More exciting work from the lab! Along with @maccoss.bsky.social (@uwgenome.bsky.social) and Gary Churchill (@jax.org), Dr. Katarina Vlajic's tour de force multi-omics profiling uncovered molecular signatures of healthy splenic aging! www.biorxiv.org/content/10.6...

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

1/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...

Previously a #preprint, now a peer reviewed @dschweppe.bsky.social work a fine, insightful, useful reference for the growing #gastruloid community . Proteomics, protein-RNA discordances, mouse-human comparison www.nature.com/articles/s41... Insights into human embryos for a growing #SCBEM community

Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio! Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development. www.nature.com/articles/s41...

🔬 Meet panelist #3: Parag Mallick, co-founder of NautilusBio and Stanford professor. Hear how he turned a bold proteomics idea into a NASDAQ-listed company and how IP plays a key role. April 27. 📅 Register now: https://us02web.zoom.us/webinar/register/WN_VW3QxNzkTXCQXkY2Z2y7Mw#3 #USHUPO #Proteomics

Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes https://www.biorxiv.org/content/10.64898/2026.04.17.719305v1

⚖️ Meet panelist #2: George Fox, VP of IP at SeerBio. IP strategy is a scientific competency, not just a legal one. 💬Hear his take at the US HUPO "Idea to IP" panel, April 27. 📅 Free to attend: https://us02web.zoom.us/webinar/register/WN_VW3QxNzkTXCQXkY2Z2y7Mw#2 #USHUPO #Proteomics

This program transformed my career! Please apply. @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Congratulations to Kyra Fetter, Kayla Ly, and Mary Krebs on receiving NSF fellowships and to Katrina Peterson and Ivan Woo on receiving honorable mention!

First co-author paper from the first year of my time here at UW is now live! Always happy to chat about it with anyone who is interested ☺️

💡 From Idea to IP - Free Webinar Coming April 27: "Idea to IP," a US HUPO panel on turning proteomics research into intellectual property and real-world impact. 📅 Register now https://us02web.zoom.us/webinar/register/WN_VW3QxNzkTXCQXkY2Z2y7Mw #USHUPO #Proteomics

The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...

📢 Publication alert🌶️! Congrats to the @maccoss.bsky.social lab who show the use #Mag_Net for enrichment of EV's from #serum to study the effects of monoclonal antibody therapy on the fate and function of T-cells in people with type 1 diabetes! biorxiv.org/content/10.6...

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards

News in Proteomics Research blog post | The Proteomics Show is back! Check out chapter one of "All the Parts!" proteomicsnews.blogs... --- #proteomics #prot-other

In academia, we're good at talking about successes, but sweep unfunded grants & unsuccessful job apps under the rug. It can be a tough road, filled w/ failure* For anyone discouraged about the process, here's my failure CV #AcademicSky 🧪 *None are really failures if you learn from them

Acquisition news for bottom up and top down proteomics with Thermo acquiring Proteinaceous and MSAID. Proteinaceous was founded in 2016 (possibly earlier) as a spin out from Neil Kelleher’s lab at Northwestern. MSAID was spun out from Mathias Wilhelm and Bernhardt Kuster’s labs in 2019.

@jyates.bsky.social MCing the President’s “Lalapalooza” happening now at #USHUPO2026. Looking forward to learning about alternative methods for proteomics @us-hupo.org

Check out our new work now published in G3! We use proteomics and phosphoproteomics to study how cells cope with tRNA variants that mis-insert amino acids.

Congratulations to #NASmember Benjamin F. Cravatt of @scripps.edu, winner of the 2026 NAS Award in Chemical Sciences for providing foundational insights into enzyme function and dysregulation in disease! Learn more about his discoveries: www.nasonline.org/award/nas-aw... #NASaward #chemistry

AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands www.biorxiv.org/cont... --- #proteomics #prot-preprint

Question for the #proteomics community 👇 What should proteomics repositories be doing today (use cases, features, research) that we’re currently missing? Would love your input—RT to reach more voices. #opendata #mass-spectrometry #proteomics

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy

Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...

I remember fondly how much fun we had with the data analysis, especially when we first identified the consistent proteomic differences between sister blastomeres. Our results exemplify why direct protein analysis is key to discovering and understanding biological mechanisms.

We are thrilled to announce our 2026 election results. Olga Vitek has been elected to serve as US HUPO's President-Elect, Devin Schweppe as Secretary, and Sasha Singh and Hanno Steen were elected to serve as Members-At-Large on our Board of Directors. Congratulations to all! 🌟 #USHUPO

Woo! Congrats @olgavitek.bsky.social , @dschweppe.bsky.social , Sasha, and Hanno!

Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...

I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below! careers.gene.com/us/en/job/20...

The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!

Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...

8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM). Only open for 2 weeks (applications due November 21). Application materials include a) CV b) vision statement c) a photocopy of doctoral degree. hr.nih.gov/careers/open...

Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests. We describe a critical concept that we call *specificity*. Led by Jeff Spence and Hakhamanesh Mostafavi:

More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1... Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight @dschweppe.bsky.social #SCBEMs

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

AlphaDIA enables DIA transfer learning for feature-free proteomics - @mannlab.bsky.social @jalew188.bsky.social go.nature.com/4qmEQMM

Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg More on their journeys to this achievement: alleninstitute.org/news/karel-s...

Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026. Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open - w.molgen.mpg.de/embryo2026

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

#microsky www.biorxiv.org/content/10.1...

The GRFP lives!! (due end of October) www.nsf.gov/funding/oppo...

Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!: Nova - lightweight dev library schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10.... Helios - a unified instrument API now @ JPR github.com/SchweppeLab/...

After five great years, my journey in the Schweppe Lab and at UW has come to a close. Huge thanks to @dschweppe.bsky.social and all the amazing labmates for making graduate school such a wonderful experience. Extremely grateful for the memories and all the help I received along the way.