an assistant professor/investigator to lead metabolism-focused research @morgridgemeta.bsky.social through a joint tenure track position with UW–Madison @bmolchem.bsky.social. Join our team! https://morgridge.org/job-posting/assistant-professor-in-metabolism-research/

Check out this nice review article from my buds on cardiometabolism, including the emerging role of microproteins! We might have something to add to this conversation in a few years, stay tuned! www.ahajournals.org/doi/full/10....

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

#Preprint alert! Kevin Chen, a brilliant @mskcancercenter.bsky.social GSK graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: www.biorxiv.org/content/10.1...

That's a wrap on the 2025 Cancer Metabolism Showcase. With everything going on it was so great to hear a fantastic career keynote from Jeff Rathmell and awesome talks and posters from students and postdocs! Hats off to @harrislab.bsky.social for running the show.

Check out this seminal study @theaacr.bsky.social by the one and only @marasherman.bsky.social aacrjournals.org/cancerdiscov... & the commentary about its importance to gain understanding on the inherent tumor-suppressive #PancreaticCancer #TME (by yours truly) aacrjournals.org/cancerdiscov...

excited to share our latest work now online @natmetabolism.nature.com, led by @kyle-flickinger.bsky.social, where we unravel a mechanistic basis for the conditional essentiality of NADK, one of the many interesting hits from our previously reported CRISPR screening with HPLM rdcu.be/ekpu6

Next up at METPHYS2025 Evan Lien is sharing how diet can influence ferroptosis sensitivity

Less than 1 week until the Showcase! We have an amazing program lined up with outstanding speakers, awesome posters, and incredible workshops! www.cancermetabolismshowcase.org/s/2025_CMSW_...

Check out this poster!!!

Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Excited to speak today at #AACR2025 in Chicago! I’ll present “Metabolic stress as a driver of stromal plasticity: Adaptation, survival, and CAF subtype conversion” in the Tumor Metabolism and Microenvironment session (10–11:30AM, S100A). Come hear about Yijuan Zhang’s amazing work! #CancerResearch

📝 #TIL about the modulation of the nutrients of the TME from Cosimo Commisso and Ilaria Elia, which dictates how the tumor cells and all the other cell types are functioning, including the CAFs and the CD8s #AACR25

Less than two weeks until the 2025 Cancer Metabolism Showcase and Workshops! Speaker lineup now online! Register today! www.cancermetabolismshowcase.org

🔥 Hot off the press: Researchers at the University of Chicago, in collaboration with the University of Pittsburgh, have published a groundbreaking study in @NatureCellBio demonstrating how the accumulation of a tumor metabolite impairs T cell function in the tumor microenvironment. ow.ly/vxWI50VEJVm

Excited to share new report from collaborative work from @delgoffelab.bsky.social and @patrickjonker.bsky.social from our team on a novel metabolic suppressor of T cell function in tumors! rdcu.be/eiyIa 1/

🌟 Excited to share our latest spotlight! 🌟 Co-wrote with @mariopalma.bsky.social and Jessalyn @ubellackerlab.bsky.social, highlighting Ueda et al.'s study on oxidative niches driving immune evasion in tumors. Check out our spotlight article here: rb.gy/zi8wj9 Ueda et al., 2025: rb.gy/674im7

Via Lustgarten.org #PancreasCancer community continues to advocate for full reinstatement of federal #pancreaticcancer research funding, sponsor breakthrough research & raise awareness. Call your representatives! lustgarten.org/leadership/y...

📢 New preprint alert! 🚨 We show that diet quality, not just quantity, is a key player in driving pancreatic cancer progression. 🔑 What you eat matters for cancer risk—much more than we previously thought. #PancreaticCancer #CancerBiology #DietAndCancer

I could not be more excited to travel back to where it all began for me, the Chicagoland area, for #ASBMB25! Can't wait to see family and old friends, as well as meet new friends! I will be giving a talk and a poster presentation on April 14th. Hope to see some of you there!!

Registration is live for the 1st ever Midwest Metabolism & TRiMAD dual meeting, hosted jointly by VAI + U of M in Ann Arbor, MI November 10-11, 2025! We have some exciting speakers but most will come from abstracts so submit your best #mitochondria & #metabolism research! www.vai.org/event/2025-m...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

www.quantamagazine.org/how-metaboli... Seems like a good time to remind you of an upcoming meeting on this exact topic: www.keystonesymposia.org/conferences/...

Best conference of the year (imo)! Hope to see everyone there!

Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking by Kelly H. Sokol, Evan C. Lien, et al at @vainstitute.bsky.social http://dlvr.it/TJfPTN

📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨 Registration free! Speakers chosen from abstracts and non-faculty only! Amazing poster session and workshops! Sign up today at: www.cancermetabolismshowcase.org

Hi #metabolism #pancreaticcancer #lipidtime twitter! Excited to share @patrickjonker.bsky.social work on how the microenvironment limits the metabolic capacity of pancreatic cancers (PDAC), which sensitizes these tumors to dietary interventions. 1/17