Online now! iPSC-derived hepatic #organoids reveal ICAM-1-IL-1β crosstalk supports hepatocyte proliferation. These organoids can be applied to model liver injury and stellate cell activation in vitro. ow.ly/Z8bu50WZsc6 @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Excited to present at the CSHL Cell Fate Conversions 2025 meeting! Connect with me there to discuss whether your research is a fit for publishing in @stemcellreports.bsky.social. invt.io/1bxba296yhc #cshldirect

New research highlights need for genetic screening in PSCs & adult stem cells. Cancer-related mutations found in mesenchymal (18%) and neural (41%) #stemcells. ow.ly/QqCv50WZryY @hebrewuniversity.bsky.social @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New #hematopoiesis research maps single-cell dynamics of endothelial-to-hematopoietic transition from iPSCs & integrates it with human embryo datasets to identify ligand-receptor interactions that drive developmental regulation. ow.ly/B1Tu50WZquR @fredhutchprotons.bsky.social @uwiscrm.bsky.social

Checkout the new podcast on VEGF-induced HSC mobilization. Listen here tinyurl.com/f5x5z3cf or wherever you get your favorite podcasts. For all the details, check out their paper tinyurl.com/4c4jn25k. @isscr.org @ucscscience.bsky.social

Optimized signaling pathway-based culture conditions stabilizes canine iPSCs & improves differentiation potential, including differentiation into cardiomyocytes. Valuable resource for future #diseasemodeling cell.com/stem-cell-re... @isscr.org @ucdavisvetmed.bsky.social

New research from @danafarber.bsky.social! Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons providing a better model for investigating human peripheral neuropathies #neuropathy #neuron #glia ow.ly/zv6X50WZpnh @harvardmed.bsky.social @isscr.org

Our review on in vivo optical imaging of adult neurogenesis in mice is now out. :) @stemcellreports.bsky.social www.cell.com/stem-cell-re...

Trophoblast stem cell derivation from naive & primed hPSC enables ELF5 functional analysis; ELF5 is dispensable for maintenance of hPSC-derived TSC-like cells. Provides transcriptional data & a new platform to model the placenta & study gene function. ow.ly/Y3gy50WVg3X @isscr.org

New study profiles the matrisome of skeletal muscle-resident cells and identified quiescent muscle #stemcells as key #ECM producers. Injury shifts muscle stem cells from ECM production to remodeling and motility. ow.ly/2GZB50WVfNt @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

The new issue online tinyurl.com/j859f4k8. It's also a special issue on neural stem cells and includes the cover article by @saxenalab.bsky.social on how progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis tinyurl.com/mrxf3ar5. @isscr.org

Thank you @stemcellreports.bsky.social for featuring our work on the Neural Stem Cells Special Issue cover! www.cell.com/stem-cell-re... Kudos to lead author Sriivatsan G. Rajan for designing the image. Check out the wide array of interesting papers in this packed issue: www.cell.com/stem-cell-re...

Join us on November 4th! The winners of our best short talk awards will be telling their research on the @isscr.org stage! Thank you @stemcellreports.bsky.social for co-organizing this webinar!

Study examines heterogeneity in iPSC-derived neurons using single-cell glycome & transcriptome profiling. Identified 4 subpopulations; pseudotime analysis shows NPC subpopulation acquired mesenchymal features & differentiate into mesenchymal cells ow.ly/1MJ450WRpqi @isscr.org

Early bird rates for the Cell Symposium: Gene and cell-based therapies are here! Register before Sept. 5 to secure your seat at this hotly anticipated event in LA #CSStemCells2025 👉 http://dlvr.it/TMh75g

Available now at @stemcellreports.bsky.social: Our #NEIfunded study led by Farhad Farjood, Nathan Boles and Jeffrey Stern reveals the surprising heterogeneity of retinal pigment epithelium cells in the human eye using single cell transcriptomics and proteomics.

Anti-inflammatory protein thymosin β4 identified in organoids as an Alzheimer's therapeutic target 📷 Peng-Ming Zeng et al Shanghai Tech University in @stemcellreports.bsky.social ➡️ bpod.org.uk/archive/2025/9/4 with @rooph.bsky.social

New research from @uwiscrm.bsky.social establishes TAOK2 kinase as a regulator of primary cilium length. 16p11.2 deletion and duplication carriers show reciprocal deficits in cilium length. ow.ly/3oMH50WNP5r @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New study identifies N-myristoyltransferase (NMT) as a novel regulator of pluripotency, with distinct roles in mice and humans. #stemcells #epiblast #pluripotency ow.ly/IJYb50WNONG @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Pen-2 maintains glial homeostasis by restraining OPC self-renewal through HES1-ASCL1 axis & suppressing OPC-to-astrocyte transdifferentation through STAT3. New insights into glial abnormalities in Pen-2-linked neurological diseases. ow.ly/EYYv50WNOsC @isscr.org

New research from @neuralstemcells.bsky.social: Single-cell transcriptome and surfaceome profiling reveal diverse retinal pigment epithelium subpopulations with distinct cell surface markers, localization, and functional capabilities. #RPE #AMD ow.ly/H8Yv50WNO97 @isscr.org @cellpress.bsky.social

Neural progenitor cells have been elusive – now researchers have found a way to ID them #NewAdultNeurons. M. Savatic, G. Cappuccio, W. Choi, F. Semerci, Z. Liu et al @bcmhouston.bsky.social #DuncanNRI @stemcellreports.bsky.social #TexasChildrensHospital blogs.bcm.edu/2025/08/28/f...

Researchers identify 129 genes enriched in murine NPCs, including 15 genes linked to novel neurological conditions, highlighting NPC molecular mechanisms in brain development and disease. #dentategyrus ow.ly/aIUq50WJMHi @bcmhouston.bsky.social @isscr.org

XPRESSO, a modular anti-silencing transposon vector, enables rapid generation of genetically modified hPSC lines. Expression is robust across cell types w/o colony picking or proprietary equipment. #geneticengineering #optogenetics ow.ly/h6Ou50WJMCo @isscr.org

New research from Roche: New protocol for differentiating brain endothelial cells from iPSCs. In cells homozygous for #ApoE4, researchers show disrupted intracellular trafficking and impaired iron homeostasis. #neuroscience #Alzheimers ow.ly/l20p50WJMeC @isscr.org

Proteomics-based receptor-ligand matching strategy inventories surface receptors on differentiated cells and refines culture conditions. A versatile approach to enhance health and functionality of hIPSC-derived cell types. #proteomics ow.ly/E3Uo50WJM0G @oistedu.bsky.social @isscr.org

The cells giving rise to new #neurons in the adult #brain have been elusive. M Maletic-Savatic, G. Cappuccio, W. Choi, F. Semerci, Z. Liu et al found a way to ID them. @bcmhouston.bsky.social #DuncanNRI @stemcellreports.bsky.social #TexasChildrensHospital www.bcm.edu/news/computa...

Toti, the first multi-omics database for totipotent stem cells, enables in silico exploration of totipotency, provides single-cell transcriptomic analyses of totipotent states, & offers motif- & pathway-based analyses. ow.ly/hgkQ50WJN80 @isscr.org

New brain #organoid research identifies thymosin beta 4 as a neuroprotective factor that may mitigate altered neurogenesis & #Alzheimers pathology, highlighting a potential for disease intervention. ow.ly/wq9N50WGc3t @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Mouse spermatogonial stem cells stored on the #ISS for 6 mos showed no significant phenotype or functional differences & produced healthy offspring with normal gene expression. A promising resource for germline preservation in space. @isscr.org ow.ly/haQj50WGbTr

IMBB scientists Sirago Spano and Niki Kretsovali in their latest publication @stemcellreports.bsky.social show how the #tumour #suppressor Promyelocytic Leukemia Protein(PML) is crucial for #stem cell differentiation, #stress tolerance and #mitochondrial integrity.

Adult hippocampal #neurogenesis and its mechanisms, role in learning & memory, and therapeutic potential. Plus, challenges and future directions for treating #CNS disorders. #stemcells ow.ly/MZnM50WGbR6 @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

ft. Peter Gearhart (@PennOBGYN), @debsfrench (@pennpathlabmed.bsky.social), Kaoru Takasaki, @menjewafula, Jian Fan, Ying Sit, Sara Kumar, David Smith, Alyssa Gagne, Christopher Thom & Stella Chou (@chopresearch.bsky.social) @stemcellreports.bsky.social www.cell.com/stem-cell-re...

New research shows role of PML in neural #stemcells. Its loss PML disrupts #autophagy, stress tolerance, and mitochondrial integrity but PPARγ agonist restores mitochondrial dysfunction. Potential target for #neurodegenerative disease. ow.ly/FF4050WBwZt @isscr.org @imbb-forth.bsky.social

New research from @stanfordmedicine.bsky.social models #glioma initiation using neural stem and progenitor cells purified from primary human brain tissue. Cell-of-origin and specific driver mutations shape the tumor landscape. ow.ly/hMJJ50Wyh5W @isscr.org

Our new study, “Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells,” is online now at @stemcellreports.bsky.social ! Spearheaded by our talented undergrad @danielgao970.bsky.social. A thread on the study: 1/

New study shows distinct #TET enzyme activities guide neural stem cell fate: 5hmC enables neuronal competence, while 5fC and 5caC are essential for #glial lineage. #neurons #stemcells ow.ly/9UX850WygWT @einsteinmededu.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Hematopoietic #stemcell defects in #Gata2 haploinsufficiency driven by impaired DNA damage response and inflammatory signaling; disrupting self-renewal, differentiation, and genomic stability ow.ly/28kC50WygLf @cardiffuni.bsky.social @isscr.org

Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida. www.cell.com/stem-cell-re... @spacex.extwitter.link @stemcellreports.bsky.social @adventhealth.bsky.social

New study from @pennmedicine.bsky.social! scRNA-seq of isogenic #iPSC reveal novel individual and cooperative #hematopoietic effects of #trisomy21 and #GATA1. #myelopoiesis #Downsyndrome ow.ly/fpHC50Wrrtm @childrensphila.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Organoid photo and inspiration for the Cover of @stemcellreports.bsky.social July issue - many thanks to the team that made APOE4's starry night the cover! 🟢 Tuj1 (beta III tubulin for neurons, 🔵 DAPI for DNA 🔴 My favorite protein, APOE

Hear from Stem Cell Reports Associate Editor Martin Pera on the 6️⃣ key tips to make your submission process smooth and efficient 👉 youtu.be/xH5OMEvYw2Y @isscr.org

Recently published: Developmental cues from epicardial cells simultaneously promote cardiomyocyte proliferation and electrochemical maturation #epicardialcells ow.ly/v1LP50WlIC9 @umnpeds.bsky.social @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Progenitor neighborhoods function as transient niches to sustain olfactory #neurogenesis via Notch/Insm1a signaling. #neuralstemcell #organogenesis #developmentalbiology ow.ly/4KJa50WlHVt @uabcdib.bsky.social @isscr.org

New review explores the shared origin of #ependymalcells & #neuralstemcells & the potential interplay among different subventricular zone cell populations. Insights into cell fate decisions will inform the therapeutic potential of ependymal cells ow.ly/v5UF50WlHLu @isscr.org

The latest podcast has dropped. Check out Ngan Huang and Soochi Kim talking about their latest publication in stem cell reports, tinyurl.com/yvm35ec7. Listen here tinyurl.com/2njkbp7k or wherever you get your podcasts. @isscr.org @uclastemcell.bsky.social

New primary breast #organoid research from @tuftsmedschool.bsky.social published in Stem Cell Reports! DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation. #organogenesis @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social ow.ly/hxl250WlH5o

Large-scale research resource models #Alzheimers disease with high and low polygenic risk in human iPSCs. 100+ lines from patients & controls, a powerful tool to study complex AD biology. ow.ly/TeMO50WlGMv @ukdri.ac.uk @ox.ac.uk @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New study shows committed hematopoietic progenitor cells proliferate, self-renew, and can initiate myelodysplastic syndrome (MDS) in mice. #MDS #hematology #stemcells ow.ly/gvYu50WlGbX @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

@stemcellreports.bsky.social @isscr.org