Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.

New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...

🎉PUBLISHED @natgenet.nature.com 📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers. By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers. ➡️ yalecancercenter.org/news-article...

Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12

Check out this new video highlighting our lab :-) Thank you @yaleschoolofmed.bsky.social Video Team for the production! m.youtube.com/watch?v=p-hE...

How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8