Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren. link.springer.com/article/10.1...

Isopropanol. Y'all. I forgot the isopropanol soak. 😭

Unexpectedly quenching and evotip'ping 7x 96-well plates' worth of samples today. It truly is the season.

#AminoAcidAdvent Day 20: Asparagine (Asn; N) You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷‍♂️. FYI was asparagiN according to Dayhoff.

HUPO 2026 is currently being promoted. Sep 27 to Oct 1, 2026, in Singapore. It’s a hub for life science research in Asia, so I’m excited to see the local proteomics research conducted there and across Asia. m.youtube.com/watch?v=ckgy...

Experience in #archaeological #proteomics? Interested in #Roman economy / organic artefacts? Background in data analysis for #ZooMS? Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy Apply by 12/01/2026

#AminoAcidAdvent Day 14: Glutamine (Gln; Q) Maybe one of the funnier Dayhoff naming moments ("Q-tamine"), this amide of glutamic acid will spontaneously cyclize and deamidate when on the N-terminus (not a rare event! Ig beware)... making this new post-doc convinced his SIS peptide was contaminated.

@asms.org only 4 more days to vote. Great candidates for this election so express yourselves. I’m at pacific chem in Honolulu checking out venues! I would like your vote.

Proteomic Ruler question: In Wiśniewski et al., MCP 2014, the histone→DNA proxy seems implicit. Is there any explicit reference stating that the Ruler uses only core histones (H2A/H2B/H3/H4) and excludes H1? #proteomics #massspec

#THEProteomicsShow is back and now we’re talking about #USHUPO2026. Me and Ben @proteomicsnews.bsky.social got to talk to Mike MacCoss @maccoss.bsky.social and it’s everything you’d want: quant, mentoring and car discussions. Find it wherever you find fine podcast or here anchor.fm/theproteomic...

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Senior Research Fellow, Proteomics Facility Manager - Adelaide, Australia www.timeshighereduca... --- #proteomics #prot-jobs

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

#AminoAcidAdvent Day 6: Cysteine (Cys; C) Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.

It is the most Whimsical of the otherwise dull, bureaucratic amino acids.

Top 8% of #TheProteomicsShow podcast listeners, who is ahead of me?! @benneely.com @proteomicsnews.bsky.social

Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...

BPC-157, a 15 amino acid peptide in the news… how is proteomics not more mainstream in pop sci?!!!! pmc.ncbi.nlm.nih.gov/articles/PMC...

#AminoAcidAdvent Day 1: Proline The kinkiest of amino acids (NSFW!), synthesized from glutamic acid, and some even call it the simplest "enzyme". Regardless, its a pro move to include the hydroxyproline variable mod if your abundant proteins have collagen domains... really, do this.

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)

This is our loading buffer on our Exploris 480 /U3000 system today. Coming to Nature Methods ASAP: The Proteomics S.P.I.D.E.R. Method (Suitability Protocol Integrating Dead Eight-legged Reference)

Small thread on biotech in Seattle before I head out to Boston: Sentiments in WA life science startup scene = very disappointed in the lack of SBIR renewal to fuel good startup ideas/commercialization efforts, and the number of clinical trials moving from the US to China, Australia, Canada.

Every year, I aspire to complete the #AdventOfCode, and every year, I lose focus within three days. Wonder how far I'll make it this year adventofcode.com

Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.

Woo! Congrats @olgavitek.bsky.social , @dschweppe.bsky.social , Sasha, and Hanno!

UNCW's Dept of Chem and Biochem is looking for four (4!) new members this cycle including: Asst Professor Analytical Chem Asst Professor Physical Chem Lecturer - Bio- and general Chem Lecturer - General Chem Our dept is a great place to work and Wilmington's a blast! #ChemSky #ChemJobs Links ⬇️

Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?

I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:

Reading papers over the weekend, I realised how often the term gene network is misused. Please refrain from using it unless you have clear, functional evidence of causal interactions between transcription factors. Otherwise, what you have are (at best) correlations. Just saying....

Today on "PI Back In The Lab After A Year", Lindsay tries to change the trap on a Neo Vanquish. Step 1: slack mass spec team and sheepishly confirm that this part is somehow the trap

Watch out, it's that time of year again. The PI is getting back into the lab.

I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below! careers.gene.com/us/en/job/20...

🚨🚨 HIRING ALERT: DATA SCIENCE INTERN (ML / METABOLOMICS) – INDIA (REMOTE) 🚨🚨 🚀 Hurry! 🚀 Hurry!🚀 Hurry! 🚀 🛑 Wanna be my #colleague at Enveda in India starting #January 2026 ? Then apply now!!! 🌿 We’re looking for a #Data #Science #Intern (#Remote – #India) #colleague !!! #ML #DL #AI

Watching Lauren Celano talk about the state of jobs in industry. The state of industry is in flux which is due to issues with funding. Funders prefer to support 1 company with a large amount of capital versus 10 companies with less each. ##ABRCMS2025

Note that the one repost on X came from me, as well as one of those likes Taking it at face value, this example suggests that Bluesky is >100x enriched over X for users interested in this topic, which covers the intersection of life science/drug development/bioinformatics/AI #Bsky #Twitter #Xitter

Nice! @nmriley.bsky.social

Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures! Great colleagues, lots of cool projects… and you’ll get to work with me 😅 Please DM if you’re interested!

New paper from Monte Rosa Therapeutics www.nature.com/articles/s41...

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1

We show that the total #RNA isolated from cell cultures can contain substantial non-RNA glycoconjugates, which was found out to be #glycoproteins (characterized in Kegel et al paper), and those glycoconjugates persist even after protease treatment and rounds of purification.

Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...

Okay, #TeamMassSpec, I have a challenge for you: I want to vary the senstivity of my Orbitrap full scan analysis. Part of my chromatogram has very little signal and part has too much. If I set AGC to 1e6 and max IT to 120 ms I get too much signal and have to reduce my injection volume.

Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs" Registration is free. Join us! tinyurl.com/f9njvnyu #chromatin #genomics #northwestern #biology #dna

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

"I have lost count of the number of times over the years that I’ve said “Huh, I didn’t think mass spec could do that”."

May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu

I've just come across a resource for finding MS prices beyond the US (GSA Advantage). It's called EU Tenders (ted.europa.eu) and has many recent MS prices on there. E.g. Astral Zoom with FAIMS Pro Duo is listed as $1.75 million Euro ($2 million USD) Limited info but probably includes an unlisted LC