Favorite talk of #ASMS2026 so far has got to be this HIGH SCHOOLER presenting in the drug discovery session!!

Amazing talk and beautiful slides, @willfondrie.com -- hope your ML short course participants were paying attention!! 🐔

Discussing #chemoproteomics at #ASMS2026 with @lindsaykpino.com of @talusbio.bsky.social

GOOD MORNING! Starting the day off at the @sciex.bsky.social breakfast seminar. All you runners put me to shame on my walk over here, but I'll be making it out for a jog one of these days. Probably. Maybe.

Does anyone else think that young Klaus Biemann had kind if a David Bowie look #ASMS2026

A historical review of computational mass spectrometry by @maccoss.bsky.social at #ASMS2026, beginning with the mother of bioinformatics, Margaret Dayhoff. 🖥️🧬🧪👩‍🔬

New work from @csneeze.bsky.social explored how common additives for thermal stability analyses affected protein-drug interaction hit calling. We were surprised to see that buffer and method selection for lysates could recapitulate findings from in cell thermal stability assays!

Hello, #ASMS2026!! The @talusbio.bsky.social team is on-site and ready to nerd out! We've got everything from drug discovery to metadata records, from chemoproteomics to file format converters. 1/n

#ASMS2026 coffee pilgrimage day 1: Bird Rock Coffee Roasters. I quite enjoyed my cortado 😉 www.birdrockcoffee.com

Chemoproteomics is back at #ASMS2026 with a bang! After the oral session mysteriously vanished last year, now we're not only back on the schedule but kicking off the conference with Ben Cravatt?! 1/n

Okay, here are the Thermo #ASMS2026 leak confirmations: - Tribrid Apex (the next Ascend + IRMPD) - Orbitrap Excedion is the downgraded version (240k max res) of the Orbitrap Excedion Pro. The name is going to cause a lot of confusion. Thanks go to my wonderful sources.

In 2025, 12% of Orbitrap units failed this QA step. New research identifies quartz insulator defects as the root cause for 600 defective units and achieved a 95% reduction in defects once addressed. Critical reading for manufacturers (including the Chinese company now making Orbitraps) #teammassspec

First PROTAC gains FDA approval, bolstering targeted protein degradation and induced proximity ambitions www.nature.com/articles/d41...

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

I'm sure @leecantrell.bsky.social will do a real tweetorial, but my favorite: "Reduced peak completeness minimally affected detectability (LOD) but substantially degraded quantifiability (LOQ), indicating that identification-centric readouts can remain stable while quantitative utility declines."

On my BOS-SEA flight home last week, a gentleman stowed a dozen Dunkin Donuts in the overhead. A specific request from his kids, he said. They made it totally intact, shockingly.

claude.com/blog/onboard... Wait I know them! (Brendan not on bsky so I'll tag @maccoss.bsky.social ) #TeamMassSpec #proteomics 🧬 🖥️ 🧪

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

I am looking for a new reserach technician. This is an entry level position ideal for a graudating senior. Please re-post and send candidates my way! [email protected]

We've been using the nf-core quantms for years, @willfondrie.com and @jspaezp.bsky.social contributed as we were getting it set up and debugged for our use cases. github.com/bigbio/quantms

Can't believe an Astral Zoom is £1.7m. crazy stuff... I mean, I can, but still.

The Ikaros family was the first to show that transcription factors could in fact be modified by medicines. In recent years, academia and industry chemists have worked to design new molecules that can target Ikaros as a way to treat cancer. #chemsky 🧪

🧵 New paper from @proteaglyco.bsky.social out in Analytical Chemistry! We used anion supercharging to unlock next-generation O-glycan structural analysis: - 4× greater signal - 5× better fragmentation Here's a thread, digging into each figure: doi.org/10.1021/acs....

Can we control cells by forcing TFs to collaborate? Interested? Read our preprint! An awesome collaboration with @cgersbach.bsky.social, @igvfconsortium.bsky.social, Christian McRoberts Amador, @rachel-savage.bsky.social: www.biorxiv.org/content/10.6... 🧵

Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio! Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development. www.nature.com/articles/s41...

We're hiring! Two fully funded PhD positions are open in my group at KTH/SciLifeLab, both in the intersection between machine learning, mass spectrometry, and proteomics. One EU MSCA-funded, one DDLS. Details below 👇

Oh boy new information for one of my favorite discussion/debate topics: data generators vs data consumers. Reskeeting to read later

#cellNexus is out! -> "Quality control, annotation, aggregation and analytical layers for the Human Cell Atlas data" - QC layers - Consensus cell annotation layers - Pseudobulk aggregation of the whole human atlas - R/Python APIs cellNexus.org Preprint: www.biorxiv.org/content/10.6...

Each passage into the nucleus is guarded by a jumble of proteins. These bouncers work together to determine which VIPs (very important proteins) are allowed in and out of the most exclusive part of the cell. Tune in to The Quanta Podcast:

Crazy demonstration of single cell top-down technology.

www.reddit.com/r/proteomics... Latest Bruker or Thermo #TeamMassSpec instrument for #proteomics? Please share your honest experience (anonymously if you want)! Sometimes it is more than just the specs (ie. price, robustness, maintenance, software) #massspectrometry

We are delighted to present DIA-NN 2.5. Redefining LC-MS proteomics with up to 70% more proteins identified and powerful capabilities for statistics, visualisation and biological interpretation.

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards

All the Parts continues on #THEProteomicsShow as me and Ben @proteomicsnews.bsky.social ask pretty dumb questions about stuff. Today is Jan Mulder chatting brain, and it was awesome talking about all things brains. Find it wherever you find fine podcasts, or here anchor.fm/theproteomic...

My skywalkers, did someone do a funny April fools and I missed it? Please share. Nerdier the better.

We are proud to announce the discovery of Glyco-Carbohydrates, a paradigm shift in glycobiology! Traditional glycoconjugates (proteins, lipids & RNA) max out at 50% carbohydrate. Ours are 100% carbohydrate AND glycans, unlocking truly homogenous properties. TBA April 1st, 2027! 🍬 #glycotime

As some of you know, I finally got a pre-release “MS”! The kind folks @veridianDynamics let me test the new Separator 5000 Top Down-MS. We’re running as MUDpit with the LC on the front, then Viz for protein ID and absolQuan. This thing creates separations better than cousin Laura, bless her heart.

Getting the ol' grad school gang back together with Carafe2 -- Bo Wen (@maccoss.bsky.social and Bill Noble) and @jspaezp.bsky.social (@willfondrie.com at @talusbio.bsky.social) teamed up for essentially some late night hackathons to build out Carafe for @brukercorporation.bsky.social timsTOF data.

"my first ASMS meeting in 1974, the only women I remember seeing were Catherine Fenselau, Chava Lifschitz, Peggy Frisch, and Sharon Lias─four women among some three hundred men!" A lot of progress has been made since then!

Wandered around ACS this morning after picking up my badge. Passed a room for current trends in biochem. Ends up it's a peptide therapeutics talk using LC-MS. Sprawling conference of thousands and I walk into a mass spec talk randomly 😂

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

You know how big research groups employed grant writers, editors and artists, even paper writers, but weren't super public about it? Well now you have those capabilities within reach for pennies on the dollar to everyone. Of course people are going to use them, whether they say it out loud or not.

As we are trying to get guests on for the new season of #THEProteomicsShow, I am venturing down some rabbit holes. TIL about ear wax diagnostics. www.nature.com/articles/s41...

You wouldn't download a HPLC, would you? (I would.)

Well, in case you missed all the work over the years from @jochwenk.bsky.social et al. about blood proteomics technical concerns, turns out our extracellular RNA compatriots basically have written the same papers. www.nature.com/articles/s41...

Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans. Integrally, O-acetyls are invisible under standard reductive conditions. Now published at Molecular Omics. Link: academic.oup.com/molecular-om...

Review from Fia B. Larsen in @rhp-lab.bsky.social with everything you always wanted to know about proteasomal control of transcription factors (but were afraid to ask about) Proteasomal control of transcription factors: mechanisms, regulation and dysregulation. doi.org/10.1007/s000...

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

why are people who do proteomics always happy? they're always working in positive mode