The time to register for this is now! It's a great opportunity for biological / biomedical researchers who want to get better in analysing their own data.

TiG's March issue is live! Huge thanks to Blake Meyers and Ximena Gil for the terrific cover image, which highlights their Review on the similarities between piRNAs in animals and phasiRNAs in plants. The complete TOC is here: www.cell.com/trends/genet...

"Sunflower Genetics and Genomics: From Fundamental Evolutionary Insights to Crop Improvement" by Loren H. Rieseberg & colleagues FREE till April 16th at authors.elsevier.com/a/1mgGacQbJI...

Review on the multifaceted #medaka by the most-prominent leaders in the field 🐟 @wittbrodtlab.bsky.social @ewanbirney.bsky.social

"Medaka: A novel model for analyzing genome-environment interactions" by Kiyoshi Naruse & colleagues "Endemic to habitats spanning from 4 to 40°C and varying salinities, [medaka] combines broad ecological adaptability with experimental tractability." Read more: authors.elsevier.com/sd/article/S...

"Leveraging allelic imbalance in accessible chromatin to prioritize putative causal variants" by Shea Ping Yip, Chien-Ling Huang, & co "By leveraging allelic imbalance in ATAC-seq, researchers can bridge the gap between GWAS signals and molecular mechanisms..." authors.elsevier.com/sd/article/S...

"Alternative splicing and climate-resilient crops" by Ling-Ling Chen, Jia-Ming Song, & colleagues FREE to read till April 9th at authors.elsevier.com/a/1mdxIcQbJI...

"Beyond the 'One Nucleus, One Whole Genome' Rule" by Xin Li, Monika Fischer, & colleagues FREE to read till April 5th at authors.elsevier.com/a/1mcXIcQbJI...

Happy #DarwinDay! 🎉We celebrate Darwin’s insight into evolution by natural selection—a reminder that science education helps us question, explore, & understand the world around us. Honor Darwin’s curiosity & learn fast genetics facts at Discover Genetics: bit.ly/4rqaDwN

"Uncovering layers of mutation in plant stem cells" by Ruqiang Zhang & Michael J. Scanlon This Spotlight highlights recent work by Luca Comai & colleagues in @pnas.org showing layer-specific mutations in plant meristematic tissue. FREE to read till April 3rd at authors.elsevier.com/a/1mbqHcQbJI...

📣 Applications are NOW OPEN for the 2026 Hastings Center Summer Bioethics Program! ✨ Highly competitive program 👥 Only 20 students will be selected 🗓 Application deadline: March 13 🔗 https://bit.ly/4cjw7qc

"Monogenic no more: are all epilepsies polygenic?" by Remi Stevelink & colleagues FREE till April 1st at authors.elsevier.com/a/1mbEocQbJI...

"Evolutionarily conserved regulation and functions of H1 linker histones in development" by Lu Wang & colleagues "Collectively, this overview positions H1 and its master regulator CRAMP1 as important players in chromatin organization..." FREE till March 27th at authors.elsevier.com/a/1mZUI_3rsx...

"Reproductive phasiRNAs are the piRNAs of plants" by María Ximena Anleu Gil & Blake C. Meyers "piRNAs and reproductive phasiRNAs emerged and evolved independently in animals and plants, yet share striking parallels..." Read more: authors.elsevier.com/sd/article/S...

"Salutogenomics: Embracing the full spectrum of human health" www.cell.com/trends/genet... Justin Lund, Melissa Ilardo & colleagues Opinion now published in @cp-trendsgenetics.bsky.social

"Salutogenomics: Embracing the Full Spectrum of Human Health" by Melissa Ilardo, Justin Lund, & colleagues "Research involving marginalized populations often centers on disease, which can pathologize these communities and reinforce harmful stigmas." Read more: authors.elsevier.com/sd/article/S...

"Gene Sharing has Stabilised the Genetic Code" by Peder Worning & Rodrigo Ibarra-Chávez FREE till March 13th at authors.elsevier.com/a/1mURqcQbJF...

"Gene Expression Noise in Development: Genome-wide Dynamics" by Hendrik Marks & colleagues FREE till March 3rd at authors.elsevier.com/a/1mQwocQbJF...

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-... Know of a relevant event that’s missing? Please reply below

Although it went online in 2025, here is our second paper of 2026! 🎉 Bravo to @jiaxuwu.bsky.social for leading this (possibly) controversial, but much-needed, analysis. Enjoy! Now out in the January 2026 issue of Trends in Genetics. 🔗 www.cell.com/trends/genet...

Happy New Year!! 🎉 TiG welcomes 2026 with a new issue! Topics include the ethics of de-extinction, AlphaGenome, DNA-based taxonomies, TEs in cancer, and more: shorturl.at/Zp7zw Thanks to @haraipapilio.bsky.social for the cover image - a female butterfly that may harbor male-killing symbionts!

Dr. Mark Peifer (@peiferlabunc.bsky.social)argues that understanding the history of eugenics is critical for up-and-coming geneticists and should be included in college curriculums. www.cell.com/news-do/pr-e... @cp-trendsgenetics.bsky.social

"The 3D genome during germline development and meiosis" by Yuka Kitamura & Satoshi Namekawa "Distinctive nuclear configurations orchestrate gene expression programs essential for each developmental stage and meiosis..." FREE till Feb 4 at authors.elsevier.com/a/1mHYpcQbJF...

🕊️🧬A Special Issue of Trends in Chemistry in online now! www.cell.com/trends/chemi... Our Dec 2025 issue is joint with @cp-cellrepphyssci.bsky.social on The Chemistry of Nucleic Acids, highlighting the innovations and thought leadership on nucleic acid research in the physical/chemical sciences.

Nice new review on my favorite topic. www.cell.com/trends/ecolo...

delighted to share our review, out today in @cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.

"Beyond the Gene: Decoding Alternative Isoforms" by Kaia Mattioli (@kaiamattioli.bsky.social) & Martha Bulyk "The degree to which alternative isoforms actually contribute to the complexity of the human proteome in their endogenous contexts has been the subject of much debate..." shorturl.at/YbNoB

How to teach genetics: you must address the eugenics. In explaining why traits like "intelligence" cannot be pinned down to a single gene or variant or correlate with any particular ethnic group or skin color, it's a great introduction to the complexity of population genetics.

"Investigative Genetic Genealogy is a Revolutionary Tool for Justice" by David Gurney "IGG is the most significant breakthrough in identifying violent criminals and unidentified human remains since forensic DNA testing in the late 1980s..." FREE till Jan 27th: authors.elsevier.com/a/1mEdIcQbJF...

I taught Genetics again this year. We need to include discussion of the problematic history of our field, especially as the claims of eugenics are once again centered in our political discourse. Last year I wrote this piece, explaining my reasoning and approach 🧪 1/n www.cell.com/trends/genet...

"Autism genetics: perspectives, discourse, and community engagement" by Benjamin E. Life & colleagues "We summarize key points from our discussion series on autism genetics, highlighting diverse perspectives." FREE till Jan 24 with this link: authors.elsevier.com/a/1mDhQcQbJF...

"Features and biomedical relevance of circular RNA biogenesis" by Xiaolin Wang & Ge Shan "Recently, modulation of circRNA biogenesis to generate tissue-specific expression patterns is coming into focus. We summarize various mechanisms involved..." authors.elsevier.com/sd/article/S...

"Lysosomal activation leaves a lasting memory" by Siu Sylvia Lee "In a recent study, Zhang et al show that lysosomal activation induces somatic histone H3.3 production, which moves to the germline and is methylated at K79 to transmit longevity" FREE till Jan 24 authors.elsevier.com/a/1mDhQcQbJF...

A new preprint Spotlight from @genomicspc.bsky.social is live! "AlphaGenome: a Swiss-army knife for exploring non-coding DNA" by Judit García-González & Krzysztof Gogolewski "Deciphering the three billion letters of the human genome has long been biology’s ultimate puzzle..." shorturl.at/qiCIk

"The evolutionary role of mutational robustness: theoretical insights" by Pieter van den Berg & co "Here, we categorize and critically discuss the main approaches for modeling the evolutionary causes and consequences of mutational robustness." FREE till Jan 18: authors.elsevier.com/a/1mBGtcQbJF...

"In silico genome transplants and the cis-regulatory basis of biodiversity" by Hunter Fraser & co "[We] provide a forward-looking perspective on the prospects for ML approaches in studying the cis-regulatory basis of phenotypic diversity." FREE till Jan. 17th: authors.elsevier.com/a/1mA%7ErcQb...

"Extended Phenotypes: A New Generation" by Liyam Chitayat, W. Nate Collison, Sam Edwards, Jay K. Goldberg, Antoine Guiguet, Ryan E. Hulett, Joani W. Viliunas, & Adeline E. Williams authors.elsevier.com/a/1m9xWcQbJF...

Excited to share our new review: The evolutionary role of mutational robustness: theoretical insights, in Trends in Genetics! Our review distils the main theoretical insights into when robustness evolves and how it shapes evolvability. www.sciencedirect.com/science/arti...

How has it already been 2 weeks since our #EREHD25 meeting in Mexico! We are still reminiscing over the great memories and amazing science that was shared. A final big congratulations to our 4 poster prize winners, and a thank you to everyone who joined us 💜

Excited to share our new Trends in Genetics review article on how transcriptional addiction drives genome instability in cancer. We discuss how hypertranscription, super-enhancers, R-loops, and TOP1/TOP2 create promoter- and gene-body DSBs — a true Achilles’ heel of oncogenes.

"Breaking the Script: Transcriptional Addiction as a Driver of Genome Instability in Cancer" by Rami Aqeilan (@ramiaqeilan.bsky.social) & co "Transcriptional reprogramming in cancer leads to frequent DNA breaks at hyperactive oncogenes..." FREE till Jan 9th: authors.elsevier.com/a/1m8ApcQbJF...

"The illusion of clarity in familiar genetics diagrams" by L. Kate Wright & colleagues "Visual representations are indispensable in genetics education; yet, their apparent simplicity can mask deep conceptual challenges for learners." FREE till Jan 6th at authors.elsevier.com/a/1m77ScQbJF...

"Returning Research Results Isn’t Rocket Science" by Sarah LeBaron von Baeyer "Effective return of results depends on cultural context, clear communication, and collaboration with communities." FREE to read till Jan 4th at this link: authors.elsevier.com/a/1m6XtcQbJF...

"Science, Society, and Agricultural Biotechnology in Sub-Saharan Africa" by Michael Okoi Itam & Kate M. Creasey Krainer "Without co-creation, inclusion, and ethical delivery, science fails to take root socially." FREE to read till Jan 4th at this link: authors.elsevier.com/a/1m6XtcQbJF...

"Strategies for studying sex differences in brain aging" http://dlvr.it/TPHP3x @bbparis1984.bsky.social @suhlab-aging.bsky.social @ctmurphy1.bsky.social @denadubal.bsky.social & colleagues @cp-trendsgenetics.bsky.social #SfN2025

SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.

"Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity" by Ting-Fang Wang (@tingfangwang.bsky.social) & Ji-Long Liao (廖吉隆) "We postulate that counter-actions of MMR and HR contribute to the post-zygotic isolation..." authors.elsevier.com/sd/article/S...

"HistENCODE: a proposed project to decipher functional interactions among and between histone PTMs" by A. Gregory Matera FREE till Dec. 24th with this link: authors.elsevier.com/a/1m2gJcQbJF...

Happy to see my illustration featured on the cover!

Meet the minds behind the manuscripts! We are so pleased to welcome Margot Brandt (@natgenet.nature.com), Anne Mirabella (@natcomms.nature.com), Maria Smit (@cp-trendsgenetics.bsky.social) & Jun Yu (Genetics, Proteomics & Bioinformatics) who have joined us for our Editor panel discussion at #EREHD25