UW Genome Sciences
@uwgenome.bsky.social
📤 280
đź“Ą 1
đź“ť 82
The Department of Genome Sciences at The University of Washington
Replaying germinal center evolution on a quantified affinity landscape
www.cell.com/cell/fulltex...
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Replaying germinal center evolution on a quantified affinity landscape
Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...
https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6
29 days ago
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A global map for introgressed structural variation and selection in humans
pubmed.ncbi.nlm.nih.gov/42275491/
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A global map for introgressed structural variation and selection in humans - PubMed
Genetic introgression from Neanderthals and Denisovans shaped modern human genomes; however, introgressed structural variants (SVs ≥ 50 base pairs) remain challenging to discover. We integrated high-q...
https://pubmed.ncbi.nlm.nih.gov/42275491/
29 days ago
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Congratulations to the winners of the GS outstanding Service Award: Bonny Brewer (faculty), Josh Malamy (staff), Joe Min (student), and Ryan Friedman (postdoc)!
about 1 month ago
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Congratulations to Joe Felsenstein on being elected to the Fellowship of the Royal Society, the UK's national academy of sciences!
royalsociety.org/people/josep...
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Professor Joe Felsenstein FRS | Royal Society Fellow
After initially work on population genetics theory of recombination, of migration, and of speciation, his main focus has been on phylogenetic inference. He s...
https://royalsociety.org/people/joseph-felsenstein-38106/
about 1 month ago
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Congratulations to Leah Anderson on winning People's Choice at the UW Three Minute Thesis competition!
grad.uw.edu/current-stud...
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2026 UW 3MT Winners
Congratulations to this year’s winners and all of the finalists for sharing their work and representing the breadth and brilliance of graduate research at the University of Washington! First Place |…
https://grad.uw.edu/current-students/student-success/3mt/2026-win/
about 1 month ago
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Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
www.cell.com/cell/fulltex...
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Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
Variant in situ sequencing (VIS-seq) links genetic variants to cell images, revealing how variants affect molecules, subcellular structures, and cells at scale. Applied to thousands of LMNA and PTEN v...
https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6
about 2 months ago
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reposted by
UW Genome Sciences
Fred Hutch Biostatistics Program
2 months ago
From our Statistical AI Symposium: Bill Noble from
@uwgenome.bsky.social
on foundation models for chromatin 3D architecture and proteomics mass spectrometry: two very different data types, one elegant framework. 🎥
youtu.be/S6sHSW_bLvY?...
#Biostatistics
#AIinHealth
#FoundationModels
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William Noble on Foundation Models
YouTube video by Fred Hutch Biostatistics Program
https://youtu.be/S6sHSW_bLvY?si=9Fq0ksXOinrdDrFc
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Congratulations to Hannah Jordt on receiving the UW Distinguished Teaching Award!
www.washington.edu/facultystaff...
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Announcing the 2026 Awards of Excellence recipients
The UW is delighted to announce the recipients of the 56th annual University of Washington Awards of Excellence! The awards honor outstanding alumni, faculty, staff, students and retirees who...
https://www.washington.edu/facultystaff/2026/04/29/uw-announces-2026-awards-of-excellence-recipients/
2 months ago
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reposted by
UW Genome Sciences
Devin Schweppe
2 months ago
Excited to see this collaborative work with
@oligopain.bsky.social
and
@keribackus.bsky.social
out as a preprint now! Took a ton of work from a great team of scientists
@uwgenome.bsky.social
and
#UCLA
The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!
add a skeleton here at some point
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Congratulations to Jesse Bloom on being elected to the National Academy of Sciences!
www.nasonline.org/news/2026-na...
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National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...
https://www.nasonline.org/news/2026-nas-election/
2 months ago
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Congratulations to Hank Cheng on being named to the Husky 100!
www.washington.edu/husky100/#na...
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Husky 100
The Husky 100 recognizes 100 UW undergraduate and graduate students who are making the most of their time at the UW.
https://www.washington.edu/husky100/#name=hank-cheng
3 months ago
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Congratulations to Kyra Fetter, Kayla Ly, and Mary Krebs on receiving NSF fellowships and to Katrina Peterson and Ivan Woo on receiving honorable mention!
3 months ago
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Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo
www.pnas.org/doi/10.1073/...
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Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo | PNAS
Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively ...
https://www.pnas.org/doi/10.1073/pnas.2524021123
3 months ago
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Q&A with Dr. Maitreya Dunham: Reflecting on MSS 2026 and Looking Ahead to the Future of Genome Science
brotmanbaty.org/news/q-and-a...
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Q&A with Dr. Maitreya Dunham: Reflecting on MSS 2026 and Looking Ahead to the Future of Genome Science | Brotman Baty Institute
BBI
https://brotmanbaty.org/news/q-and-a-with-dr-maitreya-dunham-reflecting-on-mss-2026-and-looking-ahead-to
3 months ago
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Genetic diversity and regulatory features of human-specific NOTCH2NL duplications
pubmed.ncbi.nlm.nih.gov/41916274/
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Genetic diversity and regulatory features of human-specific NOTCH2NL duplications - PubMed
NOTCH2NL (NOTCH2-N-terminus-like) genes arose from ape-specific chromosome 1 segmental duplications implicated in human brain cortical expansion, including an incomplete NOTCH2 gene. Genetic character...
https://pubmed.ncbi.nlm.nih.gov/41916274/
3 months ago
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Congratulations to Iris Jia on being awarded the Charlie Moore Award for outstanding contributions to cystic fibrosis microbiology research!
3 months ago
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Congratulations to Katy Loubet-Senear on being awarded a WRF Postdoctoral Fellowship!
3 months ago
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reposted by
UW Genome Sciences
EichlerLab
3 months ago
Check out UW Medicine's feature on the Eichler Lab
www.youtube.com/watch?v=A3Ur...
@uwgenome.bsky.social
@hhmi-science.bsky.social
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What Happens in a Genomics Lab? How Research Today Improves Lives Tomorrow
YouTube video by UW Medicine
https://www.youtube.com/watch?v=A3UrzOqEUOY
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NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development
www.nature.com/articles/s41...
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NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development - Nature Neuroscience
NeMO Analytics is a compendium of public transcriptomic data focused on the neocortex, enabling biologists without coding expertise to explore hundreds of datasets. Joint decomposition of these data y...
https://www.nature.com/articles/s41593-026-02204-4
3 months ago
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Congratulations to Maitreya Dunham and David Baker on being named AAAS Fellows!
www.washington.edu/news/2026/03...
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Four UW researchers named AAAS Fellows
Four University of Washington researchers have been named AAAS Fellows, according to an announcement by the American Association for the Advancement of Science. They are among 449 newly elected...
https://www.washington.edu/news/2026/03/26/four-uw-researchers-named-aaas-fellows/
4 months ago
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Congratulations to Lauren Fields on being selected as a Schmidt Science Fellow!
schmidtsciencefellows.org/fellow/laure...
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Lauren Fields • Schmidt Science Fellows
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no known cure. As a Schmidt Science Fellow, Lauren will use advanced mass spectrometry and protein analysis of...
https://schmidtsciencefellows.org/fellow/lauren-fields
4 months ago
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How an MD-PhD Student With Hemophilia Made a Genetic Research Breakthrough
rightasrain.uwmedicine.org/well/researc...
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An MD-PhD Student Had Hemophilia
How he made a research breakthrough.
https://rightasrain.uwmedicine.org/well/research/nick-popp-hemophilia-genetic-variant-MAVE
4 months ago
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Context dependency is essential for predicting intrahost evolution
www.nature.com/articles/s41...
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Context dependency is essential for predicting intrahost evolution - Nature Ecology & Evolution
The ability to predict rapid evolutionary processes within our bodies would advance both medical science and evolutionary biology. We discuss technologies that move us towards intrahost evolutionary p...
https://www.nature.com/articles/s41559-025-02886-2
4 months ago
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Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA
www.nature.com/articles/s41...
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Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA - Nature Communications
Short‑read sequencing misses many early and repeat‑driven mutations. Here, the authors show that long‑read sequencing in autism families increases detection of germline and postzygotic mutations and r...
https://www.nature.com/articles/s41467-026-70342-1
4 months ago
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Using the linear references from the pangenome to discover missing autism variants
www.nature.com/articles/s41...
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Using the linear references from the pangenome to discover missing autism variants - Nature Communications
Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP...
https://www.nature.com/articles/s41467-026-68378-4
4 months ago
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Congratulations to Mike MacCoss on receiving the Distinguished Contribution in Proteomics Award, Bill Noble on receiving the Computational Proteomics Award, and Nathan Basisty on receiving the New Investigator Award from US HUPO!
us-hupo.org/Awards
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US HUPO - Awards
https://us-hupo.org/Awards
5 months ago
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Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
www.micropublication.org/journals/bio...
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Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast | microPublication
https://www.micropublication.org/journals/biology/micropub-biology-001962
5 months ago
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Congratulations to Riku Yasutomi on being awarded an NRSA Fellowship!
5 months ago
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Congratulations to Andrew Stergachis on being elected to the American Society for Clinical Investigation!
5 months ago
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Congratulations to the Stergachis Lab on being awarded an AI for Science fund award from Google!
blog.google/company-news...
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We’re announcing the 12 recipients of our AI for Science fund
A look at the 12 recipients of the first AI for Science fund.
https://blog.google/company-news/outreach-and-initiatives/google-org/announcing-ai-for-science-awardees/
6 months ago
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Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback
www.nature.com/articles/s41...
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Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
https://www.nature.com/articles/s41559-025-02926-x
7 months ago
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Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...
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Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
https://www.nature.com/articles/s41587-025-02914-3
7 months ago
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Congratulations to David Baker, Riza Daza, Evan Eichler, Mike MacCoss, Brendan MacLean, Hannah Pliner, Jay Shendure, and Cole Trapnell on being named to the Clarivate Highly Cited Researchers List for 2025!
7 months ago
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Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal by the Genetics Society!
genetics.org.uk/medals-and-p...
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Mendel Medal 2026 - Professor Joe Felsenstein | Genetics Society
The Mendel Medal 2026 has been awarded to Professor Joe Felsenstein. Professor Joe Felsenstein was born in 1942, grew up in Philadelphia and studied as an
https://genetics.org.uk/medals-and-prizes/genetics-society-medals-and-lectures/mendel-medal/mendel-medal-2026-professor-joe-felsenstein/
8 months ago
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Congratulations to Alison Feder on being named a 2025 Freeman Hrabowski Scholar!
www.hhmi.org/programs/fre...
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The 2025 Freeman Hrabowski Scholars | HHMI
Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.
https://www.hhmi.org/programs/freeman-hrabowski-scholars/2025-scholars
8 months ago
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Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...
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US HUPO - Computational Proteomics Award
https://us-hupo.org/Computational-Proteomics-Award
8 months ago
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Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...
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US HUPO - Distinguished Contribution Award
https://us-hupo.org/Distinguished-Contribution-Award
8 months ago
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Congratulations to Winston Dredge on being awarded a WRF Postdoctoral Fellowship!
8 months ago
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Jay Shendure elected to National Academy of Medicine
newsroom.uw.edu/blog/jay-she...
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Jay Shendure elected to National Academy of Medicine - UW Medicine | Newsroom
https://newsroom.uw.edu/blog/jay-shendure-elected-to-national-academy-of-medicine
9 months ago
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CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity
elifesciences.org/reviewed-pre...
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https://elifesciences.org/reviewed-preprints/107531
9 months ago
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Mechanisms underlying thermally induced growth plasticity in juvenile Pacific halibut
journals.biologists.com/jeb/article/...
9 months ago
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Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk
journals.plos.org/ploscompbiol...
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Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk
Author summary We investigated factors influencing the success of oral mucosal gene therapy for Fanconi Anemia (FA), a genetic syndrome marked by DNA repair defects in conjunction with a heightened ri...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012915
10 months ago
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Registration is now open for the Mutational Scanning Symposium!! 25-27 March 2026 Melbourne, Australia Matt Hurles (Wellcome Sanger) and Maitreya Dunham (University of Washington) Deadline for abstract submissions: 2 November 2025.
www.mss2026.org
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MSS26
Mutational Scanning Symposium 2026, 25-27 March, Melbourne
https://www.mss2026.org
10 months ago
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reposted by
UW Genome Sciences
EichlerLab
10 months ago
🧬 How fast do humans mutate? Our groundbreaking study tracks DNA changes across 4 generations to reveal the pace of human evolution revealing insights into our genetic legacy. Watch now 👉
youtu.be/6TTCZdZd4Y4
#Genetics
#Evolution
#ScienceVideo
#Nature
@hhmi.org
@uwgenome.bsky.social
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How quickly do humans mutate? Four generations help answer the question
YouTube video by nature video
https://youtu.be/6TTCZdZd4Y4
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Congratulations to Zukai Liu and Bria Metzger on being awarded Parker Travel Awards for best poster at the 2025 department retreat!
10 months ago
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Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP
www.nature.com/articles/s41...
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Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology
Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...
https://www.nature.com/articles/s41594-025-01582-w
10 months ago
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Congratulations to Olivia Waltner on being awarded the Bonita and David Brewer Fellowship!
10 months ago
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Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
www.science.org/doi/10.1126/...
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Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
https://www.science.org/doi/10.1126/science.adu8249
11 months ago
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Accelerating Biomolecular Modeling with AtomWorks and RF3
www.biorxiv.org/content/10.1...
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Accelerating Biomolecular Modeling with AtomWorks and RF3
Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...
https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2.abstract
11 months ago
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Congratulations to Jenny Nathans on being awarded an NRSA Fellowship!
11 months ago
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