Well reported piece from @beebrookshire.bsky.social at the Verge on the proposed OMB grant making regulations and the likely consequences. [Gift link] www.theverge.com/science/9576... 1/4

Critical reasons to comment on the OMB rule, especially asking to extend the comment time for such a complex ruling with far reaching implications

www.regulations.gov/commenton/OM... Submit your comment here. Read this short piece by lawyer Claudia Polsky to see why science needs you and all your friends and colleagues to write. It’s fast and easy and it will make a difference.

I've gone ahead and posted my comment on the OMB rule as an example of a hyper-focused comment that looks at one portion of the OMB rule. Here, I've tackled a part of the Rule I know a lot about (international research and national security) and cross-walked with a project I've worked on a lot.

Thanks, @olibclarke.bsky.social! Identifying this complex is good news for our job security as experimentalists... As of today, we still can’t predict the full assembly with AlphaFold. So here is an #open_challenge: if anyone can recover the whole complex computationally, I’d love to hear from them!

🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5

Please share widely aimbe.org/advocate/omb...

This is a tremendous piece by Judy Stone at @forbes.com. This new OMB rule is going to hurt communities from coast to coast. Federal grants are not just about research! www.forbes.com/sites/judyst...

1/7 New preprint: we found that Chlamydomonas carries a giant and unexpectedly elaborate chloroplast RNA polymerase with 12 previously unknown subunits, overturning the idea that the complexity of this organellar enzyme emerged during plant terrestrialization! www.biorxiv.org/content/10.6...

Come join the new Novo Nordisk Foundation Center for Protein Design as a group leader Cool science in a great scientific environment in wonderful and very family friendly Copenhagen There are two positions that can either be at TT assistant or associate prof level employment.ku.dk/tenure-track...

We’re delighted to welcome @computingcaitie.bsky.social to the FMI next year! Her work will bring an interdisciplinary perspective spanning structural biology, quantitative imaging and computational analysis to our institute, opening exciting new ways to study ciliary structure and dynamics.

Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." gift link nytimes.com/2026/06/20/o...

If you like cilia, go work with my friend Caitie! 👸🏼🥳🔬 Also, guaranteed unlimited lab snacks 🍬🍫🥨🥯

Congratulations Caitie! Excited about future work from the McCafferty lab!

Incredibly grateful for the amazing mentorship I’ve had over the years @cellarchlab.com @edwardmarcotte.bsky.social David Taylor and @jbwallingford.bsky.social and can’t wait to pay it forward :D

I will be hiring at all levels so if you are interested and want to learn more, please get in touch! 📻 ❄️ 🔬 🦠 🧬 #cilia #cryoet #proteomics #exm #protistsonsky

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

#Bugsky 🐙🌿 Shared with me by a fof in SoCal - this is a gynandromorph (both male & female) valley carpenter bee (Xylocopa sonorina). Females are black, males orange, so the extreme color dimorphism really stands out. Per Doug Yanega at UC Riverside, bee gynandromorphs he’s seen are mosaic instead—

It’s truly astonishing to see how comprehensively the US government is tearing down every part of the system that has made it up until now a world-leading power in science, research, and technological development. The entire world will suffer from this wanton destruction.

Only 102 public comments so far on the biggest threat to publicly funded science in my lifetime. Please comment if you can. I know this sounds like "vote harder" but we have to keep fighting www.regulations.gov/document/OMB...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

By mapping protein networks in an ancient ancestor of all complex life, a U. of Texas at Austin-led team found new genes connected to three rare disorders. It might yield hundreds more. New study in Cell Genomics cns.utexas.edu/news/researc... @edwardmarcotte.bsky.social @jbwallingford.bsky.social

This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," www.npr.org/2026/05/21/n...

Our paper on examining sequence-structure-function relationships and constraints on protein evolution is now published! www.nature.com/articles/s41...

This prohibition affects 30% of all papers published by NIH grantees. It’s horrifically damaging to already deeply wounded American science. www.science.org/content/arti...

For anyone who is a scientist or has benefitted from basic research on model organisms (that's EVERYONE), please take the time to leave a comment about priority 1 here: rfi.grants.nih.gov?s=6998c3a23e... by the deadline May 28! I know I wouldn't be here today without modern medicine

💥 🚀 New preprint! 🎉🥳 How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪 🧵👇 (1/17)

It's finally out! Molecular architecture of mammalian AP3:ARF1 carriers - a mechanism for lysosomal membrane protein trafficking - from a combination of #biochemistry, #cryoET and #cellbiology 📝 Paper: www.science.org/doi/10.1126/... 🧵 Thread: subsequently #teamtomo #membranetrafficking

Celebrating Elliot Meyerowitz‘ 75th birthday! @caltech.edu

Introducing Genie 3, a generative protein model that substantially advances the state-of-the-art for binder design, increasing in silico success rates by up to 20x on hard multimeric targets. It also debuts a form of inference-time scaling unobserved in other design models. 🧵1/8

Congratulations to Rebecca Heald on being elected 2028 ASCB President. Heald is a leading cell biologist whose work on cell division and size control—and commitment to mentoring—has had a lasting impact on the field. https://www.ascb.org/society-news/rebecca-heald-elected-2028-ascb-president/

Published a couple of months ago, but I only saw it now. Very cool work! 'Bacteria covalently incorporate polyfluoroalkyl carboxylates into membrane lipids' ttps://www.nature.com/articles/s41564-026-02301-x

Saddened to hear of the death of Craig Venter. A polarizing figure but he had a huge impact on biology and I enjoyed working with him on CSHL projects.

I am happy to share a review I recently wrote on the design of peptide binders. It gives an overview of experimentally validated tools and discusses the challenges of why peptide design is more difficult than the design of classical protein binders. www.chimia.ch/chimia/artic...

More details on the firing of the National Science Board. The NSF now has no director, deputy director, or board. They have issued almost no new awards in 2026. The plan appears to be to completely destroyed the agency. The details are horrifying and have Russ Vought written all over them.

1/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...

Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio! Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development. www.nature.com/articles/s41...

Have you wondered what the wet lab success rates are for current AI-driven protein design models? Look no further! In our new review, @kevinkaichuang.bsky.social @avapamini.bsky.social, @sarahalamdari.bsky.social, and I report wet lab success rates for *over 200* different protein design tasks 🧬💻

This may be lost in the noise--this is as impactful or more than the cuts to NIH and NSF 🧪

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Two (or more) PhD student positions are open with me in protein structure evolution (using AI). Please apply/spread the word. su.varbi.com/en/what:job/...

If you know a graduating undergraduate looking for the chance to spend 1-2 years in a lab before graduate school, we're hiring! Our lab explores morphogenesis, defining how the cell adhesion & cytoskeletal machinery work together to allow cells to change shape & move tarheels.live/peiferlab/ 1/n RT

@compbiologist.bsky.social and @fishevodevogeno.bsky.social present newly minted Dr. Hao Yuan @yhbioinfo.bsky.social! @michiganstateu.bsky.social Amazing work @ the intersection of computational, biomedical, and evolutionary biology! Hao starts a postdoc in the @edwardmarcotte.bsky.social Lab soon.

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

The proteina-complexa paper is the 2nd this month suggesting that high K+E content, a staple of ProteinMPNN designs, is predictive of poor expression (the bits in bio benchmark paper showed a few weeks ago). In their case, they measure poor sequence recovery in phage display

Happy birthday to 🇨🇦Canadian medical researcher & #biochemist Maud Menten (1879-1960). 👩🏼‍🔬🧪🐡 #histsci Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of

Mathematician Karen Uhlenbeck is one of the founders of modern geometric analysis. #OTD in 2019, she became the first woman to win the Abel Prize, the "Nobel Prize of Math." She donated half the prize money to orgs promoting more engagement of women in research #mathematics. #WomenInSTEM #WHM

Protein language models are bad at mutational effect prediction blog.genesmindsmachines.com/p/protein-la...

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9