There is still a geomagnetic storm going on, so the #aurora prediction suggests it should be visible, at least in Canada and the northern states.

5 homes collapsed on the Outer Banks in 45 minutes this afternoon! www.accuweather.com/en/hurricane...

There already is one Gal Gadot. Is there really a need for her creepy, de-aged avatar? variety.com/2025/film/gl...

Weekend warrior "major" (who probably won't be around next year) trying to threaten a room of career flag officers. www.nbcnews.com/now/video/he...

now he is complaining about how some of the ships are ugly

HCLS1:p (hematopoietic lineage cell-specific protein 1) has a simple, high occupancy S/T+phosphoryl pattern & a rhyming, diffuse, low occupancy Y+phosphoryl pattern. The Y acceptors are believed to be marked via FES, FGR, FYN, LYN or SYK. #proteomics

At some point he is going to require an executive producer credit (& maybe a cameo) on all movies, too. www.bbc.com/news/article...

A modest geomagnetic storm has kicked up some flare in the #aurora, at the moment best seen in north central Asia.

AI chatbots have no discernable effect on firm profitability or recorded hours of work.

EPS15L1:p (epidermal growth factor receptor pathway substrate 15 like 1) is an evolutionarily conserved paralog of EPS15:p. It has a similar arrangement of the 4 nward structured domains, but has detailed differences wrt its phosphoIDRs. The paralogs do not share any tryptic peptides. #proteomics

I bet the amount of coding by folks that know nothing about coding (and have no business coding) has gone way up since AI code breakers crawled out of the swamp.

The models seem to be agreeing that both storms Imelda & Humberto will be getting the bum's rush eastward out to sea starting Tuesday, driven by the same upper level steering winds.

To my American friends: is the current deployments of troops against US cities part of a "cold civil war" or a "civil cold war"?

EPS15:p (epidermal growth factor receptor pathway substrate 15) has a single EGFR kinase signal acceptor (hs: Y849; mm: Y850), but plenty of S/T acceptors for other kinases. These acceptors flank the nward EF-hand pair & in at least 3 cward phosphoIDRs. #proteomics

I am not sure if I am more shocked by the scale of these cuts or by the fact that UTS had 1100 subjects to cut in the first place.

Can the Fixome be far behind? www.biorxiv.org/content/10.1...

EPS8:p (epidermal growth factor receptor pathway kinase substrate 8, signaling adaptor) has 2 larger nward protein-protein domains & 2 smaller ones cward (SH3 & SAM). The highest occupancy S/T phosphoIDR is between the cward domains, with grace notes around the edges of those nward. #proteomics

I heard a podcast the other day with a science journalist being interviewed. He was very adamant about the problems with describing DNA as the "blueprint for a cell". I didn't think much of it at first, but I must admit that his arguments have won me over as I thought about it.

While it may seem like the right thing to do now, why was all this allowed to be put into place to start with? www.theguardian.com/world/2025/s...

For some reading, or just an exploration of exemplary science communication, check out the @quantamagazine.bsky.social series "How We Came to Know Earth" and its presentation. Really really good stuff. www.quantamagazine.org/how-we-came-...

PACSIN1:p (Protein kinase c And Casein kinase Substrate In Neurons 1) has an nward coiled-coil dimerisation domain & a cward pTyr-peptide binding domain (SH3). Between them is a phosphoIDR that is both the protein's defining characteristic & too complex to really understand. #proteomics

This is all perfectly true. As long as it is only being said by people from within the sector, no one will listen. I am not sure why the post-secondary sector seems to have trouble understanding this.

Hurricane Gabrielle is set to make a direct hit on the Azores.

IRS2:p (insulin receptor substrate 2) is named for its pTyr kinase, but it is also a riot of pSer/pThr acceptors. I don't think there is a technical name for this type of structure made up of many low-complexity phosphoIDR regions, but there really should be. #proteomics

Okay, here's that good news! Thank you to everyone who picked it up this week! You have officially made my evening.

I can remember, back in the old days, when printing something after not printing anything for a few weeks did not require 4 hours of on-line research & multiple rounds of print nozzle/power cleaning from obscure places in your printer utilities menu.

Why is this man, who clearly has no sense of remorse for acting in a way that endangers fellow citizens, being given a sympathetic ear instead of being jailed?

This just popped up in my Amazon feed and looks like a hoot - anyone read it?

I didn't realize that Pierre Burton thought that Canada's elites (our Smug Minority) were "a small, in-bred establishment of business and political leaders who all had a vested interest in maintaining the status quo."

Rather than pursuing villains, removing barriers to pre- and post-natal care for all US residents would probably produce the largest positive effect on public health of any policy alternative.

Here’s a way to kill an academic program: let enrollment outpace TT hiring and rely on contingent labor to teach major classes. Then cut your instruction budget and say you can’t find anyone to teach those essential classes, so the program needs to be paused til the budget improves (it never does)

Btw, for anyone wondering if I am planning a move to Portugal, the answer is no. You might have seen me talking in Oeiras last May as I interviewed for a job at NIMSB (which was great btw), but alas, sticking around in Charleston for now. "What" am I doing in Charleston still seems pretty open.

DAB2:p (disabled homolog 2 adaptor protein) has a bright nward phosphotyrosine binding domain and the sort of odds-and-sods S/T phosphoIDRs that defies analysis by molecular biology methods, e.g. alanine scans. #proteomics

NO! A thousand times NO! www.bbc.com/news/article...

Powerful Typhoon #Ragasa nears the coast of Guangdong, China overnight with winds of 215 km/h (130 mph).

Tropical Depression Bualoi is expected to take a quick swipe at Manila as a Typhoon some time Thursday night.

Hearing Libs talk up the idea of giving the tri-councils a boat load of "new" money for "defence/security" in the broadest sense. I assume in separate envelopes with seprate rules. It will be new money in the sense tat the envelope is new. But no guarantee old envelope will be same size.

Hurricane Gabrielle is blowing quite a gale in the north Atlantic, while Invests 93L and 94L are still all potential.

Worth noting re: Argentina that the peso is in trouble right now not because of Milei and his policies, but rather the prospect of a Peronist resurgance that would lead to a default. (Peronism is a permanent political project to do the stupidest thing imaginable in any given economic situation)

...and disbelief suspension paused....and run ruined when chapter 8 features a scientist trying to figure out what a metal is by GCMS....

An under-appreciated consequence of this sort of announcement is that the NIH is going to be tasked with funding as many grants as necessary aimed at specifically proving these conclusions. www.bbc.com/news/article...

this is fine

Shares of Tylenol maker Kenvue bounced back sharply before the opening bell a day after President Donald Trump promoted unproven and in some cases discredited ties between Tylenol, vaccines and autism.

It was to prove that infant vaccinations cause autism... Or maybe Johnson and Johnson did not sign up for a Trump Gold Card... Or the spray tan and comb-over daily prep gave someone a headache, they took a Tylenol, and that was the only medical term they could remember at the press conference...

SGIP1 (SH3-containing growth factor receptor bound protein 2-like interacting endocytic adaptor 1) is a peppy little guy, with a cward muniscin domain that features a long rectangular twisted β sheet. The rest of the protein is a Gordian knot of a phospho-IDR that awaits its Alexander. #proteomics

Although it may not be a given that productivity matters, so long as share holder value goes in the right direction this quarter. hbr.org/2025/09/ai-g...

I guess we can add "practising medicine without a license" to the list, although I can't for the life of me understand the thought process that led here. www.cbc.ca/news/world/t...