It is Movember and prostate cancer is in the spotlight. Explore prognostic genes associated with survival based on transcriptomics data and find out more about prostate cancer gene expression and cell line models in the Human Protein Atlas Cancer resource. www.proteinatlas.org/news/2025-11...

An article in PNAS investigates factors influencing recombinant protein expression in CHO cells showing that transgene mRNA abundance is not important, while MW, disulfide bonds, cysteine composition and N-linked glycosylation have the strongest effect. www.proteinatlas.org/news/2025-10...

Join our project “Embedding Multimodal Data in a Vector Database to Build a Blood Atlas” remotely for the BioHackathon Europé 2025! Join the project kick-off meeting October 28 at 16:00 CET. Passcode: B8GwzS us05web.zoom.us/j/4205147624...

A study in Nat. commun. added OPTN as a player in the Golgi membrane-associated degradation GOMED. In HPA this ubiquitin-binding adaptor protein localize in a punctate pattern in the perinuclear region of the cytoplasm where also the Golgi apparatus resides. www.proteinatlas.org/news/2025-10...

CYLC1 a cytoskeletal protein associated with the 'head' structure of the sperm is visualized in late stage spermatogenesis with mIHC/IF and shown to be mainly localized (green) to the cytoplasm of cell state 2 (red) and 3 (white) of late spermatids. www.proteinatlas.org/news/2025-10...

In a study in Science, an international team of researchers have mapped how thousands of proteins in human blood shift as a result of aging and diseases. The molecular "fingerprints" from 59 diseases can enable blood tests to discern troubling signs from common. www.proteinatlas.org/news/2025-10...

In the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna. www.proteinatlas.org/news/2025-09...

Transcription factors SP5 and SP8 were recently shown to regulate primary cilia formation during embryogenesis. In the HPA subcellular resource they localize to the nucleus of human cell lines. www.proteinatlas.org/news/2025-09...

In a publication in PLOS One a deep learning model was successfully used to segment epithelial cells and identify invasive epithelial cells in tissue sections from breast cancer patients using IHC stainings as ground truth. www.proteinatlas.org/news/2025-09...

In depth-profiling of the expression of the antimicrobial iron-binding transport protein lactotransferrin ( LTF) in salivary gland reveals distribution in small ducts and serous acini of the ductal system. www.proteinatlas.org/news/2025-09...

In a review in Mol. Syst. Biol. recently generated big biology datasets and the application of AI and systems biology in integrating multi-omics data to enhance precision health and medicine are discussed. www.proteinatlas.org/news/2025-08...

Hepatocellular carcinoma is a high mortality cancer and many patients are immunotherapy resistant due to β-catenin mutations. A study in Nat. Comm. show RNAi-mediated β-catenin inhibition delivered by a lipid nanoparticle to be a promising way forward. www.proteinatlas.org/news/2025-08...

In an article in Immunity researchers analyzed plasma proteins in malaria and by integrating the profiles with single-cell RNA-seq data they were able to link responses to peripheral immune cells and identify a protein profile enriched in severe malaria. www.proteinatlas.org/news/2025-08...

Here Ciliogenesis-associated regulatory factor X2 (RFX2), a transcription factor believed to regulate the transcription of motile cilia genes together with FOXJ1, is visualized in ciliated epithelium of the nasopharynx. www.proteinatlas.org/news/2025-08...

A study in Genome Biology presents an integrated resource mapping gene expression across the body, using both single cell and bulk RNA sequencing data and thus providing an invaluable reference for exploring the molecular landscape of human biology. www.proteinatlas.org/news/2025-07...

Specific expression of L1CAM, a membrane glycoprotein involved in cell adhesion, in collecting duct cells in the kidney is highlighted with mIHC/IF. Read more: www.proteinatlas.org/news/2025-07...

In an interview with HPA Director Mathias Uhlén in Sweden's leading business newspaper Dagens Industri the race to build a virtual cell and the major initiatives such as AlphaFold, the Chan Zuckerberg Initiative, Pi-HuB and Alpha Cell are discussed. www.proteinatlas.org/news/2025-07...

The cell cycle is fundamental for life, enabling organisms to grow, heal, reproduce, and maintain cellular function. In the Human Protein Atlas protein imaging and single cell RNAseq analysis have been used to explore the cell cycle dependent proteome. www.proteinatlas.org/news/2025-07...

In an article in Genome Medicine HPA related researchers have used advanced multi-omics analysis to investigate the impact of genetics and environment on the metabolic profiles of healthy adults by tracking metabolic changes over a two-year period. www.proteinatlas.org/news/2025-06...

Spermatogonia are the stem cells of spermatogenesis and early mitotic stage progenitors of sperm cells. Using mIHC/IF proteins can be localized at different states of differentiation which shows the protein IGF2BP1 in undifferentiated sperm cells in testis. proteinatlas.org/news/2025-06...