This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

wow I loveeee to find a new fantasy series with Complicated Rules (just started The Will of the Many)

one of my favorite papers recently -- obsessed with @alexholehouse.bsky.social & team's work!

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

my baby is 2 😭😭 being his mom is the absolute best thing in the entire universe 🪐

With continued uncertainty over federal government support for biomedical research, PhD students are struggling to find labs willing to take on new students, @jonathanwosen.bsky.social reports. New students are the future of US science. www.statnews.com/2026/01/30/f...

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

omg huge news

10° and snowing in Boston and I've already seen 2 people out running and 1 guy with a giant iced Dunks

going out to dinner with your 2 year old is actually totally cool and fine if you understand that, like a bomb, they are going to detonate in exactly 48 minutes. you better be outta there not one second later

do any of you read papers primarily on a tablet? if so, what tablet + apps do you use? at some point i transitioned from reading on my laptop to printing papers like an Old, but my desk is becoming a Problem so i'm looking to switch it up

mRNA neoantigen vaccines appear to be working for multiple cancers feeds.issuerdirect.com/news-release...

it will never not be funny to me that we as a society have decided that interview season should be in the dead of winter, when ice-snow-tornado-monsoons can bring the nation's air travel to a halt unpredictably

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

Great overview of the damage to science over the past year. This shows NIH awarded 24% fewer new research awards in FY2025 vs 2024. The multiyear funding language in the new LHHS bill means we should expect the same amount of new science this year. www.nature.com/immersive/d4...

sending it into 2026 🥰

rarely in my career have I been as stressed as I am now: on the (extremely competitive) faculty job market, with a toddler, trying to get an extension on my K99 so I don't lose my R00, while NIH is stretched thin, grant reviews are delayed, and funding is very scarce.

these things deserve the Nobel Prize

it is actually crazy how balmy 35 degrees feels when it's been in the teens

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

today I had the absolutely devastating realization that my headshot is a decade old.

really interesting & intuitive imho -- not all proteoforms are created equal! evidence here that a BRCA2 variant that results in expression of a truncated protein (missing DBD but retaining NTD) is a dominant negative regulator of WT BRCA2, likely via partner sequestration

delighted to share our review, out today in @cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.

first day in several weeks that i didn't have to do any job-app-related work. just spent the day going to group meeting, reading some papers, and thinking. relative bliss <3

I can't imagine living my life with this little anxiety.

man that Ken Burns revolutionary war doc hits so good on the couch with a glass of Zinfandel after a twelve hour overstimulating day of parenting a feral toddler

behold my thanksgiving masterpiece. just so grateful 🫶

unbelievably poignant and devastating. if we're not putting as many possible resources towards treating cancer as we can, what are we even doing here?

We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)

in other news, sorry to report that Rosalía's LUX has become my entire personality

first daycare-induced respiratory virus of the season... while i'm on deadline..... before thanksgiving even..... the world is cruel

i remember this great talk from Biology of Genomes - the sparkle phenotype!

there's a lot to worry about these days but my toddler just started calling all of his meals "yummies" and my heart overflows every time. so.

word on the street says this year the (fewer) assistant prof posts are averaging 800 applicants... pray for us friendly neighborhood senior postdocs: doing it all despite the bleak reality that the academic system as we know it is going to have to shrink, and we'll bear (a lot of) the brunt.

"...we’ve become so used to scarcity and slow progress that anyone building differently is primarily treated as a threat, instead of a fellow human hoping for something better." (esp true in biology imo; we all have reason to look for cures, we should assume some good faith!)

having a child has radicalized me in many ways but one of the strongest is that I now know standard time is good, actually. waking up at 6am in the pitch black is NOT IT! much easier to deal with darkness at 4pm than in the early morning, and early mornings are non-negotiable 🥴

neurodegenerative diseases hate to see these guys coming. beyond proud of my better half @pierceogden.bsky.social & the super team at Manifold Bio 🚀

It’s been a pleasure to organize the Rules of Protein-DNA Recognition meeting in Cancun. Spectacular talks and an amazing and supportive scientific community!

Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation https://www.biorxiv.org/content/10.1101/2025.10.12.681955v1

absolutely delighted to be attending the Rules of Protein-DNA Recognition Meeting in Cancún this week; wonderful talks, wonderful people, & the first conference of my postdoc that hasn't been in New England or the Mid-Atlantic 🌞☺️

I have reached the stage of application writing where I think I have never accomplished a single thing and I have no good ideas or any useful technical skills. Progress 💖

ever since i was a little girl i have wanted to spend all day changing the length of my research proposals to be in compliance with different arbitrary page number requirements

tepid take: a lotttttt of job postings for bio-AI researchers, not enough job postings for generating-the-extremely-necessary-data-for-bio-AI researchers

Really cool, conceptually simple approach here: cross-referencing grant proposal scores with literature citations and explicit acknowledgments in drug patents to identify patents linked to projects that wouldn't have been funded given a smaller budget

More about @drwendieberg.bsky.social and self-advocacy leading to early cancer detection in her dense breast tissue. More than 10 years ago now.. www.auntminnie.com/clinical-new... She channeled the lessons from this experience to launch densebreast-info.org Follow her to keep up with this field

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/

New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩‍🔬 www.youtube.com/watch?v=gOta... Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation. Recently published in @natsmb.nature.com

are there any gene regulation/genomics paper/preprint-aggregating accounts on here I should be following?

editorial manager: your manuscript status is none of your business, actually

what postdocs actually want: - to not have their grants canceled - reasonable chances at getting an academic position - job security - a thriving private sector so the entire research system can flourish <3 higher ed institutions in 2025: - best i can do is an origami night