New research from Leiden University Medical Center! A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells, and highlights how AI can scale assessment of drug-induced cardiotoxicity. https://ow.ly/Z2R450Yeymp

New research in Stem Cell Reports shows that the timing of embryonic stem cell differentiation is not directly determined by the cell cycle. https://ow.ly/uKyg50Yeygy ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Improving rigor in stem cell research: New study in Stem Cell Reports highlights gaps in reporting and shows how implementing ISSCR standards can strengthen reproducibility in human stem cell studies. https://ow.ly/7PiO50Yey7Y Cell Press | The Gairdner Foundation | SickKids Foundation

In the new Stem Cell Report podcast episode, guests discuss new approaches to improving the derivation & characterization of human sensory neurons through the development of a genetic toolkit to fluorescently label specific sensory neuron subtypes. https://ow.ly/G6Fx50YcyVO

Thrilled to see our latest work featured on the cover of Stem Cell Reports: www.cell.com/stem-cell-re... !

And thanks to Stem Cell Reports @stemcellreports.bsky.social and the ISSCR @isscr.org for highlighting our work!

Online now from University of New South Wales! In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia, informing future studies in delivering a more reliable standard therapy to improve clinical outcomes. https://ow.ly/lWWV50Yaerm

#STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism, providing insights into how its loss-of-function can contribute to increased type 2 #diabetes risk. https://ow.ly/ku9z50YexWR ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study shares an improved strategy to generate porcine induced pluripotent stem cells (piPSCs) with key features including flat morphology with feeder-free culture, #teratoma and #blastoid formation, and efficient CRISP-Cas9 editing. https://ow.ly/PpVM50Yaeeh

Serve the stem cell and regenerative medicine community by participating in the editorial review process as a Stem Cell Reports Early Career Editor. Applications are due 13 March. Learn more and apply: https://ow.ly/W09t50XWbgu ISSCR | Mingxia Gu

Online now in Stem Cell Reports! Erythropoietin exposure disrupts B cell development and drives the emergence of myeloid-biased biphenotypic progenitors #lymphopoiesis #hematopoiesis #myelopoiesis https://ow.ly/Po5Q50YacSq ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study from Washington University in St. Louis is live in Stem Cell Reports: Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem cell lineage commitment. https://ow.ly/rxyU50YacMj ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study analyzes 532 RNA-seq datasets to map promoter activity in #hematopoiesis, providing insights into promoter-mediated regulation and a foundation for targeting promoter-specific mechanisms in disease. ISSCR https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(26)00002-0

Ludovic Vallier (Vallier Lab), Stem Cell Reports Associate Editor, is attending the 4th Dubai Stem Cell Congress in Dubai today! Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!

DHX9 sustains hematopoietic stem cell (HSC) function in cooperation with H3 acetylation, highlighting DHX9 as a crucial factor linking epigenetic modifications with transcriptional programs in HSC biology. https://ow.ly/AqbS50YacBH ISSCR | The Gairdner Foundation | SickKids Foundation

Learn why Stem Cell Reports Early Career Editor Harsha Devalla values serving on the early career editorial team, and consider submitting an application to join! Applications are due 13 March. https://www.isscr.org/stem-cell-reports/#eceb ISSCR

I am delighted to share that I have been appointed as Early Career Editor for @stemcellreports.bsky.social, the official journal of the International Society for Stem Cell Research @isscr.org! 🔬🌍 I look forward to seeing your research in the field of stem cells! Submit here: invt.io/1bxb9kpdtfj 👍

New research published in Stem Cell Reports! Histone methyltransferase Setd8 safeguards mouse retinal progenitor cell (RPC) identity by maintaining RPC-specific chromatin accessibility, thereby ensuring proper retinal development. https://ow.ly/Iql150Y6jaV ISSCR

Expand your network and understanding of the editorial review process by serving as an Early Career Editor for ISSCR's open access, peer reviewed journal, Stem Cell Reports. Applications are due 13 March. https://ow.ly/xSe050XWaC6 Bruno Di Stefano

Online now in Stem Cell Reports! Human neuronal networks on micro-electrode arrays as a tool to assess genotype-phenotype correlation in CACNA1A-related disorders. https://ow.ly/ZIxE50Y1mut Cell Press | The Gairdner Foundation | SickKids Foundation | ISSCR

New study from King's College London: Generation and characterization of iPSC models from HIV-1-positive individuals with divergent clinical outcomes. Resource supports lentiviral vector transduction and replicating HIV-1 studies https://ow.ly/s81Z50Y1m16 ISSCR | Cell Press

Ludovic Vallier, (Vallier Lab) Stem Cell Reports Associate Editor, is attending Biotherapy Days 2026 in Toulouse, France starting today! Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!

Online now in Stem Cell Reports! Charting the translational pathway: ISSCR Best Practices for PSC-derived therapies. A comprehensive global framework guiding academia and industry through the translational pipeline and key decision points. https://ow.ly/orgU50Y1mle ISSCR | Cell Press

Aging-associated changes in the composition of the microbiota result in reduced canonical Wnt signaling through Ascl2 in intestinal stem cells (ISC), which causes a decline in the regenerative potential of aged ISCs in vivo. https://ow.ly/Mh3x50Y1mc0 ISSCR | Cell Press

New #organoid research: Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids https://ow.ly/b0H650Y1lRz Cell Press | The Gairdner Foundation | SickKids Foundation | Universität Bayreuth

Meet Associate Editor Ludovic Vallier at the 4th Dubai Stem Cell Congress, February 7-8 2026. Connect with Dr. Vallier to discuss whether your research is a fit for publishing in Stem Cell Reports!

Aspartoacylase human iPSC-derived neural progenitor cells transplantation can effectively reverse established Canavan disease pathology, suggesting therapeutic potential for treating symptomatic patients https://ow.ly/2aAO50Y1lH1 The Gairdner Foundation | SickKids Foundation

Stem Cell Reports Early Career Editor Amy Wong 🇨🇦 shares how serving as an Early Career Editor for ISSCR's society journal has impacted her career. Applications are open now through 13 March to serve on the Stem Cell Reports Early Career Editorial team. Learn more: https://ow.ly/6L9850XWajH

Meet Early Career Editor Harsha Devalla at the New Cardiology: Engineering, Vascular, and Molecular Insights meeting in Heidelberg, Germany in February. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!

New #xenotransplation research from KU Leuven: Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts. https://ow.ly/tFqn50XSA6e ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New #organoid research! Differential synaptic signaling responses in human cortical organoids after photon & proton irradiation. Findings underscore distinct biological effects of spread-out Bragg peak protons & their potential impact on the developing brain. https://ow.ly/hGFW50XVBE5 ISSCR

Improvements to iPSC-based somatosensory disease models by generating and validating a genetic toolset to fluorescently label all or distinct (nociceptor, low threshold mechanoreceptor, and proprioceptor) somatosensory subtypes. https://ow.ly/bp0j50XSAgZ

Ludovic Vallier, Stem Cell Reports Associate Editor, is attending Biotherapy Days 2026 in Toulouse, France 28-30 January 2026. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!

Stem Cell Reports is calling for applications to serve on its editorial team as an Early Career Editor, a prestigious opportunity for outstanding, early-career scientists to help shape the future of stem cell publishing. The deadline to apply is 13 March 2026. https://ow.ly/8iiP50XWscj

New #cardiomyocyte research maps temporal alternative splicing regulation during cardiac regulation and uncovers altered splicing events in iPSC-cardiomyocytes, providing insights into the limitations of these models in cardiovascular research. https://ow.ly/kr4550XSzCS

New research from National Institute of Environmental Health Sciences: Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs https://ow.ly/FNNw50XSznN ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New research from UC Berkeley and NIH! Evidence for a latent activated stem cell state in which a subset of quiescent olfactory epithelial stem cells are epigenetically primed to support injury-induced regeneration. https://ow.ly/fkpG50XVBmo The Gairdner Foundation | SickKids Foundation | ISSCR

Comparative lipidomics show that iPSC-derived microglia differentiation methods have a major impact on microglial lipidomes & warrant attention when studying #Alzheimers and neuroinflammatory processes involving lipids. https://ow.ly/aesW50XVB4Y The Gairdner Foundation | SickKids Foundation | ISSCR

Chaperonin proteins CCT5 and CCT7 epigenetically restrict the transition from pluripotency to totipotency in embryonic stem cells, underlining the role of CCT5 and CCT7 in maintaining telomere integrity and regulating pluripotent state dynamics. https://ow.ly/13K950XSzcb

Transitioning from human primordial germ cells to embryonic germ cells. New research applies multi-omic profiling to resolve their pluripotent & epigenetic dynamics, providing new insights into potential mechanisms underlying human germ cell tumorigenesis. https://ow.ly/XhAs50XSz3Y

Hsp70-Bim as a potential therapeutic target for chronic myeloid leukemia (CML) stem cells. Inhibition of Hsp70-Bim blocks mitophagy, leading to differentiation of leukemic stem cells (LSC) and loss of quiescence & LSC self-renewal potential. https://ow.ly/ZHUU50XSyQL

Elevated Spy1 drives sustained expansion of neural stem cells, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation. #neuralstemcells #braindevelopment https://ow.ly/c7AR50XSyaf ISSCR | The Gairdner Foundation | SickKids Foundation

New research using ex vivo vibrissae explant and skin #organoids identifies IGF1R as a potential regulator of Merkel cell formation, which likely exerts its effects through the AKT pathway #skinorganoid https://ow.ly/zsgS50XS7sg ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

New review on hematopoietic #organoids summarizes recent progress in HO construction, explores their potential applications, & discusses opportunities & challenges in modeling human hematopoiesis & diseases in vitro. https://ow.ly/Ku0z50XS7fX ISSCR | The Gairdner Foundation | SickKids Foundation

Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from stem cells to diseases modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!

Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

New in vitro model provides a highly tractable system to study human pluripotent & early developmental transition. High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans https://ow.ly/hssJ50XMx1s Human Technopole | ISSCR

Human CRX regulates #photoreceptor cell development via bidirectional transcriptional control in retinal #organoids, providing critical insights into the role of human CRX in retinal development and implications for retinal degenerative diseases. https://ow.ly/BRZr50XMwQz ISSCR

Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh

New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR