Lymphoid gene expression supports neuroprotective microglia function www.nature.com/articles/s41...

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology www.nature.com/articles/s42...

Evidence for improved DNA repair in long-lived bowhead whale www.nature.com/articles/s41...

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle www.sciencedirect.com/science/arti...

Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders www.cell.com/neuron/fullt...

Thrilled to welcome Chiara Garsia to the lab as a visiting PhD student. With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells. Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch

Artificial intelligence in metabolic research www.nature.com/articles/s42...

A full life cycle biological clock based on routine clinical data and its impact in health and diseases | Nature Medicine www.nature.com/articles/s41...

Alzheimer’s disease causes bone marrow myelopoiesis dysfunction | bioRxiv www.biorxiv.org/content/10.1...

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function www.sciencedirect.com/science/arti...

😮| Label-free robotic mitochondrial biopsy www.science.org/doi/10.1126/...

Are these the happiest PhD students in the world?  Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate? www.nature.com/articles/d41...

Transcriptional regulation of disease-relevant microglial activation programs www.biorxiv.org/content/10.1...

Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice | PLOS Biology journals.plos.org/plosbiology/...

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism. www.nature.com/articles/d41...

Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab journals.sagepub.com/doi/10.1177/...

WHITE MATTER IN FOCUS SYMPOSIUM: EXPLORING THE ROLE OF MYELIN AND OLIGODENDROCYTES IN NEURODEGENERATION neuroscience.cam.ac.uk/event-posts/...

🚨Scientists have identified a rare brain cell that may drive inflammation in progressive multiple sclerosis (MS) 🔎This important discovery could pave the way for more effective therapies 🔗 For more info: bit.ly/48xJvW1 @cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function www.cell.com/neuron/fullt...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics www.nature.com/articles/s42...

Preserving clinical skills in the age of AI assistance www.thelancet.com/journals/lan...

Scientists Identify Cells Driving Inflammation in Multiple Sclerosis www.ibt.cas.cz/en/news/Scie...

MRI-based multi-organ clocks for healthy aging and disease assessment | Nature Medicine www.nature.com/articles/s41...

Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...

Constructing artificial neurons with functional parameters comprehensively matching biological values www.nature.com/articles/s41...

The lipidomic architecture of the mouse brain | bioRxiv www.biorxiv.org/content/10.1...

Mechanisms of cellular fitness and cell competition: Towards an integrated view - ScienceDirect www.sciencedirect.com/science/arti...

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier. CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in www.nature.com/articles/d41...

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell cambridgebrc.nihr.ac.uk/2025/10/10/d...

DARG cells may drive neurodegeneration in progressive MS www.drugtargetreview.com/news/189552/...

The Rogue Cell: Scientists Uncover a Key Driver of Progressive Multiple Sclerosis neuroscience.zeitgeist.university/the-rogue-ce...

www.biorxiv.org/content/10.1... very cool work and a massive effort from Sanju Sinha lab

Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson’s disease: Cell www.cell.com/cell/fulltex...

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD www.embopress.org/doi/full/10....

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell www.eurekalert.org/news-release...

Unusual Brain Cell Type Linked to Progressive MS, Could Point to Therapeutics www.genengnews.com/topics/trans...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

Delighted to see this out in @NeuroCellPress!!! Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS www.cell.com/neuron/fullt...

A deep single cell mass cytometry approach to capture canonical and noncanonical cell cycle states www.nature.com/articles/s41...

Engineered neural stem cell vesicles activating Wnt promote blood–brain barrier repair after cerebral haemorrhage academic.oup.com/brain/advanc...

Data-driven fine-grained region discovery in the mouse brain with transformers www.nature.com/articles/s41...

Aging: the wound that never starts healing | Nature Communications www.nature.com/articles/s41...

As @Cambridge_Uni PI, I am delighted to have contributed to the @MsStat2 trial on simvastatin for secondary progressive MS. It highlights the REAL challenges of running efficacy trials in progressive MS. #ClinicalTrials #ProgressiveMS www.thelancet.com/journals/lan...

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis www.science.org/doi/10.1126/...

Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors www.cell.com/cell-stem-ce...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects: Neuron www.cell.com/neuron/fullt...

A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...

Artificial intelligence in metabolic research | Nature Metabolism www.nature.com/articles/s42...