Although the SGD website will be available over the next few weeks, SGD staff will be on winter break until Jan 5, 2026. SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️

#APOYG !! #YeastResearch

Some absolutely beautiful artwork here! Really love to see #yeast #cerevisae representing so well in yet another category: #fineart 🍻🥖🩺🔬🧪🧬🎨 #YeastResearch

🔬How do single amino acid changes cause severe diseases? New #Structure study uses #Yeast to reveal the structural basis of PRoteasome-Associated Autoinflammatory Syndromes; 15 crystal structures show PRAAS-linked mutations 🔗 www.yeastgenome.org/reference/S1... #Proteasome #YeastResearch

🧬 Researchers have developed a microfluidic protocol to continuously observe ENTIRE microbial life cycles in real-time, including transitions! 🔬 #Yeast #YeastResearch #Microfluidics #CellBiology #Science #AgScience #Biomed www.yeastgenome.org/reference/S1...

Don't wait to book your stay at Fungal 2026! The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26 genetics-gsa.org/fungal-2026/...

As many of us 🎁 things up for the year, make sure all your ℹ️'s are dotted- and all your #yeast emojis are downloaded! If you haven't yet, make sure to add the emojyeast collection to all your 📱💻🖥️⌚️ mayaschuldiner.wixsite.com/schuldinerla... Thanks to the amazing Schuldiner lab for these!

How’s the #yeast community closing out 2025? SGD is saying a heartfelt farewell, revealing new Resource links, announcing a simple way to support the #Database you rely on, and more. Read our December newsletter: www.yeastgenome.org/blog/sgd-new... #SGD #science

Calling all #YeastResearch -ers! Who would like to work in beautiful Barcelona? 🌴🌊 And even better, work on #cerevisiae? #ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast

Enhanced #Yeast for better #ethanol production: After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance. 🍷 🍺 🧬 #Biotech #YeastResearch www.yeastgenome.org/reference/S1...

COQ5-related primary #CoQ10 deficiency: #RareDisease of #mitochondria. S.cerevisiae #complementation tests #COQ5 variants, revealing CoQ intermediate buildup and impaired biosynthesis, speeding variant interpretation, informing CoQ10 therapy. #Yeast #modelOrganism www.yeastgenome.org/reference/41...

#Yeast biodiversity + #MachineLearning enable strain/pathway design in other yeasts #MetabolicEngineering S. cerevisiae ✅genetic tractability ✅robust growth ❌industrial biotech Y. lipolytica/O. polymorpha ✅thermo/acid resistance ✅amass lipids ❌ genetic tools www.yeastgenome.org/reference/S1...

#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more: www.yeastgenome.org/reference/S1...

Targeted changes in interaction of Nab3p with low-abundant #mRNA of highly conserved #mitochondrial #transporter PIC2 alters its stability and can trigger significant system-wide defects and profoundly impact cellular #fitness www.yeastgenome.org/reference/41... #yeast #regulation

And wine, and beer, and the list of uses for this versatile little organism goes on and on! There is evidence that humans domesticated yeast >7000 years ago! Read a short summary here, including what "shmooing" has to do with yeast: sites.google.com/view/yeastge... #YeastBiology #ScienceIsFun

The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.

Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair www.yeastgenome.org/reference/39...

New insights into #meiosisI reveal distinct roles of spindle checkpoint proteins. Mad2p drives transition to #metaphase, Mad3p ensures microtubule-dependent #chromosome capture on spindle, safeguarding fidelity of segregation #Yeast #CellBiology #Genetics www.yeastgenome.org/reference/39...

Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 13 Prompt DRINK Pdb: 7BTW A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer. Cheers! Next: TRUNK Suggestions?

In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway. onlinelibrary.wiley.com/doi/10.1002/...

Unlocking secrets of #meiosis! Wei et al. reveal how Mei5-Sae3 complex enhances Dmc1p assembly by stabilizing Dmc1p clusters on ssDNA, altering RPA dynamics, paving way for successful interhomolog recombination. Fascinating proteins in action! #yeast #Genetics www.yeastgenome.org/reference/39...

Insights into mitochondrial #ribosome reveal mL44 mutations linked to childhood #cardiomyopathy, neuro issues. Box et al. study #yeast homolog MRPL3, show evolutionary divergence, translation hierarchy in mitochondrial protein synthesis #Mitochondria #Genetics www.yeastgenome.org/reference/38...

Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26 genetics-gsa.org/yeast-2026/

The 33rd Fungal Genetics Conference is accepting abstracts - due December 4, 2025! genetics-gsa.org/fungal-2026/... #FUNGAL26

📣Advance your skills in #pathogen genomics — no coding required — with the #Fungal Pathogen Genomics (Virtual) course #FungiDB @ensembl.org #mycocsm @yeastgenome.bsky.social #CGD 🗓️ 1–5 June 2026 Deadline: 16 March 2026 Apply here: coursesandconferences.wellcomeconnectingscience.org/event/fungal...

Abstract submission and registration now open for the 33rd #Fungal #Genetics Conference at #Asilomar! Abstracts due December 4, early registration deadline December 5. genetics-gsa.org/fungal-2026/

Nature has published an article on the crisis facing MODs Model organism databases face budget cuts and closures www.nature.com/articles/d41... @zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com

Utterly devastating: FlyBase zapped. www.thetransmitter.org/community/ha... #modelOrganism

Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited

Latest #yeast #microPublication: Schiemann et al. Functional Analysis of the Yeast Counterpart to the Human GCN2 p.Glu738_Asp739insArgArg Variant www.micropublication.org/journals/bio... @micropub7n.bsky.social

WormBase announces its final major update, WS298, will be in Oct2025. No more new WormBase releases; existing data will be moved into Alliance of Genome Resources, ensuring vital C. elegans datasets remain accessible. Stay tuned for more updates. Read more: blog.wormbase.org/2025/07/23/a...

#YeastNomenclature reminder: Protein Name Format #Yeast proteins are referred to by the relevant gene symbol, non-italic, initial letter uppercase and with the suffix ‘p’ (for example, Ade5p). The suffix can be omitted if the word 'protein' is appended (for example, the Ade5 protein).

On 16 June, a federal court in Boston will hear two cases challenging the terminations of hundreds of National Institutes of Health grants.

FlyBase needs your help! Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org

Noticing slowness on the SGD website? Thank the web-scraping AI bots www.nature.com/articles/d41...

#YeastJob: 2-year postdoc available at #Sorbonne Université (central Paris) to investigate dynamic architecture of natural polyploid genomes in #Saccharomyces cerevisiae focusing on resolving complex genomic structure of polyploids at population level. More info docs.google.com/document/d/1...

Virtual #Conference: 5th Annual CanFunNet #Fungal #Biology August 6-8 "From Local to Global" canfunnet.conferences.uwo.ca Abstract submissions, early registration open until May30 Topics include: Evolutionary Pathways of Fungal Pathogens, Fungal Genomics, Host Interactions, Fungal Resilience

SGD Newsletter is out! www.yeastgenome.org/blog/sgd-new... - SGD’s Latest #GENETICS Publication - #Pathway Annotations Available as GO Annotations - New #Yeast #Phenome Links - #microPublications – Latest Yeast Papers - Alliance of #Genome Resources – Release 8.1.0 - Upcoming Conferences & Courses

There are 220 #BiochemicalPathways in #Yeast, involving 557 different #genes - all this info has now been incorporated into #GeneOntology annotations - check it out! www.yeastgenome.org/blog/yeast-b...

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...

#YeastJob: Postdoc in Environmental Micro and Genomics Food Nutrition and Health Program, UBC in Vancouver Wine Research Centre collab w/ Renaissance Bioscience Corp www.renaissancebioscience.com Lab of Dr Vivien Measday measday-lab.landfood.ubc.ca community.alliancegenome.org/t/postdoctor...

The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net

New SGD paper! Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...

Friendly reminder that community resources like SGD rely on your usage and citation for continued funding. Make sure to follow the citation guidelines and include in-text citations, not just links. #modelOrganism

Apply by March31 for the 2025 Yeast Genetics and Genomics Course Jul22–Aug12 www.yeastgenome.org/blog/apply-n... This year’s instructors –Grant Brown, Soni Lacefield @lacefieldlab.bsky.social, and Greg Lang– have designed a comprehensive course covering all things yeast from genetics to genomics!

Article by Dr. Kurt Williamson, Biology at #William&Mary: "I work with undergraduate students at the very beginning of their professional careers. The loss of training and support of new and early-career scientists is a particularly hard blow that will affect all of us for years to come."

FEBS Workshop 2025 – Conservation and diversity of gene regulatory mechanisms across eukaryotes 16–20 June 2025 │ Sant Feliu de Guixols, Spain Deadlines: Registration closing: 15 March 2025 Abstract submission: 15 March 2025 community.alliancegenome.org/t/febs-2025-...

Join #Ensembl, #FungiDB / @veupathdb.bsky.social, @yeastgenome.bsky.social / #CGD and #MycoCosm / @jgi.doe.gov at this year's Fungal Pathogen Genomics course organised by @eventswcs.bsky.social 🍄🧬💻 Applications close on Tue, 18th March 2025 📆 2nd to 6th June 2025 📍 Virtual ℹ tinyurl.com/fpg2025