Really excited to have lead this work alongside Eli and Lidan! I’d love to chat about applying our platform to your system of interest, the advantages of parallel imaging and proteomics, ability to target DNA, RNA, and protein, or advantages over enzyme-based labeling with anyone who’s interested!

More exciting work from the lab! Along with @maccoss.bsky.social (@uwgenome.bsky.social) and Gary Churchill (@jax.org), Dr. Katarina Vlajic's tour de force multi-omics profiling uncovered molecular signatures of healthy splenic aging! www.biorxiv.org/content/10.6...

1/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...

First co-author paper from the first year of my time here at UW is now live! Always happy to chat about it with anyone who is interested ☺️

Not something you see in textbooks very often: tripolar mitosis.

Surprised (but also not that surprised) that the AlphaGenome paper didn't officially cite any of the primary data used for training their model (see Fig. 1, thousands of datasets made with tremendous time and effort over >15yrs). What's up with that @nature.com ? www.nature.com/articles/s41...

Check out our new work now published in G3! We use proteomics and phosphoproteomics to study how cells cope with tRNA variants that mis-insert amino acids.

Something is deeply wrong if we, as a society, cannot agree that an administration that snatches up children, uses them as bait to hunt down others, is morally repulsive.

This is a death sentence for America. www.nytimes.com/2026/01/23/h...

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...

Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics www.nature.com/articles/s41...

This really hasn’t gotten enough attention this week. @wired.com #ICE www.wired.com/story/fbi-wa...

NEW: After paying for hotel rooms to shelter homeless people, Seattle deliberately left them vacant. By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.

Note that the Trump Administration is already going back to schools with whom it earlier reached "deals" (such as UPenn and Brown) for further concessions. Conceding to a bully has only emboldened them to make new demands.

The New York Yankees beat the Boston Red Sox in Wild Card Series to advance to the AL Division Series against the Toronto Blue Jays.

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

Elite colleges are infamous for funneling students into the Big Three—consulting, tech, and finance—high-paying fields that perpetuate status and wealth. To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!: Nova - lightweight dev library schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10.... Helios - a unified instrument API now @ JPR github.com/SchweppeLab/...

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen! Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org! doi.org/10.1073/pnas... 👇🧵