All the Parts continues on #THEProteomicsShow as me and Ben @proteomicsnews.bsky.social ask pretty dumb questions about stuff. Today is Jan Mulder chatting brain, and it was awesome talking about all things brains. Find it wherever you find fine podcasts, or here anchor.fm/theproteomic...

My skywalkers, did someone do a funny April fools and I missed it? Please share. Nerdier the better.

We are proud to announce the discovery of Glyco-Carbohydrates, a paradigm shift in glycobiology! Traditional glycoconjugates (proteins, lipids & RNA) max out at 50% carbohydrate. Ours are 100% carbohydrate AND glycans, unlocking truly homogenous properties. TBA April 1st, 2027! 🍬 #glycotime

As some of you know, I finally got a pre-release “MS”! The kind folks @veridianDynamics let me test the new Separator 5000 Top Down-MS. We’re running as MUDpit with the LC on the front, then Viz for protein ID and absolQuan. This thing creates separations better than cousin Laura, bless her heart.

Getting the ol' grad school gang back together with Carafe2 -- Bo Wen (@maccoss.bsky.social and Bill Noble) and @jspaezp.bsky.social (@willfondrie.com at @talusbio.bsky.social) teamed up for essentially some late night hackathons to build out Carafe for @brukercorporation.bsky.social timsTOF data.

"my first ASMS meeting in 1974, the only women I remember seeing were Catherine Fenselau, Chava Lifschitz, Peggy Frisch, and Sharon Lias─four women among some three hundred men!" A lot of progress has been made since then!

Wandered around ACS this morning after picking up my badge. Passed a room for current trends in biochem. Ends up it's a peptide therapeutics talk using LC-MS. Sprawling conference of thousands and I walk into a mass spec talk randomly 😂

Rumour mill going that the next generation mass spec from thermo will be the ExploreMores

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

You know how big research groups employed grant writers, editors and artists, even paper writers, but weren't super public about it? Well now you have those capabilities within reach for pennies on the dollar to everyone. Of course people are going to use them, whether they say it out loud or not.

As we are trying to get guests on for the new season of #THEProteomicsShow, I am venturing down some rabbit holes. TIL about ear wax diagnostics. www.nature.com/articles/s41...

You wouldn't download a HPLC, would you? (I would.)

Well, in case you missed all the work over the years from @jochwenk.bsky.social et al. about blood proteomics technical concerns, turns out our extracellular RNA compatriots basically have written the same papers. www.nature.com/articles/s41...

Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans. Integrally, O-acetyls are invisible under standard reductive conditions. Now published at Molecular Omics. Link: academic.oup.com/molecular-om...

Review from Fia B. Larsen in @rhp-lab.bsky.social with everything you always wanted to know about proteasomal control of transcription factors (but were afraid to ask about) Proteasomal control of transcription factors: mechanisms, regulation and dysregulation. doi.org/10.1007/s000...

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

why are people who do proteomics always happy? they're always working in positive mode

Agree that LLMs are probably not going to make huge leaps in biology. The cycle times for biology are just too slow. That doesn't mean AI won't help make huge leaps in biology. Just that LLMs are probably not gonna do it. joehorsman.substack.com/p/in-defense...

Today I was in Zandvoor to give a seminar on why we need to democratize Self Driving Labs. So i wrote a little blog post on it :) vsaggiomo.com/blog/2026/SDL/

📢 2027 US HUPO Association Awards — Nominations Now Open! 🏆 Celebrate excellence in proteomics — nominate a colleague or deserving leader today! 🙌 💡 Who can nominate: Current US HUPO members 📅 Deadline: October 2, 2026 🔗 Learn more & submit your nomination: us-hupo.org/awards #USHUPO #Proteomics

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

Truly the year of Seattle proteomics!! University of Washington Genome Sciences department almost had a clean sweep!! 💪🏆

This out of office from Wout is killing me (is he not on bluesky?!)

Waiting in the TSA line at SEATAC with this episode to pass the time

Quick proteomics question: we want to use an exogenous biotin blocking scavenger for a TurboID experiment. We tried Biolock but is very inconsistent in our hands. Does anyone have another suggestion?

@lindsaykpino.com shares how chromatogram‑based #chemoproteomics using the #ZenoTOF8600 and #Skyline enables residue‑level detection of covalent binding events with depth, robustness, and throughput. 🗓️ Feb 23 | ⏰ 12:30–13:30 📍 Grand Ballroom AB, Hyatt Regency St. Louis sciex.li/xoemx7 #USHUPO2026

New preprint! We did a systematic comparison of proteases, digestion conditions, and labeling methods for histone PTM analysis by MS-based proteomics in the Yates lab at @scripps.edu. TL;DR: you can get great results in ~3 h of sample prep. 🧵

Looks like proteomics has hit the big time!

Hannes isn't on Bluesky I don't think, so I guess I'll have to print my meme and mail it to him instead. #proteomics #massspectrometry 💻🧬

💡“DEprot” is now out on @narjournal.bsky.social Genomics and Bioinformatics. With Nils Eickhoff ( @zwartlab.bsky.social, @nkinl.bsky.social & @oncodeinstitute.bsky.social), we designed this “all-in-one” tool to facilitate the analyses of LFQ-based proteomics data. academic.oup.com/nargab/artic...

That tracks 🤣 Just about smack in the middle of "proteomics mass spec"

Great and very productive workshop on trustworthiness in proteomics in Leiden last week (www.lorentzcenter.nl/trustworthin...). 🥇 to whomever first gets what the photo in the background has to do with the topic. No cheating allowed!

It looks like the #glycoRNA commercial pipeline has found its final home (for now): 2021 - GannaBio (glycoRNA focus) start-up as part of the ReNAgade Therapeutics ecosystem 2024 - Orna Therapeutics announces strategic acquisition of ReNAgade Therapeutics 2026 - Eli Lilly to acquire Orna Therapeutics

Bonus detail: The internal development for the instrument is Chromium.

With #ASMS2026 abstracts submitted, instrument announcement leaks are only a matter of time. Aside from the Thermo IRMPD Tribrid and maybe an Excedion less-pro, any other instrument release predictions across the vendors?

As a science journalist looking through papers and being asked to 'Sign in through your institution" for two hours 🧪

Aside from the whisper network, how are #teammassspec finding out how much certain instrument models are down for (service delays, backordered parts, things breaking all the time, etc)?

#TeamMassSpec Question for XL-MS practitioners.. Looking for a suitable crosslinker to stabilise a protein complex in vitro.. What are the pros and cons for MS-cleavable vs non-cleavable cross-linkers?? Is PhoX a good choice?? Any recommendations for MS-cleavable cross-linkers?? Thanks very much..

Drug discovery requires two steps: checking whether a drug can bind to a harmful molecule or its receptor, and finding out if the drug can stop the molecule and its receptor from interacting. But a new technique does both steps at once, quickening the process. cen.acs.org/pharmaceutic... #chemsky🧪

We need FAIR practices in data and code sharing (as always), but with vibe coded tools there must be a benchmark comparison. Remember when new proteomics algorithms compared to Mascot and MS-GF+? We need that now. I would point to proteomicsML, but more is needed, and impetus lies with authors. 7/7

Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!

www.nature.com/articles/s41... @benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩‍🔬🧪🍝🧬💻

Less than a week until an incredible opportunity for postgraduate students to expand their knowledge of proteomics and #LearnConnectGrowExplore with us at #UPSS2026! The weather forecast is moderate to hot 🌞 with some periodic rain that will hopefully provide some relief!

🚀 Kicking off the year with our first Advanced #MassSpec Seminar! Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics. This is a great opportunity to see how #MassSpectrometry is driving new discoveries.

ASBMB is hiring a Director of Public Affairs to help champion fundamental biomedical research, strengthen relationships with policymakers and elevate science stories that save and improve lives. Join ASBMB in shaping the future of science advocacy! ➡️ Apply: www.asbmb.org/about/careers #STEMCareers

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social ! --> computationalproteomics.khoury.northeastern.edu

Part of me loves how bad this is, but maybe I’m also terrified someone takes it and runs with it. 😬😱

This might be the problem.... #TeamMassSpec