Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

New in vitro model provides a highly tractable system to study human pluripotent & early developmental transition. High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans https://ow.ly/hssJ50XMx1s Human Technopole | ISSCR

Human CRX regulates #photoreceptor cell development via bidirectional transcriptional control in retinal #organoids, providing critical insights into the role of human CRX in retinal development and implications for retinal degenerative diseases. https://ow.ly/BRZr50XMwQz ISSCR

Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh

New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR

New #organoid study published in Stem Cell Reports highlights the role of #autophagy in lacrimal glands along with potential therapeutic interventions for dry eye disease. https://ow.ly/9kxK50XMwiT ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30 ISSCR

New airway #clubcell research! Metabolic-immune crosstalk underlying #asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation. https://ow.ly/s5tS50XMvME ISSCR | The Gairdner Foundation | SickKids Foundation

Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from Stem Cells to Disease Modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re... @isscr.org 🧵

Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study. #m6A #X:A_dosage @isscr.org

Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org

New research provides significant insight into the role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages. https://ow.ly/76jn50XHyLs ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

Dr. Harsha Devalla, Stem Cell Reports Early Career Editor , is attending the Assembloids and Complex Cell-Cell Interactions in New York, USA 8-11 December 2025. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Dr. Bruno Di Stefano (Bruno Di Stefano) Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!

Hypoxic stress is an early pathogenic event in VCP-mutant #ALS astrocytes. Aberrant HIF-1ɑ activation drives astrocytic dysfunct. & compromises neuronal support, highlighting therapeutic potential in targeting HIF-1ɑ signaling https://ow.ly/QJh850XC6is The Francis Crick Institute | ISSCR

New research from MRC Laboratory of Molecular Biology and Cambridge Stem Cell Institute adjusts PSC culture for neural organoid generation competency based on proteomic data & published literature. Read the full paper: https://ow.ly/bP6C50XC5U6 ISSCR

Variants in the SHANK2 gene, linked to neurodevelopmental disorders like autism, were modeled using human iPSC-derived neurons & multielectrode arrays. Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism https://ow.ly/LthV50Xve9r University of Toronto | ISSCR

In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34

New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I ISSCR

New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V ISSCR | The Gairdner Foundation | SickKids Foundation

New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s University of Sydney (USYD) | ISSCR

Hi All, @stemcellreports.bsky.social, is the official meeting journal of #ISSCR2026. It communicates basic discoveries in stem cell research, plus translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbk6l8kbi

Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!

Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y ISSCR | The Gairdner Foundation | SickKids Foundation

Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!

New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay

New paper from Center for iPS Cell Research and Application (CiRA)! Aging reduces KAT7/HBO1 activity, impairing immortalized megakaryocyte progenitor cell line (imMKCL)-based platelet production by promoting immune-like properties via the cGAS-STING pathway. #cellcycle https://ow.ly/J80850XrNh1

Totally psyched that our paper is out in @stemcellreports.bsky.social! For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue? We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head. Spoiler: the chip wins. 🧵&🔗👇

Online now! #Autophagy is dispensable in germline stem cells but is required in the cap cells for maintaining the #Drosophila ovarian niche. Atg5-mediated autophagy preserves cap cell viability and BMP signaling during #aging. https://ow.ly/Zhum50XrN46 ISSCR

New research from UT Southwestern Medical Center: Analysis of 1,996,260 sequenced cells across benchmarking datasets reveals shared regulatory networks linking disease-associated enhancers and genes with downstream targets during cardiomyocyte differentiation. https://ow.ly/czPo50XrMAL ISSCR

Hear from Stem Cell Reports Associate Editor Martin Pera, PhD, as he shares expert guidance on preparing and submitting your manuscript. ISSCR 👉 https://youtu.be/xH5OMEvYw2Y

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbe646iod

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbzaorikl

@stemcellreports.bsky.social, Stem Cell Reports, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research & clinical research. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbaici36t @isscr.org

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbvzmjckk

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbdpyyw3k

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxb9jxi7fs

Online now! First derivation of nuclear transfer embryonic stem cells (ntESCs) from cloned blastocysts generated by somatic cell nuclear transfer in the #marmoset; ntESCs show normal karyotypes & #pluripotency. https://ow.ly/Xkus50XrM7Z ISSCR | The Gairdner Foundation | SickKids Foundation

New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2 ISSCR | The Gairdner Foundation | SickKids Foundation

Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF ISSCR

A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq ISSCR

Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz ISSCR

New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR ISSCR | The Gairdner Foundation | SickKids Foundation

Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!

Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY Sanford Burnham Prebys | ISSCR

Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation

New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!