How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.6... nature.com/articles/d41...

🧪 Pre-print alert! NanoCortex: A Unified Agentic System for Nanopore Sequencing Analysis A new end-to-end framework to bridge the gap between nanopore seq data and biological discovery. @srouhanifard.bsky.social, @wanunupore.bsky.social Read the full pre-print 👇 www.biorxiv.org/content/10.6... 🧬💻👩‍🔬

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What if RNA sequencing didn’t need cDNA, references, or assumptions? 🧪🧬💻 DirectSeq Biosciences is redefining the field with mass spec–based, direct RNA sequencing and a bold goal: mapping the entire Human RNome. 170+ RNA modifications. One new approach. 🎥 Watch how it works: youtu.be/xtYW8YjfvwY

RNA does more than transmit information. It shapes the nucleus itself. 🧪🧬💻 @mitchguttman.bsky.social shows how non-coding RNAs form spatial compartments that organize proteins, regulate gene expression, and influence RNA processing. youtu.be/WBw7Rdb1HUU

Introducing LaSS and GLaSS - Wenyi Feng reveals how loss of FMRP in Fragile X Syndrome leads to widespread R-loop accumulation and DNA damage, and introduces new tools to map these structures with precision. A new perspective on how genome regulation connects to disease. youtu.be/ryrOhKkLA50 🧪💻🧬👩‍🔬

Martha Bulyk presents new insights into transcription factor binding and gene regulation. 🧪💻🧬👩‍🔬 youtu.be/Oc6Nt8x_snk Innovative methods PADIT-seq and PIONEAR-seq reveal how overlapping binding sites and chromatin context shape transcription factor activity beyond traditional DNA motifs

Spatial genomics is entering the era of scale. Roy Wollman introduces ATLAS, a scalable approach to spatial transcriptomics that turns massive tissue datasets into actionable insight. 🧪💻🧬 youtu.be/0o9XCh1pOII #SpatialTranscriptomics #SystemsBiology #Genomics

Fei Chen showcases Slide-tags, a powerful approach that maps gene expression while preserving where cells live and interact in real tissue. From brain architecture to tumor ecosystems, spatial biology is revealing how cellular neighborhoods shape function and disease. 🧪🧬💻🔬 youtu.be/-lU4ODTLGZU

Recording cell lineage at scale is transforming developmental biology. @jshendure.bsky.social highlights how DNA "Typewriter" enables genome-encoded lineage tracking, and how monoclonal gastruloids reveal how early cell states influence fate decisions. youtu.be/TlDZtjFL3F8 🧪💻🧬

Epigenetic memory shapes how cells respond to the future. jbuenrostro.bsky.social highlights how single-cell ATAC-seq and computational models reveal lasting effects of environmental signals on gene regulation. youtu.be/w3l2jhlTaYA 🧪🧬💻

Final session of the Genome Technology Development Webinar Series APRIL 7 @ 1PM ET register: www.jax.org/genometechdev26 This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms. 🧪💻🧬👩‍🔬 Supported by NHGRI and @jax.org

There's still time to register for today's webinar at 2PM EDT. 👉www.jax.org/genometechdev26👈 Charting Cellular Futures: Lineage Recording and Regulatory Network Insights. 🧪💻🧬 Speakers: @jshendure.bsky.social and @jbuenrostro.bsky.social

Huge congratulations to Mark Adams, professor and interim scientific director at The Jackson Laboratory for Genomic Medicine, who has been elected a 2025 Fellow of @aaas.org — one of the most distinguished lifetime honors for scientists. 🎉 🧪

Wonder how to directly connect live-cell behavior with the molecular states driving it? Magali Soumillon, Co-Founder & CEO of Flexomics, introduces a single-cell platform that merges live-cell imaging with sequencing from the same cells. 🧪💻🧬👩‍🔬 youtu.be/RH8WBbZMXIQ

Congratulations Xin Jin! 🧪👩‍🔬🧬💻

The Genome Technology Development Webinar Series. 👉 www.jax.org/GenomeTechDev26 👈 Three webinars featuring leading scientists discussing current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Roundtable discussion following the presentations 🧪🧬💻👩‍🔬 #edusky

Have you registered for the Genome Technologies Development Webinar Series?? 🧪🧬💻👩‍🔬 www.jax.org/GenomeTechDev26 Each session includes scientific presentations and a roundtable discussion examining current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

You're invited to the webinar session: Exploring How Genome Organization Shapes Biological Function Featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman. 🧪🧬💻👩‍🔬 Free Registration: www.jax.org/genometechdev26 📅 April 7, 1:00 PM - 2:00 PM ET

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Coming Soon: March 31 @2pm ET. 📅 Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. Free webinar featuring @jshendure.bsky.social and @jbuenrostro.bsky.social. Register www.jax.org/GenomeTechDev26/ 🧪🧪💻

Genomic technologies are quickly advancing! Check out our webinar series featuring leading innovators. 🧪🧬💻 Register once for 3 Webinars: www.jax.org/genometechde... Speakers: Fei Chen Roy Wollman Martha Bulyk @mitchguttman.bsky.social Wenyi Feng @jshendure.bsky.social @jbuenrostro.bsky.social

You're invited to the webinar "Revealing Biological Complexity Through Spatial Profiling", featuring Roy Wollman and Fei Chen. Session moderator: Ramalakshmi Ramasamy March 26, 3 - 4 PM ET Free Registeration: www.jax.org/genometechde... Presented with support by @jaxeducation.bsky.social 🧪🧬💻

Genomics & single-cell researchers—expand your toolkit. 👨‍🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies. Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability

Captify: A new platform to study chromatin readers in the nucleosome context 🧪💻🧬 Recently published in Nucleic Acids Research @narjournal.bsky.social, the folks at @epicypher.bsky.social discuss development & integration of these easily adoptable biochemical and genomic tools doi.org/10.1093/nar/...

🧪🧬💻 Congratulations on the recent publication from @jshendure.bsky.social, @troymcdiarmid.bsky.social, @uwgenome.bsky.social and colleagues! 👇 www.nature.com/articles/s41...

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...

New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...

New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩‍🔬 www.youtube.com/watch?v=gOta... Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation. Recently published in @natsmb.nature.com

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬 Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing! It's all there on the GenomeTDCC YouTube channel! www.youtube.com/playlist?lis...

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41... rdcu.be/eyzXy

Martha Bulyk & Shubham Khetan just dropped a @nature.com paper redefining how we think about transcription factor binding, noncoding variants, and disease. PADIT-seq, reveals that multiple overlapping binding sites drive TF occupancy and gene expression 🧪🧬💻👩‍🔬 Highlight 📽️https://youtu.be/45hdZ6R9fX4

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What if doing something poorly could lead to something great? Rob Mitra, @washugenetics.bsky.social, dives into the evolution of genome tech, short-read sequencing, and how his lab is fighting rising drug costs with innovation. 🧪🧬💻 #STS 📺 Watch the keynote: youtu.be/C8U5WDA9ri4 #genomics #Biotech

What if DNA didn’t use ACGT, but had PZSB instead? UW and FfAME researchers describe how they were able to sequence a synthetic DNA molecule made from 4 artificial bases in @natcomms.nature.com 🧪🧬🖥️ Check out the publication highlight on “ALIEN DNA” 👇 www.youtube.com/watch?v=S6tE...

RNA isn’t just a messenger. It’s a modified masterpiece! 🧪 Over 10,000 sites in mRNA are chemically tagged, and we’re only beginning to understand why. Kristin Koutmou @umich.edu explores the tools that reveal this hidden layer of gene regulation. Must-watch! 🎥👇 www.youtube.com/watch?v=s5Bt... 👩‍🔬🧬🖥️

DNA beyond ACGT? But how do you sequence? 🧬 🖥️ youtu.be/GN6_Hc9tYow Andrew Laszlo explains how #nanopore sequencing reads modified and synthetic bases like Z, P, B, and S by measuring ion current shifts instead of chemical pairing. This technology could reshape synthetic biology and epigenetics. 🧪

Winston Timp @timp0.bsky.social explains how single-molecule seq is transforming our understanding of gene regulation and epigenetic complexity 🧪🖥️🧬 www.youtube.com/watch?v=fj1_... Direct detection of 5mC and 5hmC, supports cell-type deconvolution, and reveals tissue-specific regulatory features

DNA has become programmable. 🧬🖥️ Sasha Levy (BacStitch DNA) discusses how #DNA engineering has evolved from basic cut-and-paste to programmable systems. Learn how enzymatic synthesis and in vivo assembly are shaping the future of synthetic biology 🧪 #STS youtu.be/kSAm-2FbNus

Jingyi Jessica Li @jsb-ucla.bsky.social (@fredhutch.bsky.social) (formerly @ UCLA) explains how statistics can make genomics more reliable From RNAseq to single-cell data, she shows how permutation testing reveals flaws in popular methods and can help make better decisions 🧪🖥️🧬👩‍🔬 youtu.be/t2pxOsJ9mgE

Not that kind of Alien!👽 De novo #nanopore sequencing of ALIEN (ALternative Isoinformational ENgineered) #DNA. Direct, label-free, single-molecule sequencing. @natcomms.nature.com www.nature.com/articles/s41... Funded in part by an NHGRI Opportunity Fund (genometdcc.org/opportunity-...) 🧪🧬🖥️ #STS

RNA is never naked 🧪🖥️🧬 Gene Yeo @ucsandiego.bsky.social reveals how RNA-binding proteins (RBPs) shape gene expression, drive disease, and can unlock new therapies. From splicing to synthetic RBPs, this talk is packed with insights youtu.be/AnhbGp-pA-w #RNA #AcademicSky @sanfordstemcell.bsky.social

📢Job Opening! 🧪🖥️🧬👩‍🔬 Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing. Dr. Ya-Ming Hou at Thomas Jefferson University houlaboratory.com/research #HigherEd #EDUSky #AcademicSky #STS

Happy #RNADay! What happens to RNA after transcription? @stirlingchurchman.bsky.social tracks RNA flow through the cell, revealing key insights into gene regulation, nuclear degradation & RNA kinetics. A fascinating look into #RNA biology! 🧪🧬🖥️👩‍🔬 youtu.be/XAKMASk_fc4

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How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

📅 June 9 - Genomic Technologies Open Science Day at @washu.bsky.social and online www.jax.org/scienceday25 Register for Free by: May 30: In-Person June 8: Virtual Learn how emerging tech is used to manipulate RNA & DNA, study genome function and structure, and navigate multi-omic analysis 🧪👩‍🔬🧬🖥️

🔬 Excited about the future of genomic tech? Join NHGRI & @genometdcc.bsky.social's hybrid forum to explore how new tools and technologies are used, as well as the potential opportunities and challenges ahead. 📅 Open to grad students, postdocs & researchers! Register: www.jax.org/education-an...

HAPPY DNA DAY! 🧬🧪 Genomics research has provided humanity with a transformative understand of life at the molecular level leading to a wide range of benefits in medical advancements, synthetic biology, biotechnology, infectious disease, agriculture, and evolution. We are connected by ATGC