New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2 ISSCR | The Gairdner Foundation | SickKids Foundation

Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF ISSCR

A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq ISSCR

Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz ISSCR

New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR ISSCR | The Gairdner Foundation | SickKids Foundation

Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!

Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY Sanford Burnham Prebys | ISSCR

Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation

New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Meet our Early Career Editor at #CANCOR2025! Amy Wong is attending the Canadian Conference for Organoid Research in Ontario, Canada, 5-6 November 2025. Connect with Dr. Wong to discuss whether your research is a fit for publishing in Stem Cell Reports!

New from Mayo Clinic: Differentiation of stem cell-derived pancreatic β-cells induces #circadian clock genes, and transplanted SCβ-cells exhibit circadian rhythms in #insulin secretion & optimize insulin secretion to host’s circadian phase https://ow.ly/XMmg50XkARN ISSCR

#Hypoxia dynamically alters oligodendrocyte precursor cell (OPC)phenotypes post-stroke; “oxygen tone” as a key regulator of OPC dynamic adaptation after stroke, offering a promising strategy for stroke #celltherapy. https://ow.ly/6k0m50XkAyR ISSCR | SickKids Foundation | The Gairdner Foundation

Advance your research and career by joining the ISSCR member! Connect with a global stem cell network through webinars, International Symposia, the Annual Meeting, networking events, and our Society journal, Stem Cell Reports Discover the benefits 👉 www.isscr.org/membership

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Early Career Editor Nika Shakiba is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Associate Editor April Pyle (@aprilpyle.bsky.social) is attending the Gene and Cell-Based Therapies: Progress in Clinical Translation meeting today in California, USA. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Online now! Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis #intercellularcommunication #spermatogonia https://ow.ly/J0FZ50XhMg3 ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New mapping review of the philosophical and ethical issues associated with developing and using human #organ-on-chip models. #organoids #personalizedmedicine #digitaltwins #stemcells https://ow.ly/Eqex50XkA1m ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

New research from Boston Children’s Hospital! Dual reporter mESC line created to study joint lineage cell differentiation & the roles of TGF-β, Wnt, & MAPK signaling pathways in joint lineage specification in vitro & ex vivo https://ow.ly/bo4j50XhLUS ISSCR

Scientists from Roche Innovation Center recently joined The Stem Cell Report podcast to discuss insights from their new model of the blood-brain barrier. Listen to the full episode 👉https://ow.ly/lkRi50Xh6PV ISSCR

The LINC01612-DVL2-WNT regulatory axis promotes human endoderm differentiation – a key modulator of human definitive endoderm differentiation. #longnoncodingRNA #DVL2 #WNT #endoderm https://ow.ly/zvgJ50XhLB8 ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Online now! First comprehensive database of potential cell-cell interactions in liver cell homeostasis & regeneration. Authors identified & validated 2 previously unknown signaling interactions involved in acceleration & delaying liver regeneration https://ow.ly/8ZfM50XhLnj ISSCR

Stem Cell Reports is an open-access journal communicating the latest in basic, translational, and clinical stem cell research. Explore recent papers and discover the scope of discoveries we publish. 👉 https://bit.ly/47WgkeW

Early Career Editor Pengyi Yang is attending the upcoming Australasian Society for Stem Cell Research (ASSCR) Conference 2025 in Gold Coast, Australia. Connect with him there to discuss whether your research is a fit for publishing in Stem Cell Reports!

New study maps transcriptomic differences between in vitro skeletal muscle models & in vivo muscle, highlighting targetable processes to improve the models while paving the way for similar studies on other cell types. https://ow.ly/nCXq50XhL0L ISSCR | The Gairdner Foundation | SickKids Foundation

Early Career Editor Kai Kretzschmar is presenting at the German Society for Cell Biology Conference today in Heidelberg, Germany. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!

#Organoid research from University of Michigan Kellogg Eye Center: Multi-omics establishes METTL3-dependent m6A as a critical epitranscriptomic layer in retinal development, unveiling a genomic paradigm in which chromatin accessibility diverges from transcriptional output https://ow.ly/UrHl50XhKGr

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the upcoming CANCOR 2025: Canadian Conference for Organoid Research in Ontario, Canada. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

New #hematopoiesis research from UW–Madison: GABA produced by multiple bone marrow cell types regulate hematopoietic stem and progenitor cells. #microenvironment #bonemarrow #Bcells https://ow.ly/kSws50XeaPF ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...

Online now! EGFR, JNK & ROS signaling mediate bidirectional feedback between cyst cells and encapsulated germ cells in Drosophila testis. #germline #polarity #endocytosis #cellcommunication ow.ly/cK0o50Xeakc @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social @cellpress.bsky.social

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the North American Cystic Fibrosis Conference in Seattle, USA today! Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

Early Career Editor Nika Shakiba is attending the upcoming Till & McCulloch Meeting in Ottawa, Canada on 3-5 November. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

The Francis Crick Institute isogenic hiPSC lines provide a resource for exploring sex chromosome effects on development and disease in vitro. #diseasemodeling #sexualdimorphism https://ow.ly/UoqG50Xea4W ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the Till & McCulloch Meeting in Ottawa, Canada in two weeks. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

New #organoid research establishes human #adrenocortical organoid cultures that respond to ACT & angiotensin II, produce #cortisol, & secrete glucocorticoids in response to physiological stimuli. Platform to study adrenal homeostasis and disease https://ow.ly/JUkF50Xe8Os ISSCR

Associate editor April Pyle is attending the upcoming Gene and Cell-Based Therapies: Progress in Clinical Translation meeting in California, USA on 2-4 November. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

Become an ISSCR member for 2026 & get member benefits for the rest of 2025 at no additional cost! Learn from our international community through curated webinars, symposia, our Annual Meeting, and our journal, Stem Cell Reports. Join today 👉 www.isscr.org/membership

New in @stemcellreports.bsky.social: our study led by @srmarcon.bsky.social w/ @caulfieldtim.bsky.social looks at how “stem cell” supplements are sold on Amazon and whether the marketing aligns with U.S. & Canadian regulations. Conclusion: Amazon can do better to not enable bunk. cc @uottawa.ca

mTORC2-mediated cell-cell interactions promote BMP4-induced #WNT activation and #mesoderm differentiation in hESCs. Critical link between intracellular adhesion and the activation of canonical WNT genes. https://ow.ly/2mkF50Xe7GG ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

Early Career Editor Kai Kretzschmar is presenting at the German Society for Cell Biology Conference later this month in Heidelberg, Germany. Connect with him there to discuss whether your research is a fit for publishing in Stem Cell Reports!

Researchers find the marketing of “stem cell” supplements on Amazon often misalign with US & Canada regulations. With deceptive claims and rising risks, new regulation strategies are needed to ensure transparency and protect consumers. https://ow.ly/qelx50XaxjN ISSCR

New #salivarygland research! Human iPSC-derived salivary gland cell sheets integrate with injured glands to form glandular structures; a promising strategy for functional salivary gland regeneration. https://ow.ly/NfvL50X9sGR ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

tRF-23 promotes osteogenic differentiation of hBMSCs & protects against bone loss in ovariectomized mice, providing a foundation for characterizing the pathogenesis of osteoporosis & seeking new therapeutic targets. https://ow.ly/ApFk50X5TMC ISSCR | The Gairdner Foundation | SickKids Foundation

I will be at #NACFC25! Let’s connect and discuss how your research may be a good fit for the Stem Cell Reports journal!

New #organoid research from Michigan Medicine uses a whole-transcriptomic approach to find that retinoic acid signaling guides the efficiency of inner ear organoid-genesis & governs sensory-nonsensory fate specification https://ow.ly/MtWn50X5TI8 ISSCR | The Gairdner Foundation | SickKids Foundation

Early Career Editor Amy Wong (Amy Wong 🇨🇦) is presenting at the upcoming North American Cystic Fibrosis Conference in Seattle, USA later this month. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!

RNA-seq study maps iPSC-derived motor neurons with C9orf72, FUS, TARDBP or SOD1 mutations. Reveals early synaptic dysfunction & RBP dysregulation in ALS gene mutations. A key resource for #ALS pathogenesis. https://ow.ly/tAnL50X5ToH ISSCR | The Gairdner Foundation | SickKids Foundation

New study finds a miRNA-TF-mRNA regulatory network associated with cellular #senescence in #osteoporosis (OP). miR-22-3p-ESR1 axis drives OP development, offering a promising mechanistic foundation for future therapeutic strategies https://ow.ly/qEJ750X5Tah ISSCR