🧬 Decoding heterosis: Large-scale analysis of #Yeast hybrids shows genetic distance drives stress tolerance gains. Most hybrids display mid-parent #HybridVigor, with strongest benefits in high ethanol and high salt 🔬 #YeastResearch 🧪 #SGD #Genetics www.yeastgenome.org/reference/S1...

🍻🌏🍻 Beyond commercial strains: Native #Yeast species like S. cerevisiae, Brettanomyces & Torulaspora create unique flavors in #CraftBrewing. Review shows how local microorganisms enhance terroir expression while preserving biodiversity 🧬 #YeastResearch 🧪 #SGD www.yeastgenome.org/reference/S1...

🔋 Cellular powerhouse assembly: Review details how #Yeast builds & maintains respiratory chain complexes through coordinated nuclear import + mitochondrial protein synthesis, providing key insights into energy machinery biogenesis ⚡️ #YeastResearch 🧪 #SGD 🧬 www.yeastgenome.org/reference/S1...

💞 Cellular matchmaking: #Yeast condensin loop extrusion brings together broken DNA and repair donors during mating-type switching. Study reveals how SMC complexes facilitate homology search by creating specific chromosomal loops 🔬 #YeastResearch 🧬 #SGD 🧪 www.yeastgenome.org/reference/S1...

🍺 Perfecting nonalcoholic beer: Study compares maltose-negative #Yeast strains with arrested fermentation approach using high-gravity brewing. Strategic yeast selection + glucose oxidase treatment= ⏫ flavor & ⏬ ethanol 🧬 #YeastResearch 🔬 #SGD 🧪 www.yeastgenome.org/reference/S1...

🔥 Heat-resistant breakthrough: Evolved #Yeast strain TT-M6 thrives at high temperatures, producing 74.8 g/L ethanol from lignocellulose at 37°C. A few key mutations enable efficient biofuel production from agricultural waste 🔬 #YeastResearch 🧬 #SGD 🧪 #Biofuels www.yeastgenome.org/reference/S1...

🍾 Tiny bubbles make us happy: Picolitre microbead method screens millions of #Yeast mutants in 0.3 mL, cutting expensive antimetabolite costs. Label-free autofluorescence detection achieves 16,000-fold enrichment of resistant strains 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🐈🐕 Unexpected partnership: #Yeast mitochondrial import complex teams up with Ayr1p to create lipid droplet contact sites. The MIM complex handles protein insertion when alone, lipid metabolism when bound to Ayr1p 🧪 #YeastResearch 🧬 #SGD 🔬 #CellBiology www.yeastgenome.org/reference/S1...

🔍 #Yeast as disease detective: Humanized seipin-deficient model examines how acetyl-CoA misrouting drives futile lipid cycles in #MotorNeuronDisease, highlighting #APOYG for understanding complex human metabolic disorders 🧬#YeastResearch 🧪#SGD 🔬#ModelOrganism www.yeastgenome.org/reference/S1...

💪 Double duty: #Yeast phosphofructokinase β-subunit (Pfk2p) moonlights as RNA unwinder and translation activator for cell cycle genes- this energy enzyme controls cell proliferation independently of glycolysis. 🧬 #YeastResearch 🔬 #SGD 🧪 #CellCycle www.yeastgenome.org/reference/S1...

😩 Mood: #Yeast cells face a dilemma during stress- prioritize immediate growth or prepare for future threats? Study reveals cells that bounce back quickly from mild stress struggle more when hit with severe stress later 🧪 #YeastResearch 🧬 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔬 New aging model: #Yeast aging pathways proceed independently in parallel, not as mutually exclusive alternatives. "Competing hazards" framework explains how cells age differently based on which process reaches catastrophic failure first 🧪 #YeastResearch 🧬 #SGD www.yeastgenome.org/reference/S1...

⏰ Tik Tok! The party don't start 'til your abstracts are in! Just a few more hours to submit your #Yeast26 abstracts! Get them in before 8PM PT 🧬 #YeastResearch #SGD #GSA

📢 Reminder: #Yeast26 extended abstract submission deadline is tomorrow (Thursday) at 8PM PT! Submit your research and join us at #Asilomar this summer. Whether your work is fully fermented or still just budding, the #YeastGenetics community wants to hear from you! 🧬 @genetics-gsa.bsky.social #GSA

From #NCBI Insight | NCBI's new #Taxonomy browser | 🧬 🖥️ 🧪  #Bioinformatics #Proteomics #Genomics ⬇️ ncbiinsights.ncbi.nlm.nih.gov/2026/03/11/n... Nice, I like the page for my friendly #Saccharomyces #cerevisiae ⬇️ www.ncbi.nlm.nih.gov/datasets/tax... CC/ @yeastgenome.bsky.social

☣️ Cellular backup plan revealed: #Yeast genes UGA4 & YBR062C promote heavy metal tolerance by enabling internal ribosome entry site translation of URE2. This alternative translation pathway keeps protective proteins flowing during stress 🧪 #YeastResearch 🧬 #SGD www.yeastgenome.org/reference/S1...

🔬 Solving mitophagy mysteries: Study identifies Mfi2 as second #Yeasr mitofissin, working with Atg44 to fragment mitochondria during autophagy; reveals how mitochondria are cut when traditional Dnm1 machinery is dispensable 🧪 #YeastResearch #SGD #CellBiology www.yeastgenome.org/reference/S1...

Symposium honoring Distinguished Professor Emeritus Jeremy Thorner entitled “Saccharomyces cerevisiae: The Very Model of a Modern Model Organism”. Monday March 23, 2026 from 9a-6p in Berkeley #yeast #modelOrganism Registration still open! mcb.berkeley.edu/cdp-symposium

🧬 Proteins "kick & scream" to function: Review explores dynamic allostery, where rapid side-chain motions (not conformational changes) drive allosteric regulation. #Yeast Sgt2 chaperone is key example of how disordered tails control dynamics 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🍻 Great news!🥂 Abstract deadline for #Yeast26 extended to Thursday, March 12 @ 8:00 PM EST. Perfect opportunity to present your research, get feedback, and form new collaborations at #Asilomar this summer. Your work doesn't need to be presentation-ready - submit now! 🧬 #YeastGenetics #YGM2026 🧪

🍺 Fixing brewing #Yeast! 🧬 Experimental evolution corrects mother-daughter separation defects in ale strain over 200 generations: ✅ fewer large clusters ✅ reduced foam accumulation during fermentation 🧪 #YeastResearch #SGD #MoreGoodPours @micropub7n.bsky.social www.yeastgenome.org/reference/S1...

#Yeast #Genetics Meeting 2026 is in June - Abstract deadline is TODAY! Submit your abstract, attend the meeting this summer in Pacific Grove, CA at #Asilomar Conference Grounds, a 107-acre protected coastal state park located on the Monterey Peninsula. #Yeast26 #YGM2026 genetics-gsa.org/yeast-2026/

❓ Solving mitochondria isolation challenges: Traditional enzymatic methods compromise mitochondrial surface proteins in #Yeast; new glass bead mechanical approach preserves Atg32 integrity for quantitative #Mitophagy analysis 🔬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

📍Mapping mitochondrial proteins: APEX2 proximity labeling targets #Yeast mt compartments- intermembrane space & matrix- to identify their proteomes. Achieves ~75% coverage of known mitochondrial proteins with high confidence 🧬 #YeastResearch #SGD #Proteomics www.yeastgenome.org/reference/S1...

☠️ Why #Yeast avoids GPC toxicity: Git1 transporter has low affinity for glycerophosphocholine, preferring GPI; substrate specificity protects S. cerevisiae against GPC toxicity affecting other fungi with GPC-specific transporters 🧬 #YeastResearch #SGD #CellBiology www.yeastgenome.org/reference/S1...

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

🧬 #Yeast model suggests new inherited neuropathy treatment: Humanized yeast with nerve disease-associated HARS1 variant shows protein aggregation and stress response activation; GCN2 kinase inhibition rescues growth defect 🧪 #YeastResearch #SGD #RareDiseaseDay www.yeastgenome.org/reference/S1...

🧬 Decoding RNA Pol I dynamics: #Yeast studies using biochemistry, biophysics & molecular dynamics reveal core factor uses 2-step promoter recognition- rapid encounter⇒conformational transition, followed by DNA bending & melting for activation 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬 Streamlined DNA extraction for #SyntheticBiology: New cost-effective EASY-C method efficiently isolates mini-chromosomes and plasmids from diverse #Yeast species including Sc2.0 & nonconventional yeasts, accelerating construct validation 🧪 #YeastResearch 🔬 #SGD www.yeastgenome.org/reference/S1...

🛑 Engineering stop buttons: CRISPR KiSS system in #Yeast conditionally targets essential genes to inhibit growth. Dual gRNA approach improves performance as researchers continue optimizing for cell factory applications 🧬 #YeastResearch 🧪 #SGD #SyntheticBiology www.yeastgenome.org/reference/S1...

🌋 Ring of power: Seven exocysts form a flexible ring structure that pulls #Yeast secretory vesicles to the plasma membrane. Vesicles move stepwise from 45nm to 5nm to the PM in three metastable steps, revealing the mechanics of exocytosis 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬 Molecular network surprise: Compensating for polarity defects in #Yeast changes gene disruption tolerance genome-wide. Genes in same processes show coordinated tolerance changes; compensation rewires modules rather than individual genes 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

💕Do #Yeast celebrate #ValentinesDay? Study of nearly 100 natural strains reveals some yeast combinations prefer each other, while others avoid mating. Carbon source matters: glucose favors parental fitness, glycerol favors genetic distance 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬 #SGD evolution continues: Our #BLAST service has migrated to the @alliancegenome.bsky.social website, maintaining the functionality & comprehensive SGD datasets #Yeast researchers depend on while adding cross-species exploration & faster search results 🧪 #YeastResearch 🔗 bit.ly/newBLAST

🧬 #Yeast Dsk2 uses its STI1 domain to interact with transient helices, driving phase separation and proteasome condensate formation under stress. This reveals new details about how cells organize protein degradation machinery 🧪 #YeastResearch #SGD #ProteinQuality www.yeastgenome.org/reference/S1...

🧬 Engineering stress-resistant #Yeast: Overexpressing PIR3 & SPI1 helps yeast tolerate high-concentration molasses stress from potassium/calcium ions. Modified strains showed significantly higher ethanol production than wt 🧪 #YeastResearch #SGD #Biotechnology www.yeastgenome.org/reference/S1...

💻 Networks reveal hidden connections: #Yeast genetic & protein interaction networks share unexpected topological similarities, suggesting genetic epistasis & physical protein binding follow similar organizational rules 🧪 #YeastResearch #SGD #ComputationalBiology www.yeastgenome.org/reference/S1...

🔬 How does #Yeast optimize protein secretion? SEC72 deletion reshapes cellular functions including iron homeostasis and cell wall assembly, boosting secretion of proteins with strongly hydrophobic signal peptides 🧪 #YeastResearch #SGD #CellBiology #Biotechnology www.yeastgenome.org/reference/S1...

🩺 From #Yeast to human disease: Reseach shows metabolic pathway disruption causes amino acids to self-assemble into toxic amyloid structures, providing new insights into inherited metabolic disorders and potential treatments 🔬 #YeastResearch #SGD #DiseaseModeling www.yeastgenome.org/reference/S1...

💕 What makes partnerships last? #Yeast communities exchanging nutrients reveal asymmetric fitness effects determine which species survive. Lysine-dependent strains outlasted adenine-dependent ones ⇒ resource essentiality shapes #evolution 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 How do antifungal drugs work? New cryo-EM structures reveal how a triterpenoid drug binds #Yeast β-1,3-glucan synthases Fks1 & Fks2, reorganizing lipids and stabilizing the enzyme to block fungal cell wall synthesis 🧪 #YeastResearch #SGD #StructuralBiology www.yeastgenome.org/reference/S1...

🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬What happens when #Yeast lose their peroxisomes? New #metabolomics study reveals they affect more than just fatty acid breakdown, but also influence lipid synthesis & polyamine homeostasis-expanding our view of peroxisome function #YeastResearch #SGD #OpenScience www.yeastgenome.org/reference/S1...

🧬 Overcoming glucose preference: Newly evolved #Yeast strain efficiently co-ferments glucose and xylose from plant biomass, producing ethanol with better redox balance and reduced xylitol formation 🧪 #YeastResearch #SGD #SustainableFuels www.yeastgenome.org/reference/S1...

⚡ Unconventional zinc finger binding! Newly solved structure shows #Yeast Fzf1 transcription factor uses non-canonical DNA binding strategy with its 5 zinc fingers; unusual binding pattern controls key stress response genes like SSU1 and YHB1 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved! 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

Join SGD at #Yeast26 for cutting-edge #yeast research, networking opportunities, engaging talks, poster sessions, and workshops, for everyone from early career scientists to experienced researchers! Abstract submission by Mar5, early registration ends Apr16. See you there! @genetics-gsa.bsky.social

🧬 20 years ago, discovery of the EGO complex in #Yeast revolutionized understanding of nutrient signaling. New review explores how Rag GTPases link amino acids to TORC1 growth control, establishing blueprint for cross-species nutrient sensing 🔬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 Study uncovers critical balance in #yeast mRNA export: Elevated Mex67-Mtr2 exporter levels in nuclear ribonucleoprotein particles impairs export efficiency, showing precise, not maximal, levels are needed for proper cellular function 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...

🔬 New #yeast paper! Eukaryotic ribosome assembly follows unique pathway distinct from bacteria: Rlp7 depletion experiments show foot structure factors are essential for proper rRNA domain compaction and r-protein incorporation 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...