Literally a publication for eight-year olds 40 years ago

To me, science is about trying to figure out WTF is going on.

A lot more ink has been spilled trying to understand phosphorylation by this little guy's nward & cward static kinase domains than what's up with the prolific phosphorylation in its large central dynamic region. #proteomics

Universal Language may be the most wonderful, batshit crazy love letter to any city, ever. The fact that it is specifically to Winnipeg, with inside jokes buried a mile deep (Rod Peeler bus stop ads in Persian, Revolutionary Modernist posters of Howard Pawley in Portage Place) just fills me with joy

The AI-botstards have really upped their game for the new year: I'm going to have to up mine. They will eventually kill the goose that laid the golden egg, but thinking isn't their strong suit.

If 'Innovation' is always conflated with 'AI' and everything else is what @alexusherhesa.bsky.social is calling 'hewers of wood and drawers of water' focus then it will cost a lot of money and accomplish basically nothing.

To be an “innovation superpower” we’ll need to push back against the recent tendency for Canadian innovation talk to collapse into AI talk (with a light sprinkle of quantum). If we ignore the much bigger non-AI field of innovation opportunities, we’re cooked. financialpost.com/feature/can-...

#proteomics_101 Whoever did the publicity for the notion of a "sorbin homology domain" (gold arrow) deserves some sort of award.

I’ll be teaching this tomorrow in the context of paracetamol/NAPQI detoxification. One of the rare times I get to reference my own work.

#proteomics_101 Discuss the practical issues associated with of the concept of "canonical sequence", using these 4 splice variants of human SORBS2:p (sorbin & SH3 domain containing 2) as examples.

« Le pouvoir américain est le produit d’un attelage diabolique entre populisme et haute technologie »

I am confused: how can the "greatest naval blockade of all time" somehow be able to clobber go-fast boats but have to unsuccessfully pursue an oil tanker (which does not go fast) for days. Also, it seems to be only armed with cans of spray paint. www.cnn.com/2025/12/31/p...

Hangover cure, how did I miss this?!!! academic.oup.com/alcalc/artic...

Do any med school biochemistry departments still require a "Proteins" course of any sort?

The "atmospheric river" (blue) coming across the Pacific from the vicinity of Hawaii has broadened a bit & its intersection with North America has moved south of Haida Gwaii towards the rain forests of Vancouver Island.

#proteomics_101 Why would differential DIA analysis choose to shout S[233] (green) from the rooftops, as opposed to the other PKBP15:p pS/T acceptors (red)? How would you follow up using other laboratory screening methods?

The "Pineapple Express" I have highlighted for the last few days has developed into a very nicely delineated example of an atmospheric river.

Around here in the winter, low pressure usually means warmer weather than high pressure.

#proteomics_101 Why would differential quantitative phosphorylation analysis choose S[177] (green) as the most exciting of all the RSCD1:p pS/T acceptors (red)? How could a biological group confirm & exploit this finding?

To save you a read, the two "threats" are garbage and swearing. If that makes you scared, that is your own problem, not someone else's. Where is the actual danger here?

Yesterday's Pineapple Express has been sliding south, currently pointed at Haida Gwaii, near the north-south midpoint of the BC coast.

#proteomics_101 Just looking at the accumulated evidence, phosphorylation at S[825] (green) would probably not be front-and-centre when choosing an occupied human ACIN1:p S/T phosphorylation acceptor (red) to spend a lot of money trying to understand.

Today's weather provides what is pretty much a textbook example of the "Pineapple Express" phenomenon: a low to the west & a high to the east causing a ribbon of warm, wet (blue) air to flow up from Hawaii to the Pacific coast of North America.

This message hits hard.

This one has an obsession with running water.

#proteomics_101 Is there something special/systematic about S[1021] (green) as opposed to all of the other occupied S/T phosphorylation acceptors (red) in human PHF8:p?

One thing about not having a car is that when I rent one, I often cannot find much use for it.

I have become interested in why some S/T/Y phosphorylation acceptors end up at the extremes of log-fold change plots. They seem to be consistently individual residues that are part of large, highly modified dynamic regions (IDRs). Makes interpreting them using the typical Highlander approach dodgy.

A truly breathtaking vision of something that is, at best, a speculative view of one possible (but thoroughly undesirable) future. newsroom.servicenow.com/press-releas...

I was today years old when I realized adrenal meant location. Doh.

Liberal Partisan Brain is basically indistingusihable from MAGA when it comes to demanding journalistic fealty.

Today's attack vector, the Alibaba Cloud. All 877 CIDR IP ranges now blacklisted.

The polar vortex (winds @ 10 hPa) is a bit pinched today, with part extending down to south of the Black Sea.

Fuck off with this.

I tried Amazon again after a lengthy absence & they proved themselves to be a somewhat worse platform than the one that drove me away 5 years ago.

Quickbooks had a bunch of features like matching income to invoiced that stopped working for me for months, only to come back as a "new AI feature."

Domestic luxuriation of feral-born critter. That’s one warm 99-year-old radiator.

Utterly fascinating

#proteomics_101 Wrapping up N-acetylation is the real weirdo: V @ residue 2. V2 may act more like L2 or A2, in some way no one understands. For example: MVLDLDLFRVDKGGDPALIR… Sars:p M1 is 1.3% of Nt peptides & 81% of them are acetylated V2 is 98% of Nt peptides & 0.6% of them are acetylated

#AminoAcidAdvent Day 21: Tyrosine (Tyr; Y) This is the end my friend, tomorrow is the big day. Gird your loins and have lots of merry on hand! tYrosine is the last of the three phosphomusketeers, a fun F derivative. Why 21? Well, U know Y. Source for Dayhoff: biology.arizona.edu/biochemistry...

#AminoAcidAdvent Day 20: Asparagine (Asn; N) You know how sometimes you over do it when nogging your eggnog and you wake up feeling like ass(n), well, that’s the penultimate day of this. It’s like mini glutamine, but also maybe hydrolizes to Asp in aging 🤷‍♂️. FYI was asparagiN according to Dayhoff.

Bill Clinton releasing a statement saying 'release the Epstein files, you cowards' was not on my bingo list.

#proteomics_101 Proline is exceptional when it is residue 2, but it also influences N-acetylation when it is residue 3. For example, the terminal sequence "MAP" is most likely to have M1 removed, but the new terminus (A2) will not be acetylated, as it would be for any other X3 residue.

The definition of self-parody. www.cnn.com/2025/12/22/p...

Aw, Ben. Its christmas. You can hang baubles off those branches...

#AminoAcidAdvent Day 19: Valine (Val; V) No, this GoT reference will *not* happen. (val's name comes from similarity to an acid from a certain plant, not a rare alloy) We will never forgive you D&D for Seasons 7 and 8!!! In general I find it hard to get excited about branched-chain amino acids.

I don’t care.

The #aurora is a more active than usual because of the "Solstice Storm" effect caused by the orientation of the Earth's magnetic filed.

#AminoAcidAdvent Day 18: Aspartic Acid (Asp; D) Apologies to all you Hofmann fans, there’s no fear and loathing in peptides going on here, though Dayhoff’s “asparDic” seems a bit sus. Shorter than its acid brethren, it can still cyclize, which seems biologically important. Google it, I’m on break.