☄️ Tiny protein, big discovery: Tyc1 (Tiny #Yeast Comet 1) forms braided, comet-tail shaped polymers that wrap around microtubules and prevent their destruction by ice-cold CaCl₂ stress. Cross-species insights into cytoskeleton protection 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏰 rDNA guardian revealed: #Yeast Paf1 elongation factor prevents transcriptional arrest & maintains rDNA stability. Without Paf1, R-loops accumulate, DNA breaks, and copy number chaos ensues ➡️ transcription quality 🤝 genome integrity 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💪 Cellular pressure valve: #Yeast uses Csf1 lipid transfer protein to remodel membranes when physical stress threatens bilayer integrity. High pressure reveals hidden lipid remodeling network that maintains flexibility at ER-PM sites 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📍 Protective positioning system: #Yeast uses nuclear pore protein Nup60 to sequester SUMO protease Ulp1, preventing premature synaptonemal complex breakdown. Engineered tethering rescues defective mutants= location-based enzyme control 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔄 Smart feedback system: #Yeast SNF1 phosphorylates its own activator Sak1 to control nuclear entry timing. Blocking this self-regulation enhances nuclear SNF1 activity and glucose starvation adaptation, self-tuning metabolic control 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Reminder: Authors can submit data and information about publications! Point us to novel results, datasets (we appreciate GEO accession IDs!), or other important info using SGD’s simple “Submit Data” form: www.yeastgenome.org/submitData

🔄 Cell cycle safety net: #Yeast G1-cyclin monitors polarity establishment & boosts its own activity when cells struggle to form proper bud axis. Feedback ensures coordination but can create multinucleate cells if defects persist 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎯 Protein targeting precision: #Yeast SRP (protein escort system) preferentially binds transmembrane domains as they emerge from ribosomes, but only selects minority of signal peptides. New algorithm predicts which proteins reach ER 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔎 Strategic elimination approach: With AlphaFold modeling & mutation screening, #Yeast researchers rule out multiple Atg11 regions for Atg9 binding. Valuable #NegativeResults in @micropub7n.bsky.social help guide future search efforts 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Thanks to everyone who stopped by our #SGD booth at last night's #Yeast26 poster session! Especially our best bud who's clearly ready for some serious budding yeast research 🐕✨ Who needs AirBud when you've got a YeastBud? 🧬💙 🧪 #SGD #YeastResearch

🔥 Thanks to everyone who came to our #Yeast26 #SGD workshop! Great to see so many ready to level up their #Yeast game! 🙌 Come find us at our poster session table tonight - we're excited to help with #SGD, @alliancegenome.bsky.social & GO tools, answer questions & 🍻🍷 chat about #YeastResearch! ✨🧬

☀️🌊 #Yeast26 attendees, don't miss our #SGD workshop TODAY at 3:30 PM in Merrill Hall! Your #YeastResearch is about to hit different! 🔥 Learn the SGD tools, @alliancegenome.bsky.social & #GeneOntology shortcuts from SGD curators that actually work - no more endless database scrolling! 🧬✨

Really great opening so far to ☀️ #Yeast26 🌊, including a superb Winge-Lindegren Address from our very own Gavin Sherlock! 🧬 #YeastResearch #Yeast

📜 From #Yeast to human disease: 1997 cloning of DPL1 (first SPL gene) from S. cerevisiae provided the genetic foundation that led to identifying human SGPL1 mutations causing SPLIS syndrome; #ModelOrganism success story 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧠 Disease pathway discovery: #Yeast metal exposure mimics histone changes seen in ALS/FTD patients. Manganese creates gene silencing pattern; copper triggers hyperactivity but 🚫 DNA repair- distinct toxic patterns ID'd 🧬 #YeastResearch 🧪 #SGD 🔬 #DiseaseModeling www.yeastgenome.org/reference/S1...

⚙️ Translation control mechanism: #Yeast ribosome CAR site (regulatory region) extends tRNA function by bonding with incoming codons. Interplay with decoding center creates sequence-specific tuning of translation elongation 🧬 #YeastResearch 🧪 #SGD 🔬 #RNABiology www.yeastgenome.org/reference/S1...

Contact your reps now! New OMB rule attacking science: Makes grants terminable at will Prohibits publication costs Eliminates access to literature Replaces expert scientific review with political review Creates legal uncertainty around professional practices fight2win.standupforscience.net

🚀 Ethanol boost breakthrough: Overexpressing #Yeast MSS11 transcription factor increases ethanol production 24% by coordinating carbon metabolism and stress resistance. Dual mechanism enhances both fuel output and cellular robustness 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💂 Safeguarded crossover system: #Yeast uses hierarchical processing of meiotic DNA junctions. MutLγ preferentially creates crossovers, while Mus81-Mms4 & STR serve as backup systems when primary pathway fails 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏰 Proteotoxic stress defender: Cue1 membrane ⚓️ enables #Yeast to resist hygromycin B, an antibiotic that disrupts ribosomes & creates defective proteins, by positioning Ubc7 cleanup enzyme correctly; partnership clears damaged proteins 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

⚡ Charge-based activation: #Yeast P5A-ATPase Spf1p uses electrostatic interactions to recognize tail-anchored protein substrates. Positively charged protein tails bind acidic enzyme cavity, doubling ATP activity in ER quality control 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📚 Textbook rewrite: #Yeast reveals lysosomes get protons directly from mitochondria via membrane contacts, not from cytosol as thought. Aging breaks these contacts, causing de-acidification that disrupts autophagy & cellular function 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔍 Mitochondria self-monitor: Contrary to models requiring severe damage, #Yeast mt detect their own mild oxidative stress. ROS inactivates matrix proteases, creating aggregates that trigger protective mt unfolded protein response 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

#ISSY40 has just been announced for August 22-26, 2027 in Santos, SP - Brazil with theme #Yeast #biodiversity and #biotechnological applications www.issy40.com.br

🛂 Ribosome checkpoint revealed: When #Yeast can't make new ribosomes (Rpl32 loss), cells don't stop dividing due to poor translation. Instead, reduced cyclin 1 mRNA directly triggers G1 arrest - size-independent control mechanism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

✌️ Two-step defense system: #Yeast Yap8 needs dual binding sites at ACR3 promoter for full arsenic protection. Arsenic exposure triggers chromatin remodeling that exposes hidden Yap8 binding site, amplifying detoxification response 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📬 The May 2026 SGD Newsletter is out! ✨ New #BLAST service at the Alliance of #Genome Resources 🧬 #Gene naming guide 🔬 #Yeast #Genetics Meeting 2026 updates #Yeast26 📚 Latest #microPublications 💔 Remembering David Botstein Read it here: www.yeastgenome.org/blog/sgd-new...

🔗 Smart enzyme preferences: #Yeast Glc3 targets long sugar chains (≥10 units) as donors but creates precise 6-7 unit branches. This built-in control mechanism regulates glycogen particle size & can level up plant starch branching by 8% 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🌪️ Evolution's sledgehammer approach: Instead of surgical genome changes, #Yeast under multiple selection pressures unleashes chromosome-wide instability. Cell cycle breakdown creates reversible aneuploidy spanning many chromosomes 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🍺 One mutation, big benefits: The single amino acid change Gly351Asp in #Yeast ARG56 enzyme dramatically increases ornithine, an AA with health benefits. Chemical mutagenesis + canavanine selection revealed this brewing application 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧬 Looking for #yeast 5'- and 3'-UTR data? Three ways to access: ✅ Bulk downloads sgd-archive.yeastgenome.org/sequence/S28... ✅ #AllianceMine queries www.alliancegenome.org/bluegenes/al... ✅ #JBrowse genome browser jbrowse.yeastgenome.org Read more at SGD: www.yeastgenome.org/blog/how-to-...

🔌 Biological power plant: #Yeast fermentation creates CO2 pressure that drives passive microfluidic pumps. Perfect for space experiments, education, or remote areas where electricity is scarce- just add sugar & yeast! 🧬 #YeastResearch 🧪 #SGD 🔬 #SpaceYeast 🚀 www.yeastgenome.org/reference/S1...

⚖️ Perfect cellular balance: #Yeast Atg7 enzyme distinguishes between Atg8 & Atg12 substrates through their N-termini. Atg12's disordered region slows its own conjugation, while Atg8's helical domain speeds up #autophagy 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

#Yeast matchmaking goes interspecies: rescue by mating of meiotic spores directly post-germination screens haploid-lethal deletions. Validated between #S.cerevisiae and S.uvarum, allows study of essential #gene #evolution across #Saccharomyces. 🧬 #Genetics #APOYG www.yeastgenome.org/reference/42...

🪫 Surviving the impossible: #Yeast without functional #mitochondria adapt by redistributing proton transport to alternative pumps. Higher glucose rescues cells via ⬆️ fermentation & alcohol dehydrogenase activity 🧬 #YeastResearch 🧪 #SGD 🔬 #PowerhouseProblems www.yeastgenome.org/reference/S1...

🛟 Cross-species breakthrough: Spores with lethal gene deletions can mate across species before dying, creating viable S. cerevisiae x S. uvarum hybrids. Several knockouts successfully rescued ➡️ new tool for studying gene evolution 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💍 One protein to rule them all: #Yeast Mmm1 alone can handle lipid transport between ER and mitochondria when artificially tethered, solving the puzzle of why some ERMES components can be replaced. The lipid-binding domain is key 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📸 Better methods, clearer picture: Improved Ribo-seq reveals #Yeast Ded1 helicase works mainly by unwinding structured 5' UTRs, not suppressing upstream ORFs.- direct structure melting is the primary translation mechanism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎯 Selective assembly: Sterol-rich lipid droplets bypass factors needed for regular fat droplets, instead clustering sterol enzymes at specialized ER sites for localized production. Different droplet types ➡️ different assembly mechanisms 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🍷 Natural vs sulfite: Winemaking showdown! SO2 management and #Yeast inoculation dramatically reshape wine chemistry, color & taste. Natural fermentation boosts phenolics but risks spoilage, while sulfites deliver predictable results 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏭 Industrial enzyme production breakthrough: Evolved #Yeast strain efficiently secretes challenging proteases including collagenases, demonstrating broad utility for recombinant enzyme production in #biotechnology applications 🧪 #YeastResearch 🧬 #SGD 🔬 www.yeastgenome.org/reference/S1...

📜 Ancient wisdom, modern validation: Traditional Chinese medicinal orchid extends #Yeast & fly lifespan through conserved aging pathways, extending replicative & chronological LS. Network pharmacology validates ethnopharmacological use 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📍Location, location, location: #Yeast study maps genome-wide expression hotspots & coldspots based on chromosomal position. Lycopene pathway can be optimized by choosing integration sites. YeIP tool can enable predictive pathway design 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🚦Organelle traffic control: #Yeast Pex3p acts as regulatory switch for peroxisome inheritance. Phosphorylation abolishes Inp2p binding and reduces Pex19p association, blocking efficient organelle partitioning to daughter cells 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🌱 From glucose to skincare: Engineered #Yeast produce α-bisabolol, a key pharmaceutical and cosmetic ingredient with anti-inflammatory properties- demonstrating how yeast can replace unsustainable plant extraction methods 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💗 How cells stay the right size: #Yeast Fkh1/2 binding sites ensure WHI5 inhibitor is produced at constant levels, preventing oversized cells. Mathematical modeling reveals this is driven by cooperative transcription factor binding 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🥊 #Yeast Against Cancer: Mitochondrial Mgm101 structures reveal DNA repair mechanism shared with human RAD52, essential in BRCA1/BRCA2-deficient cancers. New DNA-binding insights could guide RAD52-targeted therapies 🧬 #YeastResearch 🧪 #SGD 🔬 #CancerResearch www.yeastgenome.org/reference/S1...

30 years ago, the yeast genome was completed by an international team of scientists. Since then, S.cerevisiae has become a key model for understanding conserved biological processes and driving discoveries. Explore the annotated Baker’s yeast R64-1-1 genome in @ensembl.org @yeastgenome.bsky.social

🧰 MoClo toolkit 2.0: Updated modular #Yeast cloning system enables mix-and-match assembly of parts for protein secretion & surface display. New anchors, fluorescence detection & secretion boosters streamline #biotechnology applications 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🦠 🤺 💊 Fighting fungal resistance: #Yeast glucan synthase structures explain how echinocandin drugs work & how resistance develops, providing blueprint for designing better antifungals against life-threatening infections 🧬 #YeastResearch 🔬 #SGD 🧪 #DrugDevelopment www.yeastgenome.org/reference/S1...