🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇 1/9

This @zohrankmamdani.bsky.social video is absolutely INCREDIBLE. The numbers he cites, the strategy and results they produced — it’s the future. When have you heard *any* campaign talk about this, ever? (Video split in 2 to fit in Bluesky’s limits)

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

Jay, please stop gaslighting early career researchers.

Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion. With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...

Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3 apnews.com/article/nih-...

. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...

The fantastically successful NIGMS MIRA R35 "expired" on May 17, after the most recent deadline--these removals are the most aggressive attack on American science in the current series of devastating actions 🧪

🤩 And this is why hate will never win.

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond. Here's an inside look into how this story was reported. It was a weird one. 🧵 www.nature.com/articles/d41...

As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening... 1/n

THIS is what NIH funding means for real people, and why we can't lose it. I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer. This is why we have to speak up, this is who we're fighting for.

This but for checking eRA Commons en.wikipedia.org/wiki/Kiss_an...

Hi, everyone! My name is Alex. I'm a microbiologist/cell biologist/biochemist, and I'm sharing some of my career biography today for #YoungScientistNetworking. 1/

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

New article up in Barron's www.barrons.com/articles/nih... 1/3

Seattle protests.

New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process 1/n

Excited to see CellCycleNet featured by @LSAjournal! CellCycleNet is a new 3D deep learning model that enables cell cycle staging using only a nuclear stain (DAPI), achieving 95% classification accuracy @oligopain.bsky.social @uwgenome.bsky.social www.life-science-alliance.org/content/8/6/...

Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD. www.nature.com/articles/d41...

BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants. This is an unlawful attack on scientific progress that puts lives at risk.

If the goal was to decimate U.S. leadership in biomedical innovation & fire scientists developing cutting-edge treatments—the Trump Administration is succeeding. Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures. It's inexcusable.

Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s. Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.

Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc. Anyone in Iowa City that can offer more insight? scienceimpacts.org H/T to Prathima !

These are training grants. 🚨 The Trump administration has launched a war on students and young people studying science. It’s a common thread. Trump is killing student fellowship grants at NIH and NSF, and is killing the NIH and CDC in-house fellows programs.

We are excited to announce our official partnership with @indivisible.org for the National Day of Action on April 5th! Stand Up for Science says: HANDS OFF OUR SCIENCE! #standupforscience #handsoffourscience Find and register for an event near you: handsoff2025.com?utm_source=s...

NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health. grants.nih.gov/grants/guide...

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

See this chart for one stark example: NIH funding has dramatically slowed down. Grant awards are down *$3 billion* so far, compared to same time period last year I asked the White House to explain. “This is not a researcher entitlement program,” said an official, defending their new approach.

Kseniia Petrova, a Russian scientist at Harvard Medical School, was detained at Logan Airport after returning from France and sent to an ICE detention in Louisiana, The Insider reports. A big critic of Putin and the war in Ukraine, she may now be deported to Russia.

A scientist in Marc Kirschner's lab

Unidentified men grabbing someone off the street and putting her in a car because she wrote an op-Ed. This as flatly authoritarian as anything we’ve seen in this country in a very long time.

Boston folks--rally this evening to support the Tufts PhD student, here on a visa, nabbed off the street yesterday 👇👇👇

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

The information I am receiving is consistent with the STAT story. The boards are being purged of women and minoritized scientists with no other obvious pattern. And for the cases where I have some information, the effects are not subtle...Boards going from 35% women to 10% women. 3/n

White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.

This is a disaster and its happening right now. Having spoken with some folks in Congress, this is a message they have not received--they are still back in Indirects and USAID (also important, BTW). Call Congress today unless you want ot lose colleagues one by one till all are gone

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

Elbows up, Canada.

every college, corporate, and nonprofit president right now

Well, this took my breath away a bit... www.nytimes.com/2025/03/21/n...

ATTENTION If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me. THANK YOU!

Acc to an article in The Atlantic, Meta, using LibGen, appears to have pirated millions of articles and book chapters to train AI. The Atlantic provides a searchable link, and I find 199 of my books, book chapter, review article and major publications, all used without my permission. www.theatlant

this stuff is happening across the country and even more intensively downstream of the veterans admin but it's happening in so many places at once and without any public notification that it's still only barely emerging in the news

Impossible to overstate the chilling effect on American science. We absolutely depend on scientific exchange with colleagues around the world.

MIT offering travel advice (or rather do not travel advice) for international visitors and green card holders. If folks at other institutions are receiving similar guidance, please consider sharing here. Please be as safe as you can.