Whenever Indeed sends me a job listing that is like "your expertise in mass spectrometry would make you an ideal fit for this opening in Florida for a clinical psychiatrist" I always take the time to confirm that their AI is doing a great job.

Ben @proteomicsnews.bsky.social and I did our big 100th episode of #THEProteomicsShow, but our guest was an extremely snarky AI overlord super fan. Not sure where it ranks on our dumb ideas list, but fun as always. Find it wherever you find fine podcasts. Upcoming live episode has real guests.

@pastelbio.bsky.social - thanks!

UofK is looking for a mass spec core director. Deadline to apply is 2/22. ukjobs.uky.edu/postings/617...

Setting technological improvements aside, what the top biological findings of the last 30 years of #proteomics?

Authors who need to comply with U.S. federal funder requirements for immediate #PublicAccess have multiple publishing options in ACS journals. Following recent engagements with NIH, we’re confident all options may be expensed against grants. Learn more: buff.ly/GFA7OzI #OpenAccess #OpenScience

(1/2) After searching 10 years for ANY evidence that SomaScan can provide ANY useful protein measurement data, my reanalysis of the data from this study found (TWO!) proteins quantified by aptamers that can be supported by real methods. this is still the dumbest f'ing way to "measure" a protein,

Steaming hot new method alert! ShtMtPro! proteomicsnews.blogspot.com/2026/02/targ...

Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.

Anyone know if tools exist that can help identify LCMS files that are altered...or...umm... completely fabricated...? @magnuspalmblad.bsky.social ?

Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!

Ep 98: bridgerton, cocaine monkeys, and birding… making sure you know we aren’t AI, right @proteomicsnews.bsky.social.

Single cell proteomics of the developing human brain! Question everything you thought made sense in LCMS based proteomics? proteomicsnews.blogspot.com/2026/01/sing...

Spatial RnaSeq plus a cocktail of dozens of antibodies (oligonucleotide tagged) squeezes loads of data out of every slide! www.nature.com/articles/s41... 6 months and $30k/slide? Probably! But it’s beautiful!

www.technology.org/2026/01/10/n.... Has anyone seen this paper? It’s not linked in the press release and I couldn’t find it with a phone.

I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...

..dear bluesky... today I saw a 1 star product review because a Pennsylvania 11 year old child's semi-automatic rifle jammed and shells detonated inside said child's semi-automatic rifle. The store has reduced said rifle by $50 to $199.99... So....ummm....how is your country today...?

Proteomics of butterfly metamorphosis with eccentric data processing still outperforms transcriptomics! proteomicsnews.blogspot.com/2026/01/prot...

How does COVID affect hamsters?!? Proteomics answers the question at the front of all of our minds today. proteomicsnews.blogspot.com/2026/01/how-...

...pushed publish by accident on a post on a new SomaScan paper that is on something truly important that really truly matters. Deleted. Please disregard. Might need to hide the keyboards. ONE PATIENT EVER. THE ONLY ONE. APTAMERS?!?!?

On this week’s #THEProteomicsShow Ben @proteomicsnews.bsky.social and I sat down with Dr. Jeff Gordon who will be giving the plenary at the upcoming #USHUPO2026 meeting. Find it wherever you find fine podcasts, or here anchor.fm/theproteomic...

Yeah! Another ion funnel to clean! www.biorxiv.org/content/10.6...

Karolinska(sp?) adds a ton of new insights into p53 control mechanisms! proteomicsnews.blogspot.com/2026/01/anot...

@benneely.com it’s finally real!!

Distraction… Doogle’s AI fell for the 2026 Karman Ghia prank. (Bored weirdos are flooding the internet with AI images of a car that won’t be made.)

Happy New Years Bluesky!!! I hope in 2026 all your experiments succeed, your grant panels are generous, and your reviewers grasp your genius 🧪

After 2 years in peer review, this paper is finally published and it features figures from a completely unrelated paper rather than crappy ones I made! www.nature.com/articles/s42...

@ucdproteomics.bsky.social dropping the first paper imma read when I can 4 factor into my work computers - pubs.acs.org/doi/10.1021/... - lack of modern proteomics data on MASLD fixed in one JPR paper!

Not a conference, but worth flagging: EMBO Practical Course “Targeted proteomics: advanced tools for biomedical research” Barcelona, 8–13 Nov 2026 Line-up not announced yet, but previous editions organized by @maccoss.bsky.social with invited speakers incl. Alexey Nesvizhskii and Vadim Demichev.

Also in Barcelona November 9-13: elixir-europe.org/events/bioha.... Usually, there are 3-4 projects related to proteomics. May be difficult to score a ticket though.

Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput analyticalsciencejou... --- #proteomics #prot-paper

MoSAIC: An Integrated and Modular Workflow for Confident Analysis of Protein Post-Translational Modification Landscapes www.mcponline.org/ar... --- #proteomics #prot-paper

I think this is called a robbery.

Direct Injection Mass Spectrometry and iFishMass for the High-Throughput Analysis of Antibody Modifications pubs.acs.org/doi/10.... --- #proteomics #prot-paper

If you know of a European conference that corresponds to any of these dates I’d possibly move it to the top of my list.

PXD069101 🚨 Targeting Mass Spectrometry-based proteomics for Continuous Directed Evolution 🚨 New dataset alert! 🚨

Me and Ben @proteomicsnews.bsky.social are bringing you some holiday science cheer with this week’s #THEProteomicsShow with @lingjun2025.bsky.social. We expect that soon everyone will want to do research they can eat, we do! Find it wherever you find fine podcasts or here anchor.fm/theproteomic...

Thanks for the fun write-up @proteomicsnews.bsky.social! Can confirm, all done with a home-built ion source attached to an Orbitrap Ascend. Only mouse and rat tissue here though. proteomicsnews.blogspot.com/2025/12/nano...

Fast spatial proteomics!! doi.org/10.1016/j.mc...

Did Thermo mass spectrometry officially move their marketing group to Copenhagen?

EEEK! proteomicsnews.blogspot.com/2025/12/how-...

Did I blindly listen to Orsburn @proteomicsnews.bsky.social on something random... yes. Will this make sense to you in a future episode of the pod... yes again.

The Human Cell Line Phosphoproteome Atlas: A Deep Empirical Resource Revealing Kinase Activity Landscapes www.biorxiv.org/cont... --- #proteomics #prot-preprint

Who has made this 🤣

A sorely needed standard in the plasma proteomics space is now available. Perfect for benchmarking peptide-level depletion methods.

The anonymouse peer reviewer who recommended my solo article for a paid ESL service owes me a new keyboard. I got nose coffee all over this one. I'm going to laugh about this all day, though.

Another weird acid that is better for proteomic sensitivity than formic acid! chemrxiv.org/engage/chemr...

Our Ultra2 has a Peak Genius on it. It is compressing(?) every 3-5 seconds with Captivespray. Anyone else have this same setup and know if this normal? It seems weird.