Xiangyu(Gigi) Ge (@xiangyuge.bsky.social)

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle.... https://www.biorxiv.org/content/10.1101/2025.06.20.660715v1