Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress. https://www.biorxiv.org/content/10.64898/2026.06.06.727699v1

Receptor-structured modelling of EGFR-driven tumor initiation: from spatially resolved cell-based simulations to reduced population dynamics https://www.biorxiv.org/content/10.64898/2026.06.05.730529v1

Intricate Dynamical Cross-Talk Between p53 Protein and Cell Cycle Regulators Governs Mammalian Cell Fate https://www.biorxiv.org/content/10.64898/2026.06.07.730771v1

Organizing principles in the Nitrogen-Carbon Landscape of Marine Heterotrophic Bacteria https://www.biorxiv.org/content/10.64898/2026.06.04.730220v1

Untargeted cord blood metabolomics reveals altered lipid metabolism in neonates with gastroschisis https://www.biorxiv.org/content/10.64898/2026.06.04.730243v1

PRIME: scalable, robust inference of mechanistic cell states from multimodal single-cell counts via probability generating functions https://www.biorxiv.org/content/10.64898/2026.06.04.730253v1

Purinergic signaling disrupts emergent patterns of multicellular coordination in basal Xenobots. https://www.biorxiv.org/content/10.64898/2026.06.04.730190v1

Antifungal tolerance and resistance dynamics depend on infection load, drug treatment, and host innate immunity https://www.biorxiv.org/content/10.64898/2026.06.04.730223v1

Comparative Evaluation of DDA and DIA Based Proteomic Workflows in Beryllium Related Lung Disease https://www.biorxiv.org/content/10.64898/2026.06.04.730108v1

Comprehensive evaluation of LLM capabilities for interpretation and analysis of genome-scale metabolic models in metabolic engineering https://www.biorxiv.org/content/10.64898/2026.06.03.730004v1

Predictive Neuromechanical Simulation Explains Gait Biomechanics in Obesity https://www.biorxiv.org/content/10.64898/2026.06.03.729794v1

HIP-MS: An ultra-high-throughput, sensitive, and versatile affinity enrichment platform for static and dynamic interactome profiling https://www.biorxiv.org/content/10.64898/2026.06.03.729763v1

Clostridial acidogenesis product profiles are discontinuous: a thermodynamic hypothesis https://www.biorxiv.org/content/10.64898/2026.06.03.729792v1

Cellular Complexity and Systemic Immune Profiles across Ancestral Diversity in Thailand and Mainland Southeast Asia https://www.biorxiv.org/content/10.64898/2026.06.08.726441v1

Digging for meaningful connections: associations between root phenotypes and rhizosphere microbial diversity in maize https://www.biorxiv.org/content/10.64898/2026.06.03.725163v1

Nutrient control enables metabolic reconstruction of L. rhamnosus GG and analysis of secretions https://www.biorxiv.org/content/10.64898/2026.06.02.729517v1

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responses https://www.biorxiv.org/content/10.64898/2026.06.02.729479v1

An extension of Modular Response Analysis for global perturbations and robust connectivity inference of gene regulatory networks. https://www.biorxiv.org/content/10.64898/2026.06.02.729263v1

RISOP, a Reference-Assisted Approach for Enhanced Identification of Oxidized Phospholipids https://www.biorxiv.org/content/10.64898/2026.06.01.728773v1

Diversity, host-specificity, and environmental drivers of the coral reef eukaryome https://www.biorxiv.org/content/10.64898/2026.06.02.729273v1

Multi-omic data fusion reveals the in vivo enzyme kinetics of Vibrio natriegens at the genome-scale https://www.biorxiv.org/content/10.64898/2026.06.02.729587v1

Model-based inference of enzyme inhibitions from perturbation-induced metabolic dynamics https://www.biorxiv.org/content/10.64898/2026.06.01.729220v1

TabularQual: A spreadsheet-based format for annotating and curating logical models in SBML-qual https://www.biorxiv.org/content/10.64898/2026.05.31.727710v1

Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell Lines https://www.biorxiv.org/content/10.64898/2026.05.30.728988v1

A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology. https://www.biorxiv.org/content/10.64898/2026.06.01.728087v1

Extracellular vesicles from Manila clam (Ruditapes philippinarum): tailored isolation from hemolymph and insights into water-derived vesicles https://www.biorxiv.org/content/10.64898/2026.05.29.727857v1

Development positions malignant cellular states but does notexplain their diversification https://www.biorxiv.org/content/10.64898/2026.05.28.728220v1

iSsus3744: A Genome-Scale Model-Guided Strategy for Rational Media Design for Cultivated Pork https://www.biorxiv.org/content/10.64898/2026.05.28.728221v1

Explainable machine learning reveals an RBP regulatory logic of exon skipping https://www.biorxiv.org/content/10.64898/2026.05.29.728731v1

Modeling of Glucosinolate Biosynthesis During Biotic Stress as a Function of mRNA https://www.biorxiv.org/content/10.64898/2026.05.29.728632v1

Ultrasensitive response in bacterial replication initiation https://www.biorxiv.org/content/10.64898/2026.05.28.728621v1

Analyzing the dynamics in defense/counter-defense games among hosts and pathogens https://www.biorxiv.org/content/10.64898/2026.05.27.728168v1

EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin https://www.biorxiv.org/content/10.64898/2026.05.27.728028v1

Intestinal Dysbiosis in Necrotic Enteritis: Dissecting the Roles of Eimeria and Clostridium perfringens https://www.biorxiv.org/content/10.64898/2026.05.27.728132v1

Growth-resolved genome-scale metabolic modeling of Priestia megaterium SR7 validated by chemostat and 13-C flux analysis https://www.biorxiv.org/content/10.64898/2026.05.27.728139v1

Endocytosis suppresses stochastic collapse in fibroblast-macrophage circuits under shared resource competition https://www.biorxiv.org/content/10.64898/2026.05.27.728330v1

Reconstructing heterogeneous metabolic trajectories of E. coli diauxie via a dynamical Maximum Entropy Principle https://www.biorxiv.org/content/10.64898/2026.05.28.728366v1

Multi-state Continuous-Time Markov Chain Modeling for Chronic Kidney Disease Progression https://www.biorxiv.org/content/10.64898/2026.05.26.727952v1

Spatiotemporal remodeling of cytoskeletal and junction networks during somatic cell reprogramming https://www.biorxiv.org/content/10.64898/2026.05.26.725436v1

Learning dynamical systems with biochemically informed neural ordinary differential equations https://www.biorxiv.org/content/10.64898/2026.05.25.727308v1

hB-PAC: A non-invasive aging clock for quantifying individual differences in aging https://www.biorxiv.org/content/10.64898/2026.05.22.727332v1

A Cross-tissue Temporal Multi-omics Atlas Reveals the Molecular Architecture of Pressure Injury https://www.biorxiv.org/content/10.64898/2026.05.21.727040v1

Fatty acid metabolic interactome atlas linked to cellular longevity https://www.biorxiv.org/content/10.64898/2026.05.20.726705v1

An atlas of the human metabolome https://www.biorxiv.org/content/10.64898/2026.05.21.726638v1

A Simulation of Semi-Infectious Particles and Genome Complementation Reproduces Interferon Response by Respiratory Epithelial Cells in vitro during Influenza A Virus Infection https://www.biorxiv.org/content/10.64898/2026.05.20.726376v1

A conserved transcriptomic model defines metabolic resilience and vulnerability in obesity https://www.biorxiv.org/content/10.64898/2026.05.20.726524v1

TORC1 integrates metabolic state transitions during aging https://www.biorxiv.org/content/10.64898/2026.05.18.726092v1

A quantitative framework for bacterial competition during starvation https://www.biorxiv.org/content/10.64898/2026.05.19.726047v1

Bayesian Parameter Balancing Enables Robust and Consistent Estimation of Kinetic Parameter Uncertainty https://www.biorxiv.org/content/10.64898/2026.05.18.726043v1

Liver-to-Atria Inflammatory Axis Driving Arrhythmia https://www.biorxiv.org/content/10.64898/2026.05.19.726408v1