Not science (again?!): I did a 3 months for $3 audible promo and got the last DCC book “This Inevitable Ruin”, not realizing Soundbooth Theatre would ruin all my future audiobook choices. I’ve pre-ordered the upcoming DCC book but have one credit remaining and might need suggestions.

New preprint! We did a systematic comparison of proteases, digestion conditions, and labeling methods for histone PTM analysis by MS-based proteomics in the Yates lab at @scripps.edu. TL;DR: you can get great results in ~3 h of sample prep. 🧵

Not science: everything’s cool on the AI front, really. Apparently no more software companies, no more movie industry, totally gonna be fine for my kids’ futures. All this great content, tools and advancements will be paid for by… them working those other jobs. www.techspot.com/news/111338-...

Not science: when I was a kid, the ads were chewing gum, dog food, soft drinks and the bud v bud lite saga. Watching Olympics now (streaming) and my kids mostly learn about a variety of syndromes and diseases from drug commercials. Bring back gum!

To all my blood proteomics skywalkers: reviewer was surprised by high Hp levels, even though is an acute phase protein. Blood Atlas has it in top 10, and I can say in ~30+ mammals it is ~top 10. Fun answer is why? Mike Janech pointed out it is a scavenger to keep Fenton reaction in check.

Not science: hard to hear about James Van Der Beek. His situation is tragically common in the US, even the fact he had issues paying for cancer treatment. I wasn't a Dawson's Creek person but dang, I loved "What Would Diplo Do?" and strongly suggest watching it (free on Tubi, etc.).

AI is killing the magic and love of life's little things. Ex. I swore this undergrad email was AI gen, but then I met with them and they are ridiculously well spoken, exactly as they wrote. The general suspicion that AI has introduced sucks. We are in the post-truth and post-originality era. Booo!

Going to make a "things AI killed" list, beyond the obvious: from poorly written emails from undergrads (even professionals) to fun works of creativity I now find sus. I didn't appreciate how jaded we will become to most/all digital interactions. Worse than the post-truth world. Now is IRL or bust.

I was reading something about the cost of LLMs, like 500 ml of water for generating an email. Images are a ton more tokens so assume a ton more water and energy. Now let’s make it an internet trend to compound it. How much do these trends cost, literally? Of course no more cheap NVME or RAM, ever.

What the heck is NCBI's SmartBlast?!!! If this is one of those tools that has been around for ages and I just not stumbled on it I am gonna be aggro. blast.ncbi.nlm.nih.gov/smartblast/s...

You might recall the concept of expansion microscopy came up on Ep 96 with @lingjunmeng.bsky.social, and turns out even @quantamagazine.bsky.social thinks its mind blowing too. www.quantamagazine.org/expansion-mi...

Big changes coming to UniProt (👀 @pwilmarth.bsky.social), though I feel like this is essentially targeting people who think it is Sprot v. TrEMBL instead of simply Sprot v Proteomes. And yes, you should likely be using proteomes, and in most cases canonical only. www.uniprot.org/help/refprot...

Ben @proteomicsnews.bsky.social and I did our big 100th episode of #THEProteomicsShow, but our guest was an extremely snarky AI overlord super fan. Not sure where it ranks on our dumb ideas list, but fun as always. Find it wherever you find fine podcasts. Upcoming live episode has real guests.

For those of you not in the eastern US, it’s been cold lately. The mid-Atlantic to NE is cosplaying Hoth, and we even got snow in the SE (not significant in Chas of course, cause we have a meteorological forcefield to anything not off the ocean). Assuming groundhogs will warn of white walkers.

The rate of AI stuff is astounding. I’m over here watching the tech demo for Google’s Project Genie, reading about Moltbook (it’s where your AI agents go to chill), and then realizing AI breaks the economy if it fails OR succeeds. It’s exciting and cool, and not worth it, but there’s no reverse.

Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.

Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!

In other words, I am trying to ask myself more "how can we make this right, or at least usable", since taking hammers to the looms is out of the question at this point, and I worry a lot of our current discussions sound way too elitist and nonconstructive, but we also can't take the other extreme. 🤷‍♂️

On the "vibe coding omics analysis is here" demo paper, and some responses (run for the hills!), a thread for myself: - we know that LLM-assisted or even driven coding is here. if you haven't tried it even in the last 3 months, you are behind - yes it is powerful and enabling 1/7

We start our group meetings with a “safety minute” and today’s speaker chose this paper as his example of a threat du jour 😂. Surprised to see this in JPR which we usually think of as a reliably rigorous journal

Ep 98: bridgerton, cocaine monkeys, and birding… making sure you know we aren’t AI, right @proteomicsnews.bsky.social.

www.nature.com/articles/s41... @benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩‍🔬🧪🍝🧬💻

It is my great honor to announce that registration for the 7th ESCP Single Cell Proteomics Conference is now open: lnkd.in/e4iyiQjf With around 250 participants, it is one of the largest SCP conferences worldwide. We are also proud to announce that there is no participation fee for our conference.

Digging around in iOS controls today I found I can limit Siri to not providing writing and/or math help. That's cool. Another find is a pretty cool paper/post on LLM "thinking" and agents, from the Claude folks. www.anthropic.com/research/tra...

This proteomics banger from @compomics.com and @ebi.embl.org folks looks great. It is one of those titles that makes some people really excited and others let out an audible groan (I’m in the former). pubs.acs.org/doi/full/10....

Machine perception liquid biopsy: is proteomics; is not proteomics (sung to Soul Coughing). I really don't know how I feel about this on many levels, but I just learned about it so 🤷‍♂️. www.nature.com/articles/s41...

Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement www.nature.com/artic... --- #proteomics #prot-paper

Really not science: when I was a kid we (and everyone else) had these rooftop carriers from Sears (ours on our small Bronco II). I just remember the snail on it. Recently I’ve seen them around and saw it was X-cargo… totally the worst pun ever. 35 years later I’m just now laughing at the joke.

Dario is all over the media. He said (summarized by @axios.com) “10 million people — 7 million in Silicon Valley, with the rest scattered — could "decouple" from the rest of society, enjoying as much as 50% GDP growth while others were left behind.” www.wsj.com/tech/ai/anth...

We’re delighted to report a global structural proteome analysis within living cells! doi.org/10.1038/s443... #proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social

🧪 Online (Zoom) 📅 23 April 2026 ⏰ 14:00–16:00 CEST ✅ Free registration is mandatory! 👉More information in comments! 🔗 ECR Day Registration: docs.google.com/forms/d/e/1F... 🔗 Science Slam Registration: docs.google.com/forms/d/e/1F... #Proteomics #EarlyCareerResearchers #YPIC #EuPA#EuBIC

very happy that the iq 2.0 paper is published. Boosting the Speed and Accuracy of Protein Quantification Algorithms in Mass Spectrometry-Based Proteomics | Journal of Proteome Research pubs.acs.org/doi/10.1021/...

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social ! --> computationalproteomics.khoury.northeastern.edu

Part of me loves how bad this is, but maybe I’m also terrified someone takes it and runs with it. 😬😱

Especially given "an emerging conflict between individual and collective incentives to adopt AI in science, where scientists receive expanded personal reach and impact, but the knowledge extent of entire scientific fields tends to shrink".

Not science: one of my favorite cold weather dishes is peas over cornbread (my cold weather window here is fleetingly random). These specific peas were sea island red peas that took over and had a late season bumper crop (👀 @iondoctor.bsky.social). Maybe not the best picture but you get the idea.

My best idea is that since no one is writing the show's email address, we give an LLM a prompt like "based on our show's transcripts, ask me or Orsburn short snarky/sarcastic/fun questions about anything", but given my new disdain for LLMs, maybe that is too on the nose. Would be hilarious though.

None of RNA’s remarkably versatile forms are built to last — not even within the cell that they came from. www.quantamagazine.org/cells-across...

Read the full article & preview all pieces in Issue 09: www.asimov.press/p/nature

Some productive procrastination today planing the next iteration of #THEProteomicsShow with Ben @proteomicsnews.bsky.social, “all the parts”, and it’s exciting. BUT, we’ve got a 100th episode to plan. Bad ideas only please.

Neely #2026EmojiScienceSneakPeak, though it is fluid (not a pun) and could easily be 😢, and I don't mean tear proteomics www.nature.com/articles/s41...). What I am hoping for is: 🍺💩🕵️🤖🦠, while also hoping for 👣 (nice idea @bakerlabms.bsky.social)

On this week’s #THEProteomicsShow Ben @proteomicsnews.bsky.social and I sat down with Dr. Jeff Gordon who will be giving the plenary at the upcoming #USHUPO2026 meeting. Find it wherever you find fine podcasts, or here anchor.fm/theproteomic...

Are you interested in #metaproteomics? We have a senior scientist position in my lab focused on metaproteomics, and xenobiotic- #microbiome -host interactions. Check it out. jobs.quadram.ac.uk/Details.asp?...

Whelp folks, I’m switching to my other red and black team. Forza Milan! (Got a few games in quick succession to push through)

Happy New Year everyone! I will not regale you with pictures of collards or peas, or how cold the ocean is this morning, but I do hope this January is better than last year. It’s a low bar but never underestimate the curve balls life can throw. Still, we can control how we deal with them. Good luck!

Hangover cure, how did I miss this?!!! academic.oup.com/alcalc/artic...

Did you wake up wondering how you could make tonight more nerdy, and maybe you hate things dropping* as the clock hits zero? Well this video is for you! youtu.be/kS43BrnzetQ?... * things dropping that I know of: balls, pickles, and flip flops (thats folly beach btw). I bet there’s more.

What were you fluent in when AI hit is key. Those who know things won’t lose that, and not to sound like a Luddite, the future generations seem in trouble if used too much as a crutch. There’s also the current business practice of removing entry jobs to make 5 years profit for collapse in 10 years.

Only 10 years later and my name is still up in the lobby. Considering how many new fancy mass specs they have now at the MUSC Proteomics Center, I wonder if i could just move back in and no one would notice?

Make a bond movie academic North by Northwest: finding out society journals were always better to begin with (Backstory, this is arguably a top 5 bond film by Hitchcock released before Dr. No, the first Bond film.)