Dena Dubal
@denadubal.bsky.social
📤 261
📥 111
📝 16
Neuroscientist, Neurologist, and Aging Researcher at UCSF
pinned post!
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by
@margaretgadek.bsky.social
in Science Advances.
www.science.org/doi/10.1126/...
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Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
https://www.science.org/doi/10.1126/sciadv.ads8169
7 months ago
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48
20
reposted by
Dena Dubal
American Federation for Aging Research (AFAR)
about 2 months ago
The Wall Street Journal recently highlighted AFAR grantees
@denadubal.bsky.social
,
@jennifergarrison.bsky.social
and
@jamienjustice.bsky.social
in a feature on pioneering women advancing aging research. Read the full article here:
www.wsj.com/health/welln...
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3
3
reposted by
Dena Dubal
Bakar Aging Research Institute
3 months ago
📣 We are thrilled to announce
@denadubal.bsky.social
is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of
#aging
,
#resilience
, and
#neurodegenerative_disease
.
#SciSky
#GeroSky
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We celebrated with chocolate, stories and tacos! Congrats Samira
@jusabdulsam.bsky.social
on starting the next chapter of your scientific journey as you set up your own lab at
@templeuniversity.bsky.social
@ucsfhealth.bsky.social
@simonsfoundation.org
4 months ago
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With gratitude for the Pignolo Prize in Aging Research from UPENN
@upenn.bsky.social
. Thanks David Wok, Edward Lee, John Pignolo, Virginia Lee - and others. Wonderful occasion!
5 months ago
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"We have far to go and more to do" - thanks Katherine Bourzac
@bourzac.bsky.social
at
@nature.com
for including me in this thoughtful piece and highlighting our work on the X chromosome. Why women experience
#Alzheimer’s
disease differently from men
www.nature.com/articles/d41...
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Why women experience Alzheimer’s disease differently from men
Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.
https://www.nature.com/articles/d41586-025-01106-y
5 months ago
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Congratulations
@margaretgadek.bsky.social
on a wildly successful PhD! On to the MD!
5 months ago
0
7
1
reposted by
Dena Dubal
Bakar Aging Research Institute
6 months ago
Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by
@denadubal.bsky.social
along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances:
bit.ly/3FlN3hj
#GeroSky
#SciSky
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Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
https://www.science.org/doi/10.1126/sciadv.ads8169
0
3
1
"A little boost went a long way". Increasing an X factor from the silent X improved cognition in aging male and female mice. Privileged to have our discovery reported in
@nytimes.com
, alongside findings from Kaitlin Casaletto and Rachel Buckley
@bucklr01.bsky.social
.
www.nytimes.com/2025/03/05/h...
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Aging Women’s Brain Mysteries Are Tested in Trio of Studies (Gift Article)
Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.
https://www.nytimes.com/2025/03/05/health/women-brains-alzheimers-aging.html?unlocked_article_code=1.2E4.mQ4F.1oDezV9hEzgQ&smid=url-share
7 months ago
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Thanks Katherine Bourzac
@bourzac.bsky.social
for this terrific article in
@nature.com
on our discovery that the "silent X awakens"!
add a skeleton here at some point
7 months ago
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3
1
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by
@margaretgadek.bsky.social
in Science Advances.
www.science.org/doi/10.1126/...
loading . . .
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
https://www.science.org/doi/10.1126/sciadv.ads8169
7 months ago
2
48
20
reposted by
Dena Dubal
Katherine Bourzac
7 months ago
Thanks to
@denadubal.bsky.social
and
@bucklr01.bsky.social
for talking to me for this story about the fascinating X chromosome!
add a skeleton here at some point
3
6
3
reposted by
Dena Dubal
Margaret Gadek
7 months ago
Our new Science Advances paper reveals activation of the silent X chromosome as a mechanism of female resilience in cognitive aging
www.science.org/doi/10.1126/...
Many thanks to
@denadubal.bsky.social
for your mentorship on this project!!
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Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
https://www.science.org/doi/10.1126/sciadv.ads8169
1
9
3
reposted by
Dena Dubal
Bérénice A. Benayoun, PhD
7 months ago
Excited to share our new review article in
@cp-trendsgenetics.bsky.social
together with the labs of
@denadubal.bsky.social
,
@ctmurphy1.bsky.social
and
#YousinSuh
, spearheaded by trainees Victor Ansere, Seung-Soo Kim, Francesca Marino and Katherine Morillo! 🧪🧬🖥️
www.sciencedirect.com/science/arti...
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9
reposted by
Dena Dubal
Emily G. Jacobs
7 months ago
More coverage of
@denadubal.bsky.social
Kaitlin Casaletto,
@bucklr01.bsky.social
et al:
www.nytimes.com/2025/03/05/h...
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Aging Women’s Brain Mysteries Are Tested in Trio of Studies
Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.
https://www.nytimes.com/2025/03/05/health/women-brains-alzheimers-aging.html
0
7
2
Wonderful talking with Mohana Ravindranath
@ravindranize.bsky.social
for her compelling article – Why do Women Live Longer than Men? Input from
@bbparis1984.bsky.social
and others
@nytimes.com
www.nytimes.com/2025/02/25/w...
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https://www.nytimes.com/2025/02/25/well/
[email protected]
7 months ago
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reposted by
Dena Dubal
Simons Foundation
8 months ago
Why do women’s brains age better than men’s? A new Simons Foundation–funded
@nature.com
study from
@denadubal.bsky.social
identifies a key player: the X chromosome. Read more:
www.simonsfoundation.org/2025/02/05/n...
#science
#neuroscience
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New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome
New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome on Simons Foundation
https://www.simonsfoundation.org/2025/02/05/new-research-identifies-a-key-player-in-how-your-brain-ages-the-x-chromosome/
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reposted by
Dena Dubal
American Federation for Aging Research (AFAR)
8 months ago
New research by AFAR Grantee
@denadubal.bsky.social
of
@ucsfhealth.bsky.social
recently published in
@nature.com
on the maternal X chromosome and cognition and brain aging in female mice.
add a skeleton here at some point
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reposted by
Dena Dubal
Bakar Aging Research Institute
8 months ago
👏 Don't miss Samira Abdulai-Saiku's manuscript published in
@nature.com
! Great work coming from
@denadubal.bsky.social
's lab, furthering our understanding of the relationship between the X chromosome and brain aging.
www.nature.com/articles/s41...
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The maternal X chromosome affects cognition and brain ageing in female mice - Nature
The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.
https://www.nature.com/articles/s41586-024-08457-y
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reposted by
Dena Dubal
Waggoner Lab
8 months ago
Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active
@nature.com
@denadubal.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
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reposted by
Dena Dubal
Bérénice A. Benayoun, PhD
8 months ago
Beautiful study from
@denadubal.bsky.social
and
#SamiraAbdulaiSaiku
showing that the parent-of-origin of the active X in mice play a huge role in
#brain
aging!!!! Congrats on this transformative work!
add a skeleton here at some point
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reposted by
Dena Dubal
Sarah CP Williams
8 months ago
Is brain aging mom's fault? When brain cells rely only on X chromosomes inherited from mom, they age more quickly, UCSF researchers led by
@denadubal.bsky.social
reported in
@nature.com
. Reversing the effect could help treat brain diseases or memory loss.
www.ucsf.edu/news/2025/01...
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Could Brain Aging Be Mom’s Fault?
Researchers found that female mice using only maternal X chromosomes showed faster cognitive decline, which could help explain the variation in brain aging between the sexes
https://www.ucsf.edu/news/2025/01/429366/could-brain-aging-be-moms-fault
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The maternal X chromosome impairs cognition and speeds up brain aging. Check out our latest
@nature.com
@ucsfhealth.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
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The maternal X chromosome affects cognition and brain ageing in female mice - Nature
The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.
https://www.nature.com/articles/s41586-024-08457-y
8 months ago
5
39
20
reposted by
Dena Dubal
Bérénice A. Benayoun, PhD
9 months ago
Biological sex is a key modifier of
#aging
phenotypes, including
#Brain
đź§ aging. See this piece out today in
#Neuron
, spearheaded by
@denadubal.bsky.social
, co-authored by
#YousinSuh
,
@ctmurphy1.bsky.social
and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky
#SexDifferences
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Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From
@ctmurphy1.bsky.social
@bbparis1984.bsky.social
Yousin Suh and me in the latest issue of Neuron
www.sciencedirect.com/science/arti...
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Biological sex matters in brain aging
Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …
https://www.sciencedirect.com/science/article/pii/S0896627324008833?dgcid=author
9 months ago
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reposted by
Dena Dubal
Coleen Murphy
9 months ago
Biological sex matters in brain aging- from my colleagues
@denadubal.bsky.social
, Yousin Suh,
@bbparis1984.bsky.social
and me:
www.sciencedirect.com/science/arti...
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Biological sex matters in brain aging
Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …
https://www.sciencedirect.com/science/article/pii/S0896627324008833?dgcid=coauthor
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With gratitude for the lovely visit to
@ucirvine.bsky.social
hosted by the md/phd students. Enjoyed time with
@elizabethhead.bsky.social
, Kim Green, Frank LaFerla, Claudia Kawas, Matthew Blurton-Jones, and Michael Leon. Thanks
@nelliekwang.bsky.social
!
9 months ago
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