Tonight at 7:30pm, Dr. Melinda Irwin @yalesph.bsky.social joins #YaleCancerAnswers to talk about the impact of weight and obesity on #cancer. 🎧Listen live #wnpr 🔁Download via #ApplePodcasts 💻Listen later #YouTube

Congratulations to Dr. Nikolai Podoltsev, @yale-hematology.bsky.social, who was awarded funding for his project "Evaluating Chronic Myeloid Leukemia Management Variation and Pharmacist-Led Symptom Assessment to Improve Care Delivery” by the #NCCN Oncology Research Program. nccn.org/home/news/ne...

We are proud of our faculty + trainees for contributing to the future of #cancer care with 90+ presentations at #AACR26. Topics spanned patient-centered #clinicaltrials, innovations in #pathology, and advancing more precise, personalized approaches to care. medicine.yale.edu/cancer/news-...

A study by Drs. Ji-Young Son, Nicole Deziel @yalesph.bsky.social, and Michelle Bell @yaleenvironment.bsky.social found positive associations between concentrated animal feeding operations #CAFOs + rates of almost all cancers. sciencedirect.com/science/arti...

Dr. Daniel Boiarsky at #AACR26: In metastatic #NSCLC, longer survival with PD-1 therapy is linked to tumors rich in CD8+ T cells and macrophages, highlighting key immune features that may help predict response. #lcsm @theaacr.bsky.social @oncoalert.bsky.social

Dr. Michael Chiorazzi shows how spatial profiling in #HPV+ #HNSCC reveals that epigenomic alteration may prime the tumor microenvironment for stronger responses to immunotherapy. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

Dr. Katerina Politi @yalepathology.bsky.social presented during the @theaacr.bsky.social Annual Meeting 2026 Highlights Plenary Session on "Basic cancer science and translational research." abstractsonline.com/pp8/#!/21436...

During the final #AACR26 poster session, we had four presenters sharing their research: Drs. Samir Zaidi; Jasmine Jathan; Daniel Boiarsky; and Michael Chiorazzi. @theaacr.bsky.social

Juan Guiza @yalepathology.bsky.social shares research mapping IL-12 signaling in #NSCLC, revealing a complex dual role. IL-12 activity is linked to stronger immune cell presence in tumors, but in some cancer cells it may also promote growth. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

Miranda Mansolf highlights NR2F2 as a key driver of high-grade serous #ovariancancer progression. NR2F2 regulates pathways tied to tumor growth and metastasis. #AACR26 @theaacr.bsky.social @krishnaswamylab.bsky.social @oncoalert.bsky.social

#AACR26 update: #PillaiLab identifies a shared mechanism behind splicing defects across splicing factor–mutant cancers. A DNA damage–driven stress response disrupts RNA processing, pointing to new treatment targets. @theaacr.bsky.social @oncoalert.bsky.social

Research presented by Mariana Do Carmo @yalepathology.bsky.social shows tumor suppressor gene loss plays a major role in how EGFR-mutant #lungcancer grows and responds to therapy. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

New research presented by Dr. Jay Bader shows #ctDNA status is a key predictor in peritoneal metastases from colorectal and appendiceal cancers. Patients with negative ctDNA had strong survival. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

Alessandro Santin and Stefania Bellone present a Yale case study #AACR26 highlighting a key challenge in treating recurrent low-grade serous #ovariancancer. @theaacr.bsky.social @oncoalert.bsky.social

Dr. Barbara Burtness chaired a session at #AACR26 on “Advancing Precision Approaches to Head and Neck Cancers,” and presented data on #HPV-independent #HNSCC. @theaacr.bsky.social @oncoalert.bsky.social

At #AACR26, @sundarraghav.bsky.social, highlighted how peritoneal metastases are polyclonal, with immune-genomic heterogeneity. Precision strategies for peritoneal metastases are urgently needed. @theaacr.bsky.social @oncoalert.bsky.social

Dr. Barbara Burtness shares Phase 2 data combining the IO102-IO103 cancer vaccine w pembrolizumab in resectable head and neck cancer. The approach was well tolerated, with early signals of response. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

Dr. Patricia LoRusso reports early first-in-human results for ZW191, showing encouraging responses (~52% ORR) and manageable safety in patients whose cancers had already been treated with multiple prior therapies. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

At #AACR26, Ece Koçak and Dr. Megan King share how PARP inhibitors increase DNA “bridges” in BRCA-deficient cancer cells that can rupture the nucleus, exposing DNA and triggering immune signaling. @mcdb-yale.bsky.social @theaacr.bsky.social @oncoalert.bsky.social

New research presented by Kira Glasmacher and Jeffrey Townsend maps how #coloncancer develops, showing which mutations happen early vs. later. #AACR26 @theaacr.bsky.social @yalesph.bsky.social @oncoalert.bsky.social

Miguel López de Rodas Gregorio presents a new tool called SCRIBE to improve cancer biomarker discovery by testing how consistent results are across different cut-points. @theaacr.bsky.social @yalepathology.bsky.social @oncoalert.bsky.social

María Villalba Esparza shows that low oxygen #hypoxia in tumors affects T cells differently over time. #AACR26 @yalepathology.bsky.social @theaacr.bsky.social @oncoalert.bsky.social

New research presented by Daulet Aiyymnayev @yalepathology.bsky.social at #AACR26 shows that loss of BAP1 in uveal #melanoma reshapes gene regulation and cell identity. It switches tumor cells away from a normal state toward a more invasive state. @theaacr.bsky.social @oncoalert.bsky.social

Suchitra Krishnan-Sarin joined leaders at #AACR26 to share ways to reduce modifiable risk factors, address barriers & implement policy to reduce the impact of #tobacco use. @theaacr.bsky.social @oncoalert.bsky.social

Rong Fan @yalembb.bsky.social opens #AACR26 symposium on “Cutting-Edge Advances in Hematology,” with key advances shaping #hematology. @yalepathology.bsky.social @yale-hematology.bsky.social @theaacr.bsky.social @oncoalert.bsky.social

Research from @yalepathology.bsky.social at #AACR26 shows that where immune cells sit in #NSCLC tumors matters. Clustering of CD8+ and CD20+ T cells inside tumors is linked to better survival, and patterns in surrounding tissue may signal worse outcomes. @theaacr.bsky.social @oncoalert.bsky.social

Longgang Zhao, PhD, at #AACR26 highlights metabolic patterns linked to #livercancer risk. Higher levels of certain acids were associated with increased risk, while others showed protective links. @theaacr.bsky.social @oncoalert.bsky.social

New preclinical work presented by Ranjini Sundaram in glioblastoma #GBM models explores overcoming resistance to treatment. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social #AACR26

Based on a challenge in biomarker discovery, Dr. Kim Blenman presents a call to re-evaluate and improve differential expression #AI tools to ensure more robust, reproducible findings in cancer research. @AACR #AACR26.

Stop by this morning's #AACR26 poster session starting at 9am PST to learn about the research from our presenters: Dr. Lajos Pusztai; Ranjini Sundaram; @ZhaoLonggang; @Elham_Samami; Dr. Pat LoRusso; and Gabriela Esnaola @ishizukalab! @SmilowCancer @AACR

At #AACR26, Mengni He @yalepathology.bsky.social shares how spatial transcriptomics explains response vs resistance to sacituzumab govitecan for metastatic #breastcancer #MBC. @theaacr.bsky.social @oncoalert.bsky.social

Newly presented #AACR26 miPEP133 emerges as a potential tumor suppressor in #ovariancancer. Restoring its expression slowed tumor cell growth and increased sensitivity to chemotherapy and MEK inhibitors. @theaacr.bsky.social @oncoalert.bsky.social

At #AACR26, new findings shared by Yan Gu show clonal diversity isn’t just noise, it fuels growth in #lungcancer. Mixed tumor cell populations grew faster than single clones, with integrin-mediated signaling playing a key role. @theaacr.bsky.social @oncoalert.bsky.social

At @theaacr.bsky.social's James S. Ewing–Thelma B. Dunn Lecture in Pathology #AACR26, Dr. David Rimm @yalepathology.bsky.social highlighted a shift in #pathology from subjective “reading” to precise measurement. @oncoalert.bsky.social

Earlier at #AACR26, Dr. Roy Herbst led a town hall on policy issues shaping #cancer research: funding, global collaboration + workforce challenges, with Jon Retzlaff @theaacr.bsky.social, Dr. Patty Spears #UNCLineberger, Dr. Cornelia Ulrich @huntsmancancer.bsky.social, and @ejohnwherry.bsky.social.

Jack Robbins shares how the use of spatial transcriptomics reveals response vs resistance to T-DXd in metastatic #breastcancer #MBC. #AACR26 @yalepathology.bsky.social @theaacr.bsky.social @oncoalert.bsky.social

New research shared by Dan McQuaid @muzumdarlab.bsky.social links #obesity-driven #pancreaticcancer to dysregulation of the hormone cholecystokinin (CCK). #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

@yalepathology.bsky.social presents AI-driven analysis of TILs in #NSCLC, showing promise as a biomarker for immunotherapy response. Quantitative TIL scoring linked to ⬆️ survival, showing potential of quantitative clinical readings in #pathology. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

An analysis of #melanomas by the Dr. Jeff Townsend lab shows aging shapes tumor evolution less by mutation rate and more by changes in selection. Yihan Liu shares how driver mutations shift with age + how tumor biology, treatment strategies evolve. #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

At #AACR26, new research from the lab of Dr. Jeff Townsend presented by Meng Liu, shows how measuring the selective advantage of copy number amplifications can better pinpoint drivers in #ovariancancer. @theaacr.bsky.social @oncoalert.bsky.social

New research on #HIV + #cancer presented by Katherine Ma at #AACR26 links HIV-associated clonal hematopoiesis to abnormal T cell growth. DNMT3A mutations may drive expansion of CD4+ T cells + could ⬆️ cancer risk despite suppressive antiretroviral therapy. @theaacr.bsky.social @oncoalert.bsky.social

Daniel A. Colón Ríos presents research at #AACR26 showing how IDH1-mutant cancers develop resistance to #PARP inhibitors. Work from the #GlazerLab identified key pathways behind PARPi resistance any d points to potential strategies to overcome it. @theaacr.bsky.social @oncoalert.bsky.social

Dr. Roy Herbst moderates a major symposium this afternoon at 3pm PST #AACR26: Researcher Town Hall: Navigating Policy Challenges and Securing Funding. abstractsonline.com/pp8/#!/21436... @theaacr.bsky.social

Congratulations Dr. Samir Zaidi, recipient of an @theaacr.bsky.social Trailblazer Cancer Research Grant for Early-Stage Investigators to support his project, "Mechanisms of cellular plasticity in neuroendocrine prostate cancer initiation." #AACR26 aacr.org/about-the-aa...

This afternoon at 2pm PST #AACR26, we are excited to share we have 11 posters being presented by many of our scientists and researchers! Stop by and show your support! @muzumdarlab.bsky.social @theaacr.bsky.social

Tonight at 7:30pm on Yale Cancer Answers, @maryamlustberg.bsky.social joins to talk about hormonally-driven #breastcancer and menopausal symptoms. 🎧 Listen live on #WNPR 🔁 Download on #ApplePodcasts 💻 Listen later #YouTube

Dr. Jeff Townsend led a discussion of #epistasis and #cancer evolution #AACR26, sharing research on smoking-driven gene–environment interactions in #lungcancer, illustrating how epistasis reveals more predictive, evolution-aware cancer treatment strategies. @theaacr.bsky.social @yalesph.bsky.social

“The burden of #cancer is not equally shared,” Dr. Pat LoRusso spotlights hybrid decentralization, a successful model for improved #clinicaltrials access. #AACR26. By blending expertise with community access, the program accelerates enrollment & brings trials closer to pts. @oncoalert.bsky.social

At #AACR26, Dr. Roy Herbst highlights that just 7% of US patients join #clinicaltrials and 80% of cancer care happens outside of major centers. “We need to listen to our patients.” Patient-centered trials that expand access and reflect real-world populations are necessary. @oncoalert.bsky.social

Dr. Jeff Townsend chairs and presents during an educational session on #epistasis this morning at 10am PST #AACR26. abstractsonline.com/pp8/#!/21436... @theaacr.bsky.social