TORC1 integrates metabolic state transitions during aging https://www.biorxiv.org/content/10.64898/2026.05.18.726092v1

A quantitative framework for bacterial competition during starvation https://www.biorxiv.org/content/10.64898/2026.05.19.726047v1

Bayesian Parameter Balancing Enables Robust and Consistent Estimation of Kinetic Parameter Uncertainty https://www.biorxiv.org/content/10.64898/2026.05.18.726043v1

Liver-to-Atria Inflammatory Axis Driving Arrhythmia https://www.biorxiv.org/content/10.64898/2026.05.19.726408v1

From time-course expression to gene regulation: direct linear ODE inference without finite-difference approximation https://www.biorxiv.org/content/10.64898/2026.05.18.726023v1

Systemic metabolic correlates of environmental sensitivity in group-housed mice https://www.biorxiv.org/content/10.64898/2026.05.18.725769v1

Computational screen of promoter configurations that robustly sense transcription factor dynamics https://www.biorxiv.org/content/10.64898/2026.05.19.726340v1

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models. https://www.biorxiv.org/content/10.64898/2026.05.17.725083v1

Global cell-state and gene-program representations reveal conserved and context-specific perturbation responses of cells https://www.biorxiv.org/content/10.64898/2026.05.16.725005v1

Discovering conserved regulatory modules in predicted gene regulatory networks across species https://www.biorxiv.org/content/10.64898/2026.05.15.725337v1

A Far-Red FRET biosensor for AMPK enables multiplexed imaging of single-cell bioenergetic homeostasis https://www.biorxiv.org/content/10.64898/2026.05.13.723899v1

Genome-scale community metabolic modeling of maize root-associated microbiota shows that root exudates stimulate diverse metabolic interactions https://www.biorxiv.org/content/10.64898/2026.05.13.724839v1

Co-expression network analysis reveals repression of Igf2bp2 by REV-ERBβ in skeletal muscle https://www.biorxiv.org/content/10.64898/2026.05.13.724827v1

Simultaneous single-cell profiling of the transcriptome and proteome https://www.biorxiv.org/content/10.64898/2026.05.14.724921v1

Coarse-graining metabolic networks via feature learning reveals cross-species growth laws https://www.biorxiv.org/content/10.64898/2026.05.13.725055v1

Protein Stability, Turnover Kinetics, and Abundance Constrain the Scaling of Protein Interaction Networks https://www.biorxiv.org/content/10.64898/2026.05.11.724303v1

Global quantification of mammalian gene expression noise https://www.biorxiv.org/content/10.64898/2026.05.11.724258v1

MechAInistic: An LLM-guided Multi-Agent System for Reasoning over Genome-Scale Constraint-Based Metabolic Models https://www.biorxiv.org/content/10.64898/2026.05.11.723319v1

The Onset of Myeloid Differentiation in Hematopoietic Progenitors In Vivo is Coordinated with S-phase Progression https://www.biorxiv.org/content/10.64898/2026.05.10.724120v1

Uncertainty-aware graph representation learning with positive-unlabeled classification for biomarker discovery in peripheral artery disease https://www.biorxiv.org/content/10.64898/2026.05.08.723757v1

Riemannian Tensor Analysis Identifies a Bifurcation State in the Single-Cell Transcriptomic Landscape of Parkinson's Disease https://www.biorxiv.org/content/10.64898/2026.05.09.724002v1

Computer experimentation on E. coli ammonium transport and assimilation reveals mechanisms for energy coupling, balanced futile cycling, and robust growth https://www.biorxiv.org/content/10.64898/2026.05.09.723968v1

Efficient Bayesian inference for ordinary differential equation models from experimental data with uncertain measurement times https://www.biorxiv.org/content/10.64898/2026.05.09.724053v1

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon https://www.biorxiv.org/content/10.64898/2026.05.09.724010v1

A multiomic lifespan signature in genetically diverse, diet-restricted mice https://www.biorxiv.org/content/10.64898/2026.05.08.723574v1

Dynamical Systems-Constrained Metabolic Modeling Enables Forecasting of Host-Microbiome Dynamics https://www.biorxiv.org/content/10.64898/2026.05.08.723020v1

TRAFIKK: systematic prediction and mechanistic interpretation of anticancer drug synergies https://www.biorxiv.org/content/10.64898/2026.05.08.723755v1

Spatially resolved transcriptomic and proteomic profiling reveals cell interaction programs that predict Barrett's esophagus progression https://www.biorxiv.org/content/10.64898/2026.05.08.723546v1

Integrative Modeling and Analysis of Fungal Central Carbon Metabolism https://www.biorxiv.org/content/10.64898/2026.05.08.723079v1

Susagi: A Microbiome World Model https://www.biorxiv.org/content/10.64898/2026.05.07.723428v1

Homeostatic feedback model of energy metabolism with adaptive enzyme levels exhibits problem solving behavior https://www.biorxiv.org/content/10.64898/2026.05.07.721661v1

Talk2QSP: Deriving Executable Scenarios from Unstructured Literature via Human-in-the-Loop Agents https://www.biorxiv.org/content/10.64898/2026.05.06.723244v1

Learning activator-inhibitor dynamics at the cell cortex with neural likelihood ratio estimation https://www.biorxiv.org/content/10.64898/2026.05.06.722433v1

Systemic stress states are reversed by NPBWR1 inhibition https://www.biorxiv.org/content/10.64898/2026.05.06.722954v1

Computational analysis reveals the requirement for cell-cell interaction in liver repopulation by transplanted hepatocytes https://www.biorxiv.org/content/10.64898/2026.05.06.723162v1

Unraveling the metabolic interactions of a Dehalobacter-containinganaerobic mixed culture for bioremediation https://www.biorxiv.org/content/10.64898/2026.05.05.723060v1

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures https://www.biorxiv.org/content/10.64898/2026.05.05.723030v1

Inter- and Intra-individual Variability in Oral Food Processing and Its Impact on Aroma Release https://www.biorxiv.org/content/10.64898/2026.05.05.721895v1

Ensemble kinetic modelling links residual enzyme activity to clinical symptoms in mitochondrial β-oxidation defects https://www.biorxiv.org/content/10.64898/2026.05.05.722902v1

Mathematical Modeling of the Canonical Aryl Hydrocarbon Receptor Pathway https://www.biorxiv.org/content/10.64898/2026.05.05.722708v1

A unified framework links infant vulnerability with aging-related mortality dynamics https://www.biorxiv.org/content/10.64898/2026.05.05.722841v1

Acetate promotes nutritional adaptation in Escherichia coli https://www.biorxiv.org/content/10.64898/2026.05.05.722864v1

COCOA.jl: A Julia package for high-performance analysis of concordance and kinetic modules in biochemical networks https://www.biorxiv.org/content/10.64898/2026.05.05.722856v1

Robotic perturbation proteomics and AI agents enable scalable drug mechanism discovery https://www.biorxiv.org/content/10.64898/2026.05.04.722718v1

Multi-omic analysis identifies mitochondrial dysfunction as a conserved driver of acute severity and long-term complications in RSV infection https://www.biorxiv.org/content/10.64898/2026.05.04.722656v1

Claim-Level Transparency Analysis of LLM-Generated Diagnostic Reports: A Metabolic and Endocrine Biomarker Study https://www.biorxiv.org/content/10.64898/2026.05.03.721751v1

Bion-M 2 Biosatellite: Multisystem Mouse Responses to 30 Days in High-Latitude Orbit as a Deep-Space Analog https://www.biorxiv.org/content/10.64898/2026.05.03.722490v1

Box-Counting Fractal Dimensions of Cranial Suture: Effects of Measurement Conditions and Model-Based Reproduction of Fractal-Like Patterns https://www.biorxiv.org/content/10.64898/2026.05.02.722422v1

Lineage-specific lncRNAs critically determine cross-species differences in tumors https://www.biorxiv.org/content/10.64898/2026.05.01.722350v1

The first digital twin of Enterococcus faecium metabolism reproduces high-throughput phenotyping data https://www.biorxiv.org/content/10.64898/2026.05.01.720924v1