💡“DEprot” is now out on @narjournal.bsky.social Genomics and Bioinformatics. With Nils Eickhoff ( @zwartlab.bsky.social, @nkinl.bsky.social & @oncodeinstitute.bsky.social), we designed this “all-in-one” tool to facilitate the analyses of LFQ-based proteomics data. academic.oup.com/nargab/artic...

That tracks 🤣 Just about smack in the middle of "proteomics mass spec"

Great and very productive workshop on trustworthiness in proteomics in Leiden last week (www.lorentzcenter.nl/trustworthin...). 🥇 to whomever first gets what the photo in the background has to do with the topic. No cheating allowed!

It looks like the #glycoRNA commercial pipeline has found its final home (for now): 2021 - GannaBio (glycoRNA focus) start-up as part of the ReNAgade Therapeutics ecosystem 2024 - Orna Therapeutics announces strategic acquisition of ReNAgade Therapeutics 2026 - Eli Lilly to acquire Orna Therapeutics

Bonus detail: The internal development for the instrument is Chromium.

With #ASMS2026 abstracts submitted, instrument announcement leaks are only a matter of time. Aside from the Thermo IRMPD Tribrid and maybe an Excedion less-pro, any other instrument release predictions across the vendors?

As a science journalist looking through papers and being asked to 'Sign in through your institution" for two hours 🧪

Aside from the whisper network, how are #teammassspec finding out how much certain instrument models are down for (service delays, backordered parts, things breaking all the time, etc)?

#TeamMassSpec Question for XL-MS practitioners.. Looking for a suitable crosslinker to stabilise a protein complex in vitro.. What are the pros and cons for MS-cleavable vs non-cleavable cross-linkers?? Is PhoX a good choice?? Any recommendations for MS-cleavable cross-linkers?? Thanks very much..

Drug discovery requires two steps: checking whether a drug can bind to a harmful molecule or its receptor, and finding out if the drug can stop the molecule and its receptor from interacting. But a new technique does both steps at once, quickening the process. cen.acs.org/pharmaceutic... #chemsky🧪

We need FAIR practices in data and code sharing (as always), but with vibe coded tools there must be a benchmark comparison. Remember when new proteomics algorithms compared to Mascot and MS-GF+? We need that now. I would point to proteomicsML, but more is needed, and impetus lies with authors. 7/7

Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!

www.nature.com/articles/s41... @benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩‍🔬🧪🍝🧬💻

Less than a week until an incredible opportunity for postgraduate students to expand their knowledge of proteomics and #LearnConnectGrowExplore with us at #UPSS2026! The weather forecast is moderate to hot 🌞 with some periodic rain that will hopefully provide some relief!

🚀 Kicking off the year with our first Advanced #MassSpec Seminar! Join us tomorrow for an exciting session featuring amazing speakers showcasing their recent research in the fields of #Proteomics & #Metabolomics. This is a great opportunity to see how #MassSpectrometry is driving new discoveries.

ASBMB is hiring a Director of Public Affairs to help champion fundamental biomedical research, strengthen relationships with policymakers and elevate science stories that save and improve lives. Join ASBMB in shaping the future of science advocacy! ➡️ Apply: www.asbmb.org/about/careers #STEMCareers

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social ! --> computationalproteomics.khoury.northeastern.edu

Part of me loves how bad this is, but maybe I’m also terrified someone takes it and runs with it. 😬😱

This might be the problem.... #TeamMassSpec

Another photo from the pump failure. Quite a doozy. On the plus side the service contract will cover this and with the new parts the instrument will be tip-top. This is a Lumos BTW, we use it for DDA HCD/EThcD on immunopeptidome samples.

I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...

It's an interesting press release as it leaves out that It's the paper that reproduces MAPS by the Searle lab (pubs.acs.org/doi/abs/10.1...). Here's the link to the paper: pubs.acs.org/doi/abs/10.1...

Lorne Proteins 2026 🏖️ features Princeton University protein cognoscenti Michael Hecht, designing an artificial proteome with new folds and functions; and Jerelle Joseph, on tractable MD simulations of multiprotein condensates & synthetic condensate engineering. 🔗 Register now www.lorneproteins.org

VERY well deserved. @rhuttenhain.bsky.social !! Congratulations 🎉

We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org

Which cysteines are hyper-reactive in specific cancer types and tissues? The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2) www.cell.com/cell-chemica... #ChemBio #ChemSky #ChemicalProteomics

Looking for a fresh start to 2026? Check out the US HUPO Job Board for new open positions in proteomics! Visit: https://us-hupo.org/US-HUPO-Job-Board #Proteomics #USHUPO #ProteomicsJobs

Is anyone else getting through a terrible project that needs to be done, just so it won't go into next year? 😂 In case you're wondering how bad it can be, this one involves Excel macros (not writing them, though). #chemchat

Advice I now give to grad students and postdocs in the sciences: Don’t just try to meet and impress senior scientists. They’ll retire soon. Get to know your fellow students - make friends where possible, be colleagues at least. These are the people you’ll be sharing the field with for decades.

Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren. link.springer.com/article/10.1...

Isopropanol. Y'all. I forgot the isopropanol soak. 😭

Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.

#AminoAcidAdvent Day 20: Asparagine (Asn; N) You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷‍♂️. FYI was asparagiN according to Dayhoff.

HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore. It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia. m.youtube.com/watch?v=ckgy...

Experience in #archaeological #proteomics? Interested in #Roman economy / organic artefacts? Background in data analysis for #ZooMS? Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy Apply by 12/01/2026

#AminoAcidAdvent Day 14: Glutamine (Gln; Q) Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.

@asms.org only 4 more days to vote. Great candidates for this election so express yourselves. I’m at pacific chem in Honolulu checking out venues! I would like your vote.

Proteomic Ruler question: In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit. Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1? #proteomics #massspec

#THEProteomicsShow is back and now we’re talking about #USHUPO2026. Me and Ben @proteomicsnews.bsky.social got to talk to Mike MacCoss @maccoss.bsky.social and it’s everything you’d want: quant, mentoring and car discussions. Find it wherever you find fine podcast or here anchor.fm/theproteomic...

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Senior Research Fellow, Proteomics Facility Manager - Adelaide, Australia www.timeshighereduca... --- #proteomics #prot-jobs

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

#AminoAcidAdvent Day 6: Cysteine (Cys; C) Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.

It is the most Whimsical of the otherwise dull, bureaucratic amino acids.

Top 8% of #TheProteomicsShow podcast listeners, who is ahead of me?! @benneely.com @proteomicsnews.bsky.social

Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...

BPC-157, a 15 amino acid peptide in the news… how is proteomics not more mainstream in pop sci?!!!! pmc.ncbi.nlm.nih.gov/articles/PMC...

#AminoAcidAdvent Day 1: Proline The kinkiest of amino acids (NSFW!), synthesized from glutamic acid, and some even call it the simplest "enzyme". Regardless, its a pro move to include the hydroxyproline variable mod if your abundant proteins have collagen domains... really, do this.

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.