ISSCR joined more than 160 biomedical and other research organizations to urge U.S. House and Senate appropriators to ensure that essential costs of research continue to be adequately supported by the federal government. Learn more: https://ow.ly/zUAW50X39Ai

@isscr.org award nominations are closing next week! ⌛ Help recognize and celebrate contributions in the fields of stem cell biology and translational medicine. Submit your nomination: https://bit.ly/4gJ5v27

Online now! iPSC-derived hepatic #organoids reveal ICAM-1-IL-1β crosstalk supports hepatocyte proliferation. These organoids can be applied to model liver injury and stellate cell activation in vitro. ow.ly/Z8bu50WZsc6 @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New research highlights need for genetic screening in PSCs & adult stem cells. Cancer-related mutations found in mesenchymal (18%) and neural (41%) #stemcells. ow.ly/QqCv50WZryY @hebrewuniversity.bsky.social @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New #hematopoiesis research maps single-cell dynamics of endothelial-to-hematopoietic transition from iPSCs & integrates it with human embryo datasets to identify ligand-receptor interactions that drive developmental regulation. ow.ly/B1Tu50WZquR @fredhutchprotons.bsky.social @uwiscrm.bsky.social

Checkout the new podcast on VEGF-induced HSC mobilization. Listen here tinyurl.com/f5x5z3cf or wherever you get your favorite podcasts. For all the details, check out their paper tinyurl.com/4c4jn25k. @isscr.org @ucscscience.bsky.social

Optimized signaling pathway-based culture conditions stabilizes canine iPSCs & improves differentiation potential, including differentiation into cardiomyocytes. Valuable resource for future #diseasemodeling cell.com/stem-cell-re... @isscr.org @ucdavisvetmed.bsky.social

New research from @danafarber.bsky.social! Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons providing a better model for investigating human peripheral neuropathies #neuropathy #neuron #glia ow.ly/zv6X50WZpnh @harvardmed.bsky.social @isscr.org

Trophoblast stem cell derivation from naive & primed hPSC enables ELF5 functional analysis; ELF5 is dispensable for maintenance of hPSC-derived TSC-like cells. Provides transcriptional data & a new platform to model the placenta & study gene function. ow.ly/Y3gy50WVg3X @isscr.org

New study profiles the matrisome of skeletal muscle-resident cells and identified quiescent muscle #stemcells as key #ECM producers. Injury shifts muscle stem cells from ECM production to remodeling and motility. ow.ly/2GZB50WVfNt @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

nice to be spotlighted by @isscr.org this month! The ISSCR is a great community for scientists, clinicians, patients, and the public -- check out www.isscr.org to learn more about stem cell initiatives +learning, public syllabi and the new Stem Cell Medicine CME course. www.isscr.org/isscr-news/m...

I am excited to present my latest research at the @isscr.org Seattle International Symposium, taking place in Seattle, USA on 9-10 October 2025. Register to hear my presentation! invt.io/1bxb5l9ty66

We are delighted to announce a new partnership with @isscr.org exploring how to reflect ethical insights in a timeframed international horizon scan. Read the announcement here: bit.ly/468W2vZ

🚀 Looking to jumpstart your career in academia or industry? Join us for the next @isscr.org ECAC Webinar "Unlock Your Career Potential: Strategies for Landing Jobs in Academia or Industry" 🗓️ Dec 2, 2025 🕘 9:00–10:30 EST Free for ISSCR members! Register now! www.isscr.org/upcoming-pro...

The new issue online tinyurl.com/j859f4k8. It's also a special issue on neural stem cells and includes the cover article by @saxenalab.bsky.social on how progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis tinyurl.com/mrxf3ar5. @isscr.org

Join us on November 4th! The winners of our best short talk awards will be telling their research on the @isscr.org stage! Thank you @stemcellreports.bsky.social for co-organizing this webinar!

Study examines heterogeneity in iPSC-derived neurons using single-cell glycome & transcriptome profiling. Identified 4 subpopulations; pseudotime analysis shows NPC subpopulation acquired mesenchymal features & differentiate into mesenchymal cells ow.ly/1MJ450WRpqi @isscr.org

Available now at @stemcellreports.bsky.social: Our #NEIfunded study led by Farhad Farjood, Nathan Boles and Jeffrey Stern reveals the surprising heterogeneity of retinal pigment epithelium cells in the human eye using single cell transcriptomics and proteomics.

New research from @uwiscrm.bsky.social establishes TAOK2 kinase as a regulator of primary cilium length. 16p11.2 deletion and duplication carriers show reciprocal deficits in cilium length. ow.ly/3oMH50WNP5r @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New study identifies N-myristoyltransferase (NMT) as a novel regulator of pluripotency, with distinct roles in mice and humans. #stemcells #epiblast #pluripotency ow.ly/IJYb50WNONG @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Pen-2 maintains glial homeostasis by restraining OPC self-renewal through HES1-ASCL1 axis & suppressing OPC-to-astrocyte transdifferentation through STAT3. New insights into glial abnormalities in Pen-2-linked neurological diseases. ow.ly/EYYv50WNOsC @isscr.org

New research from @neuralstemcells.bsky.social: Single-cell transcriptome and surfaceome profiling reveal diverse retinal pigment epithelium subpopulations with distinct cell surface markers, localization, and functional capabilities. #RPE #AMD ow.ly/H8Yv50WNO97 @isscr.org @cellpress.bsky.social

Shout out re @isscr.org awards nomination deadline SEP 30 2025! Please note the great revision & efforts that have been made to recognize excellence in industry, policy makers, clinical translation etc & from across the globe. Self-nominations are equally welcomed! www.isscr.org/awards

Researchers identify 129 genes enriched in murine NPCs, including 15 genes linked to novel neurological conditions, highlighting NPC molecular mechanisms in brain development and disease. #dentategyrus ow.ly/aIUq50WJMHi @bcmhouston.bsky.social @isscr.org

XPRESSO, a modular anti-silencing transposon vector, enables rapid generation of genetically modified hPSC lines. Expression is robust across cell types w/o colony picking or proprietary equipment. #geneticengineering #optogenetics ow.ly/h6Ou50WJMCo @isscr.org

New research from Roche: New protocol for differentiating brain endothelial cells from iPSCs. In cells homozygous for #ApoE4, researchers show disrupted intracellular trafficking and impaired iron homeostasis. #neuroscience #Alzheimers ow.ly/l20p50WJMeC @isscr.org

Proteomics-based receptor-ligand matching strategy inventories surface receptors on differentiated cells and refines culture conditions. A versatile approach to enhance health and functionality of hIPSC-derived cell types. #proteomics ow.ly/E3Uo50WJM0G @oistedu.bsky.social @isscr.org

Toti, the first multi-omics database for totipotent stem cells, enables in silico exploration of totipotency, provides single-cell transcriptomic analyses of totipotent states, & offers motif- & pathway-based analyses. ow.ly/hgkQ50WJN80 @isscr.org

Dr. Annie Trinh & I just published an article on the importance of challenging reward structures & organizational cultures that promote stem cell hyperbole. The piece draws upon prior work by @caulfieldtim.bsky.social, @aregenberg.bsky.social, @isscr.org, & others. link.springer.com/article/10.1...

New brain #organoid research identifies thymosin beta 4 as a neuroprotective factor that may mitigate altered neurogenesis & #Alzheimers pathology, highlighting a potential for disease intervention. ow.ly/wq9N50WGc3t @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Mouse spermatogonial stem cells stored on the #ISS for 6 mos showed no significant phenotype or functional differences & produced healthy offspring with normal gene expression. A promising resource for germline preservation in space. @isscr.org ow.ly/haQj50WGbTr

Adult hippocampal #neurogenesis and its mechanisms, role in learning & memory, and therapeutic potential. Plus, challenges and future directions for treating #CNS disorders. #stemcells ow.ly/MZnM50WGbR6 @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Implement the ISSCR Standards for Human Stem Cell Use in Research with confidence! We’ve partnered with @isscr.org to create a free, on-demand course to help researchers align with best practices and incorporate ISSCR Standards into their work. 🔗 Read more: bit.ly/4mZqqjx

New research shows role of PML in neural #stemcells. Its loss PML disrupts #autophagy, stress tolerance, and mitochondrial integrity but PPARγ agonist restores mitochondrial dysfunction. Potential target for #neurodegenerative disease. ow.ly/FF4050WBwZt @isscr.org @imbb-forth.bsky.social

📆 Mark your calendars! Thinking about your future after grad school 🎓 or planning a career move 💼? Gain valuable insights & position yourself for success in academia or industry with the next @isscr.org Early Career Advisory Committee webinar! www.isscr.org/upcoming-pro... Don't miss it!

New research from @stanfordmedicine.bsky.social models #glioma initiation using neural stem and progenitor cells purified from primary human brain tissue. Cell-of-origin and specific driver mutations shape the tumor landscape. ow.ly/hMJJ50Wyh5W @isscr.org

New study shows distinct #TET enzyme activities guide neural stem cell fate: 5hmC enables neuronal competence, while 5fC and 5caC are essential for #glial lineage. #neurons #stemcells ow.ly/9UX850WygWT @einsteinmededu.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Hematopoietic #stemcell defects in #Gata2 haploinsufficiency driven by impaired DNA damage response and inflammatory signaling; disrupting self-renewal, differentiation, and genomic stability ow.ly/28kC50WygLf @cardiffuni.bsky.social @isscr.org

New study from @pennmedicine.bsky.social! scRNA-seq of isogenic #iPSC reveal novel individual and cooperative #hematopoietic effects of #trisomy21 and #GATA1. #myelopoiesis #Downsyndrome ow.ly/fpHC50Wrrtm @childrensphila.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

#ISSCR submitted comments on @ema.europa.eu’s concept paper revising the GMP Guidelines specific to ATMPs, supporting efforts to improve clarity and proposing an alternative approach to strengthen guidance for developers. ow.ly/MBjH50Wqyy2

Hear from Stem Cell Reports Associate Editor Martin Pera on the 6️⃣ key tips to make your submission process smooth and efficient 👉 youtu.be/xH5OMEvYw2Y @isscr.org

Recently published: Developmental cues from epicardial cells simultaneously promote cardiomyocyte proliferation and electrochemical maturation #epicardialcells ow.ly/v1LP50WlIC9 @umnpeds.bsky.social @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Progenitor neighborhoods function as transient niches to sustain olfactory #neurogenesis via Notch/Insm1a signaling. #neuralstemcell #organogenesis #developmentalbiology ow.ly/4KJa50WlHVt @uabcdib.bsky.social @isscr.org

New review explores the shared origin of #ependymalcells & #neuralstemcells & the potential interplay among different subventricular zone cell populations. Insights into cell fate decisions will inform the therapeutic potential of ependymal cells ow.ly/v5UF50WlHLu @isscr.org

The latest podcast has dropped. Check out Ngan Huang and Soochi Kim talking about their latest publication in stem cell reports, tinyurl.com/yvm35ec7. Listen here tinyurl.com/2njkbp7k or wherever you get your podcasts. @isscr.org @uclastemcell.bsky.social

We’re delighted to welcome Future Science Prize 2024 winner Hongkui Deng @pku1898.bsky.social to the speaker lineup at the upcoming @CellSymposia #CSStemCells2025. Submit an abstract for a chance to join him in LA in November! http://dlvr.it/TLn6XX

New primary breast #organoid research from @tuftsmedschool.bsky.social published in Stem Cell Reports! DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation. #organogenesis @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social ow.ly/hxl250WlH5o

We have a special episode out for you now, recorded live at #ISSCR2025! Drs. Hongkui Deng and Candice Liew share the story behind their groundbreaking study transplanting CiPSC-derived islets into a patient with #Type1Diabetes. Listen now: bit.ly/4n9c54K

#ISSCR2025 co-chaired by Prof Kathryn Cheah culminated in June with a panel session featuring members of the HK Spinal Muscular Atrophy community, highlighting the transformative power of patient advocacy, clinical expertise & gov't collaboration in improving treatment access.

1/ 🌏🧬 Just back from Hong Kong and still buzzing from #ISSCR2025. I had the chance to present our latest on Cancer Cores – assembloids where tumors are fully surrounded by healthy neural tissue. Great conversations and thoughtful feedback at the poster session. 🧠🧪