I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!

@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!

We are hiring! Communications role for our Global Alliance! sanger.wd103.myworkdayjobs.com/en-US/Wellco... #job #hiring #Communications Hinxton, Cambridgeshire UK

Submit your abstract for the upcoming Mutational Scanning Symposium (deadline is Nov 2nd, 2025!) General info: www.mss2026.org Abstract submission form: docs.google.com/forms/d/e/1F...

Next up! Two applications of MAVE! 🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants. 🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.

This is one not to miss! We look forward to seeing you all in Melbourne. #VariantEffect26 ⏰Abstract deadline is Nov 2nd 2025.

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social #VariantEffect26 Register soon for the early bird rate! ℹ️➡️https://www.mss2026.org

🧬 Out this month in Nature Reviews Cardiology: A powerful look at how multiplexed assays of variant effects (MAVEs) are reshaping our understanding of cardiovascular disease genetics. Contributors include members of the AVE Alliance. 📑 www.nature.com/articles/s41... #Cardiology #FunctionalGenomics

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP www.nature.com/articles/s41...

MSS is a cornerstone event for the functional genomics community. Did you know that the Mutational Scanning Symposium has been held eight times since 2017? We have an amazing community! Join us next year in Australia! www.mss2026.org (Registration to open soon). #VariantEffect26

The 9th Annual Mutational Scanning Symposium will be held in Melbourne, Australia March 25-27, 2026 🌟 #VariantEffect26 www.mss2026.org Registration will open soon!!!!

📢 Empower Genomic Innovation with Your Sponsorship! 🧬 We are looking for generous #sponsors to support the upcoming Mutational Scanning Symposium. #VariantEffect26 ℹ️ www.mss2026.org For sponsorship inquiries, please contact 📩 [email protected]

Variant Effects Seminar is today! (9am Pacific) www.varianteffect.org/seminar-seri...

Interested in viewing a talk from a previous Mutational Scanning Symposium? Visit our youtube channel. 📺 🍿 www.youtube.com/@cmap_cegs84... @isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio

Critical Assessment of Genome Interpretation (CAGI) challenges are live! 🧬💻 genomeinterpretation.org/cagi7-challe... A total of 12 challenges have launched Including #DeepMutationalScanning Challenges ⏰ Deadlines approaching! #CAGI #GenomeInterpretation #VariantEffect

Why yes! You can watch previous Variant Effects Seminar Series talks on our YouTube channel! ℹ️ www.varianteffect.org/previous-sem... 📺 www.youtube.com/playlist?lis... #Genomics #Seminar #EarlyCareerResearchers #ScientificSeminar #PrecisionMedicine

‪🗓️ Join us tomorrow! August 5 with @nurdankuru.bsky.social (CSHL) @cshlnews.bsky.social and Ferdy van Geest (ErasmusMC) #Genetics #RareDisease #MedicalGenetics ℹ️ www.varianteffect.org/seminar-seri...

Ever wondered how your genes shape your health? Dive into the Variants and Us (VUS) Podcast—where cutting-edge science meets real-world impact. 🎧 varianteffect.org/podcast/ #Genetics #RareDisease #VariantEffect #SciencePodcast #PersonalizedMedicine

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇 1/9

Highly recommend the Variants and Us podcast! Listen to all episodes here>> www.varianteffect.org/podcast/

'Science can feel like magic. When you begin to understand how and why things work, it’s incredible.' Learn more about Katie Partington, an 'intellectually adventurous' promising young scientist in the lab of BBI's Dr. Doug Fowler. brotmanbaty.org/news/promisi... @dougfowler.bsky.social @hmc.edu

The University of Washington Department of Genome Sciences @uwgenome.bsky.social hosts 'Wednesday Evenings at the Genome' public lecture series each summer! Admission is free and open to anyone interested. ℹ️ www.gs.washington.edu/news/publicl...

Starting soon! 🕑 Join us at 2:00 p.m. EDT for today’s Accessibility in #STEM workshop: Disability inclusion at in-person conferences. Hear panelists share their experiences and ideas for more accessible conferences. Make sure you're registered: buff.ly/pkncxIL

📢 Applications are now open for the new SeaBridge postdoctoral fellowship program! 40 postdocs will collaborate with @uwmnewsroom.bsky.social, @fredhutch.bsky.social, and @seattlechildrens.bsky.social to advance Seattle Hub’s technologies. 📝 Learn more and apply: bit.ly/44kwDzK

A US judge has ordered hundreds of terminated research projects at the US National Institutes of Health to be reinstated, calling the processes that led to their cancellation “bereft of reasoning”. https://go.nature.com/4kOmXDy

You can now view #VariantEffect25 presentations from @pollyfordyce.bsky.social @davidjadams.bsky.social @nickywhiffin.bsky.social along with many many others! on our YouTube channel www.youtube.com/@cmap_cegs84... (hat tip to @isabellease.bsky.social for the excellent illustrations)

Coming up in July! www.varianteffect.org/seminar-seri...

"It's a horror show. We're under attack in every way all the time," says Sarah Kobrin, who has worked at the National Cancer Institute for more than 21 years. "We're told we're worthless. We're told we're cheats.… They're breaking things that won't be repairable." www.npr.org/sections/sho...

very nice and clear piece on the govt-university partnership, by @labonnelab.bsky.social www.washingtonpost.com/opinions/202...

Thanks to @genetics-gsa.bsky.social for starting a Genetics Department (and related) Chairs group. The hope is we will be able to share information & strategize across institutions. Initial invitations have now gone out, but please let me know if we missed you and you would be interested in joining.

Next up at #VariantEffect25: Translating computational genomics into clinical clarity we have @shawnfayer.bsky.social from @uwgenome.bsky.social presenting "A cluster-based method for guiding the use of variant effect predictors in clinical variant classification clinical clarity"

And now for the last talk of day 1 of #VariantEffect25 we have Steven Brenner @stevenbrenner.bsky.social: From Computer to Clinic: Calibrating variant impact predictors yields a ClinGen clinical recommendation up to strong evidence in genome variation interpretation

Diving into the 1st session of #VariantEffect25 we have David Adams @davidjadams.bsky.social from the Wellcome Sanger Institute presenting “Decoding Cancer: Clinical and Functional Roles of Nucleotide Variants in Cancer Genes”

Next up at #VariantEffect25 we have Megan Lancaster presenting “Uncovering ion channel biology and predicting arrhythmia risk with KCNQ1 and SCN5A MAVEs” ⚡

A lovely summary of what we have learnt about scaling from ProteinGym -- Have we reached a performance plateau? More on this later in the week from @cwjpugh.bsky.social

A one-slide intro to retrieval!

Next at #VariantEffect25 we have @pascalnotin.bsky.social who is Advancing Protein Fitness Prediction via Differentiable Retrieval and Cross-Landscape Transfer Learning #AI #ProteinML

Time for ☕🌞🌊#VariantEffect25

Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!

MSS 2025 is underway in Barcelona. Many thanks to Jonathan Frazier for posting updates regularly. Several BBI researchers are participating. @jonnyfrazer.bsky.social @leastarita.bsky.social @dougfowler.bsky.social @muffley.bsky.social @shawnfayer.bsky.social #VariantEffect25

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

Honored and grateful to receive this award! Wow! A huge thank you to everyone who has supported me along the way—this means so much. brotmanbaty.org/news/bbis-la...

Coming up in June! You can find more information on our website www.varianteffect.org

Countdown officially started! #VariantEffect25 @varianteffect.bsky.social

Talks are now available to view on our YouTube channel. www.youtube.com/@cmap_cegs84...

🗓️ Coming up on May 6th! w/ Timothy Tan timothyjtan.bsky.social and Mustafa Tekpinar #ProteinDesign #VariantEffectPredictor #AI4Science #Seminar ℹ️➡️ www.varianteffect.org/seminar-seri...

NIH is ending billions of dollars in foreign subawards, jeopardizing thousands of projects on infectious diseases, cancer and more. Unless foreign researchers secure funding directly from NIH by October — a tall order for any researcher — clinical trials abroad and other research will shut down.