🎉PUBLISHED @natgenet.nature.com 📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers. By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers. ➡️ yalecancercenter.org/news-article...

This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12

Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12

Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12

Excited to share our latest paper in @natgenet.nature.com with #SiyuanWang @yale.edu on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to #MiaoLiu #SherrySu! @yalecancer.bsky.social www.nature.com/articles/s41...

🎉 So proud of my wife Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed! 🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection. www.science.org/doi/10.1126/...

Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social

Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...

1/🚨 New preprint out!🚨 We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance. 🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator. 📄 www.biorxiv.org/content/10.1...

🚨New preprint!🚨 Venturing out of the nuclear genome to explore #mtDNA: "Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis" www.biorxiv.org/content/10.1... Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social Please help to spread the word! Adverts with full details below ⬇️

📢 New preprint alert! 🚨 We show that diet quality, not just quantity, is a key player in driving pancreatic cancer progression. 🔑 What you eat matters for cancer risk—much more than we previously thought. #PancreaticCancer #CancerBiology #DietAndCancer