bioRxiv SysBio
@biorxiv-sysbio.bsky.social
📤 858
📥 0
📝 1700
Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes
https://www.biorxiv.org/content/10.1101/2025.11.10.687674v1
about 20 hours ago
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Systematic structural and functional analysis of metal-binding sites in native proteomes
https://www.biorxiv.org/content/10.1101/2025.11.10.687516v1
about 22 hours ago
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A Quantitative Design Guideline for Biomolecular Positive Feedback Systems
https://www.biorxiv.org/content/10.1101/2025.11.09.687517v1
1 day ago
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Computational Cellular Programming: In Silico Modeling of Direct and Reprogrammed Hepatic Lineage Induction via Gene Regulatory and Functional Dynamics
https://www.biorxiv.org/content/10.1101/2025.11.09.687523v1
1 day ago
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Scalable imaging-based profiling of CRISPR perturbations with protein barcodes
https://www.biorxiv.org/content/10.1101/2025.11.11.687767v1
2 days ago
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Androgen receptor activation stabilizes a hybrid epithelial/mesenchymal phenotype in presence of Notch-Jagged signaling
https://www.biorxiv.org/content/10.1101/2025.11.09.687414v1
3 days ago
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Ecological and Stochastic Determinants of the Growth and Persistence of the Oral Pathogen Porphyromonas gingivalis
https://www.biorxiv.org/content/10.1101/2025.11.08.687400v1
3 days ago
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Beyond synthetic lethality in large-scale metabolic and regulatory network models via genetic minimal intervention sets
https://www.biorxiv.org/content/10.1101/2025.11.07.687323v1
3 days ago
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Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection
https://www.biorxiv.org/content/10.1101/2025.11.07.687316v1
3 days ago
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A Deep Learning Framework for Quantifying Dynamic Self-Organization in Myxococcus xanthus
https://www.biorxiv.org/content/10.1101/2025.11.07.686839v1
3 days ago
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Attractors are less stable than their basins: Canalization creates a coherence gap in gene regulatory networks
https://www.biorxiv.org/content/10.1101/2025.11.06.687062v1
5 days ago
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Cell state plasticity emerging from co-regulated, competitive, and configurable interactions within the AP-1 network
https://www.biorxiv.org/content/10.1101/2025.11.06.686987v1
5 days ago
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1
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The TEAIV model: Extending the standard TEIV model to account for viral budding ramp up
https://www.biorxiv.org/content/10.1101/2025.11.07.687137v1
6 days ago
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Collective parameter estimation of related models with an initial stability constraint
https://www.biorxiv.org/content/10.1101/2025.11.07.684636v1
6 days ago
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Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinsons disease
https://www.biorxiv.org/content/10.1101/2025.11.06.686787v1
6 days ago
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Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polarity
https://www.biorxiv.org/content/10.1101/2025.11.05.686808v1
7 days ago
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Integration of Hematopoietic and Thymus-like Niches in a Human iPSC-derived Bone Marrow Organoid
https://www.biorxiv.org/content/10.1101/2025.11.04.686649v1
7 days ago
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Bootstrap-based criteria for identifying differences between learned Bayesian networks
https://www.biorxiv.org/content/10.1101/2025.11.04.686685v1
7 days ago
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Integrated control of redox and energy metabolism by the membrane-bound and soluble transhydrogenases of Pseudomonas putida across metabolic regimes
https://www.biorxiv.org/content/10.1101/2025.11.04.686620v1
7 days ago
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Harnessing Interpretable Deep Learning to Predict Meropenem Resistance in Klebsiella pneumoniae
https://www.biorxiv.org/content/10.1101/2025.11.04.686393v1
8 days ago
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Inferring absolute counts from proportions by constraining multivariate normal distributions
https://www.biorxiv.org/content/10.1101/2025.11.04.686543v1
8 days ago
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BudFinder: A Masked Auto-Encoder Vision Transformer Framework for Yeast Budding Detection
https://www.biorxiv.org/content/10.1101/2025.11.04.686463v1
8 days ago
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Predicting strain-specific metabolic capabilities in the Genus Pseudomonas using a Flux-to-AI approach unravels hidden cell envelope properties.
https://www.biorxiv.org/content/10.1101/2025.11.04.686459v1
8 days ago
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CycleVI: Isolating cell cycle variation with an interpretable deep generative model
https://www.biorxiv.org/content/10.1101/2025.11.04.686009v1
8 days ago
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End-to-end high-throughput single-cell proteomics via SPRINT and dual-spray LC-MS
https://www.biorxiv.org/content/10.1101/2025.11.03.686420v1
8 days ago
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M4 drug discovery: human drug predictions from integrated pre-clinical insights exemplified with a GLP1-R agonist
https://www.biorxiv.org/content/10.1101/2025.11.03.686224v1
8 days ago
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Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach
https://www.biorxiv.org/content/10.1101/2025.11.03.686281v1
9 days ago
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Phenotypic heterogeneity in lag reflects an evolutionarily stable bet-hedging strategy
https://www.biorxiv.org/content/10.1101/2025.11.02.686100v1
9 days ago
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Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding
https://www.biorxiv.org/content/10.1101/2025.10.31.685889v1
11 days ago
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Revisiting graph-based approaches for small protein analysis: Insights from anti-CRISPR protein networks
https://www.biorxiv.org/content/10.1101/2025.10.31.685784v1
13 days ago
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Glycolytic ATP production enables rapid mammalian cell growth
https://www.biorxiv.org/content/10.1101/2025.10.30.685682v1
13 days ago
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Decay in transcriptional information flow is a hallmark of cellular aging
https://www.biorxiv.org/content/10.1101/2025.10.30.685689v1
13 days ago
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STAT1 -- p53 Dynamics Program Cell Fate through p21 and PUMA
https://www.biorxiv.org/content/10.1101/2025.10.28.685172v1
14 days ago
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An Improved Systematic Method for Constructing ecGEMs using a Protein-Chemical Transformer
https://www.biorxiv.org/content/10.1101/2025.10.29.684458v1
14 days ago
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Integrative Network Analysis Reveals Organizational Principles of the Endocannabinoid System
https://www.biorxiv.org/content/10.1101/2025.10.28.685143v1
14 days ago
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Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
https://www.biorxiv.org/content/10.1101/2025.10.28.685134v1
14 days ago
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Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer's disease
https://www.biorxiv.org/content/10.1101/2025.10.28.685084v1
15 days ago
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Integrated tissue proteomics and lipidomics from ovine organs suggests novel functional implications for fatty acids and lipid mediators.
https://www.biorxiv.org/content/10.1101/2025.10.28.685055v1
15 days ago
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Elucidating a potential role of the infant gut microbiome on the bioavailability of L-tyrosine in phenylketonuria
https://www.biorxiv.org/content/10.1101/2025.10.28.685037v1
15 days ago
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Genome-scale metabolic model guided metabolic flux analysis in the endophyte Alternaria burnsii NCIM1409
https://www.biorxiv.org/content/10.1101/2025.10.28.685040v1
15 days ago
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A structured evaluation and benchmarking of Boolean logical modelling tools
https://www.biorxiv.org/content/10.1101/2025.10.28.684998v1
16 days ago
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SPIN: Inkjet-Driven Nanowell Workflow for Scalable and Sensitive Single-Cell Proteomics
https://www.biorxiv.org/content/10.1101/2025.10.27.684859v1
16 days ago
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Sex differences in thyroid aging and their implications in thyroid disorders: insights from gene regulatory networks
https://www.biorxiv.org/content/10.1101/2025.10.27.684890v1
16 days ago
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Systems modeling of mitochondrial dynamics in different exercise regimes
https://www.biorxiv.org/content/10.1101/2025.10.27.684912v1
16 days ago
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Quantum Algorithm for Metabolic Network Analysis
https://www.biorxiv.org/content/10.1101/2025.10.26.684702v1
17 days ago
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Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells
https://www.biorxiv.org/content/10.1101/2025.10.27.684723v1
17 days ago
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Unraveling the Mechanistic Links Between Blood Pressure Regulation and Calcium-Magnesium Homeostasis: Insights into Hypertension, Hyperparathyroidism, and Mineral Disorders
https://www.biorxiv.org/content/10.1101/2025.10.26.684662v1
17 days ago
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Rapid Parameter Inference for Spatiotemporal Stochastic Biological Models using Neural Posterior Estimation
https://www.biorxiv.org/content/10.1101/2025.10.26.684706v1
17 days ago
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A phenotype-structured PDE framework for investigating the role of hypoxic memory on tumor invasion under cyclic hypoxia
https://www.biorxiv.org/content/10.1101/2025.10.26.684650v1
17 days ago
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Design principles underlying nearly-homeostatic biological networks
https://www.biorxiv.org/content/10.1101/2025.10.23.683559v1
17 days ago
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