New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease | Nature Neuroscience www.nature.com/articles/s41...

In this blog post, I use #RStats to analyze ICE detention data. #Datavisualization shows record numbers of detainees without any criminal records. Further more/bigger ICE facilities are popping up far from the border. Code along and take a look for yourself: jef.works/blog/2025/07... #CodeTutorial

While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

At the myelin-axon interface, axon-glial signaling, paranodal architecture, and β-amyloid aggregation are altered in Alzheimer's disease, implicating myelin-axon disruption in disease progression @jgrutzendler.bsky.social @yifeicai.bsky.social www.nature.com/articles/s41...

Heat shock proteins function as signaling molecules to mediate neuron–glia communication via extracellular vesicles during aging in C. elegans www.nature.com/articles/s41...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity www.nature.com/articles/s41...

Emerging connections between myelin and Alzheimer’s disease www.nature.com/articles/s41...

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions onlinelibrary.wiley.com/doi/10.1111/...

Happy 18th birthday ggplot2! #rstats

We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore! Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠

What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis molecularneurodegeneration.biomedcentral.com/articles/10....

Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease @cp-cellstemcell.bsky.social sciencedirect.com/science/article/pii/S1934590925000992

A Review on #microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration www.nature.com/articles/s41...

"We have far to go and more to do" - thanks Katherine Bourzac @bourzac.bsky.social at @nature.com for including me in this thoughtful piece and highlighting our work on the X chromosome. Why women experience #Alzheimer’s disease differently from men www.nature.com/articles/d41...

New online! Alzheimer disease seen through the lens of sex and gender

For #FluorescenceFriday, tau (cyan) and neurofilament proteins (fire) are shown in these primary hippocampal neurons 🔬 #Neuroscience #Microscopy

The Trump administration’s war on science is slashing funding, shutting down labs, and driving top researchers overseas. The cost? Medical breakthroughs, technological innovation, and America’s future. My latest adamkinzinger.substack.com/p/the-scienc...

Removing the top leadership at NIAID, NIH and other health agencies, including the CDC and FDA, will damage America’s position as a leader in groundbreaking research in disease prevention and treatment. That puts us all at risk. Read our statement: asm.org/Press-Releas...

How I will remember April Fools' Day 2025. Reckless. My heart is out for these dedicated folks at NIH, FDA and CDC www.statnews.com/2025/04/01/h...

NEW: The CDC has been gutted this morning. Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die. from me, @makenakelly.bsky.social, @knibbs.bsky.social:

It’s stunning to me that the New York Times did not put the story on the bloodbath at the NIH, CDC, and FDA on its front page this morning.

Here's another great talk on #FlowSig, a useful tool for inferring pattern-driving intercellular flows from #scRNA-seq and #spatial-transcriptomics data. This talk was given by Axel Almet, postdoc from the Nie lab, whose work was published in Nature Methods. www.nature.com/articles/s41...

A plug for the UC Irvine Genomics Practical Applications and Learning Seminar (GenPALS) YouTube channel- lots of useful gems here for fellow bioinformaticians. It's been awesome getting to organize these talks for the #omics researchers at UCI! www.youtube.com/@ucigenpals4...

Earnest post, but: a thing I like here is it’s okay to have moments of happiness in public without being broadly scolded, and I believe that sustaining this kind of humanity will be very important as we resist fascism. We have to sustain each other. Making joy isn’t denial, it’s how we will survive

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...

Generation of an Inducible Destabilized-Domain Cre Mouse Line to Target Disease Associated Microglia onlinelibrary.wiley.com/doi/full/10....

NIH is rescinding grants focusing on factors related to Alzheimer disease (risk, caregiving, etc) in LGBTQ populations. lgbtqcaregivers.org/rise-registry/. Brilliant scientists and people they care about are being devastated @schiff.senate.gov @altnih4science.bsky.social @jaceflatt.bsky.social

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published. www.cell.com/cell-reports...

White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠 www.nature.com/articles/s41...

New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1... Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏

I feel like I'm going insane every time I see a media story about DOGE that doesn't also mention the fact that the Government Accountability Office exists and performs the exact function that DOGE pretends to, only in a credibly constitutional, non-partisan, and conflict-of-interest-free manner

Exquisite study characterizing morphological differences between plaque-associated microglia and coffin-like microglia and their association with astrocytes in AD 😳 link.springer.com/article/10.1...

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

It's not "Breaking News" now, since it was announced by NIH yesterday. But it is breaking....... washingtonpost.com/health/2025/...

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants. —> Deep budget cuts & program closures coming to a university near you. Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus jneuroinflammation.biomedcentral.com/articles/10....

NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research. Such grants fund the work/salaries of 300k people at more than 2,500 institutions

#APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉

This is so important. Consequences of microglial depletion differ by sex. www.cell.com/cell-reports...