💕 What makes partnerships last? #Yeast communities exchanging nutrients reveal asymmetric fitness effects determine which species survive. Lysine-dependent strains outlasted adenine-dependent ones ⇒ resource essentiality shapes #evolution 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 How do antifungal drugs work? New cryo-EM structures reveal how a triterpenoid drug binds #Yeast β-1,3-glucan synthases Fks1 & Fks2, reorganizing lipids and stabilizing the enzyme to block fungal cell wall synthesis 🧪 #YeastResearch #SGD #StructuralBiology www.yeastgenome.org/reference/S1...

🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬What happens when #Yeast lose their peroxisomes? New #metabolomics study reveals they affect more than just fatty acid breakdown, but also influence lipid synthesis & polyamine homeostasis-expanding our view of peroxisome function #YeastResearch #SGD #OpenScience www.yeastgenome.org/reference/S1...

🧬 Overcoming glucose preference: Newly evolved #Yeast strain efficiently co-ferments glucose and xylose from plant biomass, producing ethanol with better redox balance and reduced xylitol formation 🧪 #YeastResearch #SGD #SustainableFuels www.yeastgenome.org/reference/S1...

⚡ Unconventional zinc finger binding! Newly solved structure shows #Yeast Fzf1 transcription factor uses non-canonical DNA binding strategy with its 5 zinc fingers; unusual binding pattern controls key stress response genes like SSU1 and YHB1 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved! 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

Join SGD at #Yeast26 for cutting-edge #yeast research, networking opportunities, engaging talks, poster sessions, and workshops, for everyone from early career scientists to experienced researchers! Abstract submission by Mar5, early registration ends Apr16. See you there! @genetics-gsa.bsky.social

🧬 20 years ago, discovery of the EGO complex in #Yeast revolutionized understanding of nutrient signaling. New review explores how Rag GTPases link amino acids to TORC1 growth control, establishing blueprint for cross-species nutrient sensing 🔬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 Study uncovers critical balance in #yeast mRNA export: Elevated Mex67-Mtr2 exporter levels in nuclear ribonucleoprotein particles impairs export efficiency, showing precise, not maximal, levels are needed for proper cellular function 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 New #yeast paper! Eukaryotic ribosome assembly follows unique pathway distinct from bacteria: Rlp7 depletion experiments show foot structure factors are essential for proper rRNA domain compaction and r-protein incorporation 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🥊 Knocking out MNN11 glycosyltransferase in #yeast = ⬆︎ taxadiene synthase expression & boosts taxadiene yield. New #YeastResearch shows endogenous glycosylation modifications can limit heterologous protein function in #pharmaceutical precursor production. 🧬 #SGD www.yeastgenome.org/reference/S1...

🧬 New #YeastResearch shows Tif35 (eIF3g) recognizes specific RNA sequences - GUCG boxes - and boosts production of heat shock proteins during stress, revealing how #yeast cells selectively increase translation of protective genes when needed #SGD www.yeastgenome.org/reference/S1...

🔬Study reveals how #Yeast regulates mitochondrial DNA copy number: Mrx6 forms complex with Mam33 to modulate Lon protease Pim1 substrate specificity, controlling degradation of key mtDNA maintenance proteins Rpo41 and Cim1 www.yeastgenome.org/reference/S1... #YeastResearch #SGD #MitochondrialBiology

🧬 New #YeastResearch provides insights into chromosome segregation: Research shows Cdc5 & Cdc14 orchestrate timely resolution of sister chromatid intertwines by coordinating spindle elongation with DNA linkage removal through Top2 regulation #SGD www.yeastgenome.org/reference/S1...

🔬Surprising finding: Perturbing 2′-O-methylation at Gm1271 affects both ribosomal ac4C sites despite being spatially close to only one; reveals unexpected crosstalk in rRNA modification networks that correlates with altered translation fidelity #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬Novel flow cytometry method tracks fluorescent wt vs unlabeled mutant mtDNA inheritance in heteroplasmic #Yeast. Cells selectively eliminate defective mito genomes through local bioenergetic monitoring, even under non-respiratory conditions #SGD #YeastResearch 🔬 www.yeastgenome.org/reference/S1...

#EMBO Workshop: The rules of the game – #biophysical & #molecular principles in cellular #evolution | Oeiras, Portugal | 2-5 June 2026 | Hybrid format community.alliancegenome.org/t/embo-works...

🧬 #YeastResearch on DNA mismatch repair: Study reveals Mlh1-Pms1 endonuclease directly catalyzes mispair excision through nicked-strand-specific cleavage. Research explains the universal requirement for Mlh1-Pms1 in preventing cancer-causing mutations. #SGD www.yeastgenome.org/reference/S1...

New #YeastResearch into spliceosome assembly unlocks 🧬therapeutic potential for cancer & neurodegenerative diseases! Study reveals how conserved residues control spliceosome active site remodeling, identifying hotspots for structure-based drug design. www.yeastgenome.org/reference/S1... 🔬 #SGD

New insights into ncRNA quality control! Research shows #yeast cells use mRNA guard proteins Npl3, Gbp2, Hrb1 and novel factor Lhp1 to monitor U6 snRNA maturation, while faulty RNAs are degraded to protect spliceosome function. 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬New #YeastResearch: Comprehensive RNA-seq analysis looks at 🧬 expression changes in "a" mating type cells treated with α-factor. 957 DEGs were identified: 448 ⬆︎, 509 ⬇︎. This dataset includes novel candidates potentially involved in mating responses! www.yeastgenome.org/reference/S1... #SGD #APOYG

Specific amino acids define functional attributes: Cryo-EM of #yeast Rad51p vs Dmc1p filaments on ssDNA shows conserved “aromatic stack” in Rad51p that Dmc1p lacks. Mutational + other analyses show Rad51p tightly constrained, Dmc1p more flexible #cryoEM #DNArepair www.yeastgenome.org/reference/41...

#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5! community.alliancegenome.org/t/yeast-gene...

Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...

Although the SGD website will be available over the next few weeks, SGD staff will be on winter break until Jan 5, 2026. SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️

#APOYG !! #YeastResearch

Some absolutely beautiful artwork here! Really love to see #yeast #cerevisae representing so well in yet another category: #fineart 🍻🥖🩺🔬🧪🧬🎨 #YeastResearch

🔬How do single amino acid changes cause severe diseases? New #Structure study uses #Yeast to reveal the structural basis of PRoteasome-Associated Autoinflammatory Syndromes; 15 crystal structures show PRAAS-linked mutations 🔗 www.yeastgenome.org/reference/S1... #Proteasome #YeastResearch

🧬 Researchers have developed a microfluidic protocol to continuously observe ENTIRE microbial life cycles in real-time, including transitions! 🔬 #Yeast #YeastResearch #Microfluidics #CellBiology #Science #AgScience #Biomed www.yeastgenome.org/reference/S1...

Don't wait to book your stay at Fungal 2026! The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26 genetics-gsa.org/fungal-2026/...

As many of us 🎁 things up for the year, make sure all your ℹ️'s are dotted- and all your #yeast emojis are downloaded! If you haven't yet, make sure to add the emojyeast collection to all your 📱💻🖥️⌚️ mayaschuldiner.wixsite.com/schuldinerla... Thanks to the amazing Schuldiner lab for these!

How’s the #yeast community closing out 2025? SGD is saying a heartfelt farewell, revealing new Resource links, announcing a simple way to support the #Database you rely on, and more. Read our December newsletter: www.yeastgenome.org/blog/sgd-new... #SGD #science

Calling all #YeastResearch -ers! Who would like to work in beautiful Barcelona? 🌴🌊 And even better, work on #cerevisiae? #ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast

Enhanced #Yeast for better #ethanol production: After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance. 🍷 🍺 🧬 #Biotech #YeastResearch www.yeastgenome.org/reference/S1...

COQ5-related primary #CoQ10 deficiency: #RareDisease of #mitochondria. S.cerevisiae #complementation tests #COQ5 variants, revealing CoQ intermediate buildup and impaired biosynthesis, speeding variant interpretation, informing CoQ10 therapy. #Yeast #modelOrganism www.yeastgenome.org/reference/41...

#Yeast biodiversity + #MachineLearning enable strain/pathway design in other yeasts #MetabolicEngineering S. cerevisiae ✅genetic tractability ✅robust growth ❌industrial biotech Y. lipolytica/O. polymorpha ✅thermo/acid resistance ✅amass lipids ❌ genetic tools www.yeastgenome.org/reference/S1...

#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more: www.yeastgenome.org/reference/S1...

Targeted changes in interaction of Nab3p with low-abundant #mRNA of highly conserved #mitochondrial #transporter PIC2 alters its stability and can trigger significant system-wide defects and profoundly impact cellular #fitness www.yeastgenome.org/reference/41... #yeast #regulation

And wine, and beer, and the list of uses for this versatile little organism goes on and on! There is evidence that humans domesticated yeast >7000 years ago! Read a short summary here, including what "shmooing" has to do with yeast: sites.google.com/view/yeastge... #YeastBiology #ScienceIsFun

The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.

Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair www.yeastgenome.org/reference/39...

New insights into #meiosisI reveal distinct roles of spindle checkpoint proteins. Mad2p drives transition to #metaphase, Mad3p ensures microtubule-dependent #chromosome capture on spindle, safeguarding fidelity of segregation #Yeast #CellBiology #Genetics www.yeastgenome.org/reference/39...

Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 13 Prompt DRINK Pdb: 7BTW A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer. Cheers! Next: TRUNK Suggestions?

In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway. onlinelibrary.wiley.com/doi/10.1002/...

Unlocking secrets of #meiosis! Wei et al. reveal how Mei5-Sae3 complex enhances Dmc1p assembly by stabilizing Dmc1p clusters on ssDNA, altering RPA dynamics, paving way for successful interhomolog recombination. Fascinating proteins in action! #yeast #Genetics www.yeastgenome.org/reference/39...

Insights into mitochondrial #ribosome reveal mL44 mutations linked to childhood #cardiomyopathy, neuro issues. Box et al. study #yeast homolog MRPL3, show evolutionary divergence, translation hierarchy in mitochondrial protein synthesis #Mitochondria #Genetics www.yeastgenome.org/reference/38...

Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26 genetics-gsa.org/yeast-2026/