Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social #VariantEffect26 Register soon for the early bird rate! ℹ️➡️https://www.mss2026.org

It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...

So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...

Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

Our annual "Wednesday Evening at the Genome" public lecture series starts this week! Talks by Andrew Stergachis, Ivan Liachko, Gaurav Bhardwaj, & Mary-Claire King geared toward a general audience. 6:00 in Foege auditorium, followed by time to meet the speakers. www.gs.washington.edu/news/publicl...

We have co-organized a MAVE course with Wellcome Connecting Science! Meeting is in November, but the 🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/

Very fun lab party today to celebrate the graduation of several lab undergraduate researchers! Congratulations!

We also had 4 tetrad dissection microscopes join the lab this week, as part of the @uw-nsc.bsky.social renewal! These belonged to Matt Kaeberlein as part of their large scale efforts to measure replicative lifespan in yeast. We are now offering them as loaners for labs who want to try lifespans.

Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

Had a great day at UBC with a cohort from my lab for the Pacific Northwest Yeast Club meeting! Great science and community, and my student Leah won best talk!

POSTDOC ALERT: Applications now open for SeaBridge postdoc fellowship; opportunity to work on leading-edge biotech w/researchers at the Seattle Hub for Synthetic Biology. brotmanbaty.org/news/new-pos... @marionpepper.bsky.social @jshendure.bsky.social @coletrapnell.bsky.social

Another art piece created by argot chen last week during Sxaffold, this one snippets of text pulled from one of my papers. how do you Hope to be changed

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team. Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵 www.biorxiv.org/content/10.1...

Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches https://www.biorxiv.org/content/10.1101/2025.06.06.658356v1

Had a great time collaborating with artist argot chen this week as part of the inaugural Sxaffold scientist/artist encounter. We made Mt. Rainier from agar using a 3D printed mold, then painted with colorful yeast strains www.sxaffold.org

Second of Taylor’s hybrid genetics preprints: A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus. www.biorxiv.org/content/10.1...

Two preprints posting today from prior lab grad student Taylor on doing genetics with interspecific yeast hybrids! #1: Meiotic null MSH2 and SGS1 alleles in S. cerevisiae x S. uvarum hybrids result in near-haploid offspring with mixed parental chromosomal inheritance www.biorxiv.org/content/10.1...

The schedule for the Pacific Northwest Yeast Club meeting (June 20 in Vancouver) looks really great! Love the addition of an Industry Session this year. Less than 30 registration spots remaining, and the poster abstract deadline has been extended to June 6. www.pnwyc.net/schedule

Thanks to @genetics-gsa.bsky.social for starting a Genetics Department (and related) Chairs group. The hope is we will be able to share information & strategize across institutions. Initial invitations have now gone out, but please let me know if we missed you and you would be interested in joining.

Researchers pinpoint the genes responsible for the final three pea traits studied by Gregor Mendel more than 160 years ago https://go.nature.com/3EC3eqT

The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...

This is one of the best features I have seen on blue sky yet- a custom feed of papers from people you follow. I had to un-follow the various biorxiv channels, as it was dominant, but now I am seeing lots of cool papers from people I follow. Great work on this feed, @paper-feed.bsky.social team!

Microbiologists, check out this genius trick for orienting flat toothpicks that comes from the legendary Beth Jones by way of Bonny Brewer. Video taken by my lab manager, Emily.

Nothing like new data to lift the spirits. 44 new caspofungin-resistant @yevolab.bsky.social genomes! Can't wait to get these back in the hands of the high school students who evolved these yeast strains.

Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.

Genome Sciences is looking for a Grants Manager for the Model Organism Genetics labs (which include me!): uwhires.admin.washington.edu/ENG/candidat...

Genome Sciences is on Bluesky now!

New work in Genetics by @reneegeck.bsky.social when she was in my lab, Nick Powell, et al. delving into novel variants in G6PD in the All of Us resource. Functional analysis of G6PD variants associated with low G6PD activity in the All of Us Research Program academic.oup.com/genetics/art...

After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY

Work with Nick Powell is out on Genetics! Nick used data from the All of Us Research Project to connect G6PD genotypes and phenotypes, and I tested some variant functions in yeast with @maitreya.bsky.social! Power of human+yeast genetics! academic.oup.com/genetics/adv...

Had a great workshop today with the Hutch SEP & a bunch of local teachers interested in using our Yeast Madness kit in their classes. This module uses strains evolved by previous yEvo high school students and teaches about mutations, fitness, & cell biology. www.fredhutch.org/en/education...

Question for the #CryoEM crowd: does anyone happen to recognize this lovely ~10-15nm diameter protein complex we stumbled across while imaging slime mold protein lysate (as one does)?

I made a starter pack of folks affiliated with UW Genome Sciences (past and present) go.bsky.app/L8RAbiJ It's fairly sparse for now, so please let me know if you'd like to be added!

Calling all microbiologists in the PNW! Registration is now open for the 2024 American Society for Microbiology Northwest Branch meeting, to be held in Seattle, WA over November 9-10. Register and submit your abstracts at www.nwasm.org!

Well how nice is this interview with @blakebillmyre.bsky.social about the impact on him of a talk I gave about @ivanliachko.bsky.social's ARS genomics project! That was a pretty fun conference :) mSphere of Influence: When a sequencer is more than a sequencer journals.asm.org/doi/full/10....

The department surprised me with a very nice "new chair" toast at the retreat and gave me a literal UW camping chair as a gift 🥹

Excited for Dunham/@kelleyharris.bsky.social graduate student Gabby's selection for the Human Genetics Scholars program from ASHG! www.ashg.org/publications...

As we head into the new school year, if you're an intro genetics instructor and would like to share exams, slides, problem sets, activities, and other teaching materials, you're invited to join the Genetics Educators Exchange. Please request access here: forms.gle/535PnGhBbJU7...

Validating all my lab hoarding instincts, we just came up with a use for these tiny glass Petri dishes that I saved from the Botstein lab lo many years ago. Turns out the shipping date on the box was 1960 to Stanford, so now I’m very curious who David got them from!

Today is @taykatwang.bsky.social's last day in my group! She's stayed on for a remote mini-postdoc to finish up a few things (stay tuned!) after graduating with her PhD in December. Thanks to David Gresham for hosting her at NYU. I'm very excited for her as she starts a postdoc with Snow Zhou!

Good luck to star postdoc @reneegeck.bsky.social as she goes off to start as a professor at Gonzaga!

One of the great lessons of being “midcareer” is that you can literally just will something into being if you want it to exist and are willing to put in a little work. I sometimes feel like Dorothy Gale that I’ve had the power all along and just didn’t realize!

Final schedule posted for the Pacific Northwest Yeast Club regional meeting! No registration required, so you can just show up Friday (directions on website), with or without a poster. Thanks to Sunrise Science and Fred Hutch for sponsoring food/drinks! www.pnwyc.net/schedule

Nice new lab website, thanks to grad student @geneticswithrae.bsky.social! depts.washington.edu/dunhamlab/

It's not every day that you get voted on by the UW Board of Regents and get a letter signed by the president and provost. Looks like I'm officially Chair! (effective July 1, which is why this article is from earlier this month) huddle.uwmedicine.org/maitreya-dun...

New @yevolab.bsky.social paper in G3 led by @reneegeck.bsky.social and featuring work from the classrooms of Tim Renz and Rebecca Brewer! Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways academic.oup.com/g3journal/ar...

Learn about how yEvo helps students think like scientists and see themselves as scientists from The Downtown School teacher Kelsey Kovarik! tinyurl.com/yedzpdw7